Most-read articles are from the articles published in 2021 during the last three month.
Review Articles
- Diabetes, Obesity and Metabolism
- Effects of Intermittent Fasting on the Circulating Levels and Circadian Rhythms of Hormones
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Bo Hye Kim, Yena Joo, Min-Seon Kim, Han Kyoung Choe, Qingchun Tong, Obin Kwon
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Endocrinol Metab. 2021;36(4):745-756. Published online August 27, 2021
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DOI: https://doi.org/10.3803/EnM.2021.405
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- Intermittent fasting has become an increasingly popular strategy in losing weight and associated reduction in obesity-related medical complications. Overwhelming studies support metabolic improvements from intermittent fasting in blood glucose levels, cardiac and brain function, and other health benefits, in addition to weight loss. However, concerns have also been raised on side effects including muscle loss, ketosis, and electrolyte imbalance. Of particular concern, the effect of intermittent fasting on hormonal circadian rhythms has received little attention. Given the known importance of circadian hormonal changes to normal physiology, potential detrimental effects by dysregulation of hormonal changes deserve careful discussions. In this review, we describe the changes in circadian rhythms of hormones caused by intermittent fasting. We covered major hormones commonly pathophysiologically involved in clinical endocrinology, including insulin, thyroid hormones, and glucocorticoids. Given that intermittent fasting could alter both the level and frequency of hormone secretion, decisions on practicing intermittent fasting should take more considerations on potential detrimental consequences versus beneficial effects pertaining to individual health conditions.
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Citations
Citations to this article as recorded by

- Fasting intervention and its clinical effects on the human host and microbiome
Sofia K. Forslund
Journal of Internal Medicine.2023; 293(2): 166. CrossRef - Umbrella review of time-restricted eating on weight loss, fasting blood glucose, and lipid profile
Han Shi Jocelyn Chew, Wei How Darryl Ang, Zhen Yang Abel Tan, Wen Wei Ang, Kin Sun Chan, Ying Lau
Nutrition Reviews.2023; 81(9): 1180. CrossRef - Thermodynamic Assessment of the Effects of Intermittent Fasting and Fatty Liver Disease Diets on Longevity
Melek Ece Öngel, Cennet Yildiz, Özge Başer, Bayram Yilmaz, Mustafa Özilgen
Entropy.2023; 25(2): 227. CrossRef - Effects of Intermittent Fasting on Hypothalamus–Pituitary–Thyroid Axis, Palatable Food Intake, and Body Weight in Stressed Rats
Cinthia García-Luna, Ixchel Prieto, Paulina Soberanes-Chávez, Elena Alvarez-Salas, Iván Torre-Villalvazo, Gilberto Matamoros-Trejo, Patricia de Gortari
Nutrients.2023; 15(5): 1164. CrossRef - Possible homeostatic, glucose uptake mechanisms and hepato-pancreatic histological effects of intermittent fasting, exercise, starvation, and honey in streptozotocin-induced diabetes in rats
Ejime A. Chijiokwu, Eze K. Nwangwa, Mega O. Oyovwi, Benneth Ben-Azu, Alexander O. Naiho, Emuesiri Goodies Moke, Victor Emojevwe, Prosper A. Ehiwarior, Udoka S. Nwabuoku
Nutrire.2023;[Epub] CrossRef - Mid-Point of the Active Phase Is Better to Achieve the Natriuretic Effect of Acute Salt Load in Mice
Momoko Imamura, Hiroyuki Sasaki, Katsuki Hayashi, Shigenobu Shibata
Nutrients.2023; 15(7): 1679. CrossRef - All That Glitters Is Not Gold: The Same Sleep Time, but Different Diabetogenic Outcomes
Bohye Kim, Obin Kwon
Endocrinology and Metabolism.2023; 38(1): 78. CrossRef - The emerging role of circadian rhythms in the development and function of thermogenic fat
Xuemin Peng, Yong Chen
Frontiers in Endocrinology.2023;[Epub] CrossRef - Time-restricted Feeding Changes as Inspiration for Drug Design
Zhangyuting He, Huayu Yang, Yilei Mao
Current Pharmaceutical Design.2023; 29(8): 559. CrossRef - Brain Dopamine–Clock Interactions Regulate Cardiometabolic Physiology: Mechanisms of the Observed Cardioprotective Effects of Circadian-Timed Bromocriptine-QR Therapy in Type 2 Diabetes Subjects
Anthony H. Cincotta
International Journal of Molecular Sciences.2023; 24(17): 13255. CrossRef - Adaptive Circadian Rhythms for Autonomous and Biologically Inspired Robot Behavior
Marcos Maroto-Gómez, María Malfaz, Álvaro Castro-González, Sara Carrasco-Martínez, Miguel Ángel Salichs
Biomimetics.2023; 8(5): 413. CrossRef - Common and divergent molecular mechanisms of fasting and ketogenic diets
Antonio Paoli, Grant M. Tinsley, Mark P. Mattson, Immaculata De Vivo, Ravi Dhawan, Tatiana Moro
Trends in Endocrinology & Metabolism.2023;[Epub] CrossRef - Intermittent Fasting on Human Health and Disease
Denisa Marilena Margină, Cristina Manuela Drăgoi
Nutrients.2023; 15(21): 4491. CrossRef - Synthetic augmentation of bilirubin metabolism in human pluripotent stem cell-derived liver organoids
Hasan Al Reza, Zishaan Farooqui, Abid Al Reza, Callen Conroy, Kentaro Iwasawa, Yasuhiro Ogura, Keisuke Okita, Kenji Osafune, Takanori Takebe
Stem Cell Reports.2023; 18(11): 2071. CrossRef - Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models
Hailong Cui, Die Hu, Yanling Liu, Jiejie Zhao
Gene.2023; : 148053. CrossRef - Intermittent fasting, high-intensity interval training, or a combination of both have beneficial effects in obese mice with nonalcoholic fatty liver disease
Patrícia de Castro-de-Paiva, Thatiany de Souza Marinho, Carlos Alberto Mandarim-de-Lacerda, Marcia Barbosa Aguila
The Journal of Nutritional Biochemistry.2022; 104: 108997. CrossRef - Optimal Timing of Thyroid Hormone Replacement During Ramadan Fasting: A Randomized Controlled Trial in Patients with Prior Total Thyroidectomy
Khalid M. Al-Qahtani, Ibraheem Ahmed Aldeeri, Amal M. Alshaibi, Norah Salman Alshabib, Rakan M. Barghouthi, Ebtihal Y. Alyusuf, Anwar Ali Jammah
Thyroid.2022; 32(9): 1029. CrossRef - Exploring the Effects of Energy Constraints on Performance, Body Composition, Endocrinological/Hematological Biomarkers, and Immune System among Athletes: An Overview of the Fasting State
Hadi Nobari, Saber Saedmocheshi, Eugenia Murawska-Ciałowicz, Filipe Manuel Clemente, Katsuhiko Suzuki, Ana Filipa Silva
Nutrients.2022; 14(15): 3197. CrossRef - Alternate day fasting and time-restricted feeding may confer similar neuroprotective effects during aging in male rats
Sukanya Bhoumik, Rashmi Kesherwani, Raushan Kumar, Syed Ibrahim Rizvi
Biogerontology.2022; 23(6): 757. CrossRef - Intermittent Fasting—A Healthy Dietary Pattern for Diabetic Nephropathy
