Fibroblast growth factor 21 (FGF21) is an attractive target for treating metabolic disease due to its wide-ranging beneficial effects on glucose and lipid metabolism. Circulating FGF21 levels are increased in insulin-resistant states; however, endogenous FGF21 fails to improve glucose and lipid metabolism in obesity, suggesting that metabolic syndrome is an FGF21-resistant state. Therefore, transcription factors for FGF21 are potential drug targets that could increase FGF21 expression in obesity and reduce FGF21 resistance. Despite many studies on the metabolic effects of FGF21, the transcriptional regulation of FGF21 gene expression remains controversial and is not fully understood. As the FGF21 transcription factor pathway is one of the most promising targets for the treatment of metabolic syndrome, further investigation of FGF21 transcriptional regulation is required.

Citations

Citations to this article as recorded by  

• Glucosamine Enhancement of Learning and Memory Functions by Promoting Fibroblast Growth Factor 21 Production
  Yu-Ming Chao, Hon-Yen Wu, Sin-Huei Yeh, Ding-I Yang, Lu-Shiun Her, Yuh-Lin Wu
  International Journal of Molecular Sciences.2024; 25(8): 4211.     CrossRef
• Relationship between FGF21 and drug or nondrug therapy of type 2 diabetes mellitus
  Chang Guo, Li Zhao, Yanyan Li, Xia Deng, Guoyue Yuan
  Journal of Cellular Physiology.2021; 236(1): 55.     CrossRef
• Serum fibroblast growth factor 21 levels after out of hospital cardiac arrest are associated with neurological outcome
  Pirkka T. Pekkarinen, Markus B. Skrifvars, Ville Lievonen, Pekka Jakkula, Laura Albrecht, Pekka Loisa, Marjaana Tiainen, Ville Pettilä, Matti Reinikainen, Johanna Hästbacka
  Scientific Reports.2021;[Epub]     CrossRef
• Epigenetic Regulation of Processes Related to High Level of Fibroblast Growth Factor 21 in Obese Subjects
  Teresa Płatek, Anna Polus, Joanna Góralska, Urszula Raźny, Agnieszka Dziewońska, Agnieszka Micek, Aldona Dembińska-Kieć, Bogdan Solnica, Małgorzata Malczewska-Malec
  Genes.2021; 12(2): 307.     CrossRef
• Nutritional Regulation of Hepatic FGF21 by Dietary Restriction of Methionine
  Han Fang, Kirsten P. Stone, Laura A. Forney, Desiree Wanders, Thomas W. Gettys
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• The Presence of Urinary Ketones according to Metabolic Status and Obesity
  Bo-Reum Kim, Jeong Woo Seo, Sang Man Kim, Kyu-Nam Kim, Nam-Seok Joo
  Journal of Korean Medical Science.2020;[Epub]     CrossRef
• MS-275 induces hepatic FGF21 expression via H3K18ac-mediated CREBH signal
  Qi Zhang, Qin Zhu, Ruyuan Deng, Feiye Zhou, Linlin Zhang, Shushu Wang, Kecheng Zhu, Xiao Wang, Libin Zhou, Qing Su
  Journal of Molecular Endocrinology.2019; 62(4): 187.     CrossRef
• Spontaneous ketonuria and risk of incident diabetes: a 12 year prospective study
  Gyuri Kim, Sang-Guk Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Ele Ferrannini, Yong-ho Lee, Nam H. Cho
  Diabetologia.2019; 62(5): 779.     CrossRef
• Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges
  Úrsula Martínez-Garza, Daniel Torres-Oteros, Alex Yarritu-Gallego, Pedro F. Marrero, Diego Haro, Joana Relat
  International Journal of Molecular Sciences.2019; 20(19): 4692.     CrossRef
• Berberine-induced activation of AMPK increases hepatic FGF21 expression via NUR77
  Feiye Zhou, Mengyao Bai, Yuqing Zhang, Qin Zhu, Linlin Zhang, Qi Zhang, Shushu Wang, Kecheng Zhu, Yun Liu, Xiao Wang, Libin Zhou
  Biochemical and Biophysical Research Communications.2018; 495(2): 1936.     CrossRef
• Practical prospects for boosting hepatic production of the “pro-longevity” hormone FGF21
  Mark F. McCarty
  Hormone Molecular Biology and Clinical Investigation.2017;[Epub]     CrossRef
• The regulation of FGF21 gene expression by metabolic factors and nutrients
  Anjeza Erickson, Régis Moreau
  Hormone Molecular Biology and Clinical Investigation.2017;[Epub]     CrossRef
• Diabetes Mellitus and Sepsis
  Silvia C. Trevelin, Daniela Carlos, Matteo Beretta, João S. da Silva, Fernando Q. Cunha
  Shock.2017; 47(3): 276.     CrossRef
• The U-shaped relationship between fibroblast growth factor 21 and microvascular complication in type 2 diabetes mellitus
  Chan-Hee Jung, Sang-Hee Jung, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
  Journal of Diabetes and its Complications.2017; 31(1): 134.     CrossRef
• Fibroblast Growth Factor 21—Metabolic Role in Mice and Men
  Harald Staiger, Michaela Keuper, Lucia Berti, Martin Hrabě de Angelis, Hans-Ulrich Häring
  Endocrine Reviews.2017; 38(5): 468.     CrossRef
• Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21
  Jay W Porter, Joe L Rowles, Justin A Fletcher, Terese M Zidon, Nathan C Winn, Leighton T McCabe, Young-Min Park, James W Perfield, John P Thyfault, R Scott Rector, Jaume Padilla, Victoria J Vieira-Potter
  Journal of Endocrinology.2017; 235(2): 97.     CrossRef
• Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice
  Panos Ziros, Zoi Zagoriti, George Lagoumintzis, Venetsana Kyriazopoulou, Ralitsa P. Iskrenova, Evagelia I. Habeos, Gerasimos P. Sykiotis, Dionysios V. Chartoumpekis, Ioannis G Habeos, Kostas Pantopoulos
  PLOS ONE.2016; 11(9): e0162024.     CrossRef
• Association between insulin resistance and impairment of FGF21 signal transduction in skeletal muscles
  Ja Young Jeon, Sung-E Choi, Eun Suk Ha, Tae Ho Kim, Jong Gab Jung, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, Yup Kang, Kwan-Woo Lee
  Endocrine.2016; 53(1): 97.     CrossRef
• Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury
  Yanlong Liu, Cuiqing Zhao, Jian Xiao, Liming Liu, Min Zhang, Cuiling Wang, Guicheng Wu, Ming-Hua Zheng, Lan-Man Xu, Yong-Ping Chen, Moosa Mohammadi, Shao-Yu Chen, Matthew Cave, Craig McClain, Xiaokun Li, Wenke Feng
  Scientific Reports.2016;[Epub]     CrossRef
• The Impact of Organokines on Insulin Resistance, Inflammation, and Atherosclerosis
  Kyung Mook Choi
  Endocrinology and Metabolism.2016; 31(1): 1.     CrossRef
• Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases
  Peng Cheng, Fangfang Zhang, Lechu Yu, Xiufei Lin, Luqing He, Xiaokun Li, Xuemian Lu, Xiaoqing Yan, Yi Tan, Chi Zhang
  Journal of Diabetes Research.2016; 2016: 1.     CrossRef
• Minireview: Roles of Fibroblast Growth Factors 19 and 21 in Metabolic Regulation and Chronic Diseases
  Fangfang Zhang, Lechu Yu, Xiufei Lin, Peng Cheng, Luqing He, Xiaokun Li, Xuemian Lu, Yi Tan, Hong Yang, Lu Cai, Chi Zhang
  Molecular Endocrinology.2015; 29(10): 1400.     CrossRef
• AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells
  Jinmi Lee, Seok-Woo Hong, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
  Molecular and Cellular Endocrinology.2015; 414: 148.     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef

As the prevalence and life expectancy of type 2 diabetes mellitus (T2DM) continue to increase, the importance of effective detection and intervention for the complications of T2DM, especially neurocognitive complications including cognitive dysfunction and dementia, is receiving greater attention. T2DM is thought to influence cognitive function through an as yet unclear mechanism that involves multiple factors such as hyperglycemia, hypoglycemia, and vascular disease. Recent developments in neuroimaging methods have led to the identification of potential neural correlates of T2DM-related neurocognitive changes, which extend from structural to functional and metabolite alterations in the brain. The evidence indicates various changes in the T2DM brain, including global and regional atrophy, white matter hyperintensity, altered functional connectivity, and changes in neurometabolite levels. Continued neuroimaging research is expected to further elucidate the underpinnings of cognitive decline in T2DM and allow better diagnosis and treatment of the condition.

