Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Previous issues

Page Path
HOME > BROWSE ARTICLES > Previous issues
23 Previous issues
Filter
Filter
Article type
Keywords
Authors
Volume 32(1); March 2017
Prev issue Next issue
Namgok Lecture 2016
New Potential Targets of Glucagon-Like Peptide 1 Receptor Agonists in Pancreatic β-Cells and Hepatocytes
Won-Young Lee
Endocrinol Metab. 2017;32(1):1-5.   Published online February 6, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.1
  • 4,010 View
  • 42 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract PDFPubReader   

It is well known that both insulin resistance and decreased insulin secretory capacity are important factors in the pathogenesis of type 2 diabetes mellitus (T2DM). In addition to genetic factors, obesity and lipotoxicity can increase the risk of T2DM. Glucagon-like peptide 1 (GLP-1) receptor agonists are novel antidiabetic drugs with multiple effects. They can stimulate glucose-dependent insulin secretion, inhibit postprandial glucagon release, delay gastric emptying, and induce pancreatic β-cell proliferation. They can also reduce the weight of patients with T2DM and relieve lipotoxicity at the cellular level. Many intracellular targets of GLP-1 have been found, but more remain to be identified. Elucidating these targets could be a basis for developing new potential drugs. My colleagues and I have investigated new targets of GLP-1, with a particular focus on pancreatic β-cell lines and hepatic cell lines. Herein, I summarize the recent work from my laboratory, with profound gratitude for receiving the prestigious 2016 Namgok Award.

Citations

Citations to this article as recorded by  
  • Venom Peptides, Polyphenols and Alkaloids: Are They the Next Antidiabetics That Will Preserve β-Cell Mass and Function in Type 2 Diabetes?
    Michele Lodato, Valérie Plaisance, Valérie Pawlowski, Maxime Kwapich, Alexandre Barras, Emeline Buissart, Stéphane Dalle, Sabine Szunerits, Jérôme Vicogne, Rabah Boukherroub, Amar Abderrahmani
    Cells.2023; 12(6): 940.     CrossRef
  • Diabetes, Incretin Therapy and Thoracic Aortic Aneurysm – What Does the Evidence Show?
    Camilla Krizhanovskii , Anders Franco-Cereceda
    Current Vascular Pharmacology.2019; 17(5): 432.     CrossRef
  • Toll-like receptor 4 is necessary for glucose-dependent glucagon-like peptide-1 secretion in male mice
    Lijuan Wang, Xiandong Zhan, Zhenhui Wang, Jing Ma, Xiaotong Chang, Xiaobo Zhu
    Biochemical and Biophysical Research Communications.2019; 510(1): 104.     CrossRef
Close layer
Review Articles
The SCAP/SREBP Pathway: A Mediator of Hepatic Steatosis
Young-Ah Moon
Endocrinol Metab. 2017;32(1):6-10.   Published online January 19, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.6
  • 7,154 View
  • 201 Download
  • 71 Web of Science
  • 70 Crossref
AbstractAbstract PDFPubReader   

Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance, obesity, and dyslipidemia. NAFLD encompasses a wide range of states from the simple accumulation of triglycerides in the hepatocytes to serious states accompanied by inflammation and fibrosis in the liver. De novo lipogenesis has been shown to be a significant factor in the development of hepatic steatosis in insulin-resistant states. Sterol regulatory element binding protein-1c (SREBP-1c) is the main transcription factor that mediates the activation of lipogenesis, and SREBP cleavage activating protein (SCAP) is required for the activation of SREBPs. Here, recent animal studies that suggest SCAP as a therapeutic target for hepatic steatosis and hypertriglyceridemia are discussed.