Ming Yang, Wei Chen, Liyu He, Di Liu, Li Zhao, Xi Wang
Nutrients.2022; 14(19): 3995. CrossRef - β-hydroxybutyrate as an Anti-Aging Metabolite
Lian Wang, Peijie Chen, Weihua Xiao
Nutrients.2021; 13(10): 3420. CrossRef
- Thyroid
- Update from the 2022 World Health Organization Classification of Thyroid Tumors: A Standardized Diagnostic Approach
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Chan Kwon Jung, Andrey Bychkov, Kennichi Kakudo
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Endocrinol Metab. 2022;37(5):703-718. Published online October 4, 2022
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DOI: https://doi.org/10.3803/EnM.2022.1553
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- The fifth edition of the World Health Organization (WHO) histologic classification of thyroid neoplasms released in 2022 includes newly recognized tumor types, subtypes, and a grading system. Follicular cell-derived neoplasms are categorized into three families (classes): benign tumors, low-risk neoplasms, and malignant neoplasms. The terms “follicular nodular disease” and “differentiated high-grade thyroid carcinoma” are introduced to account for multifocal hyperplastic/neoplastic lesions and differentiated thyroid carcinomas with high-grade features, respectively. The term “Hürthle cells” is replaced with “oncocytic cells.” Invasive encapsulated follicular and cribriform morular variants of papillary thyroid carcinoma (PTC) are now redefined as distinct tumor types, given their different genetic alterations and clinicopathologic characteristics from other PTC subtypes. The term “variant” to describe a subclass of tumor has been replaced with the term “subtype.” Instead, the term “variant” is reserved to describe genetic alterations. A histologic grading system based on the mitotic count, necrosis, and/or the Ki67 index is used to identify high-grade follicular-cell derived carcinomas and medullary thyroid carcinomas. The 2022 WHO classification introduces the following new categories: “salivary gland-type carcinomas of the thyroid” and “thyroid tumors of uncertain histogenesis.” This review summarizes the major changes in the 2022 WHO classification and their clinical relevance.
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Citations
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- Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma
Chan Kwon Jung, Shipra Agarwal, Jen-Fan Hang, Dong-Jun Lim, Andrey Bychkov, Ozgur Mete
Endocrine Pathology.2023; 34(1): 1. CrossRef - The 5th edition of WHO classification of tumors of endocrine organs: changes in the diagnosis of follicular-derived thyroid carcinoma
Fulvio Basolo, Elisabetta Macerola, Anello Marcello Poma, Liborio Torregrossa
Endocrine.2023; 80(3): 470. CrossRef - Preoperative Risk Stratification of Follicular-patterned Thyroid Lesions on Core Needle Biopsy by Histologic Subtyping and RAS Variant-specific Immunohistochemistry
Meejeong Kim, Sora Jeon, Chan Kwon Jung
Endocrine Pathology.2023; 34(2): 247. CrossRef - Ultrasound evolution of parenchymal changes in the thyroid gland with autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma – a follow-up study
Dominika Januś, Monika Kujdowicz, Małgorzata Wójcik, Anna Taczanowska-Niemczuk, Aleksandra Kiszka-Wiłkojć, Wojciech Górecki, Jerzy B. Starzyk
Frontiers in Endocrinology.2023;[Epub] CrossRef - Papillary thyroid carcinoma with aggressive fused follicular and solid growth pattern: A unique histological subtype with high‐grade malignancy?
Shin‐ichi Murata, Ibu Matsuzaki, Mitsuo Kishimoto, Naomi Katsuki, Toshinori Onishi, Mitsuyoshi Hirokawa, Fumiyoshi Kojima
Pathology International.2023; 73(5): 207. CrossRef - Multi-Omics and Management of Follicular Carcinoma of the Thyroid
Thifhelimbilu Emmanuel Luvhengo, Ifongo Bombil, Arian Mokhtari, Maeyane Stephens Moeng, Demetra Demetriou, Claire Sanders, Zodwa Dlamini
Biomedicines.2023; 11(4): 1217. CrossRef - Molecular Genetics of Diffuse Sclerosing Papillary Thyroid Cancer
Meshael Alswailem, Balgees Alghamdi, Anwar Alotaibi, Abeer Aljomiah, Hindi Al-Hindi, Avaniyapuram Kannan Murugan, Mohamed Abouelhoda, Yufei Shi, Ali S Alzahrani
The Journal of Clinical Endocrinology & Metabolism.2023; 108(9): e704. CrossRef - Multifunctional Phase-Transition Nanoparticles for Effective Targeted Sonodynamic-Gene Therapy Against Thyroid Papillary Carcinoma
Shihui Guan, Dengke Teng, Hui Wang, Qimeihui Wang, Xi Zhen, Guoqing Sui, Yang Wang, Lingyu Zhu, Yuanqiang Lin, Dan Jiao, Feng Guo
International Journal of Nanomedicine.2023; Volume 18: 2275. CrossRef - Utilizing Dynamic Risk Stratification in Patients With Tall Cell Variant Papillary Thyroid Cancer
David Zimmer, Gilman Plitt, Brandon Prendes, Jamie Ku, Natalie Silver, Eric Lamarre, Emrullah Yilmaz, Jessica Geiger, Christian Nasr, Lea El Hage, Mario Skugor, Shauna Cambpell, Shlomo Koyfman, Jacob Miller, Neil Woody, Katherine Heiden, Nikhil Joshi, Tar
The Laryngoscope.2023; 133(9): 2430. CrossRef - Ultrasound, laboratory and histopathological insights in diagnosing papillary thyroid carcinoma in a paediatric population: a single centre follow-up study between 2000-2022
Dominika Januś, Małgorzata Wójcik, Anna Taczanowska-Niemczuk, Aleksandra Kiszka-Wiłkojć, Monika Kujdowicz, Małgorzata Czogała, Wojciech Górecki, Jerzy B. Starzyk
Frontiers in Endocrinology.2023;[Epub] CrossRef - Medullary Thyroid Carcinoma: A Single Institute Experience
Sonal Trivedi, T. Salahuddin, Mohamed Taher Mithi, Priyank Rathod, Arpit Bandi, Shashank J. Pandya, Mohit Sharma, Shailesh Patel, Vikas Warikoo, Ketul Puj, Abhijeet Salunkhe, Keval Patel, Shivam Pandya
Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(4): 2884. CrossRef - FNAC (Fine needle aspiration cytology) and histopathological correlation and reclassification of thyroid neoplasm in accordance with WHO classification 2022
Fareeda Joshi, Shreya Hegde
Indian Journal of Pathology and Oncology.2023; 10(2): 132. CrossRef - Papillary thyroid carcinoma associated with non‑functioning parathyroid carcinoma with Warthin's tumor of the parotid gland: A case report and brief literature review
Ari Abdullah, Aras Qaradakhy, Yadgar Saeed, Abdulwahid Salih, Seema Karim, Osama Ali, Shko Hassan, Shalaw Nasraldeen, Shvan Mohammed, Fahmi Kakamad
Medicine International.2023;[Epub] CrossRef - Warthin-like papillary thyroid carcinoma: a case report and comprehensive review of the literature
Abdel Mouhaymen Missaoui, Fatma Hamza, Wafa Belabed, Manel Mellouli, Mohamed Maaloul, Slim Charfi, Issam Jardak, Tahya Sellami-Boudawara, Nabila Rekik, Mohamed Abid
Frontiers in Endocrinology.2023;[Epub] CrossRef - Reevaluating diagnostic categories and associated malignancy risks in thyroid core needle biopsy