Citations

Citations to this article as recorded by  

• The level of serum retinol-binding protein is associated with diabetic mild cognitive impairment
  Wenjie Zhang, Yuqi Yuan, Xiaoxia Cui, Shihong Chen, Xianghua Zhuang
  Brain Research.2024; 1822: 148670.     CrossRef
• Research Progress on Lipocalin-2 in Diabetic Encephalopathy
  Wenjie Zhang, Shihong Chen, Xianghua Zhuang
  Neuroscience.2023; 515: 74.     CrossRef
• Voluntary Attention and Quality of Life in Patients With Type 1 and Type 2 Diabetes Mellitus: Differences in Changes Depending on Disease Type and Duration
  N. E. Tadevosyan, A. S. Khachunts, M. Gohargani, A. A. Sahakyan, A. A. Tumanyan
  Journal of Evolutionary Biochemistry and Physiology.2022; 58(2): 569.     CrossRef
• Modifiable risk factors for neurocognitive and psychosocial problems after Hodgkin lymphoma
  AnnaLynn M. Williams, Sedigheh Mirzaei Salehabadi, Mengqi Xing, Nicholas S. Phillips, Matthew J. Ehrhardt, Rebecca Howell, Yutaka Yasui, Kevin C. Oeffinger, Todd Gibson, Eric J. Chow, Wendy Leisenring, Deokumar Srivastava, Melissa M. Hudson, Leslie L. Rob
  Blood.2022; 139(20): 3073.     CrossRef
• Type 2 Diabetes Independent of Glycemic Control is Associated With Cognitive Impairments: Findings From NHANES
  Rozmin Jiwani, Brittany Dennis, Alfonso L. Neri, Chandler Bess, Sara Espinoza, Jing Wang, Monica C. Serra
  Clinical Nursing Research.2022; 31(7): 1225.     CrossRef
• Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis
  Nathalie Marissal-Arvy, Marie-Pierre Moisan
  Metabolism Open.2022; 15: 100202.     CrossRef
• Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies
  Bhaskar Jyoti Dutta, Shamsher Singh, Sanket Seksaria, Ghanshyam Das Gupta, Amrita Singh
  Pharmacological Research.2022; 182: 106358.     CrossRef
• The role of LRP1 in Aβ efflux transport across the blood-brain barrier and cognitive dysfunction in diabetes mellitus
  Xue P, Long Zz, Jiang Gg, Wang Lp, Bian Cm, Wang Yl, M.F. Chen, Li W
  Neurochemistry International.2022; 160: 105417.     CrossRef
• Childhood Neurotoxicity and Brain Resilience to Adverse Events during Adulthood
  AnnaLynn M. Williams, Yin Ting Cheung, Geehong Hyun, Wei Liu, Kirsten K. Ness, Matthew J. Ehrhardt, Daniel A. Mulrooney, Nickhill Bhakta, Pia Banerjee, Tara M. Brinkman, Daniel M. Green, Wassim Chemaitilly, I‐Chan Huang, Deokumar Srivastava, Melissa M. Hu
  Annals of Neurology.2021; 89(3): 534.     CrossRef
• Metformin restores hippocampal neurogenesis and learning and memory via regulating gut microbiota in the obese mouse model
  Xiaoyi Ma, Wenchang Xiao, Hao Li, Pei Pang, Feixiao Xue, Lu Wan, Lei Pei, Huanhuan Yan
  Brain, Behavior, and Immunity.2021; 95: 68.     CrossRef
• Promoting Successful Cognitive Aging: A Ten-Year Update
  Taylor J. Krivanek, Seth A. Gale, Brittany M. McFeeley, Casey M. Nicastri, Kirk R. Daffner
  Journal of Alzheimer's Disease.2021; 81(3): 871.     CrossRef
• Association of Vitamin D Level and Nerve Conduction Study Parameters with Cognitive Function in Diabetic Neuropathy Patients
  Aida Fithrie, Fasihah Irfani Fitri, Muhammad Reza Putra
  Open Access Macedonian Journal of Medical Sciences.2021; 9(B): 72.     CrossRef
• Insulin resistance takes center stage: a new paradigm in the progression of bipolar disorder
  Cynthia V. Calkin
  Annals of Medicine.2019; 51(5-6): 281.     CrossRef
• Vitamin D Supplementation and Cognition in People with Type 2 Diabetes: A Randomized Control Trial
  Mary A. Byrn, William Adams, Sue Penckofer, Mary Ann Emanuele
  Journal of Diabetes Research.2019; 2019: 1.     CrossRef
• Neurocognitive impairment in type 2 diabetes mellitus
  Marianna Karvani, P. Simos, S. Stavrakaki, D. Kapoukranidou
  Hormones.2019; 18(4): 523.     CrossRef
• Benefits of combination low-dose pioglitazone plus fish oil on aged type 2 diabetes mice
  Yuzuru Iizuka, Hyounju Kim, Satoshi Hirako, Kanako Chiba, Masahiro Wada, Akiyo Matsumoto
  Journal of Food and Drug Analysis.2018; 26(4): 1265.     CrossRef
• Association of ApoE Genetic Polymorphism and Type 2 Diabetes with Cognition in Non-Demented Aging Chinese Adults: A Community Based Cross-Sectional Study
  Jie Zhen, Tong Lin, Xiaochen Huang, Huiqiang Zhang, Shengqi Dong, Yifan Wu, Linlin Song, Rong Xiao, Linhong Yuan
  Aging and disease.2018; 9(3): 346.     CrossRef
• Chronic Health Conditions and Neurocognitive Function in Aging Survivors of Childhood Cancer: A Report from the Childhood Cancer Survivor Study
  Yin Ting Cheung, Tara M Brinkman, Chenghong Li, Yasmin Mzayek, Deokumar Srivastava, Kirsten K Ness, Sunita K Patel, Rebecca M Howell, Kevin C Oeffinger, Leslie L Robison, Gregory T Armstrong, Kevin R Krull
  JNCI: Journal of the National Cancer Institute.2018; 110(4): 411.     CrossRef
• Diabetes, Depression, and Cognition: a Recursive Cycle of Cognitive Dysfunction and Glycemic Dysregulation
  Sheila Black, Kyle Kraemer, Avani Shah, Gaynell Simpson, Forrest Scogin, Annie Smith
  Current Diabetes Reports.2018;[Epub]     CrossRef
• Hypoglycemia is associated with dementia in elderly patients with type 2 diabetes mellitus: An analysis based on the Korea National Diabetes Program Cohort
  Sang Ouk Chin, Sang Youl Rhee, Suk Chon, Sei Hyun Baik, Yongsoo Park, Moon Suk Nam, Kwan Woo Lee, Ki Hong Chun, Jeong-taek Woo, Young Seol Kim
  Diabetes Research and Clinical Practice.2016; 122: 54.     CrossRef
• Bipolar disorders, type 2 diabetes mellitus, and the brain
  Tomas Hajek, Roger McIntyre, Martin Alda
  Current Opinion in Psychiatry.2016; 29(1): 1.     CrossRef
• 1,5-Anhydro-D-Glucitol Could Reflect Hypoglycemia Risk in Patients with Type 2 Diabetes Receiving Insulin Therapy
  Min Kyeong Kim, Hye Seung Jung, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Seong Yeon Kim
  Endocrinology and Metabolism.2016; 31(2): 284.     CrossRef
• Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood
  Seung-Hwan Lee, Janice M. Zabolotny, Hu Huang, Hyon Lee, Young-Bum Kim
  Molecular Metabolism.2016; 5(8): 589.     CrossRef
• Toll-like receptor 2 and type 2 diabetes
  Zahra Sepehri, Zohre Kiani, Ali Akbar Nasiri, Farhad Kohan
  Cellular & Molecular Biology Letters.2016;[Epub]     CrossRef
• Long-term Variability in Glycemic Control Is Associated With White Matter Hyperintensities in APOE4 Genotype Carriers With Type 2 Diabetes
  Abigail Livny, Ramit Ravona-Springer, Anthony Heymann, Rachel Priess, Tammar Kushnir, Galia Tsarfaty, Leeron Rabinov, Reut Moran, Hadass Hoffman, Itzik Cooper, Lior Greenbaum, Jeremy Silverman, Mary Sano, Sterling C. Johnson, Barbara B. Bendlin, Michal Sc
  Diabetes Care.2016; 39(6): 1056.     CrossRef
• DIABETES MELLITUS Y SU ASOCIACIÓN CON DETERIORO COGNITIVO Y DEMENCIA
  Gonzalo Muñoz A., Christina Degen, Johannes Schröder, Pablo Toro E.
  Revista Médica Clínica Las Condes.2016; 27(2): 266.     CrossRef
• Blood electrolyte disturbances during severe hypoglycemia in Korean patients with type 2 diabetes
  Mi Yeon Kang
  The Korean Journal of Internal Medicine.2015; 30(5): 648.     CrossRef
• Whenever You Lose Connection, Take Intranasal Insulin?
  Antje Gottschalk, Björn Ellger
  Diabetes.2015; 64(3): 687.     CrossRef
• Spatial Patterns of Structural Brain Changes in Type 2 Diabetic Patients and Their Longitudinal Progression With Intensive Control of Blood Glucose
  Guray Erus, Harsha Battapady, Tianhao Zhang, James Lovato, Michael E. Miller, Jeff D. Williamson, Lenore J. Launer, R. Nick Bryan, Christos Davatzikos
  Diabetes Care.2015; 38(1): 97.     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
• Cerebrolysin reverses hippocampal neural atrophy in a mice model of diabetes mellitus type 1
  Lizzette Sanchez‐Vega, Ismael Juárez, Maria De Jesus Gomez‐Villalobos, Gonzalo Flores
  Synapse.2015; 69(6): 326.     CrossRef

Adipocyte differentiation, termed adipogenesis, is a complicated process in which pluripotent mesenchymal stem cells differentiate into mature adipocytes. The process of adipocyte differentiation is tightly regulated by a number of transcription factors, hormones and signaling pathway molecules. Recent studies have demonstrated that microRNAs, which belong to small noncoding RNA species, are also involved in adipocyte differentiation. In vivo and in vitro studies have revealed that various microRNAs affect adipogenesis by targeting several adipogenic transcription factors and key signaling molecules. In this review, we will summarize the roles of microRNAs in adipogenesis and their target genes associated with each stage of adipocyte differentiation.

