Warning: fopen(/home/virtual/enm-kes/journal/upload/ip_log/ip_log_2024-03.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 88 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 89 Recurrent Hypoglycemia Triggered by Sorafenib Therapy in a Patient with Hemangiopericytoma
Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > Endocrinol Metab > Volume 29(2); 2014 > Article
Case Report
Recurrent Hypoglycemia Triggered by Sorafenib Therapy in a Patient with Hemangiopericytoma
Si Won Lee1, Eun Kyung Lee1, Tak Yun1, Young-Woong Won1*, Eun Jeong Ko1, Mihong Choi1, Sang Il Choi1, Sun Seob Park1, Eun Kyung Hong2
Endocrinology and Metabolism 2014;29(2):202-205.
DOI: https://doi.org/10.3803/EnM.2014.29.2.202
Published online: June 26, 2014

1Department of Internal Medicine, National Cancer Center, Goyang, Korea.

2Department of Pathology, National Cancer Center, Goyang, Korea.

Corresponding author: Eun Kyung Lee. Department of Internal Medicine, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 410-769, Korea. Tel: +82-31-920-1743, Fax: +82-31-920-2798, waterfol@gmail.com
*Current affiliation: Center for Clinical Trials, National Cancer Center, Goyang and Division of Hematology and Oncology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
• Received: April 15, 2013   • Accepted: June 27, 2013