Chan Kwon Jung
Journal of Pathology and Translational Medicine.2023; 57(4): 208. CrossRef - Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street
Ioana Balinisteanu, Monica-Cristina Panzaru, Lavinia Caba, Maria-Christina Ungureanu, Andreea Florea, Ana Maria Grigore, Eusebiu Vlad Gorduza
Biomedicines.2023; 11(8): 2143. CrossRef - Deep learning prediction model for central lymph node metastasis in papillary thyroid microcarcinoma based on cytology
Wenhao Ren, Yanli Zhu, Qian Wang, Yuntao Song, Zhihui Fan, Yanhua Bai, Dongmei Lin
Cancer Science.2023; 114(10): 4114. CrossRef - Cytology and Histology of Thyroid Nodules: Exploring Novel Insights in the Molecular Era for Enhanced Patient Management
Beatrix Cochand-Priollet, Zahra Maleki
Current Oncology.2023; 30(8): 7753. CrossRef - Agrin is a novel oncogenic protein in thyroid cancer
Anna Adamiok‑Ostrowska, Małgorzata Grzanka, Barbara Czarnocka
Oncology Letters.2023;[Epub] CrossRef - Analysis of Pathological Features of Thyroid Carcinoma in the Western Yunnan
身吾 王
Advances in Clinical Medicine.2023; 13(10): 15820. CrossRef - Insight of novel biomarkers for papillary thyroid carcinoma through multiomics
Wei Liu, Junkan Zhu, Zhen Wu, Yongxiang Yin, Qiao Wu, Yiming Wu, Jiaojiao Zheng, Cong Wang, Hongyan Chen, Talal Jamil Qazi, Jun Wu, Yuqing Zhang, Houbao Liu, Jingmin Yang, Daru Lu, Xumin Zhang, Zhilong Ai
Frontiers in Oncology.2023;[Epub] CrossRef - Identification of NIFTP-Specific mRNA Markers for Reliable Molecular Diagnosis of Thyroid Tumors
So-Yeon Lee, Jong-Lyul Park, Kwangsoon Kim, Ja Seong Bae, Jae-Yoon Kim, Seon-Young Kim, Chan Kwon Jung
Endocrine Pathology.2023; 34(3): 311. CrossRef - Somatostatin Receptor Type 2 and Thyroid-Stimulating Hormone Receptor Expression in Oncocytic Thyroid Neoplasms: Implications for Prognosis and Treatment
Andrea Gillis, Rui Zheng-Pywell, Chandler McLeod, Dezhi Wang, John M. Ness, Rachael Guenter, Jason Whitt, Tomas A. Prolla, Herbert Chen, Manuel Lora Gonzalez, Bart Rose, Ricardo V. Lloyd, Renata Jaskula-Sztul, Diana Lin
Modern Pathology.2023; 36(12): 100332. CrossRef - Comparison of Treatment and Prognosis Between Follicular Variant
Papillary Thyroid Carcinoma and Classical Papillary Thyroid
Carcinoma
Bing Zhang, Wenming Wu, Jinjing Liu, Zhou Liang, Liang Zong
Hormone and Metabolic Research.2023; 55(12): 855. CrossRef - Sentinel lymph node mapping: current applications and future perspectives in thyroid carcinoma
Isabella Merante Boschin, Loris Bertazza, Carla Scaroni, Caterina Mian, Maria Rosa Pelizzo
Frontiers in Medicine.2023;[Epub] CrossRef - Utility of the Growth Differentiation Factor-15 in the Differential Diagnosis of Follicular-Patterned Lesions of the Thyroid on Cytopathologic and Histopathologic Samples
Prasanna V Perumal, Neelaiah Siddaraju, Sunil K Saxena, Soundravally Rajendiran, Ramachandra V Bhat
Cureus.2023;[Epub] CrossRef - Tumeurs de la thyroïde : nouveautés de la classification OMS 2022
Serge Guyétant, Myriam Decaussin Petrucci, Emmanuelle Leteurtre
Annales de Pathologie.2023;[Epub] CrossRef - Investigation of pre‐operative demographic, biochemical, sonographic and cytopathological findings in low‐risk thyroid neoplasms
Muzaffer Serdar Deniz, Didem Özdemir, Narin Nasıroğlu İmga, Hüsniye Başer, Fatma Neslihan Çuhacı Seyrek, Ayşegül Aksoy Altınboğa, Oya Topaloğlu, Reyhan Ersoy, Bekir Çakır
Clinical Endocrinology.2023; 99(5): 502. CrossRef - Applications of machine and deep learning to thyroid cytology and histopathology: a review
Greg Slabaugh, Luis Beltran, Hasan Rizvi, Panos Deloukas, Eirini Marouli
Frontiers in Oncology.2023;[Epub] CrossRef - The Asian Thyroid Working Group, from 2017 to 2023
Kennichi Kakudo, Chan Kwon Jung, Zhiyan Liu, Mitsuyoshi Hirokawa, Andrey Bychkov, Huy Gia Vuong, Somboon Keelawat, Radhika Srinivasan, Jen-Fan Hang, Chiung-Ru Lai
Journal of Pathology and Translational Medicine.2023; 57(6): 289. CrossRef - Anaplastic thyroid cancer: Pathogenesis, prognostic factors and genetic landscape (Review)
Abdul-Mohsen Alhejaily, Omar Alhuzim, Yazeed Alwelaie
Molecular and Clinical Oncology.2023;[Epub] CrossRef - Simultaneous Occurrence of Medullary Thyroid Carcinoma and Papillary Thyroid Carcinoma: A Case Series with Literature Review
Poupak Fallahi, Armando Patrizio, Giulio Stoppini, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Eugenia Balestri, Valeria Mazzi, Chiara Botrini, Gilda Varricchi, Salvatore Ulisse, Marco Ghionzoli, Alessandro Antonelli, Silvia Martina Ferrari
Current Oncology.2023; 30(12): 10237. CrossRef - Reprogramming of Cellular Metabolism and Its Therapeutic Applications in Thyroid Cancer
Yuji Nagayama, Koichiro Hamada
Metabolites.2022; 12(12): 1214. CrossRef - Developments to improve outcomes in thyroid surgery
Thomas J. Musholt
Innovative Surgical Sciences.2022; 7(3-4): 77. CrossRef - The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure
Tetiana Bogdanova, Serhii Chernyshov, Liudmyla Zurnadzhy, Tatiana I. Rogounovitch, Norisato Mitsutake, Mykola Tronko, Masahiro Ito, Michael Bolgov, Sergii Masiuk, Shunichi Yamashita, Vladimir A. Saenko
Frontiers in Endocrinology.2022;[Epub] CrossRef
- Thyroid
- Current Guidelines for Management of Medullary Thyroid Carcinoma
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Mijin Kim, Bo Hyun Kim
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Endocrinol Metab. 2021;36(3):514-524. Published online June 22, 2021
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DOI: https://doi.org/10.3803/EnM.2021.1082
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- Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating from the parafollicular cells. The diagnostic and therapeutic strategies for the condition are different from those used for well-differentiated thyroid cancer. Since the 2015 American Thyroid Association guidelines for the diagnosis and treatment of MTC, the latest, including the National Comprehensive Cancer Network and European Association for Medical Oncology guidelines have been updated to reflect several recent advances in the management of MTC. Advances in molecular diagnosis and postoperative risk stratification systems have led to individualized treatment and follow-up strategies. Multi-kinase inhibitors, such as vandetanib and cabozantinib, can prolong disease progression-free survival with favorable adverse effects. In addition, potent selective rearranged during transfection (RET) inhibitors (selpercatinib and pralsetinib) have shown a promising efficacy in recent clinical trials. This review summarizes the management of MTC in recent guidelines focused on sporadic MTC.