Citations

Citations to this article as recorded by  

• Investigation of adipocyte differentiation based on proteomics and intact N-glycopeptide modificationomics
  Xin-Yu Li, Nuerbiye Nuermaimaiti, Xuanyu Meng, Xiaozheng Zhang, Aikedaimu Abudukeremu, Yihuai He, Wenting Ma, Xuelei Chen, Shangkun Li, Jiaxin Sun, Yaqun Guan
  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.2025; 1873(1): 141052.     CrossRef
• A review of the role of transcription factors in regulating adipogenesis and lipogenesis in beef cattle
  Belete Kuraz Abebe, Hongbao Wang, Anning Li, Linsen Zan
  Journal of Animal Breeding and Genetics.2024; 141(3): 235.     CrossRef
• A review of the role of epigenetic studies for intramuscular fat deposition in beef cattle
  Belete Kuraz Abebe, Jianfang Wang, Juntao Guo, Hongbao Wang, Anning Li, Linsen Zan
  Gene.2024; 908: 148295.     CrossRef
• Adenovirus 36 seropositivity is related to the expression of anti-adipogenic lncRNAs GAS5 and MEG3 in adipose tissue obtained from subjects with obesity
  Víctor Manríquez, Roberto Brito, Monica Pavez, Jorge Sapunar, Luis Fonseca, Víctor Molina, Eugenia Ortiz, Romilio Baeza, Camila Reimer, Maria Charles, Constance Schneider, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata, Alvaro Cerda
  International Journal of Obesity.2024;[Epub]     CrossRef
• Current Evidence of Natural Products against Overweight and Obesity: Molecular Targets and Mechanisms of Action
  Cristina Alicia Elizalde-Romero, Nayely Leyva-López, Laura Aracely Contreras-Angulo, Rigoberto Cabanillas Ponce de-León, Libia Zulema Rodriguez-Anaya, Josefina León-Félix, J. Basilio Heredia, Saul Armando Beltrán-Ontiveros, Erick Paul Gutiérrez-Grijalva
  Receptors.2024; 3(3): 362.     CrossRef
• miR-449a mediated repression of the cell cycle machinery prevents neuronal apoptosis
  Monika Chauhan, Komal Singh, Chen Chongtham, Aneeshkumar A.G., Pushkar Sharma
  Journal of Biological Chemistry.2024; 300(9): 107698.     CrossRef
• Vine Tea Extract (VTE) Inhibits High-Fat Diet-Induced Adiposity: Evidence of VTE’s Anti-Obesity Effects In Vitro and In Vivo
  Wonchul Lim, Seongmin Choi, Jinhak Kim, Kwang-Soo Baek, Minkuk Park, Gakyung Lee, Tae-Gyu Lim
  International Journal of Molecular Sciences.2024; 25(22): 12042.     CrossRef
• Transcriptome analysis of miRNAs during myoblasts adipogenic differentiation
  Chengchuang Song, Xue Fang, Qi Wang, Yaqi Chen, Bei Zhao, Yanhong Wang, Xingtang Fang, Chunlei Zhang
  Animal Biotechnology.2023; 34(4): 1406.     CrossRef
• Advances in the regulation of adipogenesis and lipid metabolism by exosomal ncRNAs and their role in related metabolic diseases
  Cong Liu, Xilin Liu, Hong Li, Zhichen Kang
  Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
• Indian gooseberry and barley sprout mixture prevents obesity by regulating adipogenesis, lipogenesis, and lipolysis in C57BL/6J mice with high-fat diet-induced obesity
  Soo-Jeung Park, Jong-Lae Kim, Mi-Ryeong Park, Jong Wook Lee, Ok-Kyung Kim, Jeongmin Lee
  Journal of Functional Foods.2022; 90: 104951.     CrossRef
• Interleukin-6 mimics insulin-dependent cellular distribution of some cytoskeletal proteins and Glut4 transporter without effect on glucose uptake in 3T3-L1 adipocytes
  Maciej Błaszczyk, Małgorzata Gajewska, Marta Dymowska, Alicja Majewska, Tomasz Domoradzki, Adam Prostek, Rafał Pingwara, Magdalena Hulanicka, Katarzyna Grzelkowska-Kowalczyk
  Histochemistry and Cell Biology.2022;[Epub]     CrossRef
• Heat-Killed Enterococcus faecalis Prevents Adipogenesis and High Fat Diet-Induced Obesity by Inhibition of Lipid Accumulation through Inhibiting C/EBP-α and PPAR-γ in the Insulin Signaling Pathway
  Jin-Ho Lee, Keun-Jung Woo, Min-Ah Kim, Joonpyo Hong, Jihee Kim, Sun-Hong Kim, Kwon-Il Han, Masahiro Iwasa, Tack-Joong Kim
  Nutrients.2022; 14(6): 1308.     CrossRef
• The delivery of miR-21a-5p by extracellular vesicles induces microglial polarization via the STAT3 pathway following hypoxia-ischemia in neonatal mice
  Dan-Qing Xin, Yi-Jing Zhao, Ting-Ting Li, Hong-Fei Ke, Cheng-Cheng Gai, Xiao-Fan Guo, Wen-Qiang Chen, De-Xiang Liu, Zhen Wang
  Neural Regeneration Research.2022; 17(10): 2238.     CrossRef
• Extracellular Vesicles from Adipose Tissue Could Promote Metabolic Adaptation through PI3K/Akt/mTOR
  Jaime Delgadillo-Velázquez, Herminia Mendivil-Alvarado, Carlos Daniel Coronado-Alvarado, Humberto Astiazaran-Garcia
  Cells.2022; 11(11): 1831.     CrossRef
• Adipocyte differentiation between obese and lean conditions depends on changes in miRNA expression
  Yerim Heo, Hyunjung Kim, Jiwon Lim, Sun Shim Choi
  Scientific Reports.2022;[Epub]     CrossRef
• Comparison of Selected Non-Coding RNAs and Gene Expression Profiles between Common Osteosarcoma Cell Lines
  Mateusz Sikora, Katarzyna Krajewska, Klaudia Marcinkowska, Anna Raciborska, Rafał Jakub Wiglusz, Agnieszka Śmieszek
  Cancers.2022; 14(18): 4533.     CrossRef
• Mesenchymal Stem Cell Secreted-Extracellular Vesicles are Involved in Chondrocyte Production and Reduce Adipogenesis during Stem Cell Differentiation
  Yu-Chen Tsai, Tai-Shan Cheng, Hsiu-Jung Liao, Ming-Hsi Chuang, Hui-Ting Chen, Chun-Hung Chen, Kai-Ling Zhang, Chih-Hung Chang, Po-Cheng Lin, Chi-Ying F. Huang
  Tissue Engineering and Regenerative Medicine.2022; 19(6): 1295.     CrossRef
• Tissue and circulating microRNAs as biomarkers of response to obesity treatment strategies
  G. Catanzaro, T. Filardi, C. Sabato, A. Vacca, S. Migliaccio, S. Morano, E. Ferretti
  Journal of Endocrinological Investigation.2021; 44(6): 1159.     CrossRef
• Benzyl Butyl Phthalate Induced Early lncRNA H19 Regulation in C3H10T1/2 Stem Cell Line
  Jian Zhang, Mahua Choudhury
  Chemical Research in Toxicology.2021; 34(1): 54.     CrossRef
• Inhibition of preadipocyte differentiation by Lycium barbarum polysaccharide treatment in 3T3-L1 cultures
  Xiaochun Xu, Wenjuan Chen, Shukun Yu, Qian Lei, Lihong Han, Wenping Ma
  Electronic Journal of Biotechnology.2021; 50: 53.     CrossRef
• MiR-25-3p regulates the differentiation of intramuscular preadipocytes in goat via targeting <i>KLF4</i>
  Yu Du, Yue Zhao, Yong Wang, Qingyong Meng, Jiangjiang Zhu, Yaqiu Lin
  Archives Animal Breeding.2021; 64(1): 17.     CrossRef
• MiR-208b Regulates Rabbit Preadipocyte Proliferation and Differentiation
  Jiahao Shao, Ting Pan, Jie Wang, Tao Tang, Yanhong Li, Xianbo Jia, Songjia Lai
  Genes.2021; 12(6): 890.     CrossRef
• Comparing the effect of cinnamaldehyde and metformin on expression of MiR320 and MiR26-b in insulin resistant 3T3L1 adipocytes
  Yousof Naghiaee, Mahmood Vakili, Mohammad Mohammadi, Azra Mohiti, Javad Mohiti-Ardakani
