Endocrinology and Metabolism

Original Article

Calcium & Bone Metabolism
Association between Elevated Plasma Homocysteine and Low Skeletal Muscle Mass in Asymptomatic Adults: Jae-Hyeong Choi, Jin-Woo Seo, Mi-Yeon Lee, Yong-Taek Lee, Kyung Jae Yoon, Chul-Hyun Park; Endocrinol Metab. 2022;37(2):333-343. Published online February 8, 2022; DOI: https://doi.org/10.3803/EnM.2021.1202

7,934 View
188 Download
6 Web of Science
6 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Homocysteine has been drawing attention with a closed linkage with skeletal muscle. However, the association of hyperhomocysteinemia with decreased skeletal muscle mass remains unclear. We aimed to investigate the association of hyperhomocysteinemia with low skeletal muscle mass (LMM) in asymptomatic adults.
Methods
This was a cross-sectional study of 114,583 community-dwelling adults without cancer, stroke, or cardiovascular diseases who underwent measurements of plasma homocysteine and body composition analysis from 2012 to 2018. Hyperhomocysteinemia was defined as >15 μmol/L. Skeletal muscle mass index (SMI) was calculated based on appendicular muscle mass (kg)/height (m)². Participants were classified into three groups based on SMI: “normal,” “mildly low,” and “severely low.”
Results
The prevalence of hyperhomocysteinemia was the highest in subjects with severely LMM (12.9%), followed by those with mildly LMM (9.8%), and those with normal muscle mass (8.5%) (P for trend <0.001). In a multivariable logistic regression model, hyperhomocysteinemia was significantly associated with having a mildly LMM (odds ratio [OR], 1.305; 95% confidence interval [CI], 1.224 to 1.392) and severely LMM (OR, 1.958; 95% CI, 1.667 to 2.286), respectively. One unit increment of log-transformed homocysteine was associated with 1.360 and 2.169 times higher risk of having mildly LMM and severely LMM, respectively.
Conclusion
We demonstrated that elevated homocysteine has an independent association with LMM in asymptomatic adults, supporting that hyperhomocysteinemia itself can be a risk for decline in skeletal musculature.

Citations

Citations to this article as recorded by

The role of the mitochondrial trans-sulfuration in cerebro-cardio renal dysfunction during trisomy down syndrome
Sathnur Pushpakumar, Mahavir Singh, Utpal Sen, N. Tyagi, Suresh C. Tyagi
Molecular and Cellular Biochemistry.2024; 479(4): 825. CrossRef
Association of vitamins B1 and B2 intake with early-onset sarcopenia in the general adult population of the US: a cross-sectional study of NHANES data from 2011 to 2018
Sha Yang, Zhenyu Dong, Jiaqi Zhao, Lijia Yuan, Yao Xiao, Xing Luo, Zhuyang Zhao, Xia Kang, Kanglai Tang, Ming Chen, Liu Feng
Frontiers in Nutrition.2024;[Epub] CrossRef
Association of Triglyceride-Glucose Index with the Risk of Hyperhomocysteinemia Among Chinese Male Bus Drivers: A Longitudinal Study
Juan Xiong, Yanxia Wu, Lingling Huang, Xujuan Zheng
International Journal of General Medicine.2023; Volume 16: 2857. CrossRef
Relationship between hyperhomocysteinemia and coexisting obesity with low skeletal muscle mass in asymptomatic adult population
Tae Kyung Yoo, Hye Chang Rhim, Yong-Taek Lee, Kyung Jae Yoon, Chul-Hyun Park
Scientific Reports.2022;[Epub] CrossRef
Causal effects of homocysteine levels on the components of sarcopenia: A two-sample mendelian randomization study
Hongwei Yu, Gan Luo, Tianwei Sun, Qiong Tang
Frontiers in Genetics.2022;[Epub] CrossRef
Association between serum homocysteine and sarcopenia among hospitalized older Chinese adults: a cross-sectional study
Bing Lu, Lingyu Shen, Haiqiong Zhu, Ling Xi, Wei Wang, Xiaojun Ouyang
BMC Geriatrics.2022;[Epub] CrossRef

Review Article

Obesity and Metabolism
An Update on Contraception in Polycystic Ovary Syndrome: Seda Hanife Oguz, Bulent Okan Yildiz; Endocrinol Metab. 2021;36(2):296-311. Published online April 15, 2021; DOI: https://doi.org/10.3803/EnM.2021.958

11,893 View
754 Download
14 Web of Science
16 Crossref

Abstract PDF PubReader ePub

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive-aged women, characterized by hyperandrogenism, oligo/anovulation, and polycystic ovarian morphology. Combined oral contraceptives (COCs), along with lifestyle modifications, represent the first-line medical treatment for the long-term management of PCOS. Containing low doses of estrogen and different types of progestin, COCs restore menstrual cyclicity, improve hyperandrogenism, and provide additional benefits such as reducing the risk of endometrial cancer. However, potential cardiometabolic risk associated with these agents has been a concern. COCs increase the risk of venous thromboembolism (VTE), related both to the dose of estrogen and the type of progestin involved. Arterial thrombotic events related to COC use occur much less frequently, and usually not a concern for young patients. All patients diagnosed with PCOS should be carefully evaluated for cardiometabolic risk factors at baseline, before initiating a COC. Age, smoking, obesity, glucose intolerance or diabetes, hypertension, dyslipidemia, thrombophilia, and family history of VTE should be recorded. Patients should be re-assessed at consecutive visits, more closely if any baseline cardiometabolic risk factor is present. Individual risk assessment is the key in order to avoid unfavorable outcomes related to COC use in women with PCOS.