Citations

Citations to this article as recorded by  
  • SREBPs as the potential target for solving the polypharmacy dilemma
    Xue Wang, Yanqiu Chen, Heyu Meng, Fanbo Meng
    Frontiers in Physiology.2024;[Epub]     CrossRef
  • The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis
    Preethi Chandrasekaran, Ralf Weiskirchen
    International Journal of Molecular Sciences.2024; 25(2): 1109.     CrossRef
  • Expression and correlation analysis of silent information regulator 1 (SIRT1), sterol regulatory element-binding protein-1 (SREBP1), and pyroptosis factor in gestational diabetes mellitus
    Ning Han, Xin-yuan Chang, Zi-li Yuan, Yi-zhan Wang
    The Journal of Maternal-Fetal & Neonatal Medicine.2024;[Epub]     CrossRef
  • Uxi (Endopleura uchi (Huber) Cuatrec) bark extract mitigates HFD-induced adiposity in rats via targeting oxidative stress, and lipogenic genes expression
    Eman A.R. Abdelghffar, Zuhair M. Mohammedsaleh, Raha Osailan, Aisha Elaimi, Wafae Ouchari, Mohamed A.O. Abdelfattah, Mona F. Mahmoud, Mansour Sobeh
    Journal of Functional Foods.2024; 114: 106034.     CrossRef
  • Evolutionary analysis of buffalo sterol regulatory element-binding factor (SREBF) family genes and their affection on milk traits
    Tingzhu Ye, Jing Yuan, Sayed Haidar Abbas Raza, Tingxian Deng, Lv Yang, Muhammad Jamil Ahmad, Seyed Mahdi Hosseini, Xinxin Zhang, Muna O Alamoudi, Qwait AlGabbani, Youssef S Alghamdi, Chao Chen, Aixin Liang, Nicola M. Schreurs, Liguo Yang
    Animal Biotechnology.2023; 34(7): 2082.     CrossRef
  • Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines
    Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Akifumi Kushiyama, Midori Fujishiro, Hideyuki Sakoda, Hiraku Ono, Koji Arihiro, Tomoichiro Asano
    International Journal of Molecular Sciences.2023; 24(10): 8847.     CrossRef
  • Dietary acetate promotes growth and nutrients deposition in Nile tilapia (Oreochromis niloticus) through increasing acetyl-CoA-triggered energy production
    Wen-Hao Zhou, Samwel M. Limbu, Yuan Luo, Rui-Xin Li, Jiong Ren, Fang Qiao, Mei-Ling Zhang, Zhen-Yu Du
    Aquaculture.2023; 575: 739750.     CrossRef
  • Palmitate로 유발된 비알코올성 지방간 세포 모델에서 블랙커런트 초임계 추출물의 지방증 개선효과
    수정 이, 은숙 양, 영호 김, 혜연 김, 혜란 최, 석 김, 태호 류
    Korean Journal of Food and Cookery Science.2023; 39(3): 178.     CrossRef
  • PM2.5 induced liver lipid metabolic disorders in C57BL/6J mice
    Chenxiao Zhang, Tengfei Ma, Chang Liu, Ding Ma, Jian Wang, Meng Liu, Jinjun Ran, Xueting Wang, Xiaobei Deng
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • High Gamma-Aminobutyric Acid (GABA) Oolong Tea Alleviates High-Fat Diet-Induced Metabolic Disorders in Mice
    Monthana Weerawatanakorn, Sang He, Chun-Han Chang, Yen-Chun Koh, Meei-Ju Yang, Min-Hsiung Pan
    ACS Omega.2023; 8(37): 33997.     CrossRef
  • MicroRNA-19a regulates milk fat metabolism by targeting SYT1 in bovine mammary epithelial cells
    Baojun Yu, Jiamin Liu, Zhengyun Cai, Tong Mu, Di Zhang, Xiaofang Feng, Yaling Gu, Juan Zhang
    International Journal of Biological Macromolecules.2023; 253: 127096.     CrossRef
  • SREBP Regulation of Lipid Metabolism in Liver Disease, and Therapeutic Strategies
    Na Li, Xiaodan Li, Yifu Ding, Xiao Liu, Karin Diggle, Tatiana Kisseleva, David A. Brenner
    Biomedicines.2023; 11(12): 3280.     CrossRef
  • Daidzein stimulates fatty acid-induced fat deposition in C2C12 myoblast cells via the G protein-coupled receptor 30 pathway
    Chengjian Zhou, Ping Li, Meihong Han, Xuejun Gao
    Animal Biotechnology.2022; 33(5): 851.     CrossRef
  • Hepatocyte steatosis inhibits hepatitis B virus secretion via induction of endoplasmic reticulum stress
    Qichuang Liu, Maoyuan Mu, Huan Chen, Guoyuan Zhang, Yanqing Yang, Jun Chu, Ying Li, Fangwan Yang, Shide Lin
    Molecular and Cellular Biochemistry.2022; 477(11): 2481.     CrossRef
  • The cholesterol pathway: impact on immunity and cancer
    Ryan J. King, Pankaj K. Singh, Kamiya Mehla
    Trends in Immunology.2022; 43(1): 78.     CrossRef
  • Hepatic retinaldehyde dehydrogenases are modulated by tocopherol supplementation in mice with hepatic steatosis
    Amanda D'Espessailles, Valeria Campos, Nevenka Juretić, Gladys S. Tapia, Paulina Pettinelli
    Nutrition.2022; 94: 111539.     CrossRef
  • CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing
    Han Zeng, Hong Qin, Meng Liao, Enze Zheng, Xiaoqing Luo, Anhua Xiao, Yiyu Li, Lin Chen, Li Wei, Lei Zhao, Xiong Z. Ruan, Ping Yang, Yaxi Chen
    Molecular Metabolism.2022; 57: 101428.     CrossRef
  • Biogenesis and Breakdown of Lipid Droplets in Pathological Conditions
    Claudio M. Fader Kaiser, Patricia S. Romano, M. Cristina Vanrell, Cristian A. Pocognoni, Julieta Jacob, Benjamín Caruso, Laura R. Delgui
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • Efficacy and safety of an orally administered DGAT2 inhibitor alone or coadministered with a liver-targeted ACC inhibitor in adults with non-alcoholic steatohepatitis (NASH): rationale and design of the phase II, dose-ranging, dose-finding, randomised, pl
    Neeta B Amin, Amanda Darekar, Quentin M Anstee, Vincent Wai-Sun Wong, Frank Tacke, Manoli Vourvahis, Douglas S Lee, Michael Charlton, Naim Alkhouri, Atsushi Nakajima, Carla Yunis
    BMJ Open.2022; 12(3): e056159.     CrossRef
  • Identification of microRNA Transcriptome Involved in Bovine Intramuscular Fat Deposition
    Susan K. Duckett, Maslyn A. Greene
    Frontiers in Veterinary Science.2022;[Epub]     CrossRef
  • Camellia (Camellia oleifera bel.) seed oil reprograms gut microbiota and alleviates lipid accumulation in high fat-fed mice through the mTOR pathway
    Jing Gao, Li Ma, Jie Yin, Gang Liu, Jie Ma, SiTing Xia, SaiMing Gong, Qi Han, TieJun Li, YongZhong Chen, YuLong Yin
    Food & Function.2022; 13(9): 4977.     CrossRef
  • The Perirenal Fat Thickness Was Associated with Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Mellitus
    Yuxian Yang, Shuting Li, Yuechao Xu, Jing Ke, Dong Zhao
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 1505.     CrossRef
  • Vanadium(IV)-Chlorodipicolinate Protects against Hepatic Steatosis by Ameliorating Lipid Peroxidation, Endoplasmic Reticulum Stress, and Inflammation
    Yuanli Wang, Rulong Chen, Jingyi Li, Guodong Zeng, Juntao Yuan, Jingran Su, Chunyan Wu, Zhongbing Lu, Fang Zhang, Wenjun Ding
    Antioxidants.2022; 11(6): 1093.     CrossRef
  • Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis
    Satoshi Kawamura, Yuki Matsushita, Shigeyuki Kurosaki, Mizuki Tange, Naoto Fujiwara, Yuki Hayata, Yoku Hayakawa, Nobumi Suzuki, Masahiro Hata, Mayo Tsuboi, Takahiro Kishikawa, Hiroto Kinoshita, Takuma Nakatsuka, Masaya Sato, Yotaro Kudo, Yujin Hoshida, At
    Journal of Clinical Investigation.2022;[Epub]     CrossRef
  • Baicalein Prevents Fructose-Induced Hepatic Steatosis in Rats: In the Regulation of Fatty Acid De Novo Synthesis, Fatty Acid Elongation and Fatty Acid Oxidation
    Pan Li, Ruoyu Zhang, Meng Wang, Yuwei Chen, Zhiwei Chen, Xiumei Ke, Ling Zuo, Jianwei Wang
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Identification and validation of immune related core transcription factors GTF2I in NAFLD
    Minbo Zhang, Yu Zhang, Xiaoxiao Jiao, Linying Lai, Yiting Qian, Bo Sun, Wenzhuo Yang
    PeerJ.2022; 10: e13735.     CrossRef
  • Lipid-lowering effect of microencapsulated peptides from brewer's spent grain in high-sucrose diet-fed rats
    M.R. Ferreira, A.G. Garzón, M.E. Oliva, R.E. Cian, S.R. Drago, M.E. D'Alessandro
    Food Bioscience.2022; 49: 101981.     CrossRef
  • The SREBP-dependent regulation of cyclin D1 coordinates cell proliferation and lipid synthesis
    Arwa Aldaalis, Maria T. Bengoechea-Alonso, Johan Ericsson
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Targets of statins intervention in LDL-C metabolism: Gut microbiota
    ChangXin Sun, ZePing Wang, LanQing Hu, XiaoNan Zhang, JiYe Chen, ZongLiang Yu, LongTao Liu, Min Wu
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Regulation of lipid droplet (LD) formation in hepatocytes via regulation of SREBP1c by non-coding RNAs
    Shereen A. El Sobky, Nourhan K. Aboud, Nihal M. El Assaly, Injie O. Fawzy, Nada El-Ekiaby, Ahmed I. Abdelaziz
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Aspalathin-rich green rooibos tea in combination with glyburide and atorvastatin enhances lipid metabolism in a db/db mouse model
    Oelfah Patel, Christo J. F. Muller, Elizabeth Joubert, Bernd Rosenkranz, Johan Louw, Charles Awortwe
    Frontiers in Clinical Diabetes and Healthcare.2022;[Epub]     CrossRef
  • Capparis spinosa improves non-alcoholic steatohepatitis through down-regulating SREBP-1c and a PPARα-independent pathway in high-fat diet-fed rats
    Rasoul Akbari, Hamid Yaghooti, Mohammad Taha Jalali, Laya Sadat Khorsandi, Narges Mohammadtaghvaei
    BMC Research Notes.2022;[Epub]     CrossRef
  • Gypenosides counteract hepatic steatosis and intestinal barrier injury in rats with metabolic associated fatty liver disease by modulating the adenosine monophosphate activated protein kinase and Toll-like receptor 4/nuclear factor kappa B pathways
    Shuhua Shen, Kungen Wang, Yihui Zhi, Yue Dong
    Pharmaceutical Biology.2022; 60(1): 1949.     CrossRef
  • CYP51-mediated cholesterol biosynthesis is required for the proliferation of CD4+ T cells in Sjogren’s syndrome
    Junhao Yin, Jiayao Fu, Yanxiong Shao, Jiabao Xu, Hui Li, Changyu Chen, Yijie Zhao, Zhanglong Zheng, Chuangqi Yu, Lingyan Zheng, Baoli Wang
    Clinical and Experimental Medicine.2022; 23(5): 1691.     CrossRef
  • Differential TM4SF5‐mediated SIRT1 modulation and metabolic signaling in nonalcoholic steatohepatitis progression
    Jihye Ryu, Eunmi Kim, Min‐Kyung Kang, Dae‐Geun Song, Eun‐Ae Shin, Haesong Lee, Jae Woo Jung, Seo Hee Nam, Ji Eon Kim, Hye‐Jin Kim, Taekwon Son, Semi Kim, Hwi Young Kim, Jung Weon Lee
    The Journal of Pathology.2021; 253(1): 55.     CrossRef
  • Changes in Glutathione Content in Liver Diseases: An Update
    Mariapia Vairetti, Laura Giuseppina Di Pasqua, Marta Cagna, Plinio Richelmi, Andrea Ferrigno, Clarissa Berardo
    Antioxidants.2021; 10(3): 364.     CrossRef
  • Metreleptin therapy for nonalcoholic steatohepatitis: Open-label therapy interventions in two different clinical settings
    Baris Akinci, Angela Subauste, Nevin Ajluni, Nazanene H. Esfandiari, Rasimcan Meral, Adam H. Neidert, Akin Eraslan, Rita Hench, Diana Rus, Barbara Mckenna, Hero K. Hussain, Thomas L. Chenevert, Marwan K. Tayeh, Amit R. Rupani, Jeffrey W. Innis, Christos S
    Med.2021; 2(7): 814.     CrossRef
  • Prediction of Srebp-1 as a Key Target of Qing Gan San Against MAFLD in Rats via RNA-Sequencing Profile Analysis
    Bendong Yang, Jingyue Sun, Shufei Liang, Peixuan Wu, Rui Lv, Yanping He, Deqi Li, Wenlong Sun, Xinhua Song
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake
    Miaoqing Hu, Fan Yang, Yawen Huang, Xin You, Desheng Liu, Shan Sun, Sen-Fang Sui
    Science Advances.2021;[Epub]     CrossRef
  • Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease
    Justin K. Murray, Jason Long, Lei Liu, Shivani Singh, Danielle Pruitt, Michael Ollmann, Elissa Swearingen, Miki Hardy, Oliver Homann, Bin Wu, Jerry Ryan Holder, Kelvin Sham, Brad Herberich, Mei-Chu Lo, Hui Dou, Artem Shkumatov, Monica Florio, Ingrid C. Ru
    Nucleic Acid Therapeutics.2021; 31(5): 324.     CrossRef
  • Molecular mechanism of DLBS3733, a bioactive fraction of Lagerstroemia speciosa (L.) Pers., on ameliorating hepatic lipid accumulation in HepG2 cells
    Olivia M. Tandrasasmita, Guntur Berlian, Raymond R. Tjandrawinata
    Biomedicine & Pharmacotherapy.2021; 141: 111937.     CrossRef
  • The Role of Gut Microbiota on Cholesterol Metabolism in Atherosclerosis
    Margaret Vourakis, Gaétan Mayer, Guy Rousseau
    International Journal of Molecular Sciences.2021; 22(15): 8074.     CrossRef
  • Inhibition of Atherosclerosis and Liver Steatosis by Agmatine in Western Diet-Fed apoE-Knockout Mice Is Associated with Decrease in Hepatic De Novo Lipogenesis and Reduction in Plasma Triglyceride/High-Density Lipoprotein Cholesterol Ratio
    Anna Wiśniewska, Aneta Stachowicz, Katarzyna Kuś, Magdalena Ulatowska-Białas, Justyna Totoń-Żurańska, Anna Kiepura, Kamila Stachyra, Maciej Suski, Mariusz Gajda, Jacek Jawień, Rafał Olszanecki
    International Journal of Molecular Sciences.2021; 22(19): 10688.     CrossRef
  • Therapeutic Targeting of Nonalcoholic Fatty Liver Disease by Downregulating SREBP-1C Expression via AMPK-KLF10 Axis
    Yu-Chi Chen, Rong-Jane Chen, Szu-Yuan Peng, Winston C. Y. Yu, Vincent Hung-Shu Chang
    Frontiers in Molecular Biosciences.2021;[Epub]     CrossRef
  • Regulation of Key Genes for Milk Fat Synthesis in Ruminants
    Tong Mu, Honghong Hu, Yanfen Ma, Xiaofang Feng, Juan Zhang, Yaling Gu
    Frontiers in Nutrition.2021;[Epub]     CrossRef
  • Visceral-to-Subcutaneous Abdominal Fat Ratio Is Associated with Nonalcoholic Fatty Liver Disease and Liver Fibrosis
    Chan-Hee Jung, Eun-Jung Rhee, Hyemi Kwon, Yoosoo Chang, Seungho Ryu, Won-Young Lee
    Endocrinology and Metabolism.2020; 35(1): 165.     CrossRef
  • Lipidomic profiling analysis of the phospholipid molecules in SCAP-induced lipid droplet formation in bovine mammary epithelial cells
    Liqiang Han, Kun Pang, Xiu ling Li, Juan J Loor, Guo yu Yang, Tengyun Gao
    Prostaglandins & Other Lipid Mediators.2020; 149: 106420.     CrossRef
  • Sexual Dimorphism of NAFLD in Adults. Focus on Clinical Aspects and Implications for Practice and Translational Research
    Amedeo Lonardo, Ayako Suzuki
    Journal of Clinical Medicine.2020; 9(5): 1278.     CrossRef
  • Smurf1 aggravates non‐alcoholic fatty liver disease by stabilizing SREBP‐1c in an E3 activity‐independent manner
    Xin Zhang, Yutao Zhan, Wenjun Lin, Fei Zhao, Chaojing Guo, Yujiao Chen, Mengge Du, Dongnian Li, Lingqiang Zhang, Wei An, Hong‐Rui Wang, Ping Xie
    The FASEB Journal.2020; 34(6): 7631.     CrossRef
  • Beneficial Effects of SREBP Decoy Oligodeoxynucleotide in an Animal Model of Hyperlipidemia
    Hyun-Jin An, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyemin Gu, Hyun-Ju Kim, Jaechan Leem, Sung Won Youn, Kwan-Kyu Park
    International Journal of Molecular Sciences.2020; 21(2): 552.     CrossRef
  • Lack of Augmenter of Liver Regeneration Disrupts Cholesterol Homeostasis of Liver in Mice by Inhibiting the AMPK Pathway
    Xin Wang, Ling‐yue Dong, Qu‐jing Gai, Wei‐lun Ai, Yuan Wu, Wei‐chun Xiao, Jing Zhang, Wei An
    Hepatology Communications.2020; 4(8): 1149.     CrossRef
  • HESA-A Attenuates Hepatic Steatosis in NAFLD Rat Model Through the Suppression of SREBP-1c and NF-kβ
    M. Efati, M. Khorrami, Z. Jangravi, A. Z. Mahmoudabadi, M. Raeiszadeh, J. R. Sarshoori
    International Journal of Peptide Research and Therapeutics.2020; 26(3): 1283.     CrossRef
  • Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c
    Kairui Tang, Yuanjun Deng, Chuiyang Zheng, Huan Nie, Maoxing Pan, Runsen Chen, Jiqian Xie, Qinhe Yang, Yupei Zhang
    Oxidative Medicine and Cellular Longevity.2020; 2020: 1.     CrossRef
  • (−)-Epicatechin and the comorbidities of obesity
    Eleonora Cremonini, Dario E. Iglesias, Jiye Kang, Giovanni E. Lombardo, Zahra Mostofinejad, Ziwei Wang, Wei Zhu, Patricia I. Oteiza
    Archives of Biochemistry and Biophysics.2020; 690: 108505.     CrossRef
  • microRNAs targeting cellular cholesterol: implications for combating anticancer drug resistance
    Bernice Monchusi, Mandeep Kaur
    Genes & Cancer.2020; 11(1-2): 20.     CrossRef
  • Cellular acidosis triggers human MondoA transcriptional activity by driving mitochondrial ATP production
    Blake R Wilde, Zhizhou Ye, Tian-Yeh Lim, Donald E Ayer
    eLife.2019;[Epub]     CrossRef
  • Differential Recovery Speed of Activity and Metabolic Rhythms in Rats After an Experimental Protocol of Shift-Work
    Nadia Saderi, Adrián Báez-Ruiz, Lucia E. Azuara-Álvarez, Carolina Escobar, Roberto C. Salgado-Delgado
    Journal of Biological Rhythms.2019; 34(2): 154.     CrossRef
  • Genetically modified mouse models to study hepatic neutral lipid mobilization
    Guenter Haemmerle, Achim Lass
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2019; 1865(5): 879.     CrossRef
  • Preventive effect of trans-chalcone on non-alcoholic steatohepatitis: Improvement of hepatic lipid metabolism
    Elham Karimi-Sales, Abbas Ebrahimi-Kalan, Mohammad Reza Alipour
    Biomedicine & Pharmacotherapy.2019; 109: 1306.     CrossRef
  • A new pathway to eSCAPe lipotoxicity
    Fadila Benhamed, Catherine Postic
    Clinics and Research in Hepatology and Gastroenterology.2018; 42(1): 3.     CrossRef
  • Overexpression of SREBF chaperone (SCAP) enhances nuclear SREBP1 translocation to upregulate fatty acid synthase (FASN) gene expression in bovine mammary epithelial cells
    L.Q. Han, T.Y. Gao, G.Y. Yang, J.J. Loor
    Journal of Dairy Science.2018; 101(7): 6523.     CrossRef
  • Statin use and the risk of hepatocellular carcinoma in patients at high risk: A nationwide nested case-control study
    Gyuri Kim, Suk-Yong Jang, Chung Mo Nam, Eun Seok Kang
    Journal of Hepatology.2018; 68(3): 476.     CrossRef
  • Changes of the Fatty Acid Profile in Erythrocyte Membranes of Patients following 6-Month Dietary Intervention Aimed at the Regression of Nonalcoholic Fatty Liver Disease (NAFLD)
    Dominika Maciejewska, Wojciech Marlicz, Karina Ryterska, Marcin Banaszczak, Dominika Jamioł-Milc, Ewa Stachowska
    Canadian Journal of Gastroenterology and Hepatology.2018; 2018: 1.     CrossRef
  • Systems Analysis of the Liver Transcriptome in Adult Male Zebrafish Exposed to the Plasticizer (2-Ethylhexyl) Phthalate (DEHP)
    Matthew Huff, Willian A. da Silveira, Oliana Carnevali, Ludivine Renaud, Gary Hardiman
    Scientific Reports.2018;[Epub]     CrossRef
  • Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division
    Andreas Bickert, Paul Kern, Martina van Uelft, Stefanie Herresthal, Thomas Ulas, Katharina Gutbrod, Bernadette Breiden, Joachim Degen, Konrad Sandhoff, Joachim L. Schultze, Peter Dörmann, Dieter Hartmann, Reinhard Bauer, Klaus Willecke
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2018; 1863(7): 734.     CrossRef
  • Paradoxical Protective Effect of Perfluorooctanesulfonic Acid Against High-Fat Diet–Induced Hepatic Steatosis in Mice
    Ian Huck, Kevin Beggs, Udayan Apte
    International Journal of Toxicology.2018; 37(5): 383.     CrossRef
  • Developmental and extrahepatic physiological functions of SREBP pathway genes in mice
    Luke J. Engelking, Mary Jo Cantoria, Yanchao Xu, Guosheng Liang
    Seminars in Cell & Developmental Biology.2018; 81: 98.     CrossRef
  • Herbacetin, a flaxseed flavonoid, ameliorates high percent dietary fat induced insulin resistance and lipid accumulation through the regulation of hepatic lipid metabolizing and lipid-regulating enzymes
    Chinnadurai Veeramani, Mohammed A. Alsaif, Khalid S. Al-Numair
    Chemico-Biological Interactions.2018; 288: 49.     CrossRef
  • Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals
    Giuseppe Della Pepa, Claudia Vetrani, Gianluca Lombardi, Lutgarda Bozzetto, Giovanni Annuzzi, Angela Rivellese
    Nutrients.2017; 9(10): 1065.     CrossRef
  • MDG-1, a Potential Regulator of PPARα and PPARγ, Ameliorates Dyslipidemia in Mice
    Xu Wang, Linlin Shi, Sun Joyce, Yuan Wang, Yi Feng
    International Journal of Molecular Sciences.2017; 18(9): 1930.     CrossRef
Close layer
Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation
Minsang Shin, Hye Suk Kang, Jae-Hyung Park, Jae-Hoon Bae, Dae-Kyu Song, Seung-Soon Im
Endocrinol Metab. 2017;32(1):11-17.   Published online January 19, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.11
  • 4,697 View
  • 64 Download
  • 20 Web of Science
  • 23 Crossref
AbstractAbstract PDFPubReader   

Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region.