  Phytomedicine Plus.2021; 1(4): 100122.     CrossRef
• Lower miR‐26a levels in breastmilk affect gene expression in adipose tissue of offspring
  Catalina A. Pomar, Francisca Serra, Andreu Palou, Juana Sánchez
  The FASEB Journal.2021;[Epub]     CrossRef
• MicroRNA-378 regulates adipogenic differentiation in bovine intramuscular preadipocytes by targeting CaMKK2
  Dongwei Li, Heng Wang, Yongmin Li, Changqing Qu, Yunhai Zhang, Hongyu Liu, Xiaorong Zhang
  Adipocyte.2021; 10(1): 483.     CrossRef
• miR-6315 Attenuates Methotrexate Treatment-Induced Decreased Osteogenesis and Increased Adipogenesis Potentially through Modulating TGF-β/Smad2 Signalling
  Ya-Li Zhang, Liang Liu, Yu-Wen Su, Cory J. Xian
  Biomedicines.2021; 9(12): 1926.     CrossRef
• Inhibitory Effects of Pinostilbene on Adipogenesis in 3T3-L1 Adipocytes: A Study of Possible Mechanisms
  You Chul Chung, Chang-Gu Hyun
  International Journal of Molecular Sciences.2021; 22(24): 13446.     CrossRef
• Regulation of Methylase METTL3 on Fat Deposition
  Gang Luo, Jialing Chen, Zhanjun Ren
  Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 4843.     CrossRef
• miR-214-5p Regulating Differentiation of Intramuscular Preadipocytes in Goats via Targeting KLF12
  Yu Du, Yong Wang, Yanyan Li, Quzhe Emu, Jiangjiang Zhu, Yaqiu Lin
  Frontiers in Genetics.2021;[Epub]     CrossRef
• Screening and identification of MicroRNAs expressed in perirenal adipose tissue during rabbit growth
  Guoze Wang, Guo Guo, Xueting Tian, Shenqiang Hu, Kun Du, Qinghai Zhang, Jingxin Mao, Xianbo Jia, Shiyi Chen, Jie Wang, Songjia Lai
  Lipids in Health and Disease.2020;[Epub]     CrossRef
• Descending Expression of miR320 in Insulin-Resistant Adipocytes Treated with Ascending Concentrations of Metformin
  Yousof Naghiaee, Reza Didehdar, Zahra Malekpour-Dehkordi, Fatemeh Pourrajab, Javad Mohiti-Ardakani
  Biochemical Genetics.2020; 58(5): 661.     CrossRef
• Citrus aurantium L. Dry Extracts Ameliorate Adipocyte Differentiation of 3T3-L1 Cells Exposed to TNFα by Down-Regulating miR-155 Expression
  Michele Campitelli, Antonella Desiderio, Giuseppe Cacace, Cecilia Nigro, Immacolata Prevenzano, Alessia Leone, Sonia de Simone, Pietro Campiglia, Pietro Formisano, Gregory A. Raciti, Francesco Beguinot, Claudia Miele
  Nutrients.2020; 12(6): 1587.     CrossRef
• Metabolic Benefits of MicroRNA-22 Inhibition
  Marc Thibonnier, Christine Esau
  Nucleic Acid Therapeutics.2020; 30(2): 104.     CrossRef
• Differentially Expressed miRNA-Gene Targets Related to Intramuscular Fat in Musculus Longissimus Dorsi of Charolais × Holstein F2-Crossbred Bulls
  Bilal Ahmad Mir, Henry Reyer, Katrin Komolka, Siriluck Ponsuksili, Christa Kühn, Steffen Maak
  Genes.2020; 11(6): 700.     CrossRef
• MiR224-5p Inhibitor Restrains Neuronal Apoptosis by Targeting NR4A1 in the Oxygen-Glucose Deprivation (OGD) Model
  Ling-Ling Liu, Shan Qiao, Mei-Ling Wang, Huai-Kuan Wu, Yong-Xin Su, Ke-Mo Wang, Xue-Wu Liu
  Frontiers in Neuroscience.2020;[Epub]     CrossRef
• Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways
  Melvin A. Ambele, Priyanka Dhanraj, Rachel Giles, Michael S. Pepper
  International Journal of Molecular Sciences.2020; 21(12): 4283.     CrossRef
• MicroRNA‑449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice
  Ya‑Xin Tan, Ying Hong, Shui Jiang, Min‑Nan Lu, Shan Li, Bo Chen, Li Zhang, Tao Hu, Rui Mao, Rong Mei, Yan‑Bin Xiyang
  International Journal of Molecular Medicine.2020;[Epub]     CrossRef
• Influence of adenovirus 36 seropositivity on the expression of adipogenic microRNAs in obese subjects
  Víctor Manríquez, Alvaro Gutierrez, Alexis Morales, Roberto Brito, Monica Pavez, Jorge Sapunar, Luis Fonseca, Víctor Molina, Eugenia Ortiz, Maria Ines Barra, Camila Reimer, Maria Charles, Constance Schneider, Alvaro Cerda
  International Journal of Obesity.2020; 44(11): 2303.     CrossRef
• Metformin downregulates miR223 expression in insulin-resistant 3T3L1 cells and human diabetic adipose tissue
  Yousof Naghiaee, Reza Didehdar, Fatemeh Pourrajab, Masoud Rahmanian, Naeime Heiranizadeh, Azra Mohiti, Javad Mohiti-Ardakani
  Endocrine.2020; 70(3): 498.     CrossRef
• Metabolic and energetic benefits of microRNA-22 inhibition
  Marc Thibonnier, Christine Esau, Sujoy Ghosh, Edward Wargent, Claire Stocker
  BMJ Open Diabetes Research & Care.2020; 8(1): e001478.     CrossRef
• Bta-miR-376a Targeting KLF15 Interferes with Adipogenesis Signaling Pathway to Promote Differentiation of Qinchuan Beef Cattle Preadipocytes
  Xingyi Chen, Sayed Haidar Abbas Raza, Gong Cheng, Xinhao Ma, Jianfang Wang, Linsen Zan
  Animals.2020; 10(12): 2362.     CrossRef
• The cross-talk between adipokines and miRNAs in health and obesity-mediated diseases
  Ahmad Ghasemi, Seyed Isaac Hashemy, Mohsen Azimi-Nezhad, Alireza Dehghani, Jafar Saeidi, Mahnaz Mohtashami
  Clinica Chimica Acta.2019; 499: 41.     CrossRef
• MicroRNAs and long noncoding RNAs: new regulators in cell fate determination of mesenchymal stem cells
  Zixiang Wu, Shujing Liang, Wenyu Kuai, Lifang Hu, Airong Qian
  RSC Advances.2019; 9(64): 37300.     CrossRef
• Harnessing adipogenesis to prevent obesity
  Nida Haider, Louise Larose
  Adipocyte.2019; 8(1): 98.     CrossRef
• MiR‐127 attenuates adipogenesis by targeting MAPK4 and HOXC6 in porcine adipocytes
  Yun Gao, Yingqian Wang, Xiaochang Chen, Ying Peng, Fenfen Chen, Yulin He, Weijun Pang, Gongshe Yang, Taiyong Yu
  Journal of Cellular Physiology.2019; 234(12): 21838.     CrossRef
• MicroRNA-425 controls lipogenesis and lipolysis in adipocytes
  Renli Qi, Jing Wang, Qi Wang, Xiaoyu Qiu, Feiyun Yang, Zuohua Liu, Jinxiu Huang
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2019; 1864(5): 744.     CrossRef
• miRNA-7a-2-3p Inhibits Neuronal Apoptosis in Oxygen-Glucose Deprivation (OGD) Model
  Zi-Bin Zhang, Ya-Xin Tan, Qiong Zhao, Liu-Lin Xiong, Jia Liu, Fei-Fei Xu, Yang Xu, Larisa Bobrovskaya, Xin-Fu Zhou, Ting-Hua Wang
  Frontiers in Neuroscience.2019;[Epub]     CrossRef
• IL‐1α inhibits proliferation and adipogenic differentiation of human adipose‐derived mesenchymal stem cells through NF‐κB‐ and ERK1/2‐mediated proinflammatory cytokines
  Xuerong Sun, Tangbin Zou, Changqing Zuo, Mingmeng Zhang, Benyan Shi, Zhiwen Jiang, Hongjing Cui, Xiaoxin Liao, Xiaoyi Li, Yuelian Tang, Yusheng Liu, Xinguang Liu
  Cell Biology International.2018; 42(7): 794.     CrossRef
• MicroRNA‐224‐5p regulates adipocyte apoptosis induced by TNFα via controlling NF‐κB activation
  Renli Qi, Jinxiu Huang, Qi Wang, Hong Liu, Ruisheng Wang, Jing Wang, Feiyun Yang
  Journal of Cellular Physiology.2018; 233(2): 1236.     CrossRef
• Potential role of microRNAs in the regulation of adipocytes liposecretion and adipose tissue physiology