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Citations
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- Update on Management of Medullary Thyroid Carcinoma: Focus on Nuclear Medicine
Giorgio Treglia, Vittoria Rufini, Arnoldo Piccardo, Alessio Imperiale
Seminars in Nuclear Medicine.2023; 53(4): 481. CrossRef - Cabozantinib, Vandetanib, Pralsetinib and Selpercatinib as Treatment for Progressed Medullary Thyroid Cancer with a Main Focus on Hypertension as Adverse Effect
Linnea Højer Wang, Markus Wehland, Petra M. Wise, Manfred Infanger, Daniela Grimm, Michael C. Kreissl
International Journal of Molecular Sciences.2023; 24(3): 2312. CrossRef - A proposed grading scheme for predicting recurrence in medullary thyroid cancer based on the Ki67 index and metastatic lymph node ratio
Pengfei Xu, Di Wu, Xuekui Liu
Endocrine.2023; 81(1): 107. CrossRef - Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Adults with Inoperable or Metastatic Somatostatin Receptor-Positive Pheochromocytomas/Paragangliomas, Bronchial and Unknown Origin Neuroendocrine Tumors, and Medullary Thyroid Carcinoma: A Systematic Literatur
Marianna Hertelendi, Oulaya Belguenani, Azzeddine Cherfi, Ilya Folitar, Gabor Kollar, Berna Degirmenci Polack
Biomedicines.2023; 11(4): 1024. CrossRef - PET/CT with various radiopharmaceuticals in the complex diagnosis of medullary thyroid carcinoma: a review
N. V. Tsentr, A. E. Ertman, D. V. Ryzhkova
Diagnostic radiology and radiotherapy.2023; 14(2): 31. CrossRef - Physical activity and reduced risk of fracture in thyroid cancer patients after thyroidectomy — a nationwide cohort study
Jinyoung Kim, Kyungdo Han, Jin-Hyung Jung, Jeonghoon Ha, Chaiho Jeong, Jun-Young Heu, Se-Won Lee, Jeongmin Lee, Yejee Lim, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Ho Song, Ki-Hyun Baek
Frontiers in Endocrinology.2023;[Epub] CrossRef - Different RONS Generation in MTC-SK and NSCL Cells Lead to Varying Antitumoral Effects of Alpha-Ketoglutarate + 5-HMF
Joachim Greilberger, Katharina Erlbacher, Philipp Stiegler, Reinhold Wintersteiger, Ralf Herwig
Current Issues in Molecular Biology.2023; 45(8): 6503. CrossRef - Medullary thyroid carcinoma
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Expert Review of Anticancer Therapy.2023; 23(9): 943. CrossRef - Mixed medullary‑follicular thyroid carcinoma: A case report and literature review
Yonghui Wang, Dandan Yin, Guifang Ren, Zhengjiang Wang, Fanhua Kong
Oncology Letters.2023;[Epub] CrossRef - Circulating cell-free DNA (cfDNA) in patients with medullary thyroid carcinoma is characterized by specific fragmentation and methylation changes with diagnostic value
Anna Citarella, Zein Mersini Besharat, Sofia Trocchianesi, Tanja Milena Autilio, Antonella Verrienti, Giuseppina Catanzaro, Elena Splendiani, Zaira Spinello, Silvia Cantara, Patrizia Zavattari, Eleonora Loi, Cristina Romei, Raffaele Ciampi, Luciano Pezzul
Biomarker Research.2023;[Epub] CrossRef - Molecular imaging and related therapeutic options for medullary thyroid carcinoma: state of the art and future opportunities
Alessio Imperiale, Valentina Berti, Mickaël Burgy, Roberto Luigi Cazzato, Arnoldo Piccardo, Giorgio Treglia
Reviews in Endocrine and Metabolic Disorders.2023;[Epub] CrossRef - Advances in Diagnostics and Therapy of Medullary Thyroid Carcinoma (MTC)– A Mini-Review
Michał Miciak, Krzysztof Jurkiewicz
Clinical Cancer Investigation Journal.2023; 12(5): 1. CrossRef - The Evolving Treatment Landscape of Medullary Thyroid Cancer
Marta Laganà, Valentina Cremaschi, Andrea Alberti, Danica M. Vodopivec Kuri, Deborah Cosentini, Alfredo Berruti
Current Treatment Options in Oncology.2023;[Epub] CrossRef - Pralsetinib: chemical and therapeutic development with FDA authorization for the management of RET fusion-positive non-small-cell lung cancers
Faraat Ali, Kumari Neha, Garima Chauhan
Archives of Pharmacal Research.2022; 45(5): 309. CrossRef - Psychosocial Characteristics and Experiences in Patients with Multiple Endocrine Neoplasia Type 2 (MEN2) and Medullary Thyroid Carcinoma (MTC)
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Children.2022; 9(6): 774. CrossRef - Aggressive clinical course of medullary thyroid microcarcinoma
Tamara Janić, Mirjana Stojković, Sanja Klet, Bojan Marković, Beleslin Nedeljković, Jasmina Ćirić, Miloš Žarković
Medicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma.2022; 27(85): 63. CrossRef - Comparative evaluation of somatostatin and CXCR4 receptor expression in different types of thyroid carcinoma using well-characterised monoclonal antibodies
Max Czajkowski, Daniel Kaemmerer, Jörg Sänger, Guido Sauter, Ralph M. Wirtz, Stefan Schulz, Amelie Lupp
BMC Cancer.2022;[Epub] CrossRef - Metastatic Risk Stratification of 2526 Medullary Thyroid Carcinoma Patients: A Study Based on Surveillance, Epidemiology, and End Results Database
Minh-Khang Le, Masataka Kawai, Toru Odate, Huy Gia Vuong, Naoki Oishi, Tetsuo Kondo
Endocrine Pathology.2022; 33(3): 348. CrossRef - Update on the Diagnosis and Management of Medullary Thyroid Cancer: What Has Changed in Recent Years?