Citations

Citations to this article as recorded by  
  • Predictive potential of various plasma inflammation-, angiogenesis-, and extracellular matrix remodeling-associated mediators for intra-amniotic inflammation and/or microbial invasion of the amniotic cavity in preterm labor
    Eunwook Joo, Subeen Hong, Kyo Hoon Park, Hyeon Ji Kim, Min Jung Lee, Sue Shin
    Archives of Gynecology and Obstetrics.2024;[Epub]     CrossRef
  • Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis
    Chiahsuan Chin, Ranjithkumar Ravichandran, Kristina Sanborn, Timothy Fleming, Stephen B. Wheatcroft, Mark T. Kearney, Sofya Tokman, Rajat Walia, Michael A. Smith, David J. Flint, Thalachallour Mohanakumar, Ross M. Bremner, Angara Sureshbabu
    Cell Reports Medicine.2023; 4(3): 100945.     CrossRef
  • Circulating IGF-1 and IGFBP-2 may be biomarkers for risk stratification in patients with acute coronary syndrome: A prospective cohort study
    Wei Wang, Ying Sun, De-Gang Mo, Tai Li, Heng-Chen Yao
    Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(9): 1740.     CrossRef
  • Receptor Tyrosine Kinase: Still an Interesting Target to Inhibit the Proliferation of Vascular Smooth Muscle Cells
    Yilin Xiong, Yan Wang, Tao Yang, Yunmei Luo, Shangfu Xu, Lisheng Li
    American Journal of Cardiovascular Drugs.2023; 23(5): 497.     CrossRef
  • Octopus death and dying
    Z Yan Wang
    Integrative And Comparative Biology.2023; 63(6): 1209.     CrossRef
  • Efficient generation of functional pancreatic β cells from dental-derived stem cells via laminin-induced differentiation
    Riham M. Aly, Hadeer A. Aglan, Ghada Nour Eldeen, Nadia S. Mahmoud, Eman H. Aboul-Ezz, Hanaa H. Ahmed
    Journal of Genetic Engineering and Biotechnology.2022; 20(1): 85.     CrossRef
  • Insulin-like growth factor signalling and its significance as a biomarker in fish and shellfish research
    S. Chandhini, Bushra Trumboo, Seena Jose, Tincy Varghese, M. Rajesh, V. J. Rejish Kumar
    Fish Physiology and Biochemistry.2021; 47(4): 1011.     CrossRef
  • Nanomaterials for Chronic Kidney Disease Detection
    Solmaz Maleki Dizaj, Aziz Eftekhari, Shakar Mammadova, Elham Ahmadian, Mohammadreza Ardalan, Soodabeh Davaran, Aygun Nasibova, Rovshan Khalilov, Mahbuba Valiyeva, Sevil Mehraliyeva, Ebrahim Mostafavi
    Applied Sciences.2021; 11(20): 9656.     CrossRef
  • Producción de las proteínas de unión al factor de crecimiento insulinoide durante el desarrollo de la fibrosis hepática por hepatitis C crónica
    D. Rosique-Oramas, M. Martínez-Castillo, A. Raya, Z. Medina-Ávila, F. Aragón, J. Limón-Castillo, A. Hernández-Barragán, A. Santoyo, E. Montalvo-Javé, J.L. Pérez-Hernández, F. Higuera-de la Tijera, A. Torre, D. Kershenobich, G. Gutiérrez-Reyes
    Revista de Gastroenterología de México.2020; 85(4): 390.     CrossRef
  • Interacción cardiorrenal y evolución de la insuficiencia cardiaca. ¿Tiene un papel la proteína de unión del factor de crecimiento de tipo insulina 2?
    Susana Ravassa, Javier Beaumont, Germán Cediel, Josep Lupón, Begoña López, Ramón Querejeta, Javier Díez, Antoni Bayés-Genís, Arantxa González
    Revista Española de Cardiología.2020; 73(10): 835.     CrossRef
  • Molecular identification of grass carp igfbp2 and the effect of glucose, insulin, and glucagon on igfbp2 mRNA expression
    Guokun Yang, Wenli Zhao, Chaobin Qin, Liping Yang, Xiaolin Meng, Ronghua Lu, Xiao Yan, Xianglin Cao, Yanmin Zhang, Guoxing Nie
    Fish Physiology and Biochemistry.2020; 46(4): 1469.     CrossRef
  • Production of insulin-like growth factor-binding proteins during the development of hepatic fibrosis due to chronic hepatitis C
    D. Rosique-Oramas, M. Martínez-Castillo, A. Raya, Z. Medina-Ávila, F. Aragón, J. Limón-Castillo, A. Hernández-Barragán, A. Santoyo, E. Montalvo-Javé, J.L. Pérez-Hernández, F. Higuera-de la Tijera, A. Torre, D. Kershenobich, G. Gutiérrez-Reyes
    Revista de Gastroenterología de México (English Edition).2020; 85(4): 390.     CrossRef
  • Cardiorenal interaction and heart failure outcomes. A role for insulin-like growth factor binding protein 2?
    Susana Ravassa, Javier Beaumont, Germán Cediel, Josep Lupón, Begoña López, Ramón Querejeta, Javier Díez, Antoni Bayés-Genís, Arantxa González
    Revista Española de Cardiología (English Edition).2020;[Epub]     CrossRef
  • Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes
    Emanuele Bosi, Lorella Marselli, Carmela De Luca, Mara Suleiman, Marta Tesi, Mark Ibberson, Decio L Eizirik, Miriam Cnop, Piero Marchetti
    NAR Genomics and Bioinformatics.2020;[Epub]     CrossRef
  • Transcriptional Analysis of FOXO1, C/EBP- and PPAR-2 Genes and Their association with Obesity-Related Insulin Resistance
    Boughanem, Cabrera-Mulero, Millán-Gómez, Garrido-Sánchez, Cardona, Tinahones, Moreno-Santos, Macías-González
    Genes.2019; 10(9): 706.     CrossRef
  • Immune biomarkers in maternal plasma to identify histologic chorioamnionitis in women with preterm labor
    Jeong Woo Park, Kyo Hoon Park, Song Yi Kook, Young Mi Jung, Yu Mi Kim
    Archives of Gynecology and Obstetrics.2019; 299(3): 725.     CrossRef
  • Insulin like growth factor binding protein 2 (IGFBP-2) for risk prediction in patients with severe aortic stenosis undergoing Transcatheter Aortic Valve Implantation (TAVI)
    Johanna Maria Muessig, Michael Lichtenauer, Bernhard Wernly, Malte Kelm, Marcus Franz, Laura Bäz, Paul Christian Schulze, Victoria Racher, Georg Zimmermann, Hans-Reiner Figulla, Vera Paar, Uta C. Hoppe, Philippe Rouet, Alexander Lauten, Christian Jung
    International Journal of Cardiology.2019; 277: 54.     CrossRef
  • Molecular cloning and expression pattern of IGFBP-2a in black porgy (Acanthopagrus schlegelii) and evolutionary analysis of IGFBP-2s in the species of Perciformes
    Xinyi Zhang, Zhiyong Zhang, Zhenpeng Yu, Jiayi Li, Shuyin Chen, Ruijian Sun, Chaofeng Jia, Fei Zhu, Qian Meng, Shixia Xu
    Fish Physiology and Biochemistry.2019; 45(5): 1731.     CrossRef
  • Current Insights into the Role of the Growth Hormone-Insulin-Like Growth Factor System in Short Children Born Small for Gestational Age
    Judith S. Renes, Jaap van Doorn, Anita C.S. Hokken-Koelega
    Hormone Research in Paediatrics.2019; 92(1): 15.     CrossRef
  • Insulin-Like Growth Factor (IGF) System in Liver Diseases
    Agnieszka Adamek, Aldona Kasprzak
    International Journal of Molecular Sciences.2018; 19(5): 1308.     CrossRef
  • IGFBP2 is a potential biomarker in acute kidney injury (AKI) and resveratrol-loaded nanoparticles prevent AKI
    Hai-Lun Li, Zhuan Yan, Zun-Ping Ke, Xiao-Feng Tian, Li-Li Zhong, Yong-Tao Lin, Yong Xu, Dong-Hui Zheng
    Oncotarget.2018; 9(93): 36551.     CrossRef
  • Multiple optic gland signaling pathways implicated in octopus maternal behaviors and death
    Z. Yan Wang, Clifton W. Ragsdale
    Journal of Experimental Biology.2018;[Epub]     CrossRef
  • Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes
    Daniel Garcia de la Serrana, Daniel J. Macqueen
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
Close layer
A Simple Outline of Methods for Protein Isolation and Purification
Chang-Hun Lee
Endocrinol Metab. 2017;32(1):18-22.   Published online February 28, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.18
  • 12,274 View
  • 234 Download
  • 17 Web of Science
  • 19 Crossref
AbstractAbstract PDFPubReader   

At the summer workshop of the Korean Endocrine Society held in 2016, some examples of protein experiments were discussed in the session entitled “All about working with proteins.” In contrast to what the title suggested, it was unrealistic to comprehensively discuss all protein analytical methods. Therefore, the goal was to outline protein experimental techniques that are useful in research or in bench work. In conversations with clinicians, however, I have always felt that researchers who do not engage in bench science have different demands than those who do. Protein research tools that are useful in bench science may not be very useful or effective in the diagnostic field. In this paper, I provide a general summary of the protein analytical methods that are used in basic scientific research, and describe how they can be applied in the diagnostic field.

Citations

Citations to this article as recorded by  
  • Functional Properties of Moringa Oleifera Protein Isolates as Influenced by Different Isolation Techniques, pH, and Ionic Strength
    Kirsty A. Illingworth, Yee Ying Lee, Lee Fong Siow
    Food and Bioprocess Technology.2024;[Epub]     CrossRef
  • Evolving Paradigms of Recombinant Protein Production in Pharmaceutical Industry: A Rigorous Review
    Achuth Jayakrishnan, Wan Rosalina Wan Rosli, Ahmad Rashidi Mohd Tahir, Fashli Syafiq Abd Razak, Phei Er Kee, Hui Suan Ng, Yik-Ling Chew, Siew-Keah Lee, Mahenthiran Ramasamy, Ching Siang Tan, Kai Bin Liew
    Sci.2024; 6(1): 9.     CrossRef
  • Functional Studies of Cytogenotoxic Potential of Laticifer Proteins of Calotropis procera against Viral Disease
    Uzma Saher, Muhammad Ovais Omer, Aqeel Javeed, Aftab Ahmad Anjum, Kanwal Rehman, Tanzeela Awan, Gulbeena Saleem, Ameena Mobeen
    ACS Omega.2023; 8(7): 7119.     CrossRef
  • Advances and key considerations of liquid chromatography–mass spectrometry for porcine authentication in halal analysis
    Kifayati Rosiyanti Dewi, Maya Ismayati, Nissa Nurfajrin Solihat, Nancy Dewi Yuliana, Feri Kusnandar, Handy Riantana, Heryani Heryani, Abdul Halim, Thamina Acter, Nizam Uddin, Sunghwan Kim
    Journal of Analytical Science and Technology.2023;[Epub]     CrossRef
  • A Path to Protein Quantitation: PBMCs to Western Blot
    Sufaya Jameel, Parveen Jahan, Subbiah Ramasamy
    International Journal of Methodology.2023; 2(1): 12.     CrossRef
  • Obtención y caracterización de un hidrolizado de proteína de Vigna radiata L. (frijol mungo) con potencial Bioestimulante
    F.C. Arámbula-Castillo, M. Zegbe-Rodríguez, C. Rivas-Morales, D.G. García-Hernández , E.D. Cabello-Ruiz
    Investigación y Desarrollo en Ciencia y Tecnología de Alimentos.2023; 8(1): 170.     CrossRef
  • Optimization and evaluation of tear protein elution from Schirmer’s strips in dry eye disease
    Madhuri Amulya Koduri, Deeksha Prasad, Tejaswini Pingali, Vijay Kumar Singh, Swapna S Shanbhag, Sayan Basu, Vivek Singh
    Indian Journal of Ophthalmology.2023; 71(4): 1413.     CrossRef
  • Actinobacillus pleuropneumoniae, surface proteins and virulence: a review
    María M. Soto Perezchica, Alma L. Guerrero Barrera, Francisco J. Avelar Gonzalez, Teodulo Quezada Tristan, Osvaldo Macias Marin
    Frontiers in Veterinary Science.2023;[Epub]     CrossRef
  • Emerging on‐chip electrokinetic based technologies for purification of circulating cancer biomarkers towards liquid biopsy: A review
    Leilei Shi, Leyla Esfandiari
    ELECTROPHORESIS.2022; 43(1-2): 288.     CrossRef
  • Mag-spinner: a next-generation Facile, Affordable, Simple, and porTable (FAST) magnetic separation system
    Sanghoon Lee, Miseon Jeong, Soojin Lee, Sang Hun Lee, Jin-sil Choi
    Nanoscale Advances.2022; 4(3): 792.     CrossRef
  • Leveraging multiomics approaches for producing lignocellulose degrading enzymes
    Kavya Dashora, Meghana Gattupalli, Zoya Javed, Gyan Datta Tripathi, Ruchi Sharma, Mansi Mishra, Atul Bhargava, Shilpi Srivastava
    Cellular and Molecular Life Sciences.2022;[Epub]     CrossRef
  • Mass spectrometric profiling of tryptic digests of trifluoroethanol extracts from core needle biopsies of breast cancer tissues is a viable sample screening tool for biomarker discovery
    Prarthana Gopinath, Gopal Gopisetty, Sridevi Veluswami, Shirley Sundersingh, Rajkumar Thangarajan
    Journal of Proteins and Proteomics.2022; 13(2): 79.     CrossRef
  • The effect of isolation techniques on the physicochemical properties of Moringa oleifera protein isolates
    Kirsty A. Illingworth, Yee Ying Lee, Lee Fong Siow
    Food Chemistry Advances.2022; 1: 100029.     CrossRef
  • Physical, Chemical and Biochemical Modification Approaches of Potato (Peel) Constituents for Bio-Based Food Packaging Concepts: A Review
    Katharina Miller, Corina L. Reichert, Markus Schmid, Myriam Loeffler
    Foods.2022; 11(18): 2927.     CrossRef
  • Identification of transient receptor potential melastatin 3 proteotypic peptides employing an efficient membrane protein extraction method for natural killer cells
    Chandi T. Magawa, Natalie Eaton-Fitch, Cassandra Balinas, Etianne Martini Sasso, Kiran Thapaliya, Leighton Barnden, Rebekah Maksoud, Breanna Weigel, Penny A. Rudd, Lara J. Herrero, Sonya Marshall-Gradisnik
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Comparative Analysis of Universal Protein Extraction Methodologies for Screening of Lipase Activity from Agricultural Products
    Jisu Ha, Jun-Young Park, Yoonseok Choi, Pahn-Shick Chang, Kyung-Min Park
    Catalysts.2021; 11(7): 816.     CrossRef
  • Solid-Phase Peptide Capture and Release for Bulk and Single-Molecule Proteomics
    Cecil J. Howard, Brendan M. Floyd, Angela M. Bardo, Jagannath Swaminathan, Edward M. Marcotte, Eric V. Anslyn
    ACS Chemical Biology.2020; 15(6): 1401.     CrossRef
  • A flexible, robust microbead-based assay for quantification and normalization of target protein concentrations
    Eric J. Snider, Alexandra R. Crowley, Julia Raykin, R. Kijoon Kim, Fiona Splaine, C. Ross Ethier
    Analytical Biochemistry.2020; 590: 113510.     CrossRef
  • Applications of Converged Various Forces for Detection of Biomolecules and Novelty of Dielectrophoretic Force in the Applications
    Seungjun Lee, Seong Min Roh, Eunji Lee, Yejin Park, Byung Chul Lee, Youngeun Kwon, Hye Jin Kim, Jinsik Kim
    Sensors.2020; 20(11): 3242.     CrossRef
Close layer
Acute Hyperglycemia Associated with Anti-Cancer Medication
Yul Hwangbo, Eun Kyung Lee
Endocrinol Metab. 2017;32(1):23-29.   Published online March 20, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.23
  • 5,968 View
  • 124 Download
  • 41 Web of Science
  • 43 Crossref
AbstractAbstract PDFPubReader   

Hyperglycemia during chemotherapy occurs in approximately 10% to 30% of patients. Glucocorticoids and L-asparaginase are well known to cause acute hyperglycemia during chemotherapy. Long-term hyperglycemia is also frequently observed, especially in patients with hematologic malignancies treated with L-asparaginase-based regimens and total body irradiation. Glucocorticoid-induced hyperglycemia often develops because of increased insulin resistance, diminished insulin secretion, and exaggerated hepatic glucose output. Screening strategies for this condition include random glucose testing, hemoglobin A1c testing, oral glucose loading, and fasting plasma glucose screens. The management of hyperglycemia starts with insulin or sulfonylurea, depending on the type, dose, and delivery of the glucocorticoid formulation. Mammalian target of rapamycin (mTOR) inhibitors are associated with a high incidence of hyperglycemia, ranging from 13% to 50%. Immunotherapy, such as anti-programmed death 1 (PD-1) antibody treatment, induces hyperglycemia with a prevalence of 0.1%. The proposed mechanism of immunotherapy-induced hyperglycemia is an autoimmune process (insulitis). Withdrawal of the PD-1 inhibitor is the primary treatment for severe hyperglycemia. The efficacy of glucocorticoid therapy is not fully established and the decision to resume PD-1 inhibitor therapy depends on the severity of the hyperglycemia. Diabetic patients should achieve optimized glycemic control before initiating treatment, and glucose levels should be monitored periodically in patients initiating mTOR inhibitor or PD-1 inhibitor therapy. With regard to hyperglycemia caused by anti-cancer therapy, frequent monitoring and proper management are important for promoting the efficacy of anti-cancer therapy and improving patients' quality of life.