  Giulia Maurizi, Lucia Babini, Lucio Della Guardia
  Journal of Cellular Physiology.2018; 233(12): 9077.     CrossRef
• Chronic hyperinsulinemia induced miR-27b is linked to adipocyte insulin resistance by targeting insulin receptor
  Ankita Srivastava, Kripa Shankar, Muheeb Beg, Sujith Rajan, Abhishek Gupta, Salil Varshney, Durgesh Kumar, Sanchita Gupta, Raj Kumar Mishra, Anil Nilkanth Gaikwad
  Journal of Molecular Medicine.2018; 96(3-4): 315.     CrossRef
• Bta-miR-130a/b regulates preadipocyte differentiation by targeting PPARG and CYP2U1 in beef cattle
  Xueyao Ma, Dawei Wei, Gong Cheng, Shijun Li, Li Wang, Yaning Wang, Xiaoyu Wang, Song Zhang, Hongbao Wang, Linsen Zan
  Molecular and Cellular Probes.2018; 42: 10.     CrossRef
• Transdifferentiation of adipocytes to osteoblasts: potential for orthopaedic treatment
  Daphne P L Lin, Crispin R Dass
  Journal of Pharmacy and Pharmacology.2018; 70(3): 307.     CrossRef
• Characterization of miRNA transcriptome profiles related to breast muscle development and intramuscular fat deposition in chickens
  Shouyi Fu, Yinli Zhao, Yuanfang Li, Guoxi Li, Yi Chen, Zhuanjian Li, Guirong Sun, Hong Li, Xiangtao Kang, Fengbin Yan
  Journal of Cellular Biochemistry.2018; 119(8): 7063.     CrossRef
• Transcriptomic Analyses of Adipocyte Differentiation From Human Mesenchymal Stromal‐Cells (MSC)
  Antonio Casado‐Díaz, Jaouad Anter, Sören Müller, Peter Winter, José Manuel Quesada‐Gómez, Gabriel Dorado
  Journal of Cellular Physiology.2017; 232(4): 771.     CrossRef
• Downregulated miR-29a/b/c during Contact Inhibition Stage Promote 3T3-L1 Adipogenesis by Targeting DNMT3A
  Yingjie Zhu, Guangyong Zheng, Huichao Wang, Yudong Jia, Ying Zhang, Yanfeng Tang, Wenlong Li, Yanan Fan, Xiaodong Zhang, Youwen Liu, Sanhong Liu, Makoto Kanzaki
  PLOS ONE.2017; 12(1): e0170636.     CrossRef
• Potential miRNA involvement in the anti-adipogenic effect of resveratrol and its metabolites
  Itziar Eseberri, Arrate Lasa, Jonatan Miranda, Ana Gracia, Maria P. Portillo, Cristina Óvilo
  PLOS ONE.2017; 12(9): e0184875.     CrossRef
• Identification and characterization of differentially expressed miRNAs in subcutaneous adipose between Wagyu and Holstein cattle
  Yuntao Guo, Xiuxiu Zhang, Wanlong Huang, Xiangyang Miao
  Scientific Reports.2017;[Epub]     CrossRef
• Integrated analysis of mRNA and miRNA expression profiles in livers of Yimeng black pigs with extreme phenotypes for backfat thickness
  Wentong Li, Yalan Yang, Ying Liu, Shuai Liu, Xiuxiu Li, Yingping Wang, Yanmin Zhang, Hui Tang, Rong Zhou, Kui Li
  Oncotarget.2017; 8(70): 114787.     CrossRef
• Small non coding RNAs in adipocyte biology and obesity
  Ez-Zoubir Amri, Marcel Scheideler
  Molecular and Cellular Endocrinology.2017; 456: 87.     CrossRef
• Role of MicroRNA Regulation in Obesity-Associated Breast Cancer: Nutritional Perspectives
  Ravi Kasiappan, Dheeran Rajarajan
  Advances in Nutrition.2017; 8(6): 868.     CrossRef
• Biomolecular features of inflammation in obese rheumatoid arthritis patients: management considerations
  Barbara Tolusso, Stefano Alivernini, Maria Rita Gigante, Gianfranco Ferraccioli, Elisa Gremese
  Expert Review of Clinical Immunology.2016; 12(7): 751.     CrossRef
• Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study
  Giuseppe Iacomino, Paola Russo, Ilaria Stillitano, Fabio Lauria, Pasquale Marena, Wolfgang Ahrens, Pasquale De Luca, Alfonso Siani
  Genes & Nutrition.2016;[Epub]     CrossRef
• Role of MicroRNAs in NAFLD/NASH
  Gyongyi Szabo, Timea Csak
  Digestive Diseases and Sciences.2016; 61(5): 1314.     CrossRef
• MicroRNA‐29b promotes the adipogenic differentiation of human adipose tissue‐derived stromal cells
  Xi‐Mei Zhang, Li‐Hong Wang, Dong‐Ju Su, Dan Zhu, Qiu‐Ming Li, Mei‐Hua Chi
  Obesity.2016; 24(5): 1097.     CrossRef
• MiR-181a-5p regulates 3T3-L1 cell adipogenesis by targeting <italic>Smad7</italic> and <italic>Tcf7l2</italic>
  Dan Ouyang, Lifeng Xu, Lihua Zhang, Dongguang Guo, Xiaotong Tan, Xiaofang Yu, Junjie Qi, Yaqiong Ye, Qihong Liu, Yongjiang Ma, Yugu Li
  Acta Biochimica et Biophysica Sinica.2016; 48(11): 1034.     CrossRef
• Metformin-suppressed differentiation of human visceral preadipocytes: Involvement of microRNAs
  Koji Fujita, Hisakazu Iwama, Kyoko Oura, Tomoko Tadokoro, Kayo Hirose, Miwako Watanabe, Teppei Sakamoto, Akiko Katsura, Shima Mimura, Takako Nomura, Joji Tani, Hisaaki Miyoshi, Asahiro Morishita, Hirohito Yoneyama, Keiichi Okano, Yasuyuki Suzuki, Takashi
  International Journal of Molecular Medicine.2016; 38(4): 1135.     CrossRef
• Systematic study of cis-antisense miRNAs in animal species reveals miR-3661 to target PPP2CA in human cells
  Jian Wang, Zongcheng Li, Bailong Liu, Guangnan Chen, Ningsheng Shao, Xiaomin Ying, Ya Wang
  RNA.2016; 22(1): 87.     CrossRef
• Oxidative stress, redox regulation and diseases of cellular differentiation
  Zhi-Wei Ye, Jie Zhang, Danyelle M. Townsend, Kenneth D. Tew
  Biochimica et Biophysica Acta (BBA) - General Subjects.2015; 1850(8): 1607.     CrossRef
• Noncoding RNAs, cytokines, and inflammation-related diseases
  José Luiz Marques-Rocha, Mirian Samblas, Fermin I. Milagro, Josefina Bressan, J. Alfredo Martínez, Amelia Marti
  The FASEB Journal.2015; 29(9): 3595.     CrossRef
• Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes
  Jan Machal, Jan Novak, Renata Hezova, Filip Zlamal, Anna Vasku, Ondrej Slaby, Julie Bienertova-Vasku
  Genes & Nutrition.2015;[Epub]     CrossRef
• Mitochondria-related miR-141-3p contributes to mitochondrial dysfunction in HFD-induced obesity by inhibiting PTEN
  Juan Ji, Yufeng Qin, Jing Ren, Chuncheng Lu, Rong Wang, Xiuliang Dai, Ran Zhou, Zhenyao Huang, Miaofei Xu, Minjian Chen, Wei Wu, Ling Song, Hongbing Shen, Zhibin Hu, Dengshun Miao, Yankai Xia, Xinru Wang
  Scientific Reports.2015;[Epub]     CrossRef
• MicroRNAs in Bone Balance and Osteoporosis
  Junying Chen, Min Qiu, Ce Dou, Zhen Cao, Shiwu Dong
  Drug Development Research.2015; 76(5): 235.     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
• MicroRNA regulatory networks in human adipose tissue and obesity
  Peter Arner, Agné Kulyté
  Nature Reviews Endocrinology.2015; 11(5): 276.     CrossRef
• Epigenomics, gestational programming and risk of metabolic syndrome
  M Desai, J K Jellyman, M G Ross
  International Journal of Obesity.2015; 39(4): 633.     CrossRef
• Expression Profiling and Structural Characterization of MicroRNAs in Adipose Tissues of Hibernating Ground Squirrels
  Cheng-Wei Wu, Kyle K. Biggar, Kenneth B. Storey
  Genomics, Proteomics & Bioinformatics.2014; 12(6): 284.     CrossRef