Citations

Citations to this article as recorded by

Clinical management of androgen excess and defect in women
Elena Rosato, Francesca Sciarra, Marianna Minnetti, Anisa Degjoni, Mary Anna Venneri
Expert Review of Endocrinology & Metabolism.2024; 19(1): 21. CrossRef
Il rischio tromboembolico nella sindrome dell’ovaio policistico
Davide Ceccato, Francesca Dassie, Pietro Maffei, Roberto Mioni
L'Endocrinologo.2024; 25(2): 151. CrossRef
Systematic exploration of network pharmacology, in silico modeling and pharmacokinetic profiling for vitamin E in polycystic ovarian syndrome
Rukaiah Fatma Begum, Sumithra Mohan
Future Science OA.2024;[Epub] CrossRef
Current and emerging drug treatment strategies for polycystic ovary syndrome
Nafiye Helvaci, Bulent Okan Yildiz
Expert Opinion on Pharmacotherapy.2023; 24(1): 105. CrossRef
Weighted Gene Co-Expression Network Analysis (WGCNA) Discovered Novel Long Non-Coding RNAs for Polycystic Ovary Syndrome
Roozbeh Heidarzadehpilehrood, Maryam Pirhoushiaran, Malina Binti Osman, Habibah Abdul Hamid, King-Hwa Ling
Biomedicines.2023; 11(2): 518. CrossRef
The mechanism of Leonuri Herba in improving polycystic ovary syndrome was analyzed based on network pharmacology and molecular docking
Mali Wu, Hua Liu, Jie Zhang, Fangfang Dai, Yiping Gong, Yanxiang Cheng
Journal of Pharmacy & Pharmaceutical Sciences.2023;[Epub] CrossRef
Evaluation of the efficacy of an antioxidant combination for the modulation of metabolic, endocrine, and clinical parameters in patients with polycystic ovary syndrome
Carmen Pingarrón Santofímia, Silvia Poyo Torcal, Helena López Verdú, Alexandra Henríquez Linares, Virginia Calvente Aguilar, Pablo Terol Sánchez, María Sol Martínez García, Pilar Lafuente González
Gynecological Endocrinology.2023;[Epub] CrossRef
Contemporary Management of the Patient with Polycystic Ovary Syndrome
Nicolás Omar Francone, Tia Ramirez, Christina E. Boots
Obstetrics and Gynecology Clinics of North America.2023; 50(4): 695. CrossRef
Challenges in diagnosis and health care in polycystic ovary syndrome in Canada: a patient view to improve health care
Beate C. Sydora, Michaelann S. Wilke, Maggie McPherson, Sarah Chambers, Mahua Ghosh, Donna F. Vine
BMC Women's Health.2023;[Epub] CrossRef
Effect of Berberine Phytosome on reproductive, dermatologic, and metabolic characteristics in women with polycystic ovary syndrome: a controlled, randomized, multi-centric, open-label clinical trial
Francesco Di Pierro, Ruqqia Sultana, Amna Zia Eusaph, Saida Abrar, Mahroo Bugti, Fauzia Afridi, Umer Farooq, Somia Iqtadar, Fareeha Ghauri, Syeda Makhduma, Shazia Nourin, Ayesha Kanwal, Aasiya Bano, Ali Akbar Bugti, Shah Mureed, Ayesha Ghazal, Romana Irsh
Frontiers in Pharmacology.2023;[Epub] CrossRef
Investigation of taste function and eating behavior in women with polycystic ovary syndrome
Sila Cetik, Aylin Acikgoz, Bulent Okan Yildiz
Appetite.2022; 168: 105776. CrossRef
microRNAs and long non‐coding RNAs as biomarkers for polycystic ovary syndrome
Mona Tamaddon, Mostafa Azimzadeh, Seyed Mohammad Tavangar
Journal of Cellular and Molecular Medicine.2022; 26(3): 654. CrossRef
Effect of orlistat during individualized comprehensive life-style intervention on visceral fat in overweight or obese PCOS patients
Min Min, Xiangyan Ruan, Husheng Wang, Jiaojiao Cheng, Suiyu Luo, Zhongting Xu, Meng Li, Alfred Otto Mueck
Gynecological Endocrinology.2022; 38(8): 676. CrossRef
Effect of metformin and exenatide on pregnancy rate and pregnancy outcomes in overweight or obese infertility PCOS women: long-term follow-up of an RCT
Renyuan Li, Tingting Mai, Siyuan Zheng, Ying Zhang
Archives of Gynecology and Obstetrics.2022; 306(5): 1711. CrossRef
Oral contraceptives and stroke: Foes or friends
Varun Reddy, Megan Wurtz, Shahil H. Patel, Micheline McCarthy, Ami P. Raval
Frontiers in Neuroendocrinology.2022; 67: 101016. CrossRef
Clinical profiling of polycystic ovary syndrome patients in Kashmir population
Ahila Ashraf, Rajesh Singh, Shahnawaz Mir
Matrix Science Pharma.2022; 6(1): 23. CrossRef

Original Articles

Clinical Study
Efficacy of Ethanol Ablation for Benign Thyroid Cysts and Predominantly Cystic Nodules: A Systematic Review and Meta-Analysis: Cheng-Chun Yang, Yung Hsu, Jyun-Yan Liou; Endocrinol Metab. 2021;36(1):81-95. Published online February 24, 2021; DOI: https://doi.org/10.3803/EnM.2020.833

5,894 View
219 Download
11 Web of Science
15 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Ultrasound-guided minimally invasive procedures are widely used to treat thyroid diseases. The objective of this study was to assess the efficacy and safety of ethanol ablation (EA) in comparison with other non-surgical options in the treatment of benign thyroid cystic nodules.
Methods
We conducted a systematic search of studies on EA for thyroid cystic nodules, mainly in the Ovid-MEDLINE and Embase, Web of Science, and Cochrane databases. The standardized mean difference (SMD) of the volume reduction ratio (VRR) after EA versus other non-surgical treatments comprised the primary outcome, whereas the odds ratio (OR) of therapeutic success rates between the two groups comprised the secondary outcome.
Results
The meta-analysis included 19 studies (four randomized controlled trials and 15 non-randomized studies) with 1,514 participants. The cumulative VRR of EA was 83.908% (95% confidence interval [CI], 79.358% to 88.457%). EA had a significantly higher pooled VRR (SMD, 0.381; 95% CI, 0.028 to 0.734; P=0.030), but not a significantly higher pooled therapeutic success rate (OR, 0.867; 95% CI, 0.132 to 5.689; P=0.880), than other forms of non-surgical management including radiofrequency ablation (RFA), polidocanol sclerotherapy, and simple aspiration with or without saline flush. However, the VRR and therapeutic success rate were not significantly different between EA and RFA. Major complications were recorded only in six patients (0.53%) with self-limiting dysphonia.
Conclusion
The role of EA as the first-line treatment for benign thyroid cysts and predominantly cystic nodules is supported by its high effectiveness and good safety profile compared to other currently available non-surgical options.

Citations

Citations to this article as recorded by

Ultrasound-guided ethanol ablation versus the Sistrunk operation as a primary treatment for thyroglossal duct cysts
Dongbin Ahn, Ji Hye Kwak, Gil Joon Lee, Jin Ho Sohn
Ultrasonography.2024; 43(1): 25. CrossRef
The Comparison of Efficacy and Safety between Radiofrequency Ablation Alone and Ethanol Ablation Followed by Radiofrequency Ablation in the Treatment of Mixed Cystic and Solid Thyroid Nodule
Min Gang Jo, Min Kyoung Lee, Jae Ho Shin, Min Guk Seo, So Lyung Jung
Journal of the Korean Society of Radiology.2024;[Epub] CrossRef
Ultrasound-Guided Ethanol Ablation for Thyroglossal Duct Cyst: A Review of Technical Issues and Potential as a New Standard Treatment
Dongbin Ahn
Journal of Clinical Medicine.2023; 12(17): 5445. CrossRef
Ultrasound‐Guided Ethanol Ablation as a Primary Treatment for Thyroglossal Duct Cyst: Feasibility, Characteristics, and Outcomes
Dongbin Ahn, Ji Hye Kwak, Gil Joon Lee, Jin Ho Sohn
Otolaryngology–Head and Neck Surgery.2023; 168(6): 1381. CrossRef
Ultraschallgeführte lokalablative Verfahren zur Behandlung von Schilddrüsenläsionen
Johannes-Paul Richter, Carl-Philip Richter, Daniel Gröner
Angewandte Nuklearmedizin.2023; 46(02): 169. CrossRef
A Case of Thyroid Abscess Following Ethanol Ablation for Benign Thyroid Nodule
Heungrae Cho, Dongbin Ahn, Ji Hye Kwak, Gil Joon Lee
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2023; 66(9): 624. CrossRef
Sclerotherapy with a Viscum Album Extract for the Two Patients with Cystic Thyroid Nodule
Jae Ha Lee, Seung Won Lee, Ki Nam Park
International Journal of Thyroidology.2023; 16(1): 139. CrossRef
Percutaneous ethanol injection in thyroid nodular pathology and metastatic cervical adenopathies: A systematic review, meta-analysis and economic evaluation
Beatriz León-Salas, Aránzazu Hernández-Yumar, Diego Infante-Ventura, Aythami de Armas Castellano, Yadira González Hernández, Renata Linertová, Teresa Téllez Santana, Pedro de Pablos-Velasco, María M. Trujillo-Martín
Endocrinología, Diabetes y Nutrición.2023; 70(9): 572. CrossRef
Ultraschallgeführte lokalablative Verfahren zur Behandlung von Schilddrüsenläsionen
Johannes-Paul Richter, Carl-Philip Richter, Daniel Gröner
Laryngo-Rhino-Otologie.2023; 102(12): 916. CrossRef
Percutaneous ethanol injection in thyroid nodular pathology and metastatic cervical adenopathies: A systematic review, meta-analysis and economic evaluation
Beatriz León-Salas, Aránzazu Hernández-Yumar, Diego Infante-Ventura, Aythami de Armas Castellano, Yadira González Hernández, Renata Linertová, Teresa Téllez Santana, Pedro de Pablos-Velasco, María M. Trujillo-Martín
Endocrinología, Diabetes y Nutrición (English ed.).2023; 70(9): 572. CrossRef
Safety and Efficacy of Ultrasound-Guided Radiofrequency Ablation for Benign Nonfunctional Thyroid Nodules in Children: A Retrospective Study of 62 Patients with Over Four Years of Follow-Up
Liwen Li, Xinguang Qiu
Thyroid.2022; 32(5): 525. CrossRef
Ethanol ablation for the treatment of benign thyroid nodules
Gabrielle K. Steinl, Latoya A. Stewart, Catherine McManus, James A. Lee, Jennifer H. Kuo
The American Journal of Surgery.2022; 224(1): 408. CrossRef
Minimally-invasive treatments for benign thyroid nodules: recommendations for information to patients and referring physicians by the Italian Minimally-Invasive Treatments of the Thyroid group
Giovanni Mauri, Stella Bernardi, Andrea Palermo, Roberto Cesareo, Enrico Papini, Luigi Solbiati, Daniele Barbaro, Salvatore Monti, Maurilio Deandrea, Laura Fugazzola, Giovanni Gambelunghe, Roberto Negro, Stefano Spiezia, Fulvio Stacul, Luca Maria Sconfien
Endocrine.2022; 76(1): 1. CrossRef
Image-Guided Percutaneous Ablation for Primary and Metastatic Tumors
Arian Mansur, Tushar Garg, Apurva Shrigiriwar, Vahid Etezadi, Christos Georgiades, Peiman Habibollahi, Timothy C. Huber, Juan C. Camacho, Sherif G. Nour, Alan Alper Sag, John David Prologo, Nariman Nezami
Diagnostics.2022; 12(6): 1300. CrossRef
Approach to FNA of Thyroid Gland Cysts
Esther Diana Rossi, Pietro Tralongo, Vincenzo Fiorentino, Mariangela Curatolo, Carmine Bruno, Carmen De Crea, Marco Raffaelli, Alfredo Pontecorvi, Luigi Maria Larocca
Advances in Anatomic Pathology.2022; 29(6): 358. CrossRef

