Endocrinology and Metabolism

Ye An Kim (Kim YA)

8 Articles

Thyroid
Clinical Outcomes of Repeated Radioactive Iodine Therapy for Graves’ Disease: Min Joo Kim, Sun Wook Cho, Ye An Kim, Hoon Sung Choi, Young Joo Park, Do Joon Park, Bo Youn Cho; Endocrinol Metab. 2022;37(3):524-532. Published online June 16, 2022; DOI: https://doi.org/10.3803/EnM.2022.1418

2,003 View
138 Download
1 Citations

Abstract PDF Supplementary Material PubReader ePub Crossref - TDM

Background
Radioactive iodine (RAI) therapy is a successful therapeutic modality for Graves’ disease. However, RAI therapy can fail, and RAI therapy after antithyroid drugs (ATDs) has a lower remission rate. Therefore, many patients require repeated RAI therapy. This study investigated the clinical outcomes of repeated RAI therapy for Graves’ disease.
Methods
Patients who underwent RAI therapy as second-line therapy after failure of ATD treatment between 2001 and 2015 were reviewed. Remission was defined as hypothyroid or euthyroid status without ATD, and with or without levothyroxine at 12 months after RAI therapy.
Results
The 1-year remission rate after 2nd RAI therapy (66%, 152/230) is significantly higher than that after 1st RAI therapy (48%, 393/815) or long-term ATD treatment after 1st RAI therapy failure (42%). The clinical response to 2nd RAI therapy was more rapid. The median time intervals from the 2nd RAI therapy to ATD discontinuation (1.3 months) and to the start of levothyroxine replacement (2.5 months) were significantly shorter than those for the 1st RAI therapy. A smaller goiter size, a longer time interval between the 1st and 2nd RAI therapies, and a longer ATD discontinuation period predicted remission after the 2nd RAI therapy. Finally, in 78 patients who failed the 2nd RAI therapy, the mean ATD dosage significantly reduced 5.1 mg over 12 months.
Conclusion
Repeated RAI therapy can be a good therapeutic option, especially in patients with smaller goiters and those who are more responsive to the 1st RAI therapy.

Citations

Citations to this article as recorded by

Effect of liver dysfunction on outcome of radioactive iodine therapy for Graves’ disease
Yuyang Ze, Fei Shao, Xuefeng Feng, Shanmei Shen, Yan Bi, Dalong Zhu, Xiaowen Zhang
BMC Endocrine Disorders.2022;[Epub] CrossRef

Calcium & Bone Metabolism
Unveiling Genetic Variants Underlying Vitamin D Deficiency in Multiple Korean Cohorts by a Genome-Wide Association Study: Ye An Kim, Ji Won Yoon, Young Lee, Hyuk Jin Choi, Jae Won Yun, Eunsin Bae, Seung-Hyun Kwon, So Eun Ahn, Ah-Ra Do, Heejin Jin, Sungho Won, Do Joon Park, Chan Soo Shin, Je Hyun Seo; Endocrinol Metab. 2021;36(6):1189-1200. Published online December 2, 2021; DOI: https://doi.org/10.3803/EnM.2021.1241

3,234 View
153 Download
6 Citations

Abstract PDF Supplementary Material PubReader ePub Crossref - TDM

Background
Epidemiological data have shown that vitamin D deficiency is highly prevalent in Korea. Genetic factors influencing vitamin D deficiency in humans have been studied in Europe but are less known in East Asian countries, including Korea. We aimed to investigate the genetic factors related to vitamin D levels in Korean people using a genome-wide association study (GWAS).
Methods
We included 12,642 subjects from three different genetic cohorts consisting of Korean participants. The GWAS was performed on 7,590 individuals using linear or logistic regression meta- and mega-analyses. After identifying significant single nucleotide polymorphisms (SNPs), we calculated heritability and performed replication and rare variant analyses. In addition, expression quantitative trait locus (eQTL) analysis for significant SNPs was performed.
Results
rs12803256, in the actin epsilon 1, pseudogene (ACTE1P) gene, was identified as a novel polymorphism associated with vitamin D deficiency. SNPs, such as rs11723621 and rs7041, in the group-specific component gene (GC) and rs11023332 in the phosphodiesterase 3B (PDE3B) gene were significantly associated with vitamin D deficiency in both meta- and mega-analyses. The SNP heritability of the vitamin D concentration was estimated to be 7.23%. eQTL analysis for rs12803256 for the genes related to vitamin D metabolism, including glutamine-dependent NAD(+) synthetase (NADSYN1) and 7-dehydrocholesterol reductase (DHCR7), showed significantly different expression according to alleles.
Conclusion
The genetic factors underlying vitamin D deficiency in Korea included polymorphisms in the GC, PDE3B, NADSYN1, and ACTE1P genes. The biological mechanism of a non-coding SNP (rs12803256) for DHCR7/NADSYN1 on vitamin D concentrations is unclear, warranting further investigations.