Krzysztof Kaliszewski, Maksymilian Ludwig, Bartłomiej Ludwig, Agnieszka Mikuła, Maria Greniuk, Jerzy Rudnicki
Cancers.2022; 14(15): 3643. CrossRef - Immunotherapy of Neuroendocrine Neoplasms: Any Role for the Chimeric Antigen Receptor T Cells?
Giuseppe Fanciulli, Roberta Modica, Anna La Salvia, Federica Campolo, Tullio Florio, Nevena Mikovic, Alice Plebani, Valentina Di Vito, Annamaria Colao, Antongiulio Faggiano
Cancers.2022; 14(16): 3991. CrossRef - Preclinical Evaluation of Novel Tyrosine-Kinase Inhibitors in Medullary Thyroid Cancer
Davide Saronni, Germano Gaudenzi, Alessandra Dicitore, Silvia Carra, Maria Celeste Cantone, Maria Orietta Borghi, Andrea Barbieri, Luca Mignani, Leo J. Hofland, Luca Persani, Giovanni Vitale
Cancers.2022; 14(18): 4442. CrossRef - Rapid and long-lasting response to selpercatinib of paraneoplastic Cushing’s syndrome in medullary thyroid carcinoma
Marine Sitbon, Porhuoy Chou, Seydou Bengaly, Brigitte Poirot, Marie Laloi-Michelin, Laure Deville, Atanas Pachev, Ahouefa Kowo-Bille, Clement Dumont, Cécile N Chougnet
European Thyroid Journal.2022;[Epub] CrossRef - Ginsenoside Rg3 Alleviates Antithyroid Cancer Drug Vandetanib-Induced QT Interval Prolongation
Juan Zhang, Dan Luo, Fang Li, Zhiyi Li, Xiaoli Gao, Jie Qiao, Lin Wu, Miaoling Li, Shao Liang
Oxidative Medicine and Cellular Longevity.2021; 2021: 1. CrossRef - THE ROLE OF CALCITONIN IN THE PREOPERATIVE STAGE AS THE PREDICTOR OF MEDULLARY THYROID CANCER METASTASES
Volodymyr Palamarchuk , Viktor Smolyar , Oleksandr Tovkay, Oleksandr Nechay, Volodymyr Kuts , Revaz Sichinava , Oleh Mazur
Ukrainian Scientific Medical Youth Journal.2021; 127(4): 68. CrossRef
- Adrenal Gland
- Recent Updates on the Management of Adrenal Incidentalomas
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Seung Shin Park, Jung Hee Kim
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Endocrinol Metab. 2023;38(4):373-380. Published online August 16, 2023
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DOI: https://doi.org/10.3803/EnM.2023.1779
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- Adrenal incidentalomas represent an increasingly common clinical conundrum with significant implications for patients. The revised 2023 European Society of Endocrinology (ESE) guideline incorporates cutting-edge evidence for managing adrenal incidentalomas. This paper provides a concise review of the updated contents of the revised guideline. In the 2023 guideline, in patients without signs and symptoms of overt Cushing’s syndrome, a post-dexamethasone cortisol level above 50 nmol/L (>1.8 μg/dL) should be considered as mild autonomous cortisol secretion. Regarding the criteria of benign adrenal adenomas, a homogeneous adrenal mass with ≤10 Hounsfield units on non-contrast computed tomography requires no further follow-up, irrespective of its size. The updated guideline also discusses steroid metabolomics using tandem mass spectrometry to discriminate malignancy. It underscores the importance of high-volume surgeons performing adrenalectomy and emphasizes the pivotal role of a multidisciplinary team approach in deciding the treatment plan for indeterminate adrenal masses. The guideline advocates for more proactive surgical treatment for indeterminate adrenal masses in young patients (<40 years) and pregnant women. This review of the 2023 ESE guideline underscores the ongoing evolution of the adrenal incidentaloma management landscape, emphasizing the need for further research and adaptation of diagnostic and therapeutic strategies.
- Bone Metabolism
- Long-Term Treatment of Postmenopausal Osteoporosis
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Jacques P. Brown
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Endocrinol Metab. 2021;36(3):544-552. Published online June 22, 2021
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DOI: https://doi.org/10.3803/EnM.2021.301
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10,384
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- Osteoporosis is an incurable chronic condition, like heart disease, diabetes, or hypertension. A large gap currently exists in the primary prevention of fractures, and studies show that an estimated 80% to 90% of adults do not receive appropriate osteoporosis management even in the secondary prevention setting. Case finding strategies have been developed and effective pharmacological interventions are available. This publication addresses how best to use the pharmacological options available for postmenopausal osteoporosis to provide lifelong fracture protection in patients at high and very high risk of fracture. The benefit of osteoporosis therapies far outweighs the rare risks.