Clinical Study
The Modified Ferriman-Gallwey Score and Hirsutism among Filipino Women: Ma. Karen Celine C. Ilagan, Elizabeth Paz-Pacheco, Darwin Z. Totesora, Lyra Ruth Clemente-Chua, Jundelle Romulo K. Jalique; Endocrinol Metab. 2019;34(4):374-381. Published online December 23, 2019; DOI: https://doi.org/10.3803/EnM.2019.34.4.374

7,993 View
170 Download
18 Web of Science
18 Crossref

Abstract PDF PubReader ePub

Background

The modified Ferriman-Gallwey (mFG) score is the gold standard for the clinical evaluation of hirsutism. However, racial variations in terminal hair growth limit this tool. This study aimed to determine the mFG cut-off score among Filipino women and its association with biochemical hyperandrogenism.

Methods

A total of 128 Filipino women were included in this prospective cross-sectional study and were divided into two groups: a polycystic ovary syndrome (PCOS) group (n=28) and a non-PCOS group (n=100). The participants underwent mFG score determination, ovarian ultrasound conducted by a single sonographer, and hormone testing. The mFG cut-off score was determined based on the 95th percentile of the non-PCOS group. Logistic regression was used to analyze the relationship between mFG score and biochemical hyperandrogenism.

Results

Although the mFG score was generally low in both the PCOS and non-PCOS groups, the former exhibited a higher mean score than the latter (4.3±3.0 vs. 2.0±2.2, P<0.001). Normal values for the total mFG score ranged from 0 to 7. Using a cut-off score of 7, a higher proportion of hirsute women (mFG score ≥7) was observed in the PCOS group versus the non-PCOS group (17.9% vs. 5.0%, P=0.025). Elevated calculated free testosterone (FT) was also found to be significantly associated with hirsutism (odds ratio, 6.2; 95% confidence interval, 1.2 to 32.4 pmol/L; P=0.030).

Conclusion

A score of 7 and above constitutes hirsutism in this population of Filipino women. Hirsute women are more likely than non-hirsute women to have elevated calculated FT.

Citations

Citations to this article as recorded by

Understanding hirsutism in PCOS
Talita Fischer Oliveira, Fabio Vasconcellos Comim
Expert Review of Endocrinology & Metabolism.2024; 19(2): 103. CrossRef
Correlation of Body Mass Index with Anthropometric and Biochemical Parameters Among Polycystic Ovary Syndrome Phenotypes
Tanuja Mehra, Sonali Sharma, Tasneem Zahra, Sapna Jangir, Barkha Gupta
Indian Journal of Clinical Biochemistry.2023; 38(2): 231. CrossRef
Predictive factors of Sexual Quality of Life in women with polycystic ovary syndrome: a path analysis
Azam Maleki, Ensiyeh Jenabi, Bita Fereidooni, Sara Abdoli
International Journal of Impotence Research.2023; 35(8): 748. CrossRef
Free-androgen Index in Women with Polycystic Ovarian Syndrome: A Meta-Analysis
Prakash Patil, Neevan D'Souza, Sudeep D. Ghate, Lakshmi Nagendra, Harish B. Girijashankar
Journal of Health and Allied Sciences NU.2023; 13(03): 380. CrossRef
Association of free testosterone, glucose level and obesity among women with polycystic ovary syndrome in Soran city, Kurdistan-Iraq
P.J. Jalil, B.H. Shnawa, M.H. Ahmed
Clínica e Investigación en Ginecología y Obstetricia.2023; 50(4): 100903. CrossRef
Questioning PCOS phenotypes for reclassification and tailored therapy
Samuel Harry Myers, Michele Russo, Simona Dinicola, Gianpiero Forte, Vittorio Unfer
Trends in Endocrinology & Metabolism.2023; 34(11): 694. CrossRef
Clinical and Biochemical Evaluation of Hirsutism in Young, Lean Girls from Kirkuk City, Iraq: A Cross-Sectional Study
Razaw Omar Ibrahim, Najlaa Kadhim Ali, Iqbal Sameen Ali
Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ).2023; 5(1S): S51. CrossRef
Current and future perspectives on clinical management of classic 21-hydroxylase deficiency
Analia Yogi, Kenichi Kashimada
Endocrine Journal.2023; 70(10): 945. CrossRef
Effect of Berberine Phytosome on reproductive, dermatologic, and metabolic characteristics in women with polycystic ovary syndrome: a controlled, randomized, multi-centric, open-label clinical trial
Francesco Di Pierro, Ruqqia Sultana, Amna Zia Eusaph, Saida Abrar, Mahroo Bugti, Fauzia Afridi, Umer Farooq, Somia Iqtadar, Fareeha Ghauri, Syeda Makhduma, Shazia Nourin, Ayesha Kanwal, Aasiya Bano, Ali Akbar Bugti, Shah Mureed, Ayesha Ghazal, Romana Irsh
Frontiers in Pharmacology.2023;[Epub] CrossRef
Is There a Difference in Hirsutism Score in Adolescents with Polycystic Ovary Syndrome on the Basis of Ethnicity and Race?
Fatmaelzahraa Badr, Asma Javed Chattha
Journal of Pediatric and Adolescent Gynecology.2023;[Epub] CrossRef
A Body-Neutral and Gender-Neutral Modified Ferriman–Gallwey Diagram
Frances Grimstad, Quentin Moyer, Coleen R. Williams, Jessica Kremen
Journal of Pediatric and Adolescent Gynecology.2022; 35(3): 375. CrossRef
Assessment of clinical, biochemical, and hormonal profile of lean versus overweight polycystic ovarian syndrome patients: A cross-sectional study
Vikrant Ghatnatti, Shwetha Patil, Harpreet Kour
APIK Journal of Internal Medicine.2022; 10(1): 13. CrossRef
Regional variability of modified Ferriman-Gallwey scorring in premenopausal healthy women in Southern Turkey
Gurgun Tugce Vural Solak, Gamze Akkus, Yavuzalp Solak, Sevgul Kose, Murat Sert
Gynecological Endocrinology.2022; 38(8): 666. CrossRef
Detection of pure Leydig cell ovarian tumor not visible on imaging by selective venous blood sampling in a woman with secondary amenorrhea and hirsutism: A case report
Aki Oride, Haruhiko Kanasaki, Hiroe Okada, Satoru Kyo
Case Reports in Women's Health.2021; 30: e00298. CrossRef
Giant androgen-producing adrenocortical carcinoma with atrial flutter: A case report and review of the literature
Mircea-Florin Costache, Raluca-Elena Arhirii, Simona-Juliette Mogos, Corina Lupascu-Ursulescu, Cezara-Ioana Litcanu, Adi-Ionut Ciumanghel, Catalina Cucu, Cristina-Mihaela Ghiciuc, Antoniu-Octavian Petris, Nicolae Danila
World Journal of Clinical Cases.2021; 9(20): 5575. CrossRef
The effect of low glycemic index diet on the reproductive and clinical profile in women with polycystic ovarian syndrome: A systematic review and meta-analysis
Najmieh Saadati, Fatemeh Haidari, Mojgan Barati, Roshan Nikbakht, Golshan Mirmomeni, Fakher Rahim
Heliyon.2021; 7(11): e08338. CrossRef
The role of high serum uric acid levels in androgenic and non-androgenic polycystic ovarian syndrome patients
Ranakishor Pelluri, Kongara Srikanth, Harika Paritala, Vamsi Ravi, Sri Pandu Mukharjee Kamma, Kishan Dravid Piduguralla, Unnam Venkateswarlu, Jalasuthram Subrahmanyam, Kiranmayee Bannaravuri, Thanmayee Thunga, Ragini Vemparala, Sruthi Doddapaneni, Naresh
Clinical Epidemiology and Global Health.2021; 12: 100910. CrossRef
Testosterone or Dehydroepiandrosterone Sulfate as a Biomarker for Hirsutism in Women with Polycystic Ovary Syndrome
Husam Jihad Imran, Samer Abdulameer Dhaher, Abbas Ali Mansour
Biomedical and Pharmacology Journal.2020; 13(4): 1815. CrossRef