Citations

Citations to this article as recorded by  
  • Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis
    Christian M. Cohrs, Chunguang Chen, Mark A. Atkinson, Denise M. Drotar, Stephan Speier
    Diabetes.2024; 73(1): 11.     CrossRef
  • Assessment of metabolic syndrome parameters in pediatric acute lymphoblastic leukemia survivors
    Ömer Kartal, Orhan Gürsel
    Indian Journal of Cancer.2023; 60(3): 325.     CrossRef
  • Increased risk of incident diabetes after therapy with immune checkpoint inhibitor compared with conventional chemotherapy: A longitudinal trajectory analysis using a tertiary care hospital database
    Minyoung Lee, Kyeongseob Jeong, Yu Rang Park, Yumie Rhee
    Metabolism.2023; 138: 155311.     CrossRef
  • Analysis of the Incidence of Type 2 Diabetes, Requirement of Insulin Treatment, and Diabetes-Related Complications among Patients with Cancer
    Su Jung Lee, Chulho Kim, Hyunjae Yu, Dong-Kyu Kim
    Cancers.2023; 15(4): 1094.     CrossRef
  • A Case of Pembrolizumab-Induced Diabetic Ketoacidosis and Hyperthyroidism in a Patient With Recurrent Esophageal Adenocarcinoma
    Jonathan Salangsang, Surendra Sapkota, Sanjeev Kharel, Prakash Gupta, Abhishek Kalla
    Cureus.2023;[Epub]     CrossRef
  • Link between Blood Cell-Associated Inflammatory Indices and Chemotherapy-Induced Hyperglycemia in Women Affected with Breast Cancer: Clinical Studies
    Krishna Prasad, Suresh Rao, Sanath Kumar Hegde, Thomas George, Rhea Katherine D'souza, Sucharitha Suresh, Manjeshwar Shrinath Baliga
    South Asian Journal of Cancer.2023; 12(02): 118.     CrossRef
  • Insulin resistance in patients with cancer: a systematic review and meta-analysis
    Joan M. Màrmol, Michala Carlsson, Steffen H. Raun, Mia K. Grand, Jonas Sørensen, Louise Lang Lehrskov, Erik A. Richter, Ole Norgaard, Lykke Sylow
    Acta Oncologica.2023; 62(4): 364.     CrossRef
  • Metabolic obesity phenotypes and obesity‐related cancer risk in the National Health and Nutrition Examination Survey
    Maci Winn, Prasoona Karra, Heinz Freisling, Marc J. Gunter, Benjamin Haaland, Michelle L. Litchman, Jennifer A. Doherty, Mary C. Playdon, Sheetal Hardikar
    Endocrinology, Diabetes & Metabolism.2023;[Epub]     CrossRef
  • Effects of Vitamin Intake on Blood Glucose in Cancer Patients Undergoing Chemotherapy: Quantitative and Descriptive Research
    Ji Yeong Kim, Kyung Hee Lim
    Korean Journal of Adult Nursing.2023; 35(2): 148.     CrossRef
  • Oncologists’ responsibility, comfort, and knowledge managing hyperglycemia in patients with cancer undergoing chemotherapy: a cross sectional study
    Teresa M. Salgado, Rotana M. Radwan, Erin Hickey Zacholski, Emily Mackler, Tonya M. Buffington, Kerri T. Musselman, William J. Irvin, Jennifer M. Perkins, Trang N. Le, Dave L. Dixon, Karen B. Farris, Vanessa B. Sheppard, Resa M. Jones
    Supportive Care in Cancer.2023;[Epub]     CrossRef
  • Diabetes management in cancer patients. An Italian Association of Medical Oncology, Italian Association of Medical Diabetologists, Italian Society of Diabetology, Italian Society of Endocrinology and Italian Society of Pharmacology multidisciplinary conse
    N. Silvestris, T. Franchina, M. Gallo, A. Argentiero, A. Avogaro, G. Cirino, A. Colao, R. Danesi, G. Di Cianni, S. D’Oronzo, A. Faggiano, S. Fogli, D. Giuffrida, S. Gori, N. Marrano, R. Mazzilli, M. Monami, M. Montagnani, L. Morviducci, A. Natalicchio, A.
    ESMO Open.2023; 8(6): 102062.     CrossRef
  • Prognostic Factors for Hyperglycemia in Patients Receiving Chemotherapy
    Jiyeong Kim, Kyung Hee Lim
    Cancer Nursing.2023;[Epub]     CrossRef
  • Severe Insulin Resistance in a Patient Treated With Nivolumab and Brentuximab-Vedotin for Hodgkin Lymphoma
    Elif Tama, Meghan Black, Muhamad Alhaj Moustafa, Maria D Hurtado
    JCEM Case Reports.2023;[Epub]     CrossRef
  • A New Hypothesis Describing the Pathogenesis of Oral Mucosal Injury Associated with the Mammalian Target of Rapamycin (mTOR) Inhibitors
    Stephen T. Sonis, Alessandro Villa
    Cancers.2023; 16(1): 68.     CrossRef
  • Management of Phosphatidylinositol-3-Kinase Inhibitor-Associated Hyperglycemia
    Marcus D. Goncalves, Azeez Farooki
    Integrative Cancer Therapies.2022; 21: 153473542110731.     CrossRef
  • Metformin Induced Cognitive Impairment and Neuroinflammation in CMF-Treated Rats
    Ahmad H. Alhowai, Yasser Almogbel, Ahmed A.H. Abdel, Maha A. Aldubay, Hani A. Alfheeaid, Shatha G. Felemban, Sridevi Chigurupat, Ibrahim F. Alharbi, Hindi S. Alharbi
    International Journal of Pharmacology.2022; 18(2): 228.     CrossRef
  • Glucose Influences the Response of Glioblastoma Cells to Temozolomide and Dexamethasone
    Anna M Bielecka-Wajdman, Tomasz Ludyga, Daria Smyk, Wojciech Smyk, Magdalena Mularska, Patrycja Świderek, Wojciech Majewski, Christina Susanne Mullins, Michael Linnebacher, Ewa Obuchowicz
    Cancer Control.2022; 29: 107327482210754.     CrossRef
  • Cardiometabolic Comorbidities in Cancer Survivors
    Leah L. Zullig, Anthony D. Sung, Michel G. Khouri, Shelley Jazowski, Nishant P. Shah, Andrea Sitlinger, Dan V. Blalock, Colette Whitney, Robin Kikuchi, Hayden B. Bosworth, Matthew J. Crowley, Karen M. Goldstein, Igor Klem, Kevin C. Oeffinger, Susan Dent
    JACC: CardioOncology.2022; 4(2): 149.     CrossRef
  • Glucose deprivation reduces proliferation and motility, and enhances the anti-proliferative effects of paclitaxel and doxorubicin in breast cell lines in vitro
    Maitham A. Khajah, Sarah Khushaish, Yunus A. Luqmani, Yi-Hsien Hsieh
    PLOS ONE.2022; 17(8): e0272449.     CrossRef
  • Gemigliptin exerts protective effects against doxorubicin-induced hepatotoxicity by inhibiting apoptosis via the regulation of fibroblast growth factor 21 expression
    Kyeong-Min Lee, Yeo Jin Hwang, Gwon-Soo Jung
    Biochemical and Biophysical Research Communications.2022; 626: 135.     CrossRef
  • Glucocorticoid-Induced Hyperglycemia in Oncologic Outpatients: A Narrative Review Using the Quadruple Aim Framework
    Ihab Kandil, Erin Keely
    Canadian Journal of Diabetes.2022; 46(7): 730.     CrossRef
  • Real-World Experience of Monitoring Practice of Endocrinopathies Associated with the Use of Novel Targeted Therapies among Patients with Solid Tumors
    Atika AlHarbi, Majed Alshamrani, Mansoor Khan, Abdelmajid Alnatsheh, Mohammed Aseeri
    Medical Sciences.2022; 10(4): 65.     CrossRef
  • The Assessment of the Hypothalamic-Pituitary-Adrenal Axis After Oncological Treatment in Pediatric Patients with Acute Lymphoblastic Leukemia
    Barbara Hull, Anna Wedrychowicz, Magdalena Ossowska, Aleksandra Furtak, Joanna Badacz, Szymon Skoczeń, Jerzy B. Starzyk
    Journal of Clinical Research in Pediatric Endocrinology.2022; 14(4): 393.     CrossRef
  • Targeting Mitochondria and Oxidative Stress in Cancer- and Chemotherapy-Induced Muscle Wasting
    Joshua R. Huot, Dryden Baumfalk, Aridai Resendiz, Andrea Bonetto, Ashley J. Smuder, Fabio Penna
    Antioxidants & Redox Signaling.2022;[Epub]     CrossRef
  • Onkodiabetológia III.
    Róbert János Bánhegyi, Blanka Veréb, Andrea Gazdag, Beatrix Rácz, Róbert Wagner, Norbert Fülöp, Béla Pikó
    Orvosi Hetilap.2022; 163(41): 1614.     CrossRef
  • Economic burden of diabetes among medicare beneficiaries with cancer
    Cassidi C McDaniel, F Ellen Loh, Devan M Rockwell, Courtney P McDonald, Chiahung Chou
    Journal of Pharmaceutical Health Services Research.2021; 12(2): 142.     CrossRef
  • The prognostic outcome of ‘type 2 diabetes mellitus and breast cancer’ association pivots on hypoxia-hyperglycemia axis
    Ilhaam Ayaz Durrani, Attya Bhatti, Peter John
    Cancer Cell International.2021;[Epub]     CrossRef
  • Increased risk of diabetes in cancer survivors: a pooled analysis of 13 population-based cohort studies
    Y. Xiao, H. Wang, Y. Tang, J. Yan, L. Cao, Z. Chen, Z. Shao, Z. Mei, Z. Jiang
    ESMO Open.2021; 6(4): 100218.     CrossRef
  • Sublethal concentrations of high glucose prolong mitotic arrest in a spindle assembly checkpoint activity dependent manner in budding yeast
    Pinar B. Thomas, Elif E. Cavusoglu, Nur Kaluc
    Biologia.2021; 76(12): 3883.     CrossRef
  • Hyperglycemia in Childhood Acute Lymphoblastic Leukemia During Induction Chemotherapy
    Nengcy Erlina Tasik Rerung, Andi Cahyadi, Nur Rochmah, Maria Christina Shanty Larasati, Mia Ratwita Andarsini, Muhammad Faizi, IDG Ugrasena, Bambang Permono
    MEDICINUS.2021; 34(1): 18.     CrossRef
  • Effect of Acute Chemotherapy on Glucose Levels in Rats
    Ahmad H. Alhowail, Gena S. Alfawzan, Maha A. Aldubayan, Lolwah S. Alsalam
    International Journal of Pharmacology.2020; 16(3): 276.     CrossRef
  • Predictors of Disease Progression or Performance Status Decline in Patients Undergoing Neoadjuvant Therapy for Localized Pancreatic Head Adenocarcinoma
    Alessandro Paniccia, Ana L. Gleisner, Mazen S. Zenati, Amr I. Al Abbas, Jae Pil Jung, Nathan Bahary, Kenneth K. W. Lee, David Bartlett, Melissa E. Hogg, Herbert J. Zeh, Amer H. Zureikat
    Annals of Surgical Oncology.2020; 27(8): 2961.     CrossRef
  • Fasting to enhance Cancer treatment in models: the next steps
    Jing Zhang, Yanlin Deng, Bee Luan Khoo
    Journal of Biomedical Science.2020;[Epub]     CrossRef
  • Concurrent diabetic ketoacidosis and pancreatitis in Paediatric acute lymphoblastic leukemia receiving L-asparaginase
    Patel Zeeshan Jameel, Sham Lohiya, Amol Dongre, Sachin Damke, Bhavana B. Lakhkar
    BMC Pediatrics.2020;[Epub]     CrossRef
  • Hyperglycemia during Adjuvant Chemotherapy as a Prognostic Factor in Breast Cancer Patients without Diabetes
    Ha Rim Ahn, Sang Yull Kang, Hyun Jo Youn, Sung Hoo Jung
    Journal of Breast Cancer.2020; 23(4): 398.     CrossRef
  • Side effects of adjuvant chemotherapy and their impact on outcome in elderly breast cancer patients: a cohort study
    Valentina Zanuso, Vittorio Fregoni, Lorenzo Gervaso
    Future Science OA.2020; : FSO617.     CrossRef
  • Incidence of Hyperglycemia/Secondary Diabetes in Women who have Undergone Curative Chemotherapy for Breast Cancer: First Study from India
    Suresh Rao, Krishna Prasad, Soniya Abraham, Thomas George, Supreeth Kakkaje Chandran, Manjeshwar Shrinath Baliga
    South Asian Journal of Cancer.2020; 09(03): 130.     CrossRef
  • Hyperglycemic ADR Distribution of Doxorubicin From VigiBase
    Jincheng Yang, Jun Yang
    American Journal of Therapeutics.2019; 26(3): e428.     CrossRef
  • Hyperglycemia During Childhood Cancer Therapy: Incidence, Implications, and Impact on Outcomes
    Allison Grimes, Ashraf Mohamed, Jenna Sopfe, Rachel Hill, Jane Lynch
    JNCI Monographs.2019; 2019(54): 132.     CrossRef
  • Steroid-induced diabetes in cancer patients
    Gemma Dinn
    Journal of Prescribing Practice.2019; 1(12): 610.     CrossRef
  • Risk Factors for Doxorubicin-Induced Serious Hyperglycaemia-Related Adverse Drug Reactions
    Jincheng Yang, Yu Wang, Kang Liu, Wen Yang, Jianying Zhang
    Diabetes Therapy.2019; 10(5): 1949.     CrossRef
  • Effect of glucose and palmitate environment on proliferation and migration of PC3‐prostate cancer cells
    Lívia Prometti Rezende, Maria Raquel Unterkircher Galheigo, Breno Costa Landim, Amanda Rodrigues Cruz, Françoise Vasconcelos Botelho, Renata Graciele Zanon, Rejane Maira Góes, Daniele Lisboa Ribeiro
    Cell Biology International.2019; 43(4): 373.     CrossRef
  • Incidence of Diabetes After Cancer Development
    Yul Hwangbo, Danbee Kang, Minwoong Kang, Saemina Kim, Eun Kyung Lee, Young Ae Kim, Yoon Jung Chang, Kui Son Choi, So-Youn Jung, Sang Myung Woo, Jin Seok Ahn, Sung Hoon Sim, Yun Soo Hong, Roberto Pastor-Barriuso, Eliseo Guallar, Eun Sook Lee, Sun-Young Kon
    JAMA Oncology.2018; 4(8): 1099.     CrossRef
Close layer
Prevalence and Clinical Characteristics of Dyslipidemia in Koreans
Jee-Sun Jeong, Hyuk-Sang Kwon
Endocrinol Metab. 2017;32(1):30-35.   Published online March 20, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.30
  • 4,749 View
  • 45 Download
  • 22 Web of Science
  • 24 Crossref
AbstractAbstract PDFPubReader   

The prevalence of hypercholesterolemia in Koreans 30 years old and over was 19.5% in 2015 according to the Korean Nutrition and Health Examination Survey, which means that one-fifth of adults had hypercholesterolemia. The prevalence of hypertriglyceridemia in adults 30 years of age and older was 16.8% in 2015, and men had a 2-fold higher prevalence of hypertriglyceridemia than women (23.9% vs. 10.4%). The awareness of hypercholesterolemia in Koreans was higher in women than among men (62.4% vs. 51.4%). It increased with age; the level of awareness in participants 30 to 49 years of age (32.1% in men and 32.6% in women) was less than half of that observed among respondents ≥65 years old (77.5% in men and 78.0% in women). Regular check-ups for dyslipidemia and the active management thereof are urgent in Korean men aged 30 to 49. In women, the perimenopausal period is crucial for the prevention and management of metabolic syndrome, including dyslipidemia. Overall, improvements in awareness and treatment in the age group of 30 to 49 years in both men and women remain necessary.