Copyright © 2014 Korean Endocrine Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • 3,034 Views
  • 28 Download
  • 5 Web of Science
  • 5 Crossref
  • 4 Scopus
  • Targeted therapy has been proven to be one of the most effective cancer treatments. However, some endocrine disorders can occur during treatment with targeted agents. We report the case of a patient who exhibited a wax and wane pattern of hypoglycemia that was attributed to sorafenib therapy. A 32-year-old woman with metastatic hemangiopericytoma visited the emergency department in a stuporous state. Nonhyperinsulinemic hypoglycemia was diagnosed, was exacerbated shortly after sorafenib therapy, and was improved by the cessation of sorafenib with additional glucocorticoid therapy. Patients with metastatic hemangiopericytoma should be carefully monitored with particular attention to hypoglycemia when sorafenib therapy is initiated.
Targeted therapy has been proven to be one of the most successful treatment modalities in many cancers. However, some endocrine disorders have been associated with treatment with targeted agents, including hypothyroidism (sunitinib and pazopanib), hypoglycemia (sunitinib), and hyperglycemia (everolimus) [1]. Recently, tyrosine kinase inhibitors were reported to have a potential hypoglycemic effect [2]; mean declines in blood glucose were 53 mg/dL for dasatinib, 9 mg/dL for imatinib, 12 mg/dL for sorafenib, and 14 mg/dL for sunitinib. However, the exact mechanism of this hypoglycemic effect remains unclear.
Hemangiopericytoma (HPC) is a soft tissue sarcoma derived from vascular pericytes, which are normally arranged along capillaries and venules throughout the body [3]. HPC-associated hypoglycemia is a unique paraneoplastic syndrome related to high levels of insulin-like growth factor (IGF)-II, which can be improved by the surgical reduction of tumor burden. Here, we report a patient who exhibited a wax and wane pattern of hypoglycemia that was exacerbated shortly after sorafenib therapy and was improved by the cessation of sorafenib.
A 32-year-old woman was hospitalized due to loss of consciousness in March 2010. The patient had been diagnosed with HPC after a neck mass resection in 2000. In August 2009, she experienced a recurrent mass at the same site with multiple hepatic metastases. She underwent right hemihepatectomy and radiofrequency ablation of multiple nodules. However, multiple hepatic and pulmonary metastases progressed, and were treated with palliative chemotherapy. Unfortunately, the first- (doxorubicin alone) and second-line (a combination of etoposide, ifosfamide, and cisplatin) chemotherapies did not lead to any response. As the third-line chemotherapy, the patient was treated with oral sorafenib 400 mg twice a day.
Soon after starting sorafenib, the patient experienced repetitive hunger, palpitation, and diaphoresis during the nighttime. On the 8th day of sorafenib therapy, she lost consciousness and was transported to the emergency department. Her plasma glucose was 8 mg/dL and hemoglobin A1c level was 5.0%. The hypoglycemia and symptoms were resolved by a 10% intravenous dextrose infusion. She had never experienced hypoglycemia during the first- and second-line chemotherapy. Baseline serum glucose level before sorafenib started was 105 mg/dL. The patient had no past medical or family history of diabetes, she had not taken any medications except sorafenib, and her nutritional status was adequate. Her body mass index (BMI) on the day she visited emergency room was 22.5 kg/m2 (height 163 cm, weight 59.8 kg), similar to her BMI at the start of sorafenib treatment, 22 kg/m2 (height 163 cm, weight 58.5 kg). There was no change in oral intake before or during the sorafenib therapy. On average, the patient ate about 1,600 to 2,000 kcal per day. Renal function was normal and liver enzymes were mildly elevated (aspartate aminotransferase [AST] 99 IU/L, alanine aminotransferase [ALT] 46 IU/L, total bilirubin 30.8 µmol/L, prothrombin time [PT] 14.2 seconds [88%; international normalized ratio, INR 1.08]), whereas the patient's baseline values of liver enzymes had been within normal range, as follows: AST 42 IU/L, ALT 25 IU/L, total bilirubin 29.1 µmol/L, PT 14.6 seconds (80%; INR 1.16).
Because the patient experienced hypoglycemia even when the infusion rate of dextrose fluid was reduced, a prolonged fasting test was not necessary to confirm a hypoglycemic event. She had a blood glucose level of 12 mg/dL with undetectable insulin, IGF-1 3.3 nmol/L (reference range, 14.3 to 43.1) and C-peptide level 0.024 nmol/L (reference range, 0.3 to 1.3), suggesting nonhyperinsulinemic hypoglycemia.