Insulin Like Growth Factor-I and Insulin Like Growth Factor Binding Protein-3 in Human Thyroid Cystic Fluids.: In Myung Yang, Jeong Taek Woo, Sung Woon Kim, Jin Woo Kim, Young Seol Kim, Young Kil Choi, Byoung Joon Kim, Seung Joon Oh; J Korean Endocr Soc. 1995;10(4):395-404. Published online November 7, 2019

1,091 View
20 Download

Abstract PDF: In the thyroid tissue, thyrotrophin(TSH) and IGF-I played major role of the goitrogen. But the evidences and precise mechanism of these two factors were not known so much. Actually local secretion of thyroid IGF-I was originated from its fibroblasts mainly. We guessed major roles of IGFs in the thyroid tissue were local paracrine effect of thyroid cells proliferation and differentiation which concert with TSH. Recently, some reporters described the source of thyroid IGF-I were partly from thyroid follicular cells and its action were synergistic with TSH. We measured TSH, IGF-I and IGFBP-3 from sera and thyroid cystic fluids in 36 patients with simple thyroid cyst and examined into correlation between TSH, IGF-I and IGFBP-3.1) According to cyst/serum TSH ratio, we classified two groups(Group I; c/s TSH <1, n=19. Group II; c/s TSH >1, n=17). This classification criteria means that cystic TSH level were increased than that of serum or not.2) The serum TSH, IGF-I and IGFBP-3 levels are not difference between group I and II.3) Cystic TSH were dependent on the serum TSH in Group I, but negative correlation in Group II. In Group II, cystic TSH was significant increased.4) Serum IGF-I were positive correlation in each Group5) In Group II, cystic IGF-I was not exceed than those of serum IGF-I, but some cystic IGFBP-3 were more increased than those of serum.6) In Group II, cystic IGFBP-3 increased than serum TSH, and cystic IGFBP-3 was positive correlation with cystic TSH and cystic IGF-I.As these data suggested that cystic TSH and cystic IGF-I levels may influence cystic IGFBP-3 level. The main effect for maintenance of cyst was mediated by cystic TSH and cystic IGFBP-3. But the cystic IGFBP-3 has major role for thyroid cyst than cyst TSH.

Parathyroid Cysts.: Sung Kil Lim, Jin Sub Choi, Cheong Soo Park; J Korean Endocr Soc. 1994;9(2):128-135. Published online November 6, 2019

871 View
16 Download

Abstract PDF: The parathyroid cyst is a relatively uncommon disease and usually identified during the operation for a presumed thyroid mass. Thirteen cases of parathyroid cyst (2 males, 11 females) treated from 1981 to 1993 were reviewed. Ages ranged from 17 to 59 years(mean, 41 years). Gross measurement of the tumor size varied from 1.0 to 10.0 cm in diameter with a mean of 4.8cm. All of the 13 patients presented with a chief complaint of painless anterior cervical mass. Only one complained of mild symptom of dyspnea and voice change due to huge cyst in paratracheal space. No functional cyst was identified. Diagnostic studies included ^99mTc thyroid scan (n=11), ultrasonography (n=10), computerized tomography (n=4) and fine needle aspiration(FNA) (preoperative, n=4; intraoperative, n=3). All diagnostic precedures but needle aspiration were nonspecific. Cysts were found in right inferior parathyroid(n=4), left inferior parathyroid (n=7), or anterior superior mediastinum (n=2). The FNA of the cyst contents revealed watery clear fluid with elevated parathyroid hormone level and was diagnostic in each cases. Four patients were treated initially with needle aspiration, of which only one patient was successful, and 3 patients who were unsuccessful to needle aspiration and the remaining 9 were effectively treated with surgical extirpation. Our experience suggested that needle aspiration may be of significant help in diagnosis and treatment of parathyroid cyst, but most of the patient could be treated successfully by surgical extirpation with an excellent chance for curability.

Clinical Study
Associations of Metabolic Syndrome with Total Testosterone and Homocysteine Levels in Male Korean Workers: Sook Hee Sung, Nam Hee Kim, Sun Pyo Hong, Jong-Keun Lee, Seung Jin Choi; Endocrinol Metab. 2019;34(2):158-168. Published online June 24, 2019; DOI: https://doi.org/10.3803/EnM.2019.34.2.158

4,298 View
60 Download
2 Web of Science
2 Crossref

Abstract PDF PubReader ePub

Background

Low testosterone is associated with metabolic syndrome (MetS), and homocysteine (Hcy) is elevated in individuals with MetS. We investigated the relationships of total testosterone (TT) and serum Hcy levels with MetS in male Korean workers.

Methods

We conducted a cross-sectional study including 8,606 male workers, aged 20 to 58 years, who underwent a physical examination in 2015. MetS was diagnosed based on the criteria of the 2009 harmonized definition, while the Korean standard for waist circumference (WC) was used. Participants' biochemical parameters, including TT and serum Hcy, were measured, and participants were divided into quartiles. Multiple logistic regression models were used to estimate the association of MetS and its individual components depending on TT and serum Hcy quartiles.

Results

The prevalence of MetS in the study population was 16%. TT was lower in participants with MetS than in those without MetS (P<0.001). By contrast, Hcy level was similar between groups (P=0.694). In multiple logistic regression analysis, the odds ratio for the lowest TT quartile was 1.29 (95% confidence interval, 1.06 to 1.57) after adjusting for potential confounders. Participants with lower TT were more likely to have high WC, hypertriglyceridemia, and low high density lipoprotein levels. Serum Hcy levels were not significantly associated with MetS. Of the five components of MetS, only WC was significantly associated with serum Hcy.

Conclusion

In male Korean workers, TT may be an independent predictor of MetS, and serum Hcy levels could be a marker of abdominal obesity. However, future prospective studies are needed.