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Weiye Cai, Bin Sun, Chao Song, Fei Liu, Zhengliang Wu, Zongchao Liu
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Alina Hanga-Farcaș, Florina Miere (Groza), Gabriela Adriana Filip, Simona Clichici, Luminita Fritea, Laura Grațiela Vicaș, Eleonora Marian, Annamaria Pallag, Tunde Jurca, Sanda Monica Filip, Mariana Eugenia Muresan
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Biomedical Chromatography.2023;[Epub] CrossRef - Study on the Effect of Bushen Zhuanggu Tablet Combined with Conventional Regimen on Bone Mineral Density Improvement, Functional Recovery and Fracture Risk Prevention in Patients with Postmenopausal Osteoporosis
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Computational and Mathematical Methods in Medicine.2023; 2023: 1. CrossRef - Circ_0001825 promotes osteogenic differentiation in human-derived mesenchymal stem cells via miR-1270/SMAD5 axis
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Bowen Lai, Heng Jiang, Yuan Gao, Xuhui Zhou
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Frontiers in Endocrinology.2023;[Epub] CrossRef - Epigallocatechin gallate alleviates osteoporosis by regulating the gut microbiota and serum metabolites in rats
Xuebing Han, Yifeng Fu, Keyu Wang, Siying Li, Chang Jiang, Shuangshuang Wang, Zheng Wang, Gang Liu, Siwang Hu
Food & Function.2023; 14(23): 10564. CrossRef - The Molecular Role of Polyamines in Age-Related Diseases: An Update
Guadalupe Elizabeth Jimenez Gutierrez, Fabiola V. Borbolla Jiménez, Luis G. Muñoz, Yessica Sarai Tapia Guerrero, Nadia Mireya Murillo Melo, José Melesio Cristóbal-Luna, Norberto Leyva Garcia, Joaquín Cordero-Martínez, Jonathan J. Magaña
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Wei Fan, Zong-Zhe Jiang, Sheng-Rong Wan
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Yuan Zhang, Yuying Kou, Panpan Yang, Xing Rong, Rong Tang, Hongrui Liu, Minqi Li
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Beom-Jun Kim
Annals of Geriatric Medicine and Research.2022; 26(2): 63. CrossRef - Evaluation of the tolerability of zoledronic acid preparations for parenteral administration
I. A. Shafieva, S. V. Bulgakova, A. V. Shafieva
Meditsinskiy sovet = Medical Council.2022; (11): 96. CrossRef - Impact of Alendronate Sodium plus Elcatonin on Postoperative Bone Pain in Patients with Osteoporotic Fractures
Baohui Wang, Yindi Sun, Da Shi, Xiuwei Han, Na Liu, Bo Wang, Zhijun Liao
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Jacques P. Brown, Andrew Don-Wauchope, Pierre Douville, Caroline Albert, Samuel D. Vasikaran
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Nanning Lv, Xiaoxiao Feng, Haojun Liu, Xuejun Jia, Shanqin Han, Mingming Liu
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Xiaochen Sun, Chenyu Song, Chenxi Zhang, Chunlei Xing, Juan Lv, Huihui Bian, Nanning Lv, Dagui Chen, Xin Dong, Mingming Liu, Li Su
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- Thyroid
- Diagnosis and Management of Thyroid Disease during Pregnancy and Postpartum: 2023 Revised Korean Thyroid Association Guidelines
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Hwa Young Ahn, Ka Hee Yi
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Endocrinol Metab. 2023;38(3):289-294. Published online June 9, 2023
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DOI: https://doi.org/10.3803/EnM.2023.1696
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- Thyroid hormone plays a critical role in fetal growth and development, and thyroid dysfunction during pregnancy is associated with several adverse outcomes, such as miscarriage and preterm birth. In this review, we introduce and explain three major changes in the revised Korean Thyroid Association (KTA) guidelines for the diagnosis and management of thyroid disease during pregnancy: first, the normal range of thyroid-stimulating hormone (TSH) during pregnancy; second, the treatment of subclinical hypothyroidism; and third, the management of euthyroid pregnant women with positive thyroid autoantibodies. The revised KTA guidelines adopt 4.0 mIU/L as the upper limit of TSH in the first trimester. A TSH level between 4.0 and 10.0 mIU/L, combined with free thyroxine (T4) within the normal range, is defined as subclinical hypothyroidism, and a TSH level over 10 mIU/L is defined as overt hypothyroidism regardless of the free T4 level. Levothyroxine treatment is recommended when the TSH level is higher than 4 mIU/L in subclinical hypothyroidism, regardless of thyroid peroxidase antibody positivity. However, thyroid hormone therapy to prevent miscarriage is not recommended in thyroid autoantibody-positive women with normal thyroid function.
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- Management of Subclinical Hypothyroidism: A Focus on Proven Health Effects in the 2023 Korean Thyroid Association Guidelines
Eu Jeong Ku, Won Sang Yoo, Hyun Kyung Chung
Endocrinology and Metabolism.2023; 38(4): 381. CrossRef
- Thyroid
- Deiodinases and the Three Types of Thyroid Hormone Deiodination Reactions
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Laura Sabatino, Cristina Vassalle, Cristina Del Seppia, Giorgio Iervasi
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Endocrinol Metab. 2021;36(5):952-964. Published online October 21, 2021
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DOI: https://doi.org/10.3803/EnM.2021.1198
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- Thyroid hormone (TH) signaling is strictly regulated by iodothyronine deiodinase activity, which both preserves the circulating levels of the biologically active triiodothyronine (T3) and regulates TH homeostasis at the local level, in a cell- and time-dependent manner. Three deiodinases have been identified—namely iodothyronine deiodinase 1 (DIO1), DIO2, and DIO3—that differ in their catalytic properties and tissue distribution. The deiodinases represent a dynamic system that changes in the different stages of life according to their functions and roles in various cell types and tissues. Deiodinase activity at the tissue level permits cell-targeted fine regulation of TH homeostasis, mediating the activation (DIO1 and DIO2) and inactivation (DIO3) of THs. Deiodinase homeostasis is the driving force that leads T3-target cells towards customized TH signaling, which takes into account both the hormonal circulating levels and the tissue-specific response. This review analyzes the complex role of deiodinases in physiological and pathological contexts, exploring new challenges and opportunities deriving from a deeper knowledge of the dynamics underlying their roles and functions.
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- Selenoprotein Gene mRNA Expression Evaluation During Renal Ischemia–Reperfusion Injury in Rats and Ebselen Intervention Effects
Yikun Wu, Hua Shi, Yuangao Xu, Rao Wen, Maodi Gong, Guangyi Hong, Shuxiong Xu
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Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2023; 17(1): 102704. CrossRef - WITHDRAWN: The effect of deiodinase type-3 gene on the therapeutic response to levothyroxine in a sample of Iraqi hypothyroidism patients
Alaa Hashim Mohmmed, Suzanne Jubair, Ban Hoshi
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Bogumila Urgatz, Salman Razvi
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Meenu Maniradhan, Latchoumycandane Calivarathan
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K. V. Kozak, H. A. Pavlyshyn, I. Y. Avramenko, O. M. Dyvonyak, O. O. Shevchuk, K. T. Hlushko
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Elżbieta Małujło-Balcerska, Tadeusz Pietras
Journal of Clinical Medicine.2023; 12(19): 6163. CrossRef - Thyroid Dysfunction Induced by Fungicide Famoxadone Exposure Contributes to Nonalcoholic Fatty Liver Disease in Male Mice: In Vivo, In Vitro, and In Silico Studies
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In-silico
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Haritha Kalath, Abel John Koshy, Bhavya Banjan, Sowmya Soman, Gururaja Hosadevasthana, Rajesh Raju, Niyas Rehman, Amjesh Revikumar
Journal of Biomolecular Structure and Dynamics.2023; : 1. CrossRef - Advances and Perspectives of Selenocompounds as Dietary Supplements to Ameliorate Obesity Biomarkers: From Field to Market
Frineth de la Luz Limón Aguilera, Sayra N. Serrano Sandoval, Mauricio Graciano-Palacios, Janet A. Gutiérrez-Uribe, Anayansi Escalante-Aburto
Food Reviews International.2023; : 1. CrossRef - Understanding the Roles of Selenium on Thyroid Hormone-Induced Thermogenesis in Adipose Tissue
Yasmin Anissa R. Ruswandi, Ronny Lesmana, Aziiz Mardanarian Rosdianto, Julia Windi Gunadi, Hanna Goenawan, Felix Zulhendri
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Alaa Hashim MOHMMED, Ban HOSHI, Suzanne JUBAIR
Turkish Journal of Pharmaceutical Sciences.2023; 20(5): 335. CrossRef - Polycystic Ovary Syndrome and Oxidative Stress—From Bench to Bedside
Natalia Zeber-Lubecka, Michał Ciebiera, Ewa E. Hennig
International Journal of Molecular Sciences.2023; 24(18): 14126. CrossRef - Thyroid Dysfunction and COVID-19: The Emerging Role of Selenium in This Intermingled Relationship
Francesca Gorini, Laura Sabatino, Alessio Coi, Giorgio Iervasi, Cristina Vassalle
International Journal of Environmental Research and Public Health.2022; 19(11): 6912. CrossRef - Associations of bisphenol exposure with thyroid hormones in pregnant women: a prospective birth cohort study in China
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International Journal of Molecular Sciences.2022; 23(23): 15445. CrossRef - Does clinical hypothyroidism occur in obesity? here is what the lab rats may be telling us about hope on the horizon
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- Calcium & Bone Metabolism
- Discontinuing Denosumab: Can It Be Done Safely? A Review of the Literature
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Wei Lin Tay, Donovan Tay
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Endocrinol Metab. 2022;37(2):183-194. Published online April 14, 2022
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DOI: https://doi.org/10.3803/EnM.2021.1369
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- Denosumab, which has been approved for the treatment of osteoporosis since 2010, is a fully humanised monoclonal antibody against a cytokine, receptor activator of nuclear factor kappa B ligand (RANKL), involved in bone resorption. Continued use of denosumab results in a potent and sustained decrease in bone turnover, an increase in bone mineral density (BMD), and a reduction in vertebral and hip fractures. The anti-resorptive effects of denosumab are reversible upon cessation, and this reversal is accompanied by a transient marked increase in bone turnover that is associated with bone loss, and of concern, an increased risk of multiple vertebral fractures. In this review, we outline the effects of denosumab withdrawal on bone turnover markers, BMD, histomorphometry, and fracture risk. We provide an update on recent clinical trials that sought to answer how clinicians can transition away from denosumab safely with follow-on therapy to mitigate bone loss and summarise the recommendations of various international guidelines.