After cessation of sorafenib, there was no recurrence of the hypoglycemic event. However, the patient had no alternatives to sorafenib as a cancer treatment. Thus, sorafenib was resumed with oral prednisolone (60 mg per day), dextrose infusion and frequent meals. After discontinuation of dextrose infusion, the patient was discharged with minimal hypoglycemia. Ten days after discharge, she discontinued sorafenib therapy due to chemotherapy-related mucositis and insufficient recovery from hypoglycemia. Following the cessation of sorafenib, she did not experience hypoglycemia, and died of disease progression after 2 months.
Sorafenib is a tyrosine kinase inhibitor that was developed as an anti-angiogenic therapeutic, and has excellent antitumor activity in renal cell carcinoma, thyroid cancer, hepatocellular cancer, and pancreatic cancer. However, the effect of sorafenib on glucose metabolism has been reported in a few cases. This report is about a patient with metastatic HPC with repetitive hypoglycemic episodes, which were triggered by sorafenib therapy and were resolved by the discontinuation of sorafenib combined with steroid therapy.
Hypoglycemia associated with a non-islet cell tumor is a rare endocrine paraneoplastic syndrome caused by the oversecretion of IGF [4]. Tumors manifesting hypoglycemia are typically of mesodermal or epithelial origin, such as several specific liver tumors including hepatocellular carcinoma, solitary fibrous tumor of liver, and HPC. The severity of hypoglycemic episodes depends on the tumor burden; most patients experienced more profound or frequent hypoglycemia as tumors grew. A single case of refractory hypoglycemia was controlled with improvement in the primary tumor, a solitary fibrous tumor, treated by sorafenib [5].
The typical biological findings of HPC-associated hypoglycemia are as follows: low glucose, low insulin, low C-peptide, low IGF-I, low IGF binding protein (IGFBP)-3; increased levels of IGFBP-2 and IGFBP-6; and slightly elevated serum IGF-II [6]. This phenomenon is mediated through IGF families, which are produced by HPC cells [7]. A high degree of homology with the insulin A and B chains [8] and similarities between IGF-I and insulin receptor structure could explain the hypoglycemic effects of IGF, the insulin-like activity of which is estimated to be 1% to 2% of that of insulin [9,10].
In this case, there were some factors that may contribute to the development of hypoglycemia: HPC-associated paraneoplastic hypoglycemia, excessive glucose consumption as tumor grows, and impaired hepatic function due to hemihepatectomy or hepatic metastasis. From the compensatory suppression of insulin/C-peptide/IGF-I level, we could infer that the resulting hypoglycemia was nonhyperinsulinemic hypoglycemia. Much to our regret, we did not check the patient's IGF-II level and do not have remaining tissue or serum from the patient, making it impossible to exclude HPC-associated paraneoplastic hypoglycemia (IGF-II mediated hypoglycemia).
The mechanism of sorafenib-associated hypoglycemia remains unclear; however, the glucose-lowering effects of sunitinib have been previously documented. Billemont et al. [11] reported the time sequence of sunitinib treatment interventions and measured blood glucose concentrations/insulin concentrations in metastatic renal cell carcinoma patients. These authors suggested that the hypoglycemic effect comes from sunitinib itself rather than IGF-II [11], which could explain the mechanism behind our case as well. The frequency and severity of hypoglycemia was aggravated soon after starting sorafenib, and was improved after cessation of sorafenib, strongly suggesting sorafenib-associated hypoglycemia.
HPC-associated hypoglycemia can be treated by surgical resection in operable conditions. However, when debulking surgery is not feasible, other modalities such as glucocorticoid [12], somatostatin analog [13], tumor embolization [14], or radiotherapy [15] are considered. As an alternative therapy, Adams et al. [16] described a successful liver transplantation in a patient with diffuse liver metastasis and persistent hypoglycemia resulting from malignant HPC. In the case we report, prednisolone was also given (20 mg three times a day), because there was no clear evidence to exclude HPC-associated hypoglycemia at that time. The possibility of hypoglycemia caused by adrenal insufficiency may also be considered, since the patient improved after steroid replacement; however, an adrenal function test during steroid therapy in general reveals no significant findings, besides, there was no metastasis to the adrenal glands in this patient. Furthermore, the patient's oral intake and liver function were normal with no systemic symptoms of blood pressure change or general weakness, and an electrolyte imbalance such as hyponatremia or hyperkalemia was not found. In this aspect, it is hard to doubt that the patient had adrenal insufficiency.
In summary, HPC-associated hypoglycemia may be triggered by sorafenib therapy even in the patients who have never experienced hypoglycemia before. Therefore, when treating HPC patients with sorafenib, particular attention to hypoglycemia is warranted.