Citations

Citations to this article as recorded by

A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study
Shenghao Wu, Yanhong Wu, Lizi Fang, Junzhao Zhao, Yaoyao Cai, Weiting Xia
Frontiers in Endocrinology.2023;[Epub] CrossRef
Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Juan R. Ulloque-Badaracco, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Ali Al-kassab-Córdova, Juan C. Cabrera-Guzmán, Percy Herrera-Añazco, Vicente A. Benites-Zapata
Frontiers in Endocrinology.2023;[Epub] CrossRef

Obesity and Metabolism
Metabolic Syndrome and Insulin Resistance Syndrome among Infertile Women with Polycystic Ovary Syndrome: A Cross-Sectional Study from Central Vietnam: Minh Tam Le, Vu Quoc Huy Nguyen, Quang Vinh Truong, Dinh Duong Le, Viet Nguyen Sa Le, Ngoc Thanh Cao; Endocrinol Metab. 2018;33(4):447-458. Published online November 30, 2018; DOI: https://doi.org/10.3803/EnM.2018.33.4.447

4,355 View
78 Download
11 Web of Science
14 Crossref

Abstract PDF PubReader ePub

Background

Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies among reproductive-age women. Its metabolic features often overlap with those associated with metabolic syndrome (MS) and insulin resistance syndrome (IRS). The objective of this study was to determine the prevalence and predictors of MS and IRS in infertile Vietnamese women with PCOS.

Methods

A cross-sectional study was conducted at a tertiary fertility centre at Hue University Hospital from June 2016 to November 2017. A total of 441 infertile women diagnosed with PCOS based on the revised 2003 Rotterdam consensus criteria were enrolled. MS and IRS were defined based on the National Heart, Lung, and Blood Institute/American Heart Association Adult Treatment Panel III 2005 and American College of Endocrinology IRS 2003 criteria, respectively. Complete clinical and biochemical measurements of 318 women were available for analysis. Independent predictors of MS and IRS were identified using multivariate logistic regression.

Results

The overall prevalence of MS and IRS in women with PCOS was 10.4% and 27.0%, respectively. We identified older age (>30 years) and obesity as independent predictors of MS and IRS. Elevated anti-Müllerian hormone levels increased the risk of IRS, but not that of MS.

Conclusion

MS and IRS are prevalent disorders among infertile Vietnamese women with PCOS. PCOS is not solely a reproductive problem. Screening and early intervention for MS and/or IRS based on anthropometric, metabolic, and reproductive hormone risk factors should be an integral part of fertility care.

Citations

Citations to this article as recorded by

Role of the tripartite motif‐containing (TRIM) family of proteins in insulin resistance and related disorders
Jianrong Chen, Xianjie Feng, Xu Zhou, Yong Li
Diabetes, Obesity and Metabolism.2024; 26(1): 3. CrossRef
Effect of pharmacological interventions on lipid profiles and C‐reactive protein in polycystic ovary syndrome: A systematic review and meta‐analysis
Mohammed A. Abdalla, Najeeb Shah, Harshal Deshmukh, Amirhossein Sahebkar, Linda Östlundh, Rami H. Al‐Rifai, Stephen L. Atkin, Thozhukat Sathyapalan
Clinical Endocrinology.2022; 96(4): 443. CrossRef
A Cross-Sectional Study of Serum Ferritin Levels in Vietnamese Adults with Metabolic Syndrome
Thua Nguyen Tran, Huu Dang Tran, Thanh Tung Tran-Huu, Duc Minh Tran, Quang Nhat Tran
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 1517. CrossRef
The effects of metformin on clinical features, endocrine and metabolic profiles of infertile women with polycystic ovary syndrome
Sa Le Viet
Journal of Clinical Medicine- Hue Central Hospital.2022;[Epub] CrossRef
Uric acid metabolism in polycystic ovary syndrome
Yan-Nan Liu, Hai Luo, Xuan Che, Hui Peng, Ming Li, Ke-Xuan Liu
Clinica Chimica Acta.2021; 517: 74. CrossRef
PREVALENCE OF METABOLIC SYNDROME AND INSULIN RESISTANCE AMONG PCOS WOMEN ATTENDING TERTIARY CARE HOSPITAL IN NORTH INDIAN POPULATION.
Anita R Bhatia, Peyir Bagra, Jyotsna Suri, Rajni Dawar
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2021; : 35. CrossRef
“Obesity and Insulin Resistance” Is the Component of the Metabolic Syndrome Most Strongly Associated with Oxidative Stress
Grzegorz K. Jakubiak, Kamila Osadnik, Mateusz Lejawa, Tadeusz Osadnik, Marcin Goławski, Piotr Lewandowski, Natalia Pawlas
Antioxidants.2021; 11(1): 79. CrossRef
Correlation between serum AMH levels and cardiometabolic indices in PCOS women
Subarna Mitra, GautomK Saharia, SaubhagyaK Jena
Indian Journal of Endocrinology and Metabolism.2021; 25(6): 545. CrossRef
Predicting Risk of Insulin Resistance in a Chinese Population with Polycystic Ovary Syndrome: Designing and Testing a New Predictive Nomogram
Feng Jiang, Ke Wei, Wenjun Lyu, Chuyan Wu
BioMed Research International.2020; 2020: 1. CrossRef
Association of the Genetic Polymorphisms rs6259 and rs727428 of the SHBG Gene with Polycystic Ovary Syndrome Risk: A Meta-Analysis
Xihong Liao, Shujun Cao
Genetic Testing and Molecular Biomarkers.2020; 24(8): 492. CrossRef
The relationship between glomerular filtration rate, and metabolic and inflammatory parameters in obese and non-obese patients with polycystic ovary syndrome
Mustafa Can, Cevdet Duran, Ibrahim Guney, Halis Elmas, Mehmet Ayhan, Said Sami Erdem
Clínica e Investigación en Arteriosclerosis.2020; 32(6): 256. CrossRef
Effect of Central Obesity and Hyperandrogenism on Selected Inflammatory Markers in Patients with PCOS: A WHtR-Matched Case-Control Study
Małgorzata Kałużna, Magdalena Człapka-Matyasik, Katarzyna Wachowiak-Ochmańska, Jerzy Moczko, Jolanta Kaczmarek, Adam Janicki, Katarzyna Piątek, Marek Ruchała, Katarzyna Ziemnicka
Journal of Clinical Medicine.2020; 9(9): 3024. CrossRef
The relationship between glomerular filtration rate, and metabolic and inflammatory parameters in obese and non-obese patients with polycystic ovary syndrome
Mustafa Can, Cevdet Duran, Ibrahim Guney, Halis Elmas, Mehmet Ayhan, Said Sami Erdem
Clínica e Investigación en Arteriosclerosis (English Edition).2020; 32(6): 256. CrossRef
Dyslipidemia involvement in the development of polycystic ovary syndrome
Qi Liu, Yuan-jie Xie, Li-hua Qu, Meng-xia Zhang, Zhong-cheng Mo
Taiwanese Journal of Obstetrics and Gynecology.2019; 58(4): 447. CrossRef

Clinical Study
Prevalence of Reduced Kidney Function by Estimated Glomerular Filtration Rate Using an Equation Based on Creatinine and Cystatin C in Metabolic Syndrome and Its Components in Korean Adults: Yang Ho Kang, Dong Wook Jeong, Seok Man Son; Endocrinol Metab. 2016;31(3):446-453. Published online August 2, 2016; DOI: https://doi.org/10.3803/EnM.2016.31.3.446

3,675 View
34 Download
3 Web of Science
4 Crossref

Abstract PDF PubReader

Background

It is known that metabolic syndrome (MetS) is associated with chronic kidney disease. We evaluated and compared the prevalence of reduced kidney function in MetS and its components by estimated glomerular filtration rate (eGFR) using an equation based on creatinine (eGFRcr), cystatin C (eGFRcys), and combined creatinine-cystatin C (eGFRcr-cys) in Korean adults.

