Fig. 1Cumulative probability of adrenal function recovery in patients with overt and subclinical Cushing syndrome.
Table 1Baseline Characteristics of Patients with Subclinical and Overt Cushing Syndrome
Characteristic |
Overt (n=10) |
Subclinical (n=26) |
P value |
Age, yr |
47.3±12.3 (21–65) |
56.0±9.3 (37–75) |
0.028 |
Female sex |
9 (90.0) |
19 (73.1) |
0.274 |
BMI, kg/m2
|
23.7±3.2 |
24.6±3.9 |
0.391 |
Hypertension |
7 (70.0) |
11 (42.3) |
0.137 |
Diabetes mellitus |
5 (50.0) |
7 (26.9) |
0.188 |
Tumor size, cm |
2.7±0.7 |
2.4±0.9 |
0.348 |
Tumor location (right) |
2 (20.0) |
7 (26.9) |
0.667 |
ACTH, pg/mL |
11.7±6.0 |
24.3±16.1 |
0.023 |
Basal UFC, μg/day |
520.1±432.0 |
71.9±33.1 |
0.010 |
Cortisol after ODST, μg/dL |
18.1±6.0 |
7.8±5.9 |
0.001 |
UFC after LDST, μg/day |
472.8±208.4 |
56.8±77.7 |
<0.001 |
Cortisol after LDST, μg/dL |
22.2±6.2 |
8.7±6.1 |
<0.001 |
UFC after HDST, μg/day |
487.8±284.2 |
74.1±113.5 |
0.001 |
Cortisol after HDST, μg/dL |
21.1±5.8 |
10.2±9.0 |
0.001 |
DHEA-S, μg/dL |
20.3±14.1 |
43.5±71.7 |
0.490 |
Postoperative ACTH at discharge, pg/mL |
23.8±12.2 |
85.25±112.9 |
0.035 |
Postoperative cortisol at discharge, pg/mLa
|
2.9±1.8 |
10.9±8.3 |
<0.001 |
Recovery time, mo |
17.0 (5–30) |
4.0 (0–14) |
<0.001 |
Follow-up duration, mo |
23.5 (10–109) |
23.5 (4–50) |
0.422 |
Table 2Relationship between Recovery Time and Preoperative Cortisol Levels
Variable |
Median (range) |
ρa
|
R2b
|
Recovery time, mo |
5 (0–30) |
- |
- |
Basal UFC, µg/day |
74.0 (26–1,450.0) |
0.485c
|
0.197c
|
P-cortisol after ODST, µg/dL |
7.4 (2.1–24.1) |
0.645d
|
0.465d
|
UFC after LDST, µg/day |
48.3 (5.0–830.0) |
0.729d
|
0.598d
|
P-cortisol after LDST, µg/dL |
11.1 (2.7–29.7) |
0.688d
|
0.472d
|
UFC after HDST, µg/day |
57.0 (9.0–963.0) |
0.697d
|
0.495d
|
P-cortisol after HDST, µg/dL |
10.3 (2.2–39.1) |
0.606d
|
0.303c
|