Fibroblast growth factor 23 (FGF23) is a hormone that is produced by osteocytes and regulates phosphate and vitamin D metabolism through binding to the Klotho-FGF receptor complex. Excessive actions of FGF23 cause several kinds of hypophosphatemic rickets/osteomalacia. Tumor-induced rickets/osteomalacia (TIO) is a paraneoplastic syndrome caused by overproduction of FGF23 from the responsible tumors. Because TIO is cured by complete resection of the causative tumors, it is of great clinical importance to locate these tumors. Several imaging methods including skeletal survey by magnetic resonance imaging and octreotide scintigraphy have been used to identify the tumors that cause TIO. However, none of these imaging studies indicate that the detected tumors are actually producing FGF23. Recently, systemic venous sampling was conducted for locating FGF23-producing tumor in suspected patients with TIO and demonstrated that this test might be beneficial to a subset of patient. Further studies with more patients are necessary to establish the clinical utility of venous sampling in patients with TIO.

Citations

Citations to this article as recorded by  

• Progression of phosphaturic mesenchymal tumor in the femoral bone during treatment with burosumab: A case report
  Koichi Okajima, Hiroshi Kobayashi, Hayata Suzuki, Liuzhe Zhang, Yuki Ishibashi, Yusuke Tsuda, Munetoshi Hinata, Yoichi Yasunaga, Tetsuo Ushiku, Yuji Nakamoto, Yasuhiro Takeuchi, Sakae Tanaka
  JOS Case Reports.2024; 3(1): 6.     CrossRef
• Extended curettage for tumour-induced osteomalacia in the bone
  Koichi Okajima, Hiroshi Kobayashi, Nobuaki Ito, Hajime Kato, Yuki Ishibashi, Liuzhe Zhang, Yusuke Tsuda, Sakae Tanaka
  Japanese Journal of Clinical Oncology.2024; 54(4): 463.     CrossRef
• Patterns of symptoms and insufficiency fractures in patients with tumour-induced osteomalacia
  Hiroshi Kobayashi, Nobuaki Ito, Yudai Nakai, Hajime Katoh, Koichi Okajima, Liuzhe Zhang, Yusuke Tsuda, Sakae Tanaka
  The Bone & Joint Journal.2023; 105-B(5): 568.     CrossRef
• Tumor-induced Osteomalacia: A Systematic Review and Individual Patient’s Data Analysis
  Domenico Rendina, Veronica Abate, Giuseppe Cacace, Lanfranco D’Elia, Gianpaolo De Filippo, Silvana Del Vecchio, Ferruccio Galletti, Alberto Cuocolo, Pasquale Strazzullo
  The Journal of Clinical Endocrinology & Metabolism.2022; 107(8): e3428.     CrossRef
• Novel Small Molecule Fibroblast Growth Factor 23 Inhibitors Increase Serum Phosphate and Improve Skeletal Abnormalities in Hyp Mice
  Zhousheng Xiao, Jiawang Liu, Shih-Hsien Liu, Loukas Petridis, Chun Cai, Li Cao, Guangwei Wang, Ai Lin Chin, Jacob W. Cleveland, Munachi O. Ikedionwu, Jesse D. Carrick, Jeremy C. Smith, Leigh Darryl Quarles
  Molecular Pharmacology.2022; 101(6): 408.     CrossRef
• Identification of Small-Molecule Inhibitors of Fibroblast Growth Factor 23 Signaling via In Silico Hot Spot Prediction and Molecular Docking to α-Klotho
  Shih-Hsien Liu, Zhousheng Xiao, Sambit K. Mishra, Julie C. Mitchell, Jeremy C. Smith, L. Darryl Quarles, Loukas Petridis
  Journal of Chemical Information and Modeling.2022; 62(15): 3627.     CrossRef
• Osteomalacia oncogénica secundaria a tumor mesenquimal fosfatúrico del pie
  Sandra Garrote-Corral, Walter Alberto Sifuentes-Giraldo, María Eugenia Reguero-Callejas, Mónica Vázquez-Díaz
  Revista Colombiana de Reumatología.2020; 27(3): 210.     CrossRef
• Hypophosphataemic Rickets: Similar Phenotype of Different Diseases
  Francisco de la Cerda-Ojeda, Juan D. González-Rodríguez, Leire Madariaga, Guillermo Martínez-Díaz-Guerra, María L. Matoses-Ruipérez
  Advances in Therapy.2020; 37(S2): 80.     CrossRef
• Oncogenic osteomalacia secondary to phosphaturic mesenchymal tumor of the foot
  Sandra Garrote-Corral, Walter Alberto Sifuentes-Giraldo, María Eugenia Reguero-Callejas, Mónica Vázquez-Díaz
  Revista Colombiana de Reumatología (English Edition).2020; 27(3): 210.     CrossRef
• Tumor-induced Osteomalacia due to a Phosphaturic Mesenchymal Tumor in the Cervical Spine: A Case Report and Literature Review
  Nitish Agarwal, ShashankS Kale, Kalpana Kumari
  Neurology India.2019; 67(5): 1334.     CrossRef
• Review of paraneoplastic syndromes in children
  Grace MY. Ma, Jeanne S. Chow, George A. Taylor
  Pediatric Radiology.2019; 49(4): 534.     CrossRef
• Tumor-induced osteomalacia with the culprit lesion located in the palm: a case report
  Yanying Qian, Zhijuan Dai, Cong Zhu, Luya Ruan, Saroj Thapa, Chaoming Wu
  Journal of International Medical Research.2019; 47(5): 2240.     CrossRef
• Osteomalazie – Klinik, Diagnostik und Therapie
  M. Tiefenbach, M. Scheel, A. Maier, M. Gehlen, M. Schwarz-Eywill, M. Werner, U. Siebers-Renelt, M. Hammer
  Zeitschrift für Rheumatologie.2018; 77(8): 703.     CrossRef
• Tumor-induced osteomalacia caused by a massive phosphaturic mesenchymal tumor of the acetabulum: A case report
  Kimitaka Nakamura, Masanobu Ohishi, Tomoya Matsunobu, Yasuharu Nakashima, Akio Sakamoto, Akira Maekawa, Yoshinao Oda, Yukihide Iwamoto
  Modern Rheumatology.2018; 28(5): 906.     CrossRef
• A case report of phosphaturic mesenchymal tumor-induced osteomalacia
  Weiqian Wu, Chongyang Wang, Jianwei Ruan, Feng Chen, Ningjun Li, Fanghu Chen
  Medicine.2017; 96(51): e9470.     CrossRef
• Localization of Oncogenic Osteomalacia by Systemic Venous Sampling of Fibroblast Growth Factor 23
  Ji-Yeon Lee, Hye-Sun Park, Seunghee Han, Jiyu Kelly Lim, Namki Hong, Sung Il Park, Yumie Rhee
  Yonsei Medical Journal.2017; 58(5): 981.     CrossRef
• Three-dimensional fluoroscopic navigation-assisted surgery for tumors in patients with tumor-induced osteomalacia in the bones
  Hiroshi Kobayashi, Toru Akiyama, Tomotake Okuma, Yusuke Shinoda, Hiroyuki Oka, Nobuaki Ito, Seiji Fukumoto, Sakae Tanaka, Hirotaka Kawano
  Computer Assisted Surgery.2017; 22(1): 14.     CrossRef
• Effective localization in tumor-induced osteomalacia using 68Ga-DOTATOC-PET/CT, venous sampling and 3T-MRI
  Shintaro Kawai, Hiroyuki Ariyasu, Yasushi Furukawa, Reika Yamamoto, Shinsuke Uraki, Ken Takeshima, Kenji Warigaya, Yuji Nakamoto, Takashi Akamizu
  Endocrinology, Diabetes & Metabolism Case Reports.2017;[Epub]     CrossRef
• Prevalence and clinical outcomes of hip fractures and subchondral insufficiency fractures of the femoral head in patients with tumour-induced osteomalacia
  Hiroshi Kobayashi, Nobuaki Ito, Toru Akiyama, Tomotake Okuma, Yuka Kinoshita, Masachika Ikegami, Yusuke Shinoda, Seiji Fukumoto, Sakae Tanaka, Hirotaka Kawano
  International Orthopaedics.2017; 41(12): 2597.     CrossRef
• Osteomalacia tumoral: un síndrome paraneoplásico emergente
  Guillermo Alonso, Mariela Varsavsky
  Endocrinología y Nutrición.2016; 63(4): 181.     CrossRef
• Tumour-induced osteomalacia: An emergent paraneoplastic syndrome
  Guillermo Alonso, Mariela Varsavsky
  Endocrinología y Nutrición (English Edition).2016; 63(4): 181.     CrossRef
• FGFs: crucial factors that regulate tumour initiation and progression
  Qian Jing, Yuanyuan Wang, Hao Liu, Xiaowei Deng, Lin Jiang, Rui Liu, Haixing Song, Jingyi Li
  Cell Proliferation.2016; 49(4): 438.     CrossRef
• Bone Histology of Two Cases with Osteomalacia Related to Low-dose Adefovir
  Rikako Hiramatsu, Yoshifumi Ubara, Naoki Sawa, Eiko Hasegawa, Masahiro Kawada, Aya Imafuku, Keiichi Sumida, Junichi Hoshino, Kenmei Takaichi
  Internal Medicine.2016; 55(20): 3013.     CrossRef
• Tumor induced osteomalacia secondary to anaplastic thyroid carcinoma: A case report and review of the literature
  Ejigayehu G. Abate, Victor Bernet, Cherise Cortese, Hillary W. Garner
  Bone Reports.2016; 5: 81.     CrossRef
• Tumor-induced osteomalacia originating from bones: a report of two cases and literature review
  Zhuo Cai, Qiang Meng, Hanfeng Guan, Qing Yang, Caihong Yang, Jun Xiao
  Oncology and Translational Medicine.2016; 2(2): 69.     CrossRef
• Tumor-Induced Osteomalacia: an Up-to-Date Review
  Anke H. Hautmann, Matthias G. Hautmann, Oliver Kölbl, Wolfgang Herr, Martin Fleck
  Current Rheumatology Reports.2015;[Epub]     CrossRef
• Locally aggressive and multifocal phosphaturic mesenchymal tumors: two unusual cases of tumor-induced osteomalacia
  Meghan Higley, Brooke Beckett, Sandra Schmahmann, Elizabeth Dacey, Erik Foss
  Skeletal Radiology.2015; 44(12): 1825.     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef

Citations

Citations to this article as recorded by  

• Diffuse cavernous hemangioma of the skull misdiagnosed as skull metastasis in breast cancer patient: one case report and literature review
  Huizhi Liu, Xiaojing Chang, Hua Shang, Feng Li, Huandi Zhou, Xiaoying Xue
  BMC Cancer.2019;[Epub]     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef

Citations

Citations to this article as recorded by  

• Determinants of Levothyroxine Treatment in Patients with Hypothyroidism
  Savaş Karataş, Yalçın Hacıoğlu
  Cyprus Journal of Medical Sciences.2022; 7(5): 593.     CrossRef
• Subclinical Hypothyroidism: Prevalence, Health Impact, and Treatment Landscape
  Won Sang Yoo, Hyun Kyung Chung
  Endocrinology and Metabolism.2021; 36(3): 500.     CrossRef
• Thyroid disorders in Brazil: the contribution of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
  I.M. Bensenor
  Brazilian Journal of Medical and Biological Research.2019;[Epub]     CrossRef
• Risk factors for hypothyroidism in euthyroid thyroid nodule patients with lymphocytic thyroiditis on fine needle aspiration cytology
  Jeong-Min Lee, Jeonghoon Ha, Kwanhoon Jo, Yejee Lim, Min-Hee Kim, Chan-Kwan Jung, So-Lyung Jung, Moo-Il Kang, Bong-Yun Cha, Dong-Jun Lim
  The Korean Journal of Internal Medicine.2019; 34(6): 1287.     CrossRef
• Analysis of the factors affecting the evolution over time of subclinical hypothyroidism in children
  Mariella Valenzise, Tommaso Aversa, Giuseppina Zirilli, Giuseppina Salzano, Domenico Corica, Simona Santucci, Filippo De Luca
  Italian Journal of Pediatrics.2017;[Epub]     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
• Reference interval for thyrotropin in a ultrasonography screened Korean population
  Mijin Kim, Tae Yong Kim, Soo Han Kim, Yunkyoung Lee, Su-yeon Park, Hyung-don Kim, Hyemi Kwon, Yun Mi Choi, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
  The Korean Journal of Internal Medicine.2015; 30(3): 335.     CrossRef
• Subclinical hypothyroidism: a historical view and shifting prevalence
  J. V. Hennessey, R. Espaillat
  International Journal of Clinical Practice.2015; 69(7): 771.     CrossRef
• Letter: The Biochemical Prognostic Factors of Subclinical Hypothyroidism (Endocrinol Metab2014;29:154-62, Myung Won Lee et al.)
  Hwa Young Ahn, Yun Jae Chung
  Endocrinology and Metabolism.2014; 29(3): 400.     CrossRef
• The Biochemical Prognostic Factors of Subclinical Hypothyroidism
  You Jin Lee
  Endocrinology and Metabolism.2014; 29(2): 144.     CrossRef