Citations

Citations to this article as recorded by  
  • Association between weekend catch-up sleep and dyslipidemia among Korean workers
    Ye Seul Jang, Yu Shin Park, Kyungduk Hurh, Eun-Cheol Park, Sung-In Jang
    Scientific Reports.2023;[Epub]     CrossRef
  • The association between meat intake and the risk of coronary heart disease in Korean men using the Framingham risk score: A prospective cohort study
    Jiwon Jeong, Kyungjoon Lim, Sangah Shin
    Nutrition, Metabolism and Cardiovascular Diseases.2023; 33(6): 1158.     CrossRef
  • A Paradigm Shift in Dyslipidemia Management in Primary Care: A 12-Month Cohort Study
    Jun Hwa Hong, Ung Jeon, Won-Yong Shin, Weon Kim, Kayeon Seong, Sang-Ho Park, Hee-dong Kim, Joong-Wha Chung, Jaehyuk Choi
    Clinical Therapeutics.2022; 44(5): 698.     CrossRef
  • Temporal trends in heart failure over 11 years in the aging Korean population: A retrospective study using the national health insurance database
    Dong-Hyuk Cho, Chan Joo Lee, Jung-Woo Son, Jimi Choi, Jinseub Hwang, Byung-Su Yoo, Yajing Wang
    PLOS ONE.2022; 17(12): e0279541.     CrossRef
  • Cardiovascular risk and undertreatment of dyslipidemia in lung cancer survivors: A nationwide population-based study
    In Young Cho, Kyungdo Han, Dong Wook Shin, Sang Hyun Park, Dong Woog Yoon, Sujeong Shin, Su-Min Jeong, Jong Ho Cho
    Current Problems in Cancer.2021; 45(1): 100615.     CrossRef
  • Association Between Blood Heavy Metal Concentrations and Dyslipidemia in the Elderly
    Xingmeng Zhu, Yong Fan, Jie Sheng, Ling Gu, Qi Tao, Rui Huang, Kaiyong Liu, Linsheng Yang, Guimei Chen, Hongjuan Cao, Kaichun Li, Fangbiao Tao, Sufang Wang
    Biological Trace Element Research.2021; 199(4): 1280.     CrossRef
  • The prevalence of hypercholesterolemia and associated risk factors in Al-Kharj population, Saudi Arabia: a cross-sectional survey
    Jamaan Al-Zahrani, Mamdouh M. Shubair, Sameer Al-Ghamdi, Abdullah A. Alrasheed, Abdulrahman A. Alduraywish, Fayez Saud Alreshidi, Saeed Mastour Alshahrani, Majid Alsalamah, Badr F. Al-Khateeb, Aljawharah Ibraheem Ashathri, Ashraf El-Metwally, Khaled K. Al
    BMC Cardiovascular Disorders.2021;[Epub]     CrossRef
  • Prevalence, awareness, treatment, and control of dyslipidemia among diabetes mellitus patients and predictors of optimal dyslipidemia control: results from the Korea National Health and Nutrition Examination Survey
    Seung Jae Kim, Oh. Deog Kwon, Kyung-Soo Kim
    Lipids in Health and Disease.2021;[Epub]     CrossRef
  • Case Report of a Patient Diagnosed with Fatty Liver Accompanied by Hypertriglyceridemia
    Soyoung Hur, Soyeon An, Eujin Kim, Cho-Hyun Hwang, Eungyeong Jang, Youngchul Kim, Jang-Hoon Lee
    The Journal of Internal Korean Medicine.2021; 42(2): 207.     CrossRef
  • Changes in Cardiovascular Risk Factors in Residents of the Siberian Region (According to Epidemiological Studies)
    G. V. Artamonova, S. A. Maksimov, D. P. Tsygankova, E. D. Bazdyrev, E. V. Indukaeva, T. A. Mulerova, E. B. Shapovalova, A. S. Agienko, O. V. Nakhratova, O. L. Barbarash
    Rational Pharmacotherapy in Cardiology.2021; 17(3): 362.     CrossRef
  • Pre-existing Depression among Newly Diagnosed Dyslipidemia Patients and Cardiovascular Disease Risk
    Jihoon Andrew Kim, Seulggie Choi, Daein Choi, Sang Min Park
    Diabetes & Metabolism Journal.2020; 44(2): 307.     CrossRef
  • Low-density lipoprotein cholesterol goal attainment rates in high-risk patients with cardiovascular diseases and diabetes mellitus in Korea: a retrospective cohort study
    Ye Seul Yang, Bo Ram Yang, Mi-Sook Kim, Yunji Hwang, Sung Hee Choi
    Lipids in Health and Disease.2020;[Epub]     CrossRef
  • Risk factors for cardiovascular disease in ethnic Europeans and Koreans living in the Primorsky Krai
    D. Yu. Bogdanov, V. A. Nevzorova, V. B. Shumatov, E. A. Kondrashova, E. Yu. Shestopalov
    Cardiovascular Therapy and Prevention.2020; 19(1): 40.     CrossRef
  • Effect of Smartphone-Based Lifestyle Coaching App on Community-Dwelling Population With Moderate Metabolic Abnormalities: Randomized Controlled Trial
    So Mi Jemma Cho, Jung Hyun Lee, Jee-Seon Shim, Hyungseon Yeom, Su Jin Lee, Yong Woo Jeon, Hyeon Chang Kim
    Journal of Medical Internet Research.2020; 22(10): e17435.     CrossRef
  • Risk factors for cardiovascular disease in ethnic Europeans and Koreans living in the Primorsky Krai
    D. Yu. Bogdanov, V. A. Nevzorova, V. B. Shumatov, E. A. Kondrashova, E. Yu. Shestopalov
    Cardiovascular Therapy and Prevention.2020; 19(1): 40.     CrossRef
  • The effect of healthy Nordic diet on cardio-metabolic markers: a systematic review and meta-analysis of randomized controlled clinical trials
    Nahid Ramezani-Jolfaie, Mohammad Mohammadi, Amin Salehi-Abargouei
    European Journal of Nutrition.2019; 58(6): 2159.     CrossRef
  • Association between Low-Intensity Smoking and Metabolic Syndrome in Korean Men
    Minji Park, Seran Min, Yu Jin Cho, Sunwoo Kim, Hyuktae Kwon, Hee-Kyung Joh, Bumjo Oh, Seung-Won Oh, Ho Chun Choi, Cheol Min Lee
    Journal of the Korean Society for Research on Nicotine and Tobacco.2019; 10(2): 89.     CrossRef
  • Efficacy and safety of alirocumab in Korean patients with hypercholesterolemia and high cardiovascular risk: subanalysis of the ODYSSEY-KT study
    Chang-Wook Nam, Dong-Soo Kim, Jianyong Li, Marie T. Baccara-Dinet, Ivy Li, Ji-Hyun Kim, Chong-Jin Kim
    The Korean Journal of Internal Medicine.2019; 34(6): 1252.     CrossRef
  • Progress of Short-term Herbal Medicine Administration for Hypertriglyceridemia: a Case Report
    Bo-min Kim, Hee-geun Jo
    The Journal of Internal Korean Medicine.2019; 40(3): 517.     CrossRef
  • Use of fenofibrate on cardiovascular outcomes in statin users with metabolic syndrome: propensity matched cohort study
    Nam Hoon Kim, Ki Hoon Han, Jimi Choi, Juneyoung Lee, Sin Gon Kim
    BMJ.2019; : l5125.     CrossRef
  • The risk of herpes zoster virus infection in patients with depression
    Hyo Geun Choi, Eui-Joong Kim, Young Kyung Lee, Miyoung Kim
    Medicine.2019; 98(40): e17430.     CrossRef
  • Effect of Change in Total Cholesterol Levels on Cardiovascular Disease Among Young Adults
    Su‐Min Jeong, Seulggie Choi, Kyuwoong Kim, Sung Min Kim, Gyeongsil Lee, Seong Yong Park, Yeon‐Yong Kim, Joung Sik Son, Jae‐Moon Yun, Sang Min Park
    Journal of the American Heart Association.2018;[Epub]     CrossRef
  • Efficacy and Safety of Ezetimibe and Rosuvastatin Combination Therapy Versus Those of Rosuvastatin Monotherapy in Patients With Primary Hypercholesterolemia
    Woohyeun Kim, Yeonyee E. Yoon, Sung-Hee Shin, Jang-Whan Bae, Bum-Kee Hong, Soon Jun Hong, Ki Chul Sung, Seung Hwan Han, Weon Kim, Moo-Yong Rhee, Sang-Hyun Kim, Sang Eun Lee, Min Su Hyon, Gyo-Seung Hwang, Jang Won Son, Jang-Young Kim, Min Kyu Kim, Sang Woo
    Clinical Therapeutics.2018; 40(6): 993.     CrossRef
  • Prevalence of dyslipidemia among the population of a large region of Eastern Siberia and its association with sociodemographic and behavioral factors
    Yu. I. Grinshtein, V. V. Shabalin, R. R. Ruf, M. M. Petrova, S. A. Shal'nova
    Profilakticheskaya meditsina.2018; 21(5): 63.     CrossRef
Close layer
Update on Familial Hypercholesterolemia: Diagnosis, Cardiovascular Risk, and Novel Therapeutics
Sang-Hak Lee
Endocrinol Metab. 2017;32(1):36-40.   Published online January 19, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.36
  • 3,857 View
  • 55 Download
  • 11 Web of Science
  • 10 Crossref
AbstractAbstract PDFPubReader   

In recent studies, the reported prevalence of heterozygous familial hypercholesterolemia (FH) has been higher than in previous reports. Although cascade genetic screening is a good option for efficient identification of affected patients, diagnosis using only clinical criteria is more common in real clinical practice. Cardiovascular risk is much higher in FH patients due to longstanding low density lipoprotein cholesterol (LDL-C) burden and is also influenced by other risk factors. Although guidelines emphasize aggressive LDL-C reduction, the majority of patients cannot reach the LDL-C goal by conventional pharmacotherapy. Novel therapeutics such as proprotein convertase subtilisin/kexin type 9 inhibitors have shown strong lipid lowering efficacy and are expected to improve treatment results in FH patients.

Citations

Citations to this article as recorded by  
  • Effectiveness and Safety of a Fixed-Dose Combination of Valsartan and Rosuvastatin (Rovatitan® Tablet) in Patients with Concomitant Hypertension and Hyperlipidemia: An Observational Study
    Kwang Je Lee, Jae-Kean Ryu, Yun-Hyeong Cho, Won Yong Shin, Jeong Su Kim, Young Won Yoon, Ji Yong Jang, Won Ho Kim, Jong Wook Beom, Seok-Min Kang
    Drug Design, Development and Therapy.2023; Volume 17: 1047.     CrossRef
  • Role of PCSK9 Inhibitors in Patients with Familial Hypercholesterolemia
    Brian Tomlinson, Nivritti Gajanan Patil, Manson Fok, Christopher Wai Kei Lam
    Endocrinology and Metabolism.2021; 36(2): 279.     CrossRef
  • Identification and Functional Characterization of a Low-Density Lipoprotein Receptor Gene Pathogenic Variant in Familial Hypercholesterolemia
    Hong-Yan Shu, Wei Zhang, Cong-Cong Zheng, Man-Yun Gao, Yong-Cun Li, Yan-Gang Wang
    Frontiers in Genetics.2021;[Epub]     CrossRef
  • Gut Microbiota and Complications of Type-2 Diabetes
    Camelia Oana Iatcu, Aimee Steen, Mihai Covasa
    Nutrients.2021; 14(1): 166.     CrossRef
  • LDLR Gene Mutation p.Asp360His and Familial Hypercholesterolemia in a Mexican Community
    Teresita De Jesús Hernández Flores, Juan Ramón González García, Yoaly Josefina Sánchez López, Norma Alejandra Vázquez Cárdenas, Ana Gabriela Colima Fausto, Sergio Yair Rodríguez Preciado, María Teresa Magaña Torres
    Archives of Medical Research.2020; 51(2): 153.     CrossRef
  • A Rare Double Heterozygous Mutation in Low-Density Lipoprotein Receptor and Apolipoprotein B-100 Genes in a Severely Affected Familial Hypercholesterolaemia Patient
    Lilla Juhász, István Balogh, László Madar, Beáta Kovács, Mariann Harangi
    Cureus.2020;[Epub]     CrossRef
  • Efficacy and Safety of a Fixed-Dose Combination of Candesartan and Rosuvastatin on Blood Pressure and Cholesterol in Patients With Hypertension and Hypercholesterolemia: A Multicenter, Randomized, Double-Blind, Parallel Phase III Clinical Study
    Kyoung Im Cho, Bo Hyun Kim, Yong Hyun Park, Jeong-Cheon Ahn, Sang Hyun Kim, Wook Jin Chung, Weon Kim, Il Suk Sohn, Jin Ho Shin, Yong Jin Kim, Kiyuk Chang, Cheol Woong Yu, Soe Hee Ahn, Seok Yeon Kim, Jae Kean Ryu, Jong Young Lee, Bum Kee Hong, Taek Jong Ho
    Clinical Therapeutics.2019; 41(8): 1508.     CrossRef
  • Diagnosis and Treatment of Heterozygous Familial Hypercholesterolemia
    Mary P. McGowan, Seyed Hamed Hosseini Dehkordi, Patrick M. Moriarty, P. Barton Duell
    Journal of the American Heart Association.2019;[Epub]     CrossRef
  • Autosomal recessive hypercholesterolemia: Case report
    Zaneta Petrulioniene, Urte Gargalskaite, Violeta Mikstiene, Rimvydas Norvilas, Egle Skiauteryte, Algirdas Utkus
    Journal of Clinical Lipidology.2019; 13(6): 887.     CrossRef
  • Q192R polymorphism in the PON1 gene and familial hypercholesterolemia in a Saudi population
    Khalid Khalaf Alharbi, May Salem Alnbaheen, Fawiziah Khalaf Alharbi, Rana M. Hasanato, Imran Ali Khan
    Annals of Saudi Medicine.2017; 37(6): 425.     CrossRef
Close layer
The Role of Macrophage Lipophagy in Reverse Cholesterol Transport
Se-Jin Jeong, Mi-Ni Lee, Goo Taeg Oh
Endocrinol Metab. 2017;32(1):41-46.   Published online March 20, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.41
  • 4,147 View
  • 70 Download
  • 31 Web of Science
  • 34 Crossref
AbstractAbstract PDFPubReader   

Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis.