Methods

We analyzed data from 3,649 adults who participated in a comprehensive health examination.

Results

Mean values of eGFRcys were higher compared with mean values of eGFRcr (96.1±18.2 mL/min/1.73 m² vs. 91.2±13.6 mL/min/1.73 m²) in total subjects. The prevalence of reduced kidney function increased with age (9.6% for eGFRcys vs. 5.8% for eGFRcr-cys vs. 4.9% for eGFRcr, in subjects aged ≥60 years), and significantly increased with MetS, abdominal obesity, hypertension, high triglyceride, low high density lipoprotein (HDL), and high insulin resistance. The prevalence of MetS, abdominal obesity, hypertension, high insulin resistance, low HDL, and hepatic steatosis was significantly increased in subjects with reduced kidney function. This increased prevalence and the odds ratio of reduced kidney function for prevalence of MetS was highest for eGFRcys, followed by those of eGFRcr-cys, and eGFRcr.

Conclusion

The prevalence of reduced kidney function by eGFR was significantly increased in subjects with MetS and its related components. eGFRcys and eGFRcr-cys were superior to eGFRcr in detecting reduced kidney function.

Citations

Citations to this article as recorded by

Association Between CST3 Gene Polymorphisms and Large-Artery Atherosclerotic Stroke
Yarong Ding, Zhe Xu, Yuesong Pan, Xia Meng, Xianglong Xiang, Hao Li, Liping Liu, Yongjun Wang
Frontiers in Neurology.2021;[Epub] CrossRef
Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea
Seo Yeon Baik, Hyunah Kim, So Jung Yang, Tong Min Kim, Seung-Hwan Lee, Jae Hyoung Cho, Hyunyong Lee, Hyeon Woo Yim, Kun-Ho Yoon, Hun-Sung Kim
Frontiers of Medicine.2019; 13(6): 713. CrossRef
Gender specific association of parathyroid hormone and vitamin D with metabolic syndrome in population with preserved renal function
Min-Hee Kim, Jeongmin Lee, Jeonghoon Ha, Kwanhoon Jo, Dong-Jun Lim, Jung-Min Lee, Sang-Ah Chang, Moo-Il Kang, Bong Yun Cha
Scientific Reports.2018;[Epub] CrossRef
PROBLEM OF THE ASSESMENT OF GLOMERULAR FILTRATION RATE IN OBESITY
A. V. Smirnov, I. G. Kayukov, A. Sh. Rumyantsev
Nephrology (Saint-Petersburg).2017; 21(2): 20. CrossRef

Obesity and Metabolism
Correlation between Expression of Glucose Transporters in Granulosa Cells and Oocyte Quality in Women with Polycystic Ovary Syndrome: Eunju Kim, Hyun Ha Seok, Su-Yeon Lee, Dong Ryul Lee, Jisook Moon, Tae Ki Yoon, Woo Sik Lee, Kyung-Ah Lee; Endocrinol Metab. 2014;29(1):40-47. Published online March 14, 2014; DOI: https://doi.org/10.3803/EnM.2014.29.1.40

4,696 View
53 Download
22 Web of Science
22 Crossref

Abstract PDF PubReader

Background

The glucose transporters (GLUTs) exhibit different tissue-specific expression. This study aimed to investigate the types of GLUTs expressed in human granulosa cells (GCs) obtained from women with polycystic ovary syndrome (PCOS) and their relationship with insulin resistance (IR) and the outcomes of in vitro maturation (IVM) of immature oocytes.

Methods

Expression of GLUTs was evaluated in GCs from women with PCOS with or without IR. Thirty-six women with PCOS undergoing an IVM program were included. Differential gene expression between the insulin sensitive (IS) and IR group was measured by reverse transcription polymerase chain reaction.

Results

Expression of GLUTs 1, 3, 5, 8, and 13 was constitutive, whereas expression of GLUTs 2 and 7 was not observed in human GCs. The remaining GLUTs, 4, 6, 9, 10, 11, and 12, were differentially expressed among patients according to metabolic status, such as insulin sensitivity. A higher number of GCs from patients with IR (92%) expressed GLUT6 than GCs from IS PCOS patients (46.3%). Logistic regression showed that expression of GLUTs 9, 11, and 12 correlates with rates of IVM at 48 hours, fertilization, and implantation, respectively.

Conclusion

This is the first report describing the expression pattern of all 13 members of the GLUT family in human GCs. Results of the present study suggest that patients' insulin sensitivity regulates GLUT expression in GCs in PCOS patients, and this may control oocyte quality for IVM and subsequent processes such as fertilization and implantation in patients taking part in an in vitro fertilization program.