Citations

Citations to this article as recorded by  

• Comprehensive Genome-Wide Natural Variation and Expression Analysis of Tubby-like Proteins Gene Family in Brachypodium distachyon
  Sendi Mejia, Jose Lorenzo B. Santos, Christos Noutsos
  Plants.2024; 13(7): 987.     CrossRef
• Identification, gene expression and physiological response of tubby-like proteins under abiotic stress in barley
  Zohreh Hajibarat, Abbas Saidi
  Journal of Crop Science and Biotechnology.2024;[Epub]     CrossRef
• Shuttling of cellular proteins between the plasma membrane and nucleus (Review)
  Hua-Chuan Zheng, Hua-Mao Jiang
  Molecular Medicine Reports.2021;[Epub]     CrossRef
• Tubby-like Protein 2 regulates homogalacturonan biosynthesis in Arabidopsis seed coat mucilage
  Meng Wang, Zongchang Xu, Rana Imtiaz Ahmed, Yiping Wang, Ruibo Hu, Gongke Zhou, Yingzhen Kong
  Plant Molecular Biology.2019; 99(4-5): 421.     CrossRef
• The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition
  Danielle DiTirro, Alison Philbrook, Kendrick Rubino, Piali Sengupta
  eLife.2019;[Epub]     CrossRef
• The tubby-like proteins kingdom in animals and plants
  Meng Wang, Zongchang Xu, Yingzhen Kong
  Gene.2018; 642: 16.     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
• The Role of Foxo3 in Leydig Cells
  Young Suk Choi, Joo Eun Song, Byung Soo Kong, Jae Won Hong, Silvia Novelli, Eun Jig Lee
  Yonsei Medical Journal.2015; 56(6): 1590.     CrossRef

Citations

Citations to this article as recorded by  

• Intergenerational transfer of binge eating-like behavior: The additive impact of juvenile stress
  Elin Kachuki Dory, Avi Gueta, Yoni Loterstein, Lital Moshe, Devorah Matas, Lee Koren, Aron Weller
  Appetite.2024; 203: 107713.     CrossRef
• Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress
  Millie Rincón-Cortés
  Addiction Neuroscience.2023; 6: 100067.     CrossRef
• Adolescent nonpharmacological interventions for early-life stress and their mechanisms
  Yi Li, Dong-Dong Shi, Zhen Wang
  Behavioural Brain Research.2023; 452: 114580.     CrossRef
• A systematic review of studies investigating the acute effects of N-methyl-D-aspartate receptor antagonists on behavioural despair in normal animals suggests poor predictive validity
  Martin Viktorov, Matthew P. Wilkinson, Victoria C. E. Elston, Medi Stone, Emma S. J. Robinson
  Brain and Neuroscience Advances.2022;[Epub]     CrossRef
• Impact of preweaning stress on long-term neurobehavioral outcomes in Sprague-Dawley rats: Differential effects of barren cage rearing, pup isolation, and the combination
  Jenna L.N. Sprowles, Charles V. Vorhees, Michael T. Williams
  Neurotoxicology and Teratology.2021; 84: 106956.     CrossRef
• Maternal separation in rodents: a journey from gut to brain and nutritional perspectives
  Marion Rincel, Muriel Darnaudéry
  Proceedings of the Nutrition Society.2020; 79(1): 113.     CrossRef
• Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents
  Daniel Wang, Jessica L. S. Levine, Victor Avila-Quintero, Michael Bloch, Arie Kaffman
  Translational Psychiatry.2020;[Epub]     CrossRef
• Maternal Deprivation and Sex Alter Central Levels of Neurotrophins and Inflammatory Cytokines in Rats Exposed to Palatable Food in Adolescence
  Roberta Ströher, Carla de Oliveira, Dirson João Stein, Isabel Cristina de Macedo, Jéferson Ferraz Goularte, Lisiane Santos da Silva, Gabriela Gregory Regner, Helouise Richardt Medeiros, Wolnei Caumo, Iraci L.S. Torres
  Neuroscience.2020; 428: 122.     CrossRef
• Metabolic dysfunction in a rat model of early‐life scarcity–adversity: Modulatory role of cafeteria diet
  Sara C. Sagae, Bárbara Zanardini, Edson D. Ribeiro‐Paz, Ana Claudia Amaral, Gabriela A. Bronczek, Camila Lubaczeuski, Sabrina Grassiolli, Patrícia Koehler‐Santos, Jarbas Rodrigues de Oliveira, Márcio Vinícius Fagundes Donadio, Charlis Raineki
  Experimental Physiology.2018; 103(11): 1481.     CrossRef
• Effects of Fengliao-Changweikang in Diarrhea-predominant Irritable Bowel Syndrome Rats and Its Mechanism Involving Colonic Motility
  Mengdi Jia, Xiaofang Lu, Zhengfang Wang, Luqing Zhao, Shengsheng Zhang
  Journal of Neurogastroenterology and Motility.2018; 24(3): 479.     CrossRef
• Palatable Food Dampens the Long-Term Behavioral and Endocrine Effects of Juvenile Stressor Exposure but May Also Provoke Metabolic Syndrome in Rats
  Eliza Fatima Ali, Jennifer Christine MacKay, Samantha Graitson, Jonathan Stewart James, Christian Cayer, Marie-Claude Audet, Pamela Kent, Alfonso Abizaid, Zul Merali
  Frontiers in Behavioral Neuroscience.2018;[Epub]     CrossRef
• P2-type Na0.67Ni0.33−x Cu x Mn0.67O2 as new high-voltage cathode materials for sodium-ion batteries
  Sen Chen, Enshan Han, Han Xu, Lingzhi Zhu, Bin Liu, Guangquan Zhang, Min Lu
  Ionics.2017; 23(11): 3057.     CrossRef
• Ability of palatable food consumption to buffer against the short- and long-term behavioral consequences of social defeat exposure during juvenility in rats
  J.C. MacKay, P. Kent, J.S. James, C. Cayer, Z. Merali
  Physiology & Behavior.2017; 177: 113.     CrossRef
• Effect of TongXie‐YaoFang on Cl− and HCO3 - Transport in Diarrhea‐Predominant Irritable Bowel Syndrome Rats
  Xiaofang Lu, Shengsheng Zhang, Cheng Yang, Zhengfang Wang, Luqing Zhao, Zhenyu Wu, Jing Xie, Jieyun Yin
  Evidence-Based Complementary and Alternative Medicine.2016;[Epub]     CrossRef
• Early Life Stress Increases Metabolic Risk, HPA Axis Reactivity, and Depressive-Like Behavior When Combined with Postweaning Social Isolation in Rats
  Javier Vargas, Mariana Junco, Carlos Gomez, Naima Lajud, Cheryl M McCormick
  PLOS ONE.2016; 11(9): e0162665.     CrossRef
• Animal models of gastrointestinal and liver diseases. Animal models of visceral pain: pathophysiology, translational relevance, and challenges
  Beverley Greenwood-Van Meerveld, Dawn K. Prusator, Anthony C. Johnson
  American Journal of Physiology-Gastrointestinal and Liver Physiology.2015; 308(11): G885.     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
• Anxiolytic efficacy of repeated oral capsaicin in rats with partial aberration of oral sensory relay to brain
  Young-Jun Choi, Jin Young Kim, Wei-Peng Jin, Yoon-Tae Kim, Jong-Ho Lee, Jeong Won Jahng
  Archives of Oral Biology.2015; 60(7): 989.     CrossRef
• Anti-Anxiety Effect of Schisandra chinensis Baill Lignans on Mice in Elevated Plus Maze Test
  Tao Jiang, Xin Tian Fan, Chun Mei Wang, Li Mei Chen, Jing Hui Sun, Wei Jing Sun, Jian Guang Chen, He Li
  Applied Mechanics and Materials.2014; 675-677: 1580.     CrossRef

Citations

Citations to this article as recorded by  

• NRF2 and Key Transcriptional Targets in Melanoma Redox Manipulation
  Evan L. Carpenter, Alyssa L. Becker, Arup K. Indra
  Cancers.2022; 14(6): 1531.     CrossRef
• Hormonal Regulation of the Repair of UV Photoproducts in Melanocytes by the Melanocortin Signaling Axis
  Stuart G. Jarrett, John A. D'Orazio
  Photochemistry and Photobiology.2017; 93(1): 245.     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef