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Christopher M. Cirnigliaro, Michael F. La Fountaine, J. Scott Parrott, Steven C. Kirshblum, Susan J. Sauer, Sue A. Shapses, Isa A. McClure, William A. Bauman
Osteoporosis International.2023; 34(4): 741. CrossRef - Persistence with Denosumab in Male Osteoporosis Patients: A Real-World, Non-Interventional Multicenter Study
Chaiho Jeong, Jeongmin Lee, Jinyoung Kim, Jeonghoon Ha, Kwanhoon Jo, Yejee Lim, Mee Kyoung Kim, Hyuk-Sang Kwon, Tae-Seo Sohn, Ki-Ho Song, Moo Il Kang, Ki-Hyun Baek
Endocrinology and Metabolism.2023; 38(2): 260. CrossRef
- Diabetes, Obesity and Metabolism
- Recent Updates to Clinical Practice Guidelines for Diabetes Mellitus
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Jin Yu, Seung-Hwan Lee, Mee Kyoung Kim
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Endocrinol Metab. 2022;37(1):26-37. Published online February 28, 2022
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DOI: https://doi.org/10.3803/EnM.2022.105
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- Guidelines for the management of patients with diabetes have become an important part of clinical practice that improve the quality of care and help establish evidence-based medicine in this field. With rapidly accumulating evidence on various aspects of diabetes care, including landmark clinical trials of treatment agents and newer technologies, timely updates of the guidelines capture the most current state of the field and present a consensus. As a leading academic society, the Korean Diabetes Association publishes practice guidelines biennially and the American Diabetes Association does so annually. In this review, we summarize the key changes suggested in the most recent guidelines. Some of the important updates include treatment algorithms emphasizing comorbid conditions such as atherosclerotic cardiovascular disease, heart failure, and chronic kidney disease in the selection of anti-diabetic agents; wider application of continuous glucose monitoring (CGM), insulin pump technologies and indices derived from CGM such as time in range; more active screening of subjects at high-risk of diabetes; and more detailed individualization in diabetes care. Although there are both similarities and differences among guidelines and some uncertainty remains, these updates provide a good approach for many clinical practitioners who are battling with diabetes.
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Kyungdo Han, Bongsung Kim, Seung Hwan Lee, Mee Kyoung Kim
npj Parkinson's Disease.2023;[Epub] CrossRef - Optimal Low-Density Lipoprotein Cholesterol Level for Primary Prevention in Koreans with Type 2 Diabetes Mellitus
Ji Yoon Kim, Nam Hoon Kim
Diabetes & Metabolism Journal.2023; 47(1): 42. CrossRef - Efficacy and safety of enavogliflozin versus dapagliflozin added to metformin plus gemigliptin treatment in patients with type 2 diabetes: A double-blind, randomized, comparator-active study: ENHANCE-D study
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Cardiology in Review.2023;[Epub] CrossRef - Impact of mental disorders on the risk of heart failure among Korean patients with diabetes: a cohort study
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Expert Opinion on Pharmacotherapy.2023; : 1. CrossRef - Zinc Chloride Enhances the Antioxidant Status, Improving the Functional and Structural Organic Disturbances in Streptozotocin-Induced Diabetes in Rats
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Medicina.2022; 58(11): 1620. CrossRef
- Thyroid
- Subclinical Hypothyroidism: Prevalence, Health Impact, and Treatment Landscape
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Won Sang Yoo, Hyun Kyung Chung
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Endocrinol Metab. 2021;36(3):500-513. Published online June 18, 2021
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DOI: https://doi.org/10.3803/EnM.2021.1066
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- Subclinical hypothyroidism (sHypo) is defined as normal serum free thyroid hormone levels coexisting with elevated serum thyroid-stimulating hormone (TSH) levels. sHypo is a common condition observed in clinical practice with several unique features. Its diagnosis should be based on an understanding of geographic and demographic differences in biochemical criteria versus a global reference range for TSH that is based on the 95% confidence interval of a healthy population. During the differential diagnosis, it is important to remember that a considerable proportion of sHypo cases are transient and reversible in nature; the focus is better placed on persistent or progressive forms, which mainly result from chronic autoimmune thyroiditis. Despite significant evidence documenting the health impacts of sHypo, the effects of levothyroxine treatment (LT4-Tx) in patients with sHypo remains controversial, especially in patients with grade 1 sHypo and older adults. Existing evidence suggests that it is reasonable to refrain from immediate LT4-Tx in most patients if they are closely monitored, except in women who are pregnant or in progressive cases. Future research is needed to further characterize the risks and benefits of LT4-Tx in different patient cohorts.