Citations

Citations to this article as recorded by  
  • Bile salt signaling and bile salt-based therapies in cardiometabolic disease
    Claire C.J. Groenen, Thuc-Anh Nguyen, Coen C. Paulusma, Stan F.J. van de Graaf
    Clinical Science.2024; 138(1): 1.     CrossRef
  • Huazhuotongmai decoction exerts anti-atherosclerotic effects by modulating the expression of ABCA1/SR-B1/PPAR-γ in vivo and in vitro
    Ya-ru Yan, Zi-jun Jia, Ya Wang, Feng-qin Xu, Qing-bing Zhou
    Phytomedicine Plus.2023; 3(2): 100436.     CrossRef
  • The SGLT2 Inhibitor Canagliflozin Reduces Atherosclerosis by Enhancing Macrophage Autophagy
    Hongping Chen, Da Teng, Bowen Xu, Chunxiao Wang, Hua Wang, Wenjuan Jia, Lei Gong, Haibin Dong, Lin Zhong, Jun Yang
    Journal of Cardiovascular Translational Research.2023; 16(5): 999.     CrossRef
  • FURIN suppresses the progression of atherosclerosis by promoting macrophage autophagy
    Hongping Chen, Lihui Zhang, Shaohua Mi, Hua Wang, Chunxiao Wang, Wenjuan Jia, Lei Gong, Haibin Dong, Bowen Xu, Yanyan Jing, Peipei Ge, Zhigang Pei, Lin Zhong, Jun Yang
    The FASEB Journal.2023;[Epub]     CrossRef
  • Unbalanced Redox With Autophagy in Cardiovascular Disease
    Se-Jin Jeong, Goo Taeg Oh
    Journal of Lipid and Atherosclerosis.2023; 12(2): 132.     CrossRef
  • Edible Bird’s Nest Effectively Attenuates Atherosclerosis through Modulation of Cholesterol Metabolism via Activation of PPARγ/LXRα Signaling Pathway In Vivo
    Nurul Nadiah Mohamad Nasir, Ramlah Mohamad Ibrahim, Rozi Mahmud, Nor Asma Ab Razak, Norsharina Ismail, Kim Wei Chan, Md Zuki Abu Bakar, Akhilesh K. Verma
    Journal of Food Biochemistry.2023; 2023: 1.     CrossRef
  • The mitochondrial translocator protein (TSPO, 18 kDa): A key multifunctional molecule in liver diseases
    Yuchang Li, Liting Chen, Vassilios Papadopoulos
    Biochimie.2023;[Epub]     CrossRef
  • The Differential Metabolomes in Cumulus and Mural Granulosa Cells from Human Preovulatory Follicles
    Er-Meng Gao, Bongkoch Turathum, Ling Wang, Di Zhang, Yu-Bing Liu, Rong-Xin Tang, Ri-Cheng Chian
    Reproductive Sciences.2022; 29(4): 1343.     CrossRef
  • PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP-dependent lipid uptake and fatty acid synthesis pathways
    Keerthana Balamurugan, Raghavender Medishetti, Jyothi Kotha, Parameshwar Behera, Kanika Chandra, Vijay Aditya Mavuduru, Manjunath B. Joshi, Ramesh Samineni, Madhumohan R. Katika, Writoban Basu Ball, Manjunatha Thondamal, Anil Challa, Kiranam Chatti, Kisho
    iScience.2022; 25(2): 103766.     CrossRef
  • Hydrochloride Berberine ameliorates alcohol-induced liver injury by regulating inflammation and lipid metabolism
    Xiumei Ke, Ruoyu Zhang, Pan Li, Ling Zuo, Meng Wang, Junxuan Yang, Jianwei Wang
    Biochemical and Biophysical Research Communications.2022; 610: 49.     CrossRef
  • Metabolic Regulation of Macrophage Activation
    Ourania Kolliniati, Eleftheria Ieronymaki, Eleni Vergadi, Christos Tsatsanis
    Journal of Innate Immunity.2022; 14(1): 51.     CrossRef
  • Emerging Roles of Lipophagy in Cancer Metastasis
    Haimeng Yin, Ying Shan, Tian Xia, Yan Ji, Ling Yuan, Yiwen You, Bo You
    Cancers.2022; 14(18): 4526.     CrossRef
  • Genetic Factors for Coronary Heart Disease and Their Mechanisms: A Meta-Analysis and Comprehensive Review of Common Variants from Genome-Wide Association Studies
    Khairul Anwar Zarkasi, Noraidatulakma Abdullah, Nor Azian Abdul Murad, Norfazilah Ahmad, Rahman Jamal
    Diagnostics.2022; 12(10): 2561.     CrossRef
  • Caveolin-1 in autophagy: A potential therapeutic target in atherosclerosis
    Kai Hou, Shuai Li, Meng Zhang, Xuping Qin
    Clinica Chimica Acta.2021; 513: 25.     CrossRef
  • Contradictory regulation of macrophages on atherosclerosis based on polarization, death and autophagy
    Jing Zhang, Chuan-Rui Ma, Yun-Qing Hua, Lan Li, Jing-Yu Ni, Yu-Ting Huang, Sophia Esi Duncan, Sheng Li, Shan Gao, Guan-Wei Fan
    Life Sciences.2021; 276: 118957.     CrossRef
  • A meta-analysis of HDL cholesterol efflux capacity and concentration in patients with rheumatoid arthritis
    Binbin Xie, Jiang He, Yong Liu, Ting Liu, Chaoqun Liu
    Lipids in Health and Disease.2021;[Epub]     CrossRef
  • Rosmarinic Acid Increases Macrophage Cholesterol Efflux through Regulation of ABCA1 and ABCG1 in Different Mechanisms
    Jean-Baptiste Nyandwi, Young Shin Ko, Hana Jin, Seung Pil Yun, Sang Won Park, Hye Jung Kim
    International Journal of Molecular Sciences.2021; 22(16): 8791.     CrossRef
  • FGF21 induces autophagy‐mediated cholesterol efflux to inhibit atherogenesis via RACK1 up‐regulation
    Lin Xiaolong, Guo Dongmin, Mihua Liu, Wang Zuo, Hu Huijun, Tan Qiufen, Hu XueMei, Lin Wensheng, Pan Yuping, Lin Jun, Zeng Zhaolin
    Journal of Cellular and Molecular Medicine.2020; 24(9): 4992.     CrossRef
  • Lipophagy in atherosclerosis
    Qing Liu, Yuan-Mei Wang, Hong-Feng Gu
    Clinica Chimica Acta.2020; 511: 208.     CrossRef
  • Lysosomotropic Features and Autophagy Modulators among Medical Drugs: Evaluation of Their Role in Pathologies
    Tatiana A. Korolenko, Thomas P. Johnston, Vaclav Vetvicka
    Molecules.2020; 25(21): 5052.     CrossRef
  • LncRNA MALAT1 Enhances ox-LDL-Induced Autophagy through the SIRT1/MAPK/NF-κB Pathway in Macrophages
    Jiaqi Yang, Xuze Lin , Liangshan Wang, Tienan Sun, Qi Zhao, Qian Ma, Yujie Zhou
    Current Vascular Pharmacology.2020; 18(6): 652.     CrossRef
  • CTRP13 inhibits atherosclerosis via autophagy‐lysosome‐dependent degradation of CD36
    Cheng Wang, Wenjing Xu, Minglu Liang, Dan Huang, Kai Huang
    The FASEB Journal.2019; 33(2): 2290.     CrossRef
  • Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed‐forward loop between LXR and autophagy
    P. Saliba‐Gustafsson, M. Pedrelli, K. Gertow, O. Werngren, V. Janas, S. Pourteymour, D. Baldassarre, E. Tremoli, F. Veglia, R. Rauramaa, A.J. Smit, P. Giral, S. Kurl, M. Pirro, U. de Faire, S.E. Humphries, A. Hamsten, I. Gonçalves, M. Orho‐Melander, A. Fr
    Journal of Internal Medicine.2019; 286(6): 660.     CrossRef
  • PCSK9: A new participant in lipophagy in regulating atherosclerosis?
    Jun Xiao, Yi-Min Deng, Xiang-Rui Liu, Jian-Ping Cao, Min Zhou, Ya-Ling Tang, Wen-Hao Xiong, Zhi-Sheng Jiang, Zhi-Han Tang, Lu-Shan Liu
    Clinica Chimica Acta.2019; 495: 358.     CrossRef
  • Autophagy-Mediated Cholesterol Trafficking Controls Steroid Production
    Michael J. Texada, Alina Malita, Christian F. Christensen, Kathrine B. Dall, Nils J. Faergeman, Stanislav Nagy, Kenneth A. Halberg, Kim Rewitz
    Developmental Cell.2019; 48(5): 659.     CrossRef
  • Lipophagy in nonliver tissues and some related diseases: Pathogenic and therapeutic implications
    Kebing Zhou, Pingbo Yao, Jun He, Hong Zhao
    Journal of Cellular Physiology.2019; 234(6): 7938.     CrossRef
  • Autophagy differentially regulates macrophage lipid handling depending on the lipid substrate (oleic acid vs. acetylated-LDL) and inflammatory activation state
    Sapir Hadadi-Bechor, Yulia Haim, Tal Pecht, Roni Gat, Tanya Tarnovscki, Martin Gericke, Assaf Rudich
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2019; 1864(12): 158527.     CrossRef
  • Autophagy and Age-Related Eye Diseases
    Xue Yang, Xinan Pan, Xiaorui Zhao, Jin Luo, Mingpu Xu, Daoming Bai, Yan Hu, Xu Liu, Qiongfang Yu, Dian Gao
    BioMed Research International.2019; 2019: 1.     CrossRef
  • Foam cell formation and cholesterol trafficking and metabolism disturbances in atherosclerosis
    Alexandrina Volobueva, Dongwei Zhang, Andrey V. Grechko, Alexander N. Orekhov
    Cor et Vasa.2019; 61(1): 48.     CrossRef
  • Oxidative Stress, Lipid Peroxidation, and Loss of Hyaluronic Acid in the Human Vitreous Affected by Synchysis Scintillans
    Loredana Bergandi, Oleksii A Skorokhod, Rosalba La Grotta, Evelin Schwarzer, Raffaele Nuzzi
    Journal of Ophthalmology.2019; 2019: 1.     CrossRef
  • Programmed cell death protein 4 deficiency suppresses foam cell formation by activating autophagy in advanced glycation end‐product low‐density lipoprotein–induced macrophages
    Shan Li, Guangdong Gao, Fuyun Wu, Dan Liu, Hongyan Zhao, Jing Ke, Ying Liu, Fei Li, Jian Li, Zongyun Chen, Zhiming Tang, Lei Bai, Jinxuan Zhang, Wei Zheng, Xin Chen
    Journal of Cellular Biochemistry.2019; 120(5): 7689.     CrossRef
  • Mindin deficiency in macrophages protects against foam cell formation and atherosclerosis by targeting LXR-β
    Cheng Zhang, Juan-Juan Qin, Fu-Han Gong, Jing-Jing Tong, Wen-Lin Cheng, Haiping Wang, Yan Zhang, Xueyong Zhu, Zhi-Gang She, Hao Xia, Li-Hua Zhu
    Clinical Science.2018; 132(11): 1199.     CrossRef
  • LJ-1888, a selective antagonist for the A3 adenosine receptor, ameliorates the development of atherosclerosis and hypercholesterolemia in apolipoprotein E knock-out mice
    Jong-Gil Park, Se-Jin Jeong, Jinha Yu, Gyudong Kim, Lak Shin Jeong, Goo Taeg Oh
    BMB Reports.2018; 51(10): 520.     CrossRef
  • Intracellular and Plasma Membrane Events in Cholesterol Transport and Homeostasis
    Dmitry Y. Litvinov, Eugeny V. Savushkin, Alexander D. Dergunov
    Journal of Lipids.2018; 2018: 1.     CrossRef
Close layer
The Implication of Coronary Artery Calcium Testing for Cardiovascular Disease Prevention and Diabetes
Ron Blankstein, Ankur Gupta, Jamal S. Rana, Khurram Nasir
Endocrinol Metab. 2017;32(1):47-57.   Published online March 20, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.47
  • 4,598 View
  • 53 Download
  • 24 Web of Science
  • 23 Crossref
AbstractAbstract PDFPubReader   

Over the last two decades coronary artery calcium (CAC) scanning has emerged as a quick, safe, and inexpensive method to detect the presence of coronary atherosclerosis. Data from multiple studies has shown that compared to individuals who do not have any coronary calcifications, those with severe calcifications (i.e., CAC score >300) have a 10-fold increase in their risk of coronary heart disease events and cardiovascular disease. Conversely, those that have a CAC of 0 have a very low event rate (~0.1%/year), with data that now extends to 15 years in some studies. Thus, the most notable implication of identifying CAC in individuals who do not have known cardiovascular disease is that it allows targeting of more aggressive therapies to those who have the highest risk of having future events. Such identification of risk is especially important for individuals who are not on any therapies for coronary heart disease, or when intensification of treatment is being considered but has an uncertain role. This review will highlight some of the recent data on CAC testing, while focusing on the implications of those findings on patient management. The evolving role of CAC in patients with diabetes will also be highlighted.