Citations

Citations to this article as recorded by

Dysregulation of ferroptosis-related genes in granulosa cells associates with impaired oocyte quality in polycystic ovary syndrome
Jialyu Huang, Hancheng Fan, Chenxi Li, Kangping Yang, Chaoyi Xiong, Siyi Xiong, Shenghui Feng, Shen Chen, Bangqi Wang, Yufang Su, Boyun Xu, Haiyan Yang, Ni Wang, Jing Zhu
Frontiers in Endocrinology.2024;[Epub] CrossRef
Chinese herbal medicine alleviates the pathogenesis of polycystic ovary syndrome by improving oxidative stress and glucose metabolism via mitochondrial Sirtuin 3 signaling
Qing Zhang, Jun Ren, Fangfang Wang, Mingqian Li, Manman Pan, Hui Zhang, Fan Qu
Phytomedicine.2023; 109: 154556. CrossRef
Essential Role of Granulosa Cell Glucose and Lipid Metabolism on Oocytes and the Potential Metabolic Imbalance in Polycystic Ovary Syndrome
Chen-Hua Zhang, Xiang-Yi Liu, Jing Wang
International Journal of Molecular Sciences.2023; 24(22): 16247. CrossRef
Effect of Electro-acupuncture on Expression of IRS-1/PI3K/GLUT4 Pathway in Ovarian Granulosa Cells of Infertile Patients with Polycystic Ovary Syndrome-Insulin Resistance of Phlegm-Dampness Syndrome
Shan Xiang, Ming-feng Xia, Jing-yan Song, Dan-qi Liu, Fang Lian
Chinese Journal of Integrative Medicine.2021; 27(5): 330. CrossRef
Comparison of streptozotocin-induced diabetes at different moments of the life of female rats for translational studies
Yuri K Sinzato, Eduardo Klöppel, Carolina A Miranda, Verônyca G Paula, Larissa F Alves, Lívia LS Nascimento, Ana Paula Campos, Barshana Karki, Václav Hampl, Gustavo T Volpato, Débora C Damasceno
Laboratory Animals.2021; 55(4): 329. CrossRef
Molecular Insulin Actions Are Sexually Dimorphic in Lipid Metabolism
Rosa Isela Ortiz-Huidobro, Myrian Velasco, Carlos Larqué, Rene Escalona, Marcia Hiriart
Frontiers in Endocrinology.2021;[Epub] CrossRef
Potential role of tea extract in oocyte development
Lei Zhao, Qing-Yuan Sun, Zhao-Jia Ge
Food & Function.2021; 12(21): 10311. CrossRef
Thioredoxin-interacting protein regulates glucose metabolism and improves the intracellular redox state in bovine oocytes during in vitro maturation
XiaoLong Jiang, YunWei Pang, ShanJiang Zhao, HaiSheng Hao, XueMing Zhao, WeiHua Du, YaChun Wang, HuaBin Zhu
American Journal of Physiology-Endocrinology and Metabolism.2020; 318(3): E405. CrossRef
The Impact of Controlled Ovarian Stimulation Hormones on the Metabolic State and Endocannabinoid System of Human Cumulus Cells
Valentina Notarstefano, Giorgia Gioacchini, Elisabetta Giorgini, Nina Montik, Andrea Ciavattini, Anna Rita Polidori, Fulvia Antonia Candela, Lisa Vaccari, Maurizio Cignitti, Oliana Carnevali
International Journal of Molecular Sciences.2020; 21(19): 7124. CrossRef
Polycystic Ovary Syndrome and Infertility: From Molecular Perspective
Masoumeh Ghafarzadeh
Current Womens Health Reviews.2020; 16(3): 182. CrossRef
Effects of gonadotrophins and insulin on glucose uptake in the porcine cumulus–oocyte complex during IVM
Gabriel Martín Alvarez, María Josefina Barrios Expósito, Evelin Elia, Dante Paz, Sergio Morado, Pablo Daniel Cetica
Reproduction, Fertility and Development.2019; 31(8): 1353. CrossRef
Does the molecular and metabolic profile of human granulosa cells correlate with oocyte fate? New insights by Fourier transform infrared microspectroscopy analysis
Giorgia Gioacchini, Valentina Notarstefano, Elena Sereni, Carlotta Zacà, Giovanni Coticchio, Elisabetta Giorgini, Lisa Vaccari, Oliana Carnevali, Andrea Borini
MHR: Basic science of reproductive medicine.2018;[Epub] CrossRef
Association among genetic variants in the vitamin D pathway and circulating 25-hydroxyvitamin D levels in Korean adults: results from the Korea National Health and Nutrition Examination Survey 2011–2012
So-Young Kwak, Clara Yongjoo Park, Garam Jo, Oh Yoen Kim, Min-Jeong Shin
Endocrine Journal.2018; 65(9): 881. CrossRef
Abnormal expression levels of BMP15/Smad1 are associated with granulosa cell apoptosis in patients with polycystic ovary syndrome
Xiangrong Cui, Xuan Jing, Xueqing Wu, Xingyu Bi, Junfen Liu, Zhijing Long, Xiuping Zhang, Dongdong Zhang, Hongxiang Jia, Dan Su, Kai Huo
Molecular Medicine Reports.2017; 16(6): 8231. CrossRef
Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome
Tiantian Li, Hui Mo, Wenfeng Chen, Li Li, Yao Xiao, Jing Zhang, Xiaofang Li, Ying Lu
Reproductive Sciences.2017; 24(5): 646. CrossRef
Nitric Oxide–Mediated Regulation of GLUT by T3 and Follicle-Stimulating Hormone in Rat Granulosa Cells
Ye Tian, Yu Ding, Juan Liu, Dai Heng, Kaili Xu, Wenbo Liu, Cheng Zhang
Endocrinology.2017; 158(6): 1898. CrossRef
Is the canine corpus luteum an insulin-sensitive tissue?
Liza Margareth Medeiros de Carvalho Sousa, Renata dos Santos Silva, Vanessa Uemura da Fonseca, Rafael Magdanelo Leandro, Thiago Senna Di Vincenzo, Ana Bárbara Alves-Wagner, Ubiratan Fabres Machado, Paula de Carvalho Papa
Journal of Endocrinology.2016; 231(3): 223. CrossRef
Maternal obesity is associated with ovarian inflammation and upregulation of early growth response factor 1
Meghan Ruebel, Kartik Shankar, Dana Gaddy, Forrest Lindsey, Thomas Badger, Aline Andres
American Journal of Physiology-Endocrinology and Metabolism.2016; 311(1): E269. CrossRef
Insulin signalling and glucose transport in the ovary and ovarian function during the ovarian cycle
Joëlle Dupont, Rex J. Scaramuzzi
Biochemical Journal.2016; 473(11): 1483. CrossRef
Articles in 'Endocrinology and Metabolism' in 2014
Won-Young Lee
Endocrinology and Metabolism.2015; 30(1): 47. CrossRef
Chronic ethanol treatment of human hepatocytes inhibits the activation of the insulin signaling pathway by increasing cytosolic free calcium levels
YI-MIN CHEN, JIN-FANG ZHAO, YONG-LIN LIU, JIE CHEN, RONG-LIN JIANG
International Journal of Molecular Medicine.2015; 36(3): 739. CrossRef
Dysregulated hepatic expression of glucose transporters in chronic disease: contribution of semicarbazide-sensitive amine oxidase to hepatic glucose uptake
Sumera Karim, Evaggelia Liaskou, Janine Fear, Abhilok Garg, Gary Reynolds, Lee Claridge, David H. Adams, Philip N. Newsome, Patricia F. Lalor
American Journal of Physiology-Gastrointestinal and Liver Physiology.2014; 307(12): G1180. CrossRef

Review Articles

Reproduction and Metabolism: Insights from Polycystic Ovary Syndrome.: Prathima Jasti, Andrea Dunaif; Endocrinol Metab. 2012;27(3):180-190. Published online September 19, 2012; DOI: https://doi.org/10.3803/EnM.2012.27.3.180

2,046 View
29 Download
2 Crossref

Abstract PDF

Until the 1980s, polycystic ovary syndrome (PCOS) was considered to be a poorly defined reproductive disorder. During that decade, it was recognized that PCOS was associated with profound insulin resistance and a substantially increased risk for type 2 diabetes mellitus in young women. Accordingly, the mechanisms linking the reproductive and metabolic features of the syndrome became the subject of intense investigation. Insulin is now recognized as a reproductive as well as a metabolic hormone and insulin signaling in the central nervous system participates in normal reproductive function. These insights have been directly translated into a novel therapy for PCOS with insulin sensitizing drugs. Androgens also have reversible metabolic actions to decrease insulin sensitivity and increase visceral fat. Prenatal androgen administration to non-human primates, sheep and rodents produces reproductive and metabolic features of PCOS suggesting that the disorder also has developmental origins. PCOS is highly heritable and male as well as female relatives have reproductive and metabolic phenotypes. A number of confirmed genetic susceptibility loci have now been mapped for PCOS and genes in well-known as well as novel biologic pathways have been implicated in disease pathogenesis.

Citations

Citations to this article as recorded by

The Role of Foxo3 in Leydig Cells
Young Suk Choi, Joo Eun Song, Byung Soo Kong, Jae Won Hong, Silvia Novelli, Eun Jig Lee
Yonsei Medical Journal.2015; 56(6): 1590. CrossRef
FoxO1 Is a Negative Regulator of FSHβ Gene Expression in Basal and GnRH-Stimulated Conditions in Female
Young-Suk Choi, Hyeon Jeong Lee, Cheol Ryong Ku, Yoon Hee Cho, Mi Ran Seo, Yoo Jeoung Lee, Eun Jig Lee
Endocrinology.2014; 155(6): 2277. CrossRef

Polycystic Ovary Syndrome in Korean Women: Clinical Characteristics and Diagnostic Criteria.: Yeon Ah Sung; Endocrinol Metab. 2011;26(3):203-207. Published online September 1, 2011; DOI: https://doi.org/10.3803/EnM.2011.26.3.203

2,522 View
42 Download
3 Crossref

Abstract PDF

Polycystic ovary syndrome (PCOS) is a common disorder of premenopausal women, affecting 4 to 8% of this population. Diagnosis of PCOS lays on a combination of clinical, biological and ultrasound criteria that has been used variably worldwide. The phenotype of women with PCOS is variable depending on ethnic background and diagnostic criteria may rely on it. Fewer studies have extensively examined reproductive and metabolic characteristics and hyperandrogenism in Korean women. Despite the paucity of these studies, they are critical for the ascertainment of criteria for the diagnosis of PCOS. This review address the issues pertaining to diagnostic issues of PCOS in Korean women, specifically: reproductive and metabolic derangements and criteria for hyperandrogenism based on hirsutism and serum androgen concentrations. The prevalence (estimated) of PCOS in Korean women was 5.8%. To diagnose PCOS, the cut off value for hirsutism needs to be differently adjusted in Korean women. Regarding phenotypic characteristics of PCOS in Korean women, the various phenotypes of PCOS have the different overall morbidity (e.g. insulin resistance and hyperinsulinism, abnormal glucose metabolism and metabolic syndrome). Especially patients with oligomenorrhea/polycystic ovary and hyperandrogenism/polycystic ovary did not seem to have metabolic derangements. Thus these subgroups need to be determined if they can be classified as PCOS.