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Bogumila Urgatz, Salman Razvi
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Epidemiology and Health.2022; 44: e2022104. CrossRef
- Diabetes
- Continuous Glucose Monitoring in the Hospital
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M. Citlalli Perez-Guzman, Trisha Shang, Jennifer Y. Zhang, Donna Jornsay, David C. Klonoff
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Endocrinol Metab. 2021;36(2):240-255. Published online March 31, 2021
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DOI: https://doi.org/10.3803/EnM.2021.201
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14,682
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621
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- Continuous glucose monitors (CGMs) have suddenly become part of routine care in many hospitals. The coronavirus disease 2019 (COVID-19) pandemic has necessitated the use of new technologies and new processes to care for hospitalized patients, including diabetes patients. The use of CGMs to automatically and remotely supplement or replace assisted monitoring of blood glucose by bedside nurses can decrease: the amount of necessary nursing exposure to COVID-19 patients with diabetes; the amount of time required for obtaining blood glucose measurements, and the amount of personal protective equipment necessary for interacting with patients during the blood glucose testing. The United States Food and Drug Administration (FDA) is now exercising enforcement discretion and not objecting to certain factory-calibrated CGMs being used in a hospital setting, both to facilitate patient care and to obtain performance data that can be used for future regulatory submissions. CGMs can be used in the hospital to decrease the frequency of fingerstick point of care capillary blood glucose testing, decrease hyperglycemic episodes, and decrease hypoglycemic episodes. Most of the research on CGMs in the hospital has focused on their accuracy and only recently outcomes data has been reported. A hospital CGM program requires cooperation of physicians, bedside nurses, diabetes educators, and hospital administrators to appropriately select and manage patients. Processes for collecting, reviewing, storing, and responding to CGM data must be established for such a program to be successful. CGM technology is advancing and we expect that CGMs will be increasingly used in the hospital for patients with diabetes.
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- The Need for Data Standards and Implementation Policies to Integrate CGM Data into the Electronic Health Record
Juan Espinoza, Nicole Y. Xu, Kevin T. Nguyen, David C. Klonoff
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Grace B. Nelson, Kathryn M. Sumpter
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Samantha R. Spierling Bagsic, Addie L. Fortmann, Rebekah Belasco, Alessandra Bastian, Suzanne Lohnes, Anna Ritko, Haley Sandoval, Mariya Chichmarenko, Emily C. Soriano, Laura Talavera, Athena Philis-Tsimikas
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- Miscellaneous
- Quality Matters as Much as Quantity of Skeletal Muscle: Clinical Implications of Myosteatosis in Cardiometabolic Health
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Hong-Kyu Kim, Chul-Hee Kim
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Endocrinol Metab. 2021;36(6):1161-1174. Published online December 28, 2021
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DOI: https://doi.org/10.3803/EnM.2021.1348
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5,216
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- Although age-related changes in skeletal muscles are closely associated with decreases in muscle strength and functional decline, their associations with cardiometabolic diseases in the literature are inconsistent. Such inconsistency could be explained by the fact that muscle quality—which is closely associated with fatty infiltration of the muscle (i.e., myosteatosis)—is as important as muscle quantity in cardiometabolic health. However, muscle quality has been less explored compared with muscle mass. Moreover, the standard definition of myosteatosis and its assessment methods have not been established yet. Recently, some techniques using single axial computed tomography (CT) images have been introduced and utilized in many studies, as the mass and quality of abdominal muscles could be measured opportunistically on abdominal CT scans obtained during routine clinical care. Yet, the mechanisms by which myosteatosis affect metabolic and cardiovascular health remain largely unknown. In this review, we explore the recent advances in the assessment of myosteatosis and its changes associated with aging. We also review the recent literature on the clinical implication of myosteatosis by focusing on metabolic and cardiovascular diseases. Finally, we discuss the challenges and unanswered questions that need addressing to set myosteatosis as a therapeutic target for the prevention or treatment of cardiometabolic diseases.
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- Diabetes, Obesity and Metabolism
- Recent Advances in Understanding Peripheral Taste Decoding I: 2010 to 2020
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Jea Hwa Jang, Obin Kwon, Seok Jun Moon, Yong Taek Jeong
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Endocrinol Metab. 2021;36(3):469-477. Published online June 18, 2021
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DOI: https://doi.org/10.3803/EnM.2021.302
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- Taste sensation is the gatekeeper for direct decisions on feeding behavior and evaluating the quality of food. Nutritious and beneficial substances such as sugars and amino acids are represented by sweet and umami tastes, respectively, whereas noxious substances and toxins by bitter or sour tastes. Essential electrolytes including Na+ and other ions are recognized by the salty taste. Gustatory information is initially generated by taste buds in the oral cavity, projected into the central nervous system, and finally processed to provide input signals for food recognition, regulation of metabolism and physiology, and higher-order brain functions such as learning and memory, emotion, and reward. Therefore, understanding the peripheral taste system is fundamental for the development of technologies to regulate the endocrine system and improve whole-body metabolism. In this review article, we introduce previous widely-accepted views on the physiology and genetics of peripheral taste cells and primary gustatory neurons, and discuss key findings from the past decade that have raised novel questions or solved previously raised questions.
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- Multidimensional exploration of the bitterness amelioration effect of roasting on Wuyi Rock tea
Weiying Su, Li Ni, Yizhe Chen, Daoliang Wang, Chih-Cheng Lin, Yuan Liu, Zhibin Liu
Food Chemistry.2024; 437: 137954. CrossRef - Physiology of the tongue with emphasis on taste transduction
Máire E. Doyle, Hasitha U. Premathilake, Qin Yao, Caio H. Mazucanti, Josephine M. Egan
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Takahiro Shimizu, Takuto Fujii, Keisuke Hanita, Ryo Shinozaki, Yusaku Takamura, Yoshiro Suzuki, Teppei Kageyama, Mizuki Kato, Hisao Nishijo, Makoto Tominaga, Hideki Sakai
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Rebeca Fernández-Carrión, Jose V. Sorlí, Oscar Coltell, Eva C. Pascual, Carolina Ortega-Azorín, Rocío Barragán, Ignacio M. Giménez-Alba, Andrea Alvarez-Sala, Montserrat Fitó, Jose M. Ordovas, Dolores Corella
Biomedicines.2021; 10(1): 79. CrossRef
- Thyroid
- Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Maternal Thyroid Dysfunction, and Child Autism Spectrum Disorder
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Hyeong-Moo Shin, Jiwon Oh, Rebecca J. Schmidt, Elizabeth N. Pearce
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Endocrinol Metab. 2022;37(6):819-829. Published online November 23, 2022
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DOI: https://doi.org/10.3803/EnM.2022.1598
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4,077
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114
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- Autism spectrum disorder (ASD), with its high economic and societal costs, is a growing public health concern whose prevalence has risen steadily over the last two decades. Although actual increased incidence versus improved diagnosis remains controversial, the increased prevalence of ASD suggests non-inherited factors as likely contributors. There is increasing epidemiologic evidence that abnormal maternal thyroid function during pregnancy is associated with increased risk of child ASD and other neurodevelopmental disorders. Prenatal exposure to endocrine-disrupting chemicals such as per- and polyfluoroalkyl substances (PFAS) is known to disrupt thyroid function and can affect early brain development; thus, thyroid dysfunction is hypothesized to mediate this relationship. The concept of a potential pathway from prenatal PFAS exposure through thyroid dysfunction to ASD etiology is not new; however, the extant literature on this topic is scant. The aim of this review is to evaluate and summarize reports with regard to potential mechanisms in this pathway.
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- Effects of Endocrine-Disrupting Chemicals on Human Health
Jun Hyung Lee, Sung-Eun Cho
Laboratory Medicine Online.2023; 13(3): 129. CrossRef - Endocrine Disruptors and Thyroid Health
Elizabeth N. Pearce
Endocrine Practice.2023;[Epub] CrossRef