Citations

Citations to this article as recorded by  
  • Artificial Intelligence in Coronary Artery Calcium Scoring Detection and Quantification
    Khaled Abdelrahman, Arthur Shiyovich, Daniel Huck, Adam Berman, Brittany Weber, Sumit Gupta, Rhanderson Cardoso, Ron Blankstein
    Diagnostics.2024; 14(2): 125.     CrossRef
  • Association of Strict Versus Lenient Cholesterol Lowering with Cardiac Outcomes, Diabetes Progression and Complications, and Mortality in Patients with Diabetes Treated with Statins: Is Less More?
    Victoria Odeleye, Omar Masarweh, Jorge Restrepo, Carlos A Alvarez, Ishak A. Mansi
    Drug Safety.2023; 46(11): 1105.     CrossRef
  • Impact of coronary artery calcium testing on patient management
    Wanda Y. Wu, David W. Biery, Adam N. Berman, Grace Hsieh, Sanjay Divakaran, Sumit Gupta, Michael L. Steigner, Ayaz Aghayev, Hicham Skali, Donna M. Polk, Jorge Plutzky, Christopher P. Cannon, Marcelo F. Di Carli, Ron Blankstein
    Journal of Cardiovascular Computed Tomography.2022; 16(4): 303.     CrossRef
  • Application of ensemble machine learning algorithms on lifestyle factors and wearables for cardiovascular risk prediction
    Weiting Huang, Tan Wei Ying, Woon Loong Calvin Chin, Lohendran Baskaran, Ong Eng Hock Marcus, Khung Keong Yeo, Ng See Kiong
    Scientific Reports.2022;[Epub]     CrossRef
  • The Influence of Obesity and Metabolic Health on Vascular Health
    Eun-Jung Rhee
    Endocrinology and Metabolism.2022; 37(1): 1.     CrossRef
  • The role of cardiac computed tomography in predicting adverse coronary events
    Maria Emfietzoglou, Michail C. Mavrogiannis, Athanasios Samaras, Georgios P. Rampidis, George Giannakoulas, Polydoros N. Kampaktsis
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Subclinical Hypertension-Mediated Organ Damage (HMOD) in Hypertension: Atherosclerotic Cardiovascular Disease (ASCVD) and Calcium Score
    Damiano Rizzoni, Claudia Agabiti-Rosei, Carolina De Ciuceis, Gianluca Edoardo Mario Boari
    High Blood Pressure & Cardiovascular Prevention.2022; 30(1): 17.     CrossRef
  • Coronary Artery Calcium Score: Current Efficacy of Cardiac CT in Patients at Hail Region, Saudi Arabia
    Qurain Turki Alshammari, Ohood Alrashidi, Wed Almutairi, Eman Alshammari, Meshari T. Alshammari, Shashi Kumar CG, Mohammed Salih, Abdelmoneim Sulieman, Moawia Gameraddin, Bushra Abdul Malik, Amjad R. Alyahyawi
    International Journal of Pharmaceutical Research And Allied Sciences.2022; 11(3): 132.     CrossRef
  • The co-existence of diabetes and subclinical atherosclerosis in rural central Appalachia: Do residential characteristics matter?
    Hadii M. Mamudu, Antwan Jones, Timir K. Paul, Fenose Osedeme, David Stewart, Arsham Alamian, Liang Wang, Sylvester Orimaye, James Bledsoe, Amy Poole, Gerald Blackwell, Mathew Budoff
    Journal of Diabetes and its Complications.2021; 35(4): 107851.     CrossRef
  • Usefulness of skin advanced glycation end products to predict coronary artery calcium score in patients with type 2 diabetes
    Alejandra Planas, Olga Simó-Servat, Jordi Bañeras, Mónica Sánchez, Esther García, Ángel M. Ortiz, Marisol Ruiz-Meana, Cristina Hernández, Ignacio Ferreira-González, Rafael Simó
    Acta Diabetologica.2021; 58(10): 1403.     CrossRef
  • Value of addition of coronary artery calcium to risk scores in the prediction of major cardiovascular events in patients with type 2 diabetes
    Barak Zafrir, Walid Saliba, Rachel Shay Li Widder, Razi Khoury, Elad Shemesh, David A. Halon
    BMC Cardiovascular Disorders.2021;[Epub]     CrossRef
  • Coronary Artery Calcium Score - A Reliable Indicator of Coronary Artery Disease?
    Devarashetty Shreya, Diana I Zamora, Gautami S Patel, Idan Grossmann, Kevin Rodriguez, Mridul Soni, Pranay K Joshi, Saawan C Patel, Ibrahim Sange
    Cureus.2021;[Epub]     CrossRef
  • Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling
    Jinmi Lee, Seok-Woo Hong, Min-Jeong Kim, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
    Biochemical and Biophysical Research Communications.2020; 530(2): 374.     CrossRef
  • Coronary Computed Tomography Angiography From Clinical Uses to Emerging Technologies
    Khaled M. Abdelrahman, Marcus Y. Chen, Amit K. Dey, Renu Virmani, Aloke V. Finn, Ramzi Y. Khamis, Andrew D. Choi, James K. Min, Michelle C. Williams, Andrew J. Buckler, Charles A. Taylor, Campbell Rogers, Habib Samady, Charalambos Antoniades, Leslee J. Sh
    Journal of the American College of Cardiology.2020; 76(10): 1226.     CrossRef
  • Optimizing coronary artery calcium scanning to meet the challenges of population screening
    Andrew J. Einstein
    Journal of Cardiovascular Computed Tomography.2019; 13(6): 303.     CrossRef
  • Usefulness of the Coronary Artery Calcium Score in Predicting Subsequent Coronary Interventions—A Ten-Year Single-Center Perspective
    Agnieszka Mlynarska, Rafal Mlynarski, Maciej Sosnowski
    International Journal of Environmental Research and Public Health.2019; 16(12): 2132.     CrossRef
  • Cardiovascular Risk Heterogeneity in Adults with Diabetes: Selective Use of Coronary Artery Calcium in Statin Use Decision-making
    Sudipa Sarkar, Olusola A. Orimoloye, Caitlin M. Nass, Roger S. Blumenthal, Seth S. Martin
    Journal of General Internal Medicine.2019; 34(11): 2643.     CrossRef
  • CT coronary imaging–a fast evolving world
    P Rajiah, S Abbara
    QJM: An International Journal of Medicine.2018; 111(9): 595.     CrossRef
  • Being Metabolically Healthy, the Most Responsible Factor for Vascular Health
    Eun-Jung Rhee
    Diabetes & Metabolism Journal.2018; 42(1): 19.     CrossRef
  • Diabetes, subclinical atherosclerosis and multiple cardiovascular risk factors in hard-to-reach asymptomatic patients
    Hadii M Mamudu, Arsham Alamian, Timir Paul, Pooja Subedi, Liang Wang, Antwan Jones, Ali E Alamin, David Stewart, Gerald Blackwell, Matthew Budoff
    Diabetes and Vascular Disease Research.2018; 15(6): 519.     CrossRef
  • Calcium detection, its quantification, and grayscale morphology-based risk stratification using machine learning in multimodality big data coronary and carotid scans: A review
    Sumit K. Banchhor, Narendra D. Londhe, Tadashi Araki, Luca Saba, Petia Radeva, Narendra N. Khanna, Jasjit S. Suri
    Computers in Biology and Medicine.2018; 101: 184.     CrossRef
  • Association Between Coronary Artery Calcification and the Hemoglobin Glycation Index: The Kangbuk Samsung Health Study
    Eun-Jung Rhee, Jung-Hwan Cho, Hyemi Kwon, Se Eun Park, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
    The Journal of Clinical Endocrinology & Metabolism.2017; 102(12): 4634.     CrossRef
  • Increased risk for development of coronary artery calcification in subjects with non-alcoholic fatty liver disease and systemic inflammation
    Jihyun Kim, Da Young Lee, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee, Susanne Kaser
    PLOS ONE.2017; 12(7): e0180118.     CrossRef
Close layer
Editorials
How to Prepare Endocrinology and Metabolism for Reapplication to MEDLINE
Sun Huh
Endocrinol Metab. 2017;32(1):58-61.   Published online March 20, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.58
  • 3,676 View
  • 35 Download
  • 7 Web of Science
  • 9 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • How was the Diabetes Metabolism Journal added to MEDLINE?
    Hye Jin Yoo
    Science Editing.2020; 7(2): 201.     CrossRef
  • Two international public platforms for the exposure of Archives of Plastic Surgery to worldwide researchers and surgeons: PubMed Central and Crossref
    Sun Huh
    Archives of Plastic Surgery.2020; 47(5): 377.     CrossRef
  • Protection of Personal Information in Medical Journal Publications
    Sun Huh
    Neurointervention.2019; 14(1): 1.     CrossRef
  • Recent advances of medical journals in Korea and and further development strategies: Is it possible for them to publish Nobel Prize-winning research?
    Sun Huh
    Journal of the Korean Medical Association.2018; 61(9): 524.     CrossRef
  • Journal Metrics of Infection & Chemotherapy and Current Scholarly Journal Publication Issues
    Sun Huh
    Infection & Chemotherapy.2018; 50(3): 219.     CrossRef
  • Strengthened research ethics, including patient anonymity and informed consent, in MEDLINE and PubMed Central journals
    Sun Huh
    Archives of Craniofacial Surgery.2018; 19(4): 241.     CrossRef
  • Is Diabetes & Metabolism Journal Eligible to Be Indexed in MEDLINE?
    Sun Huh
    Diabetes & Metabolism Journal.2018; 42(6): 472.     CrossRef
  • Endocrinology and Metabolism Is Indexed in the Emerging Sources Citation Index
    Won-Young Lee
    Endocrinology and Metabolism.2017; 32(3): 350.     CrossRef
  • The rapid internationalization of Annals of Pediatric Endocrinology & Metabolism as evidenced by journal metrics
    Sun Huh
    Annals of Pediatric Endocrinology & Metabolism.2017; 22(2): 77.     CrossRef
Close layer
Articles in Endocrinology and Metabolism in 2016
Won-Young Lee
Endocrinol Metab. 2017;32(1):62-67.   Published online March 20, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.62
  • 3,319 View
  • 39 Download
  • 1 Web of Science
  • 2 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • Insulin Resistance and Glucose Metabolism during Infection
    Borros Arneth
    Endocrines.2023; 4(4): 685.     CrossRef
  • Effects of 6 Months of Dapagliflozin Treatment on Metabolic Profile and Endothelial Cell Dysfunction for Obese Type 2 Diabetes Mellitus Patients without Atherosclerotic Cardiovascular Disease
    Ju-Young Hong, Keun-Young Park, Jong-Dai Kim, Won-Min Hwang, Dong-Mee Lim
    Journal of Obesity & Metabolic Syndrome.2020; 29(3): 215.     CrossRef
Close layer
Original Articles
Site-Specific Difference of Bone Geometry Indices in Hypoparathyroid Patients
Hye-Sun Park, Da Hea Seo, Yumie Rhee, Sung-Kil Lim
Endocrinol Metab. 2017;32(1):68-76.   Published online February 6, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.68
  • 3,144 View
  • 31 Download
  • 3 Web of Science
  • 4 Crossref
AbstractAbstract PDFPubReader   
Background

Hypoparathyroid patients often have a higher bone mineral density (BMD) than the general population. However, an increase in BMD does not necessarily correlate with a solid bone microstructure. This study aimed to evaluate the bone microstructure of hypoparathyroid patients by using hip structure analysis (HSA).

Methods

Ninety-five hypoparathyroid patients >20 years old were enrolled and 31 of them had eligible data for analyzing bone geometry parameters using HSA. And among the control data, we extracted sex-, age-, and body mass index-matched three control subjects to each patient. The BMD data were reviewed retrospectively and the bone geometry parameters of the patients were analyzed by HSA.

Results

The mean Z-scores of hypoparathyroid patients at the lumbar spine, femoral neck, and total hip were above zero (0.63±1.17, 0.48±1.13, and 0.62±1.10, respectively). The differences in bone geometric parameters were site specific. At the femoral neck and intertrochanter, the cross-sectional area (CSA) and cortical thickness (C.th) were higher, whereas the buckling ratio (BR) was lower than in controls. However, those trends were opposite at the femoral shaft; that is, the CSA and C.th were low and the BR was high.

Conclusion

Our study shows the site-specific effects of hypoparathyroidism on the bone. Differences in bone components, marrow composition, or modeling based bone formation may explain these findings. However, further studies are warranted to investigate the mechanism, and its relation to fracture risk.

Citations

Citations to this article as recorded by  
  • Vertebral fractures, trabecular bone score and their determinants in chronic hypoparathyroidism
    S. Saha, V. Mannar, D. Kandasamy, V. Sreenivas, R. Goswami
    Journal of Endocrinological Investigation.2022; 45(9): 1777.     CrossRef
  • Epidemiology and Financial Burden of Adult Chronic Hypoparathyroidism
    Sigridur Bjornsdottir, Steven Ing, Deborah M Mitchell, Tanja Sikjaer, Line Underbjerg, Zaki Hassan-Smith, Jad Sfeir, Neil J Gittoes, Bart L Clarke L
    Journal of Bone and Mineral Research.2020; 37(12): 2602.     CrossRef
  • Effect of Endogenous Parathyroid Hormone on Bone Geometry and Skeletal Microarchitecture
    A Ram Hong, Ji Hyun Lee, Jung Hee Kim, Sang Wan Kim, Chan Soo Shin
    Calcified Tissue International.2019; 104(4): 382.     CrossRef
  • Bone responses to chronic treatment of adult hypoparathyroid patients with PTH peptides
    Sofie Malmstroem, Lars Rejnmark, Dolores M. Shoback
    Current Opinion in Endocrine and Metabolic Research.2018; 3: 51.     CrossRef
Close layer
Risk of Malignancy in Thyroid Nodules 4 cm or Larger
Uchechukwu C. Megwalu
Endocrinol Metab. 2017;32(1):77-82.   Published online February 6, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.77
  • 4,128 View
  • 56 Download
  • 17 Web of Science
  • 17 Crossref
AbstractAbstract PDFPubReader   
Background

Several authors have questioned the accuracy of fine-needle aspiration cytology (FNAC) in large nodules. Some surgeons recommend thyroidectomy for nodules ≥4 cm even in the setting of benign FNAC, due to increased risk of malignancy and increased false negative rates in large thyroid nodules. The goal of our study was to evaluate if thyroid nodule size is associated with risk of malignancy, and to evaluate the false negative rate of FNAC for thyroid nodules ≥4 cm in our patient population.

Methods

This is a retrospective study of 85 patients with 101 thyroid nodules, who underwent thyroidectomy for thyroid nodules measuring ≥4 cm.

Results

The overall risk of malignancy in nodules ≥4 cm was 9.9%. Nodule size was not associated with risk of malignancy (odds ratio, 1.02) after adjusting for nodule consistency, age, and sex (P=0.6). The false negative rate for FNAC was 0%.

Conclusion

Nodule size was not associated with risk of malignancy in nodules ≥4 cm in our patient population. FNAC had a false negative rate of 0. Patients with thyroid nodules ≥4 cm and benign cytology should not automatically undergo thyroidectomy.