Citations

Citations to this article as recorded by

Development of an integrated mobile application for lifestyle modification in women with polycystic ovarian syndrome
Hee Kyung Choi, Seon Heui Lee, Soo Yeon Yang
Journal of Clinical Nursing.2023; 32(1-2): 49. CrossRef
Trend changes and factor analysis of endometrial hyperplasia in patients with polycystic ovarian syndrome based on the Korean National Health Insurance Database
Bora Park, Hakmo Lee, Suyeon Park, Eun Sil Lee, Jeong Jae Lee, Young Lee, Je Hyun Seo
BMC Women's Health.2022;[Epub] CrossRef
Menstrual Cycle Patterns and the Prevalence of Premenstrual Syndrome and Polycystic Ovary Syndrome in Korean Young Adult Women
Young-Joo Park, Hyunjeong Shin, Songi Jeon, Inhae Cho, Yae-Ji Kim
Healthcare.2021; 9(1): 56. CrossRef

Case Report

A Case of Primary Hyperparathyroidism with Rapid Regression of a Brown Tumor after Parathyroidectomy.: Ji Young Mok, Ha Yeon Kim, Hsing Chien Ter, Sang Ock Kim, Dong Kyun Kim, Ji Sun Han, So Young Park, Sa Rah Lee, Mi Kyoung Park, Duk Kyu Kim; J Korean Endocr Soc. 2010;25(1):50-55. Published online March 1, 2010; DOI: https://doi.org/10.3803/jkes.2010.25.1.50

1,803 View
30 Download

Abstract PDF: Primary hyperparathyroidism is mainly caused by parathyroid adenoma (85%) and is characterized by hypercalcemia, osteoporosis, renal stones, and gastrointestinal and neurological disorders. Because of improvements in blood analysis over the last two decades, primary hyperparathyroidism is typically diagnosed early and asymptomatically. A rare clinical manifestations of primary hyperparathyroidism, brown tumors (osteitis fibrosa cystica), are osteolytic lesions resulting from long-term hyperparathyroidism. Radiologically, it is difficult to distinguish a brown tumor from plasmacytoma, multiple myeloma, or bone metastasis. We report a case of a 44-year-old man with primary hyperparathyroidism that caused a large brown tumor (11 x 5 x 8 cm) that mimicked plasmacytoma or cancer metastasis on pelvic magnetic resonance imaging. After a bone biopsy report that was highly suggestive of a brown tumor, serum calcium and intact parathyroid hormone levels were determined. The lesion was ultimately diagnosed as a brown tumor and a parathyroidectomy was performed. After 1 year, the lesion has nearly regressed by follow up of the anteroposterior view of the pelvis and bone mineral density has improved. The present case highlights the importance of considering brown tumors in the evaluation of patients presenting with hypercalcemia and osteolytic lesions without definite primary neoplasm.

Original Articles

Gly1057Asp Polymorphism of the Insulin Receptor Substrate-2 Genes May Not Have a Significant Impact on Insulin Resistance in Korean Women with Polycystic Ovary Syndrome.: Ji Young Oh, Jee Young Oh, Yeon Ah Sung, Hye Jin Lee, Hye Won Chung; J Korean Endocr Soc. 2009;24(2):100-108. Published online June 1, 2009; DOI: https://doi.org/10.3803/jkes.2009.24.2.100

1,642 View
21 Download
1 Crossref

Abstract PDF

BACKGROUND
Insulin resistance is a key factor in the pathogenesis of polycystic ovary syndrome (PCOS), and several candidate genes involved in insulin action such as insulin receptor or insulin recpetor substrate (IRS) have been investigated. In this study, we examined the genetic effects of the IRS-1 and IRS-2 genes on the metabolic and reproductive features in women with PCOS. METHODS: 125 patients with PCOS and 344 regular cycling controls were enrolled. Analysis of the polymorphisms of Gly972Arg in the IRS-1 gene and Gly1057Asp in the IRS-2 gene was performed and oral glucose tolerance tests and hyperinsulinemic euglycemic clamp tests were done. RESULTS: The genotype frequencies of the Gly972Arg polymorphism in the IRS-1 gene and the Gly1057Asp polymorphism in the IRS-2 gene were not significantly different between the women with PCOS and the controls. Gly972Arg polymorphism of the IRS-1 gene was extremely rare in both groups. PCOS women with the IRS-2 Asp1057Asp genotype showed significantly higher hirsutism scores, higher levels of free testosterone and higher post-load 60, 90, and 120 min plasma glucose levels compared to those women with the Gly1057Gly or Gly1057Asp genotype. In contrast, the control women with the Asp1057Asp genotype showed significantly lower post-load 60, 90, and 120 min plasma glucose levels compared with those women with the Gly1057Gly or Gly1057Asp genotype. CONCLUSION: Gly972Arg polymorphism of the IRS-1 gene was extremely rare in Korean women. Gly1057Asp polymorphism of the IRS-2 gene was associated with the phenotypic features of PCOS such as hirsutism, hyperandrogenemia and hyperglycemia, but it was not associated with the insulin sensitivity index. In conclusion, Gly1057Asp polymorphism of the IRS-2 gene may not have a significant impact on insulin resistance in Korean women with PCOS.

Citations

Citations to this article as recorded by

Insulin Receptor Substrate 1 Gly972Arg (rs1801278) Polymorphism Is Associated with Obesity and Insulin Resistance in Kashmiri Women with Polycystic Ovary Syndrome
Shayaq Ul Abeer Rasool, Mudasar Nabi, Sairish Ashraf, Shajrul Amin
Genes.2022; 13(8): 1463. CrossRef

Calpain-10 Polymorphism in Korean Women with Polycystic Ovary Syndrome.: Hye jin Lee, Gun Woo Pyun, Eun Kyung Byun, Ji Young Oh, Jee Young Oh, Youngsun Hong, Yeon Ah Sung, Hye Won Chung; J Korean Endocr Soc. 2008;23(5):319-326. Published online October 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.5.319

1,725 View
26 Download
1 Crossref

Abstract PDF

BACKGROUND
Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenism and insulin resistance, and PCOS is known to be associated with an increased risk of type 2 diabetes mellitus (DM). PCOS has also been proposed to share a common genetic background with type 2 DM. The calpain 10 (CAPN10) gene is known to be associated with type 2 DM in several different population. We examined the association of CAPN10 gene polymorphisms and their influence on the metabolic abnormalities in Korean women who suffer with PCOS. METHODS: One hundred sixty four women with PCOS and 325 control women were studied. The CAPN10 gene polymorphisms were genotyped by amplifying the genomic DNA. Anthropometric measures, a 75g oral glucose tolerance test and measurement of insulin sensitivity by the euglycemic hyperinsulinemic clamp technique were performed. RESULTS: The frequencies of CAPN10 UCSNP-43, UCSNP-19, UCSNP-63 and the haplotype combinations were not different between the women with PCOS and the control subjects. In the women with PCOS and who had the UCSNP-43 GA genotype, the post-load 90 minute plasma glucose level was significantly greater and the HDL cholesterol and insulin mediated glucose uptake were significantly lower compared to the women with PCOS and who had the GG genotype. CONCLUSION: The CAPN10 UCSNP-43 genotype might be responsible for insulin resistance, yet further study is required to confirm the role of this genetic polymorphism in the development of PCOS and the presentation of its disease features.

Citations

Citations to this article as recorded by

Comments on the latest meta-analysis of CAPN10 polymorphism associations with polycystic ovary syndrome
Sidra Raihan, Dawood Shariff, Sami Bizzari
Gene.2019; 717: 144006. CrossRef

First
Prev
Page of 3
Next
Last

Search