Citations

Citations to this article as recorded by  

• Metabolism of phenolics in coffee and plant-based foods by canonical pathways: an assessment of the role of fatty acid β-oxidation to generate biologically-active and -inactive intermediates
  Michael N. Clifford, Laurence J. King, Asimina Kerimi, Maria Gema Pereira-Caro, Gary Williamson
  Critical Reviews in Food Science and Nutrition.2024; 64(11): 3326.     CrossRef
• Comparison of muscle nutritional composition, texture quality, carotenoid metabolites and transcriptome to underling muscle quality difference between wild-caught and pond-cultured Yellow River carp (Cyprinus carpio haematopterus)
  Luming Wang, Jinrui Xiong, Chunchu Xu, Chaobin Qin, Yuru Zhang, Liping Yang, Shaoyang Zhi, Jianxin Feng, Guoxing Nie
  Aquaculture.2024; 581: 740392.     CrossRef
• Effects of microcystin-LR on immune function, lipid metabolism and intestinal microbial structure in Eriocheir sinensis
  Jinliang Du, Liping Cao, Jiancao Gao, Zhijuan Nie, Quanjie Li, Yi Sun, Nailin Shao, Jiawen Hu, Lin Zhou, Guojun Yin, Gangchun Xu
  Aquaculture Reports.2024; 35: 101994.     CrossRef
• A defect in mitochondrial fatty acid synthesis impairs iron metabolism and causes elevated ceramide levels
  Debdeep Dutta, Oguz Kanca, Seul Kee Byeon, Paul C. Marcogliese, Zhongyuan Zuo, Rishi V. Shridharan, Jun Hyoung Park, Guang Lin, Ming Ge, Gali Heimer, Jennefer N. Kohler, Matthew T. Wheeler, Benny A. Kaipparettu, Akhilesh Pandey, Hugo J. Bellen
  Nature Metabolism.2023; 5(9): 1595.     CrossRef
• Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus
  Steven F. Baker, Helene Meistermann, Manuel Tzouros, Aaron Baker, Sabrina Golling, Juliane Siebourg Polster, Mitchell P. Ledwith, Anthony Gitter, Angelique Augustin, Hassan Javanbakht, Andrew Mehle, Frank Kirchhoff
  PLOS Biology.2022; 20(12): e3001934.     CrossRef
• Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children
  Sergey A Krupenko, Shelley A Cole, Ruixue Hou, Karin Haack, Sandra Laston, Nitesh R Mehta, Anthony G Comuzzie, Nancy F Butte, V Saroja Voruganti
  The American Journal of Clinical Nutrition.2022; 116(2): 500.     CrossRef
• Simultaneous Presentation of Multiple Myeloma and Lung Cancer: Case Report and Gene Bioinformatics Analysis
  Ping-Ping Xiao, Bing-Qing Luo, Wei Fan, Xu-Yan Chen, Zhi-Gao Dong, Jin-Mei Huang, Yi Zhang, Yong-Quan Chen
  Frontiers in Oncology.2022;[Epub]     CrossRef
• Fatty acid metabolism-related genes are associated with flavor-presenting aldehydes in Chinese local chicken
  Xiaoya Yuan, Huanxian Cui, Yuxi Jin, Wenjuan Zhao, Xiaojing Liu, Yongli Wang, Jiqiang Ding, Li Liu, Jie Wen, Guiping Zhao
  Frontiers in Genetics.2022;[Epub]     CrossRef
• NRBF2-mediated autophagy contributes to metabolite replenishment and radioresistance in glioblastoma
  Jeongha Kim, Hyunkoo Kang, Beomseok Son, Min-Jung Kim, JiHoon Kang, Kang Hyun Park, Jaewan Jeon, Sunmi Jo, Hae Yu Kim, HyeSook Youn, BuHyun Youn
  Experimental & Molecular Medicine.2022; 54(11): 1872.     CrossRef
• Mitochondrial Fatty Acids and Neurodegenerative Disorders
  Alexander J. Kastaniotis, Kaija J. Autio, Remya R. Nair
  The Neuroscientist.2021; 27(2): 143.     CrossRef
• The effects of chronic cadmium exposure on Bufo gargarizans larvae: Histopathological impairment, gene expression alteration and fatty acid metabolism disorder in the liver
  Zongqi Ju, Jing Ya, Xinyi Li, Hongyuan Wang, Hongfeng Zhao
  Aquatic Toxicology.2020; 222: 105470.     CrossRef
• Exploration of targets regulated by miR-125b in porcine adipocytes
  Xiao Cheng, Xingping Chen, Peng Wang, Ting Chen, Jiajie Sun, Qianyun Xi, Yongliang Zhang
  In Vitro Cellular & Developmental Biology - Animal.2020; 56(2): 103.     CrossRef
• Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria
  Sara M Nowinski, Ashley Solmonson, Scott F Rusin, J Alan Maschek, Claire L Bensard, Sarah Fogarty, Mi-Young Jeong, Sandra Lettlova, Jordan A Berg, Jeffrey T Morgan, Yeyun Ouyang, Bradley C Naylor, Joao A Paulo, Katsuhiko Funai, James E Cox, Steven P Gygi,
  eLife.2020;[Epub]     CrossRef
• Polymorphisms in ten candidate genes are associated with conformational and locomotive traits in Spanish Purebred horses
  Natalia Sevane, Susana Dunner, Ana Boado, Javier Cañon
  Journal of Applied Genetics.2017; 58(3): 355.     CrossRef
• Deep RNA sequencing of pectoralis muscle transcriptomes during late-term embryonic to neonatal development in indigenous Chinese duck breeds
  Chunhong Zhu, Weitao Song, Zhiyun Tao, Hongxiang Liu, Wenjuan Xu, Shuangjie Zhang, Huifang Li, Cristina Óvilo
  PLOS ONE.2017; 12(8): e0180403.     CrossRef
• Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology
  Alexander J. Kastaniotis, Kaija J. Autio, Juha M. Kerätär, Geoffray Monteuuis, Anne M. Mäkelä, Remya R. Nair, Laura P. Pietikäinen, Antonina Shvetsova, Zhijun Chen, J. Kalervo Hiltunen
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2017; 1862(1): 39.     CrossRef
• Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice
  Remya R. Nair, Juha M. Kerätär, Kaija J. Autio, Ali J. Masud, Mikko A.J. Finnilä, Helena I. Autio-Harmainen, Ilkka J. Miinalainen, Pentti A. Nieminen, J. Kalervo Hiltunen, Alexander J. Kastaniotis
  Human Molecular Genetics.2017; 26(11): 2104.     CrossRef
• MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder
  Gali Heimer, Juha M. Kerätär, Lisa G. Riley, Shanti Balasubramaniam, Eran Eyal, Laura P. Pietikäinen, J. Kalervo Hiltunen, Dina Marek-Yagel, Jeffrey Hamada, Allison Gregory, Caleb Rogers, Penelope Hogarth, Martha A. Nance, Nechama Shalva, Alvit Veber, Mic
  The American Journal of Human Genetics.2016; 99(6): 1229.     CrossRef
• Genome‐wide association study with the risk of schizophrenia in a Korean population
  Lyoung Hyo Kim, Byung Lae Park, Hyun Sub Cheong, Suhg Namgoong, Ji On Kim, Jeong‐Hyun Kim, Joong‐Gon Shin, Chul Soo Park, Bong‐Jo Kim, Jae Won Kim, Ihn‐Geun Choi, Jaeuk Hwang, Hyoung Doo Shin, Sung‐Il Woo
  American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.2016; 171(2): 257.     CrossRef
• A global transcriptional analysis of Megalobrama amblycephala revealing the molecular determinants of diet-induced hepatic steatosis
  Dingdong Zhang, Kangle Lu, Guangzhen Jiang, Wenbin Liu, Zaijie Dong, Hongyan Tian, Xiangfei Li
  Gene.2015; 570(2): 255.     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef

Phosphate regulating gene with homologies to endopeptidases on the X-chromosome (PHEX) is a common cause of X-linked hypophosphatemic (XLH) rickets. Diverse PHEX gene mutations have been reported; however, gene mutations in sporadic rickets are less common than in XLH rickets. Herein, we describe a 50-year-old female patient with sporadic hypophosphatemic rickets harboring a novel splicing-site mutation in the PHEX gene (c.663+1G>A) at the exon 5-intron 5 boundary. The patient had recently suffered from right thigh pain and an aggravated waddling gait. She also presented with very short stature, generalized bone pain, and muscle weakness. Despite low serum phosphate levels, her phosphate reabsorption rate was lower than normal. Additionally, her 1,25-dihydroxyvitamin D₃ concentration was lower than normal, although FGF23 level was normal. After treatment with alfacalcidol and elemental phosphate, her rachitic symptoms subsided, and callus formation was observed in the fracture site on the right femur.

Citations

Citations to this article as recorded by  

• A pathogenic PHEX variant (c.1483-1G>C) in a Korean patient with X-linked hypophosphatemic rickets
  In Hwa Jeong, Jae-Ho Yoo, Namhee Kim
  Annals of Pediatric Endocrinology & Metabolism.2021; 26(2): 130.     CrossRef
• A novel de novo mosaic mutation in PHEX in a Korean patient with hypophosphatemic rickets
  Misun Yang, Jinsup Kim, Aram Yang, Jahyun Jang, Tae Yeon Jeon, Sung Yoon Cho, Dong-Kyu Jin
  Annals of Pediatric Endocrinology & Metabolism.2018; 23(4): 229.     CrossRef
• Rodzinna krzywica hipofosfatemiczna – opis przypadku i przegląd literatury
  Agnieszka Jędzura, Omar Bjanid, Piotr Adamczyk, Krzysztof Plesiński, Karolina Klimaszewska-Adamus, Maria Szczepańska
  Pediatria Polska.2015; 90(5): 437.     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef

Targeted therapy has been proven to be one of the most effective cancer treatments. However, some endocrine disorders can occur during treatment with targeted agents. We report the case of a patient who exhibited a wax and wane pattern of hypoglycemia that was attributed to sorafenib therapy. A 32-year-old woman with metastatic hemangiopericytoma visited the emergency department in a stuporous state. Nonhyperinsulinemic hypoglycemia was diagnosed, was exacerbated shortly after sorafenib therapy, and was improved by the cessation of sorafenib with additional glucocorticoid therapy. Patients with metastatic hemangiopericytoma should be carefully monitored with particular attention to hypoglycemia when sorafenib therapy is initiated.

Citations

Citations to this article as recorded by  

• Pazopanib-associated secondary adrenal insufficiency in a patient with malignant solitary fibrous tumor
  Muhammed Muhiddin Er, Murat Araz, Meryem Karabacak, Muzaffer Uğraklı, Melek Karakurt Eryılmaz, Mustafa Karaağaç, Mehmet Artaç
  Journal of Oncology Pharmacy Practice.2021; 27(8): 2049.     CrossRef
• Cancer, obesity, and diabetes: TKIs exert multiple effects on glucose homeostasis
  Minglin Lin, Junfei Jin
  Nature Reviews Clinical Oncology.2017; 14(5): 268.     CrossRef
• Multidisciplinary Approach to Hepatic Metastases of Intracranial Hemangiopericytoma: A Case Report and Review of the Literature
  Dimitrios K. Manatakis, Spiridon G. Delis, Nikolaos Ptohis, Penelope Korkolopoulou, Christos Dervenis
  Case Reports in Oncological Medicine.2015; 2015: 1.     CrossRef
• Articles in 'Endocrinology and Metabolism' in 2014
  Won-Young Lee
  Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
• Case report of severe Cushing’s syndrome in medullary thyroid cancer complicated by functional diabetes insipidus, aortic dissection, jejunal intussusception, and paraneoplastic dysautonomia: remission with sorafenib without reduction in cortisol concentr
  Muhammad M. Hammami, Najla Duaiji, Ghazi Mutairi, Sabah Aklabi, Nasser Qattan, Mohei El-Din M. Abouzied, Mohamed W. Sous
  BMC Cancer.2015;[Epub]     CrossRef