Citations

Citations to this article as recorded by  
  • The Utility of ACR TI-RADS in Predicting False-Negative Fine Needle Aspiration for Thyroid Cancer
    Katrina L. Dimaano, Valerie A. Dib, Taylor Parnall, Audrey Covington, Amy H. Kaji, Patrick Choi, Kathryn T. Chen
    The American Surgeon™.2024;[Epub]     CrossRef
  • Effect of thyroid nodule size on cytology reliability and incidence of malignancy: A large cohort of 1205 patients from a single center
    Muhammed Erkam Sencar, Murat Calapkulu, Hayri Bostan, Davut Sakiz, Sema Hepsen, Muhammed Kizilgul, Ilknur Ozturk Unsal, Ozgur Ozcelik, Emre Arslan, Bekir Ucan, Cem Azili, Mustafa Ozbek, Erman Cakal
    Annales d'Endocrinologie.2023; 84(2): 238.     CrossRef
  • Accuracy of fine‐needle aspiration cytopathology to differentiate malignant and benign thyroid nodules with ≥4 cm diameter: A retrospective study
    Houra Rastegar, Ashkan Torshizian, Mohammad Ali Yaghoubi, Nastaran Khoshhal, Mehdi Asadi, Negar Morovatdar, Masoud Mohebbi
    Diagnostic Cytopathology.2023; 51(4): 263.     CrossRef
  • Risk of malignancy and diagnostic accuracy of fine-needle aspiration biopsy in thyroid nodules with diameters greater than 4 centimeters
    Rafaela N. Barcelos, Cléber P. Camacho, Maria da Conceição de O. C. Mamone, Elza S. Ikejiri, Felipe A. B. Vanderlei, Ji H. Yang, Rosália P. Padovani, Leandro A. L. Martins, Rosa Paula M. Biscolla, Danielle Macellaro, Susan C. Lindsey, Rui M. B. Maciel, Jo
    Archives of Endocrinology and Metabolism.2023;[Epub]     CrossRef
  • Concordance of the ACR TI-RADS Classification With Bethesda Scoring and Histopathology Risk Stratification of Thyroid Nodules
    Elaine Y. F. Huang, Nern Hoong Kao, Snow Yunni Lin, Isabelle J. H. Jang, Kimberley Liqin Kiong, Anna See, Nanda Venkatanarasimha, Kristen Alexa Lee, Chwee Ming Lim
    JAMA Network Open.2023; 6(9): e2331612.     CrossRef
  • Probable impact of environmental radiation on thyroid swellings in areas of Eastern Hyderabad and Nalgonda
    Namit Kant Singh, Neemu Hage, Shailaja Prabhala, Balaji Ramamourthy, Sushmitha Nagaraju, Krishna Medha Kappagantu
    The Egyptian Journal of Otolaryngology.2023;[Epub]     CrossRef
  • Predictive Value of a Genomic Classifier in Indeterminate Thyroid Nodules Based on Nodule Size
    Jared C. Dublin, Michael Papazian, Elcin Zan, Thaira Oweity, Wei Sun, Adam Jacobson, Kepal Patel, Tamar C. Brandler, Babak Givi
    JAMA Otolaryngology–Head & Neck Surgery.2022; 148(1): 53.     CrossRef
  • Navigating the Debate on Managing Large (≥4 cm) Thyroid Nodules
    Samantha N. Steinmetz-Wood, Amanda G. Kennedy, Bradley J. Tompkins, Matthew P. Gilbert, Claudio Casella
    International Journal of Endocrinology.2022; 2022: 1.     CrossRef
  • Clinicopathologic features of thyroid nodules with PTEN mutations on preoperative testing
    Jacob A Quaytman, Yuri E Nikiforov, Marina N Nikiforova, Elena Morariu
    Endocrine-Related Cancer.2022; 29(9): 513.     CrossRef
  • The risk of thyroid carcinoma in multinodular goiter compared to solitary thyroid nodules: A retrospective analysis of 600 patients
    Khaled Y. Ajarma, Ashraf F. Al-Faouri, Maysoon K. Al Ruhaibeh, Feras A. Almbaidien, Rima T. Nserat, Abdallah O. Al-Shawabkeh, Khaldon K. Al-Sarihin, Yousef A. Al-Harazi, Haitham S. Rbihat, Mohammad E. Aljbour
    Medical Journal Armed Forces India.2020; 76(1): 23.     CrossRef
  • A Study to Evaluate the Size of Thyroid Nodules as an Indicator for Malignancy
    Ajay Kumar Jha, Ajit Kumar Sinha
    Academia Journal of Surgery.2020; 3(1): 16.     CrossRef
  • Thyroid nodules over 4 cm do not have higher malignancy or benign cytology false-negative rates
    Muhammed Kizilgul, Rupendra Shrestha, Angela Radulescu, Maria R. Evasovich, Lynn A. Burmeister
    Endocrine.2019; 66(2): 249.     CrossRef
  • Clinical and Ultrasound Thyroid Nodule Characteristics and Their Association with Cytological and Histopathological Outcomes: A Retrospective Multicenter Study in High-Resolution Thyroid Nodule Clinics
    María Molina-Vega, Carlos Antonio Rodríguez-Pérez, Ana Isabel Álvarez-Mancha, Gloria Baena-Nieto, María Riestra, Victoria Alcázar, Ana Reyes Romero-Lluch, Juan C. Galofré, José C. Fernández-García
    Journal of Clinical Medicine.2019; 8(12): 2172.     CrossRef
  • The influence of thyroid nodule size on the diagnostic efficacy and accuracy of ultrasound guided fine‐needle aspiration cytology
    Berna İmge Aydoğan, Mustafa Şahin, Koray Ceyhan, Olgun Deniz, Özgür Demir, Rifat Emral, Vedia Tonyukuk Gedik, Ali Rıza Uysal, Demet Çorapçıoğlu
    Diagnostic Cytopathology.2019; 47(7): 682.     CrossRef
  • Update on Thyroid Nodule Management
    Alan A Parsa, Hossein Gharib
    US Endocrinology.2019; 15(1): 32.     CrossRef
  • Large Cytologically Benign Thyroid Nodules Do Not Have High Rates of Malignancy or False-Negative Rates and Clinical Observation Should be Considered: A Meta-Analysis
    Nicole A. Cipriani, Michael G. White, Peter Angelos, Raymon H. Grogan
    Thyroid.2018; 28(12): 1595.     CrossRef
  • Hemoptisis aislada en una paciente no fumadora
    A. Hidalgo Rodríguez, C.A. Fignani Molina, I. Alfonso Zamora, J.C. Aguirre Rodríguez, M. Mene Llorente
    SEMERGEN - Medicina de Familia.2017; 43(8): e65.     CrossRef
Close layer
Clinical Characteristics of Patients with Adrenal Insufficiency in a General Hospital
Ye Yeon Lee, Nan Hee Cho, Jong Won Lee, Nam Kyung Kim, Hye Soon Kim, Mi-Kyung Kim
Endocrinol Metab. 2017;32(1):83-89.   Published online February 28, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.83
  • 4,152 View
  • 58 Download
  • 6 Web of Science
  • 6 Crossref
AbstractAbstract PDFPubReader   
Background

Adrenal insufficiency (AI) is a life-threatening disorder caused by the deficiency of adrenal steroid hormones. This retrospective cross-sectional study investigated the characteristics of patients with AI in Korea.

Methods

All consecutive patients with suspected AI who received care at a tertiary referral center in Korea in 2014 and underwent adrenocorticotropic hormone stimulation or insulin-tolerance testing were identified through a review of medical charts. Patients diagnosed with AI were enrolled. Their demographic, clinical, and treatment details were extracted.

Results

Of 771 patients with suspected AI, 183 (23.7%) received a definitive diagnosis. The most common reason for testing was the presence of suspicious AI-related symptoms (30.0%), followed by a history of steroid medications (23.5%). Their mean age was 66.7 years, and females predominated (67.8%). The most common symptoms were general weakness, anorexia, arthralgia, and fever. Approximately half (53.6%) had a history of steroid use. Hydrocortisone was the most common treatment (71.6%), with most patients taking a 30 mg dose (44.2%). The most common dose frequency was twice a day (78.6%). Fourteen patients were treated for adrenal crisis (n=10, 5.5%) or an intercurrent illness (n=4, 2.2%).

Conclusion

AI may have been caused by steroid medication use in many of the patients included in this study. The detection of AI can be improved by careful history-taking and being alert to the possibility that a patient has used steroids.

Citations

Citations to this article as recorded by  
  • Risk of Mental Illnesses in Patients With Hypopituitarism: A Nationwide Population-Based Cohort Study
    I-Hua Wei, Chih-Chia Huang
    Psychiatry Investigation.2022; 19(6): 418.     CrossRef
  • The Role of the Pharmacist in Optimizing Cancer Immunotherapy: A Retrospective Study of Nivolumab Adverse Events
    Bradley D. Menz, Jacinta L. Johnson, Davina F. Gillard, William Chong, Michael B. Ward
    Journal of Pharmacy Practice.2021; 34(3): 386.     CrossRef
  • Clinical and biochemical factors to predict biochemical adrenal insufficiency in hospitalized patients with indeterminate cortisol levels: a retrospective study
    Worapaka Manosroi, Natapong Kosachunhanan, Pichitchai Atthakomol
    BMC Endocrine Disorders.2020;[Epub]     CrossRef
  • Possible adrenal insufficiency among fatigue patients in a psychosomatic medical clinic
    Sunao Matsubayashi, Nobuhiro Nakatake, Takeshi Hara
    Endocrine Journal.2020; 67(1): 53.     CrossRef
  • Encountering COVID-19 as Endocrinologists
    Eun-Jung Rhee, Jung Hee Kim, Sun Joon Moon, Won-Young Lee
    Endocrinology and Metabolism.2020; 35(2): 197.     CrossRef
  • Glucocorticoid management of adrenal insufficiency in the United Kingdom: assessment using real-world data
    Kamran Iqbal, Kate Halsby, Robert D Murray, Paul V Carroll, Robert Petermann
    Endocrine Connections.2019; 8(1): 20.     CrossRef
Close layer
Development of Clinical Data Mart of HMG-CoA Reductase Inhibitor for Varied Clinical Research
Hun-Sung Kim, Hyunah Kim, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Sun Jung Baik, Seung-Hwan Lee, Jae Hyoung Cho, In Young Choi, Kun-Ho Yoon
Endocrinol Metab. 2017;32(1):90-98.   Published online February 28, 2017
DOI: https://doi.org/10.3803/EnM.2017.32.1.90
  • 3,926 View
  • 55 Download
  • 17 Web of Science
  • 14 Crossref
AbstractAbstract PDFPubReader   
Background

The increasing use of electronic medical record (EMR) systems for documenting clinical medical data has led to EMR data being increasingly accessed for clinical trials. In this study, a database of patients who were prescribed statins for the first time was developed using EMR data. A clinical data mart (CDM) was developed for cohort study researchers.

Methods

Seoul St. Mary's Hospital implemented a clinical data warehouse (CDW) of data for ~2.8 million patients, 47 million prescription events, and laboratory results for 150 million cases. We developed a research database from a subset of the data on the basis of a study protocol. Data for patients who were prescribed a statin for the first time (between the period from January 1, 2009 to December 31, 2015), including personal data, laboratory data, diagnoses, and medications, were extracted.

Results

We extracted initial clinical data of statin from a CDW that was established to support clinical studies; the data was refined through a data quality management process. Data for 21,368 patients who were prescribed statins for the first time were extracted. We extracted data every 3 months for a period of 1 year. A total of 17 different statins were extracted. It was found that statins were first prescribed by the endocrinology department in most cases (69%, 14,865/21,368).

Conclusion

Study researchers can use our CDM for statins. Our EMR data for statins is useful for investigating the effectiveness of treatments and exploring new information on statins. Using EMR is advantageous for compiling an adequate study cohort in a short period.

Citations

Citations to this article as recorded by  
  • Long-term stroke and major bleeding risk in patients with non-valvular atrial fibrillation: A comparative analysis between non-vitamin K antagonist oral anticoagulants and warfarin using a clinical data warehouse
    Hancheol Lee, Jung Hwa Hong, Kwon-Duk Seo
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • Digital Health Data Quality Issues: Systematic Review
    Rehan Syed, Rebekah Eden, Tendai Makasi, Ignatius Chukwudi, Azumah Mamudu, Mostafa Kamalpour, Dakshi Kapugama Geeganage, Sareh Sadeghianasl, Sander J J Leemans, Kanika Goel, Robert Andrews, Moe Thandar Wynn, Arthur ter Hofstede, Trina Myers
    Journal of Medical Internet Research.2023; 25: e42615.     CrossRef
  • Prediction of intradialytic hypotension using pre-dialysis features—a deep learning–based artificial intelligence model
    Hanbi Lee, Sung Joon Moon, Sung Woo Kim, Ji Won Min, Hoon Suk Park, Hye Eun Yoon, Young Soo Kim, Hyung Wook Kim, Chul Woo Yang, Sungjin Chung, Eun Sil Koh, Byung Ha Chung
    Nephrology Dialysis Transplantation.2023; 38(10): 2310.     CrossRef
  • Carpal tunnel syndrome and tenosynovitis in women with breast cancer associated with hormone therapy
    Dong Jae Shin, Kyung Eun Nam, Dae Heon Song, Sun Im, Sun Jae Won, Yeo Hyung Kim, Seong Hoon Lim, Jong In Lee
    Medicine.2022; 101(5): e28786.     CrossRef
  • Data Pseudonymization in a Range That Does Not Affect Data Quality: Correlation with the Degree of Participation of Clinicians
    Soo-Yong Shin, Hun-Sung Kim
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Ten-year patient journey of stage III non-small cell lung cancer patients: A single-center, observational, retrospective study in Korea (Realtime autOmatically updated data warehOuse in healTh care; UNIVERSE-ROOT study)
    Hyun Ae Jung, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park
    Lung Cancer.2020; 146: 112.     CrossRef
  • Real-time autOmatically updated data warehOuse in healThcare (ROOT: An Innovative and Automated Data Collection System) (Preprint)
    Hyun Ae Jung, Oksoon Jeong, Dong Kyung Chang, Sehhoon Park, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park
    JMIR Medical Informatics.2020;[Epub]     CrossRef
  • Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea
    Seo Yeon Baik, Hyunah Kim, So Jung Yang, Tong Min Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon, Hun-Sung Kim
    Frontiers of Medicine.2019; 13(6): 713.     CrossRef
  • Proceed with Caution When Using Real World Data and Real World Evidence
    Hun-Sung Kim, Ju Han Kim
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Change in ALT levels after administration of HMG‐CoA reductase inhibitors to subjects with pretreatment levels three times the upper normal limit in clinical practice
    Hyunah Kim, Hyeseon Lee, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung‐Hwan Lee, Jae‐Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun‐Ho Yoon, Hun‐Sung Kim
    Cardiovascular Therapeutics.2018;[Epub]     CrossRef
  • Developing a multi-center clinical data mart of ACEI and ARB for real-world evidence (RWE)
    Hun-Sung Kim, Sue Hyun Lee, Tong Min Kim, Ju Han Kim
    Clinical Hypertension.2018;[Epub]     CrossRef
  • Comparative Analysis of the Suspected Heparin‐Induced Thrombocytopenia Level in Korea
    Hun‐Sung Kim, Hyunah Kim, Yoo Jin Jeong, Hyunyong Lee, Hyeon Woo Yim, Ji il Kim, In Sung Moon, Jang‐Yong Kim
    Basic & Clinical Pharmacology & Toxicology.2017; 121(4): 360.     CrossRef
  • The differences in the incidence of diabetes mellitus and prediabetes according to the type of HMG-CoA reductase inhibitors prescribed in Korean patients
    Tong Min Kim, Hyunah Kim, Yoo Jin Jeong, Sun Jung Baik, So Jung Yang, Seung-Hwan Lee, Jae-Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, In Young Choi, Kun-Ho Yoon, Hun-Sung Kim
    Pharmacoepidemiology and Drug Safety.2017; 26(10): 1156.     CrossRef
  • Use of Moderate‐Intensity Statins for Low‐Density Lipoprotein Cholesterol Level above 190 mg/dL at Baseline in Koreans
    Hun‐Sung Kim, Hyeseon Lee, Sue Hyun Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Sun Jung Baik, Hyunah Kim, Seung‐Hwan Lee, Jae Hyoung Cho, In‐Young Choi, Kun‐Ho Yoon, Ju Han Kim
    Basic & Clinical Pharmacology & Toxicology.2017; 121(4): 272.     CrossRef
Close layer

Endocrinol Metab : Endocrinology and Metabolism