No potential conflict of interest relevant to this article was reported.

  • 1. Lee Y, Jung HS, Choi HJ, Kim MJ, Kim TM, Park KS, Kim SY. Life-threatening hypoglycemia induced by a tyrosine kinase inhibitor in a patient with neuroendocrine tumor: a case report. Diabetes Res Clin Pract 2011;93:e68–e70. ArticlePubMed
  • 2. Agostino NM, Chinchilli VM, Lynch CJ, Koszyk-Szewczyk A, Gingrich R, Sivik J, Drabick JJ. Effect of the tyrosine kinase inhibitors (sunitinib, sorafenib, dasatinib, and imatinib) on blood glucose levels in diabetic and nondiabetic patients in general clinical practice. J Oncol Pharm Pract 2011;17:197–202. ArticlePubMed
  • 3. Stout AP, Murray MR. Hemangiopericytoma: a vascular tumor featuring Zimmermann's pericytes. Ann Surg 1942;116:26–33. ArticlePubMedPMC
  • 4. Zapf J. Insulinlike growth factor binding proteins and tumor hypoglycemia. Trends Endocrinol Metab 1995;6:37–42. ArticlePubMed
  • 5. Le Jeune S, Des Guetz G, Bihan H, Cohen R, Coindre JM, Mourad JJ. Refractory hypoglycemia controlled by sorafenib in solitary fibrous tumor. J Clin Oncol 2013;31:e118–e121. ArticlePubMed
  • 6. Teale JD. Non-islet cell tumour hypoglycaemia. Clin Endocrinol (Oxf) 1999;51:147ArticlePubMed
  • 7. Pavelic K, Spaventi S, Gluncic V, Matejcic A, Pavicic D, Karapandza N, Kusic Z, Lukac J, Dohoczky C, Cabrijan T, Pavelic J. The expression and role of insulin-like growth factor II in malignant hemangiopericytomas. J Mol Med (Berl) 1999;77:865–869. ArticlePubMedPDF
  • 8. Bell GI, Merryweather JP, Sanchez-Pescador R, Stempien MM, Priestley L, Scott J, Rall LB. Sequence of a cDNA clone encoding human preproinsulin-like growth factor II. Nature 1984;310:775–777. ArticlePubMedPDF
  • 9. Froesch ER, Guler HP, Schmid C, Binz K, Zapf J. Therapeutic potential of insulinlike growth factor i. Trends Endocrinol Metab 1990;1:254–260. ArticlePubMed
  • 10. Phillips LS, Robertson DG. Insulin-like growth factors and non-islet cell tumor hypoglycemia. Metabolism 1993;42:1093–1101. ArticlePubMed
  • 11. Billemont B, Medioni J, Taillade L, Helley D, Meric JB, Rixe O, Oudard S. Blood glucose levels in patients with metastatic renal cell carcinoma treated with sunitinib. Br J Cancer 2008;99:1380–1382. ArticlePubMedPMCPDF
  • 12. Baxter RC, Holman SR, Corbould A, Stranks S, Ho PJ, Braund W. Regulation of the insulin-like growth factors and their binding proteins by glucocorticoid and growth hormone in nonislet cell tumor hypoglycemia. J Clin Endocrinol Metab 1995;80:2700–2708. ArticlePubMed
  • 13. Chung J, Henry RR. Mechanisms of tumor-induced hypoglycemia with intraabdominal hemangiopericytoma. J Clin Endocrinol Metab 1996;81:919–925. ArticlePubMed
  • 14. Nanayakkara PW, van Doorn J, van den Berg FG, van Groeningen CJ, Pinedo HM, Hoekman K. Treatment of haemangiopericytoma-associated hypoglycaemia with embolisation. Eur J Intern Med 2002;13:340–343. ArticlePubMed
  • 15. Soran H, Younis N, Joseph F, Hayat Z, Zakhour H, Scott A. A case of haemangiopericytoma-associated hypoglycaemia: beneficial effect of treatment with radiotherapy. Int J Clin Pract 2006;60:1319–1322. ArticlePubMed
  • 16. Adams J, Lodge JP, Parker D. Liver transplantation for metastatic hemangiopericytoma associated with hypoglycemia. Transplantation 1999;67:488–489. ArticlePubMed

Figure & Data

References

    Citations

    Citations to this article as recorded by  
    • Pazopanib-associated secondary adrenal insufficiency in a patient with malignant solitary fibrous tumor
      Muhammed Muhiddin Er, Murat Araz, Meryem Karabacak, Muzaffer Uğraklı, Melek Karakurt Eryılmaz, Mustafa Karaağaç, Mehmet Artaç
      Journal of Oncology Pharmacy Practice.2021; 27(8): 2049.     CrossRef
    • Cancer, obesity, and diabetes: TKIs exert multiple effects on glucose homeostasis
      Minglin Lin, Junfei Jin
      Nature Reviews Clinical Oncology.2017; 14(5): 268.     CrossRef
    • Multidisciplinary Approach to Hepatic Metastases of Intracranial Hemangiopericytoma: A Case Report and Review of the Literature
      Dimitrios K. Manatakis, Spiridon G. Delis, Nikolaos Ptohis, Penelope Korkolopoulou, Christos Dervenis
      Case Reports in Oncological Medicine.2015; 2015: 1.     CrossRef
    • Articles in 'Endocrinology and Metabolism' in 2014
      Won-Young Lee
      Endocrinology and Metabolism.2015; 30(1): 47.     CrossRef
    • Case report of severe Cushing’s syndrome in medullary thyroid cancer complicated by functional diabetes insipidus, aortic dissection, jejunal intussusception, and paraneoplastic dysautonomia: remission with sorafenib without reduction in cortisol concentr
      Muhammad M. Hammami, Najla Duaiji, Ghazi Mutairi, Sabah Aklabi, Nasser Qattan, Mohei El-Din M. Abouzied, Mohamed W. Sous
      BMC Cancer.2015;[Epub]     CrossRef

    • PubReader PubReader
    • Cite
      CITE
      export Copy
      Close
    • XML DownloadXML Download

    Endocrinol Metab : Endocrinology and Metabolism