Citations

Citations to this article as recorded by

Recent Information on Vitamin D Deficiency in an Adult Korean Population Visiting Local Clinics and Hospitals
Rihwa Choi, Sung-Eun Cho, Sang Gon Lee, Eun Hee Lee
Nutrients.2022; 14(9): 1978. CrossRef
The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies
Massimiliano Berretta, Vincenzo Quagliariello, Alessia Bignucolo, Sergio Facchini, Nicola Maurea, Raffaele Di Francia, Francesco Fiorica, Saman Sharifi, Silvia Bressan, Sara N. Richter, Valentina Camozzi, Luca Rinaldi, Carla Scaroni, Monica Montopoli
Antioxidants.2022; 11(6): 1090. CrossRef
A Genome-Wide Association Study of Genetic Variants of Apolipoprotein A1 Levels and Their Association with Vitamin D in Korean Cohorts
Young Lee, Ji Won Yoon, Ye An Kim, Hyuk Jin Choi, Byung Woo Yoon, Je Hyun Seo
Genes.2022; 13(9): 1553. CrossRef
Genetic Determinants of 25-Hydroxyvitamin D Concentrations and Their Relevance to Public Health
Elina Hyppönen, Karani S. Vimaleswaran, Ang Zhou
Nutrients.2022; 14(20): 4408. CrossRef
On the Centennial of Vitamin D—Vitamin D, Inflammation, and Autoimmune Thyroiditis: A Web of Links and Implications
Leonidas H. Duntas, Krystallenia I. Alexandraki
Nutrients.2022; 14(23): 5032. CrossRef
The genetic and epigenetic contributions to the development of nutritional rickets
Innocent Ogunmwonyi, Adewale Adebajo, Jeremy Mark Wilkinson
Frontiers in Endocrinology.2022;[Epub] CrossRef

Star-Shaped Intense Uptake of ¹³¹I on Whole Body Scans Can Reflect Good Therapeutic Effects of Low-Dose Radioactive Iodine Treatment of 1.1 GBq: Sung Hye Kong, Jung Ah Lim, Young Shin Song, Shinje Moon, Ye An Kim, Min Joo Kim, Sun Wook Cho, Jae Hoon Moon, Ka Hee Yi, Do Joon Park, Bo Youn Cho, Young Joo Park; Endocrinol Metab. 2018;33(2):228-235. Published online May 4, 2018; DOI: https://doi.org/10.3803/EnM.2018.33.2.228

4,163 View
37 Download
3 Citations

Abstract PDF PubReader ePub Crossref - TDM

Background

After initial radioactive iodine (RAI) treatment in differentiated thyroid cancer patients, we sometimes observe a star-shaped region of intense uptake of ¹³¹I on whole body scans (WBSs), called a ‘star artifact.’ We evaluated the clinical implications of star artifacts on the success rate of remnant ablation and long-term prognosis.

Methods

Total 636 patients who received ¹³¹I dose of 1.1 GBq for the initial RAI therapy and who did not show distant metastasis at the time of diagnosis were retrospectively evaluated. A negative second WBS was used for evaluating the ablation efficacy of the RAI therapy. Among them, 235 patients (36.9%) showed a star artifact on their first WBS.

Results

In patients with first stimulated thyroglobulin (sTg) levels ≤2 ng/mL, patients with star artifacts had a higher rate of negative second WBS compared with those without star artifacts (77.8% vs. 63.9%, P=0.044), and showed significantly higher recurrence-free survival (P=0.043) during the median 8.0 years (range, 1.0 to 10.0) of follow-up. The 5- and 10-year recurrence rates (5YRR, 10YRR) were also significantly lower in patients with star artifacts compared with those without (0% vs. 4.9%, respectively, P=0.006 for 5YRR; 0% vs. 6.4%, respectively, P=0.005 for 10YRR). However, ablation success rate or recurrence-free survival was not different among patients whose first sTg levels >2 ng/mL regardless of star artifacts.

Conclusion

Therefore, star artifacts at initial RAI therapy imply a good ablation efficacy or a favorable long-term prognosis in patients with sTg levels ≤2 ng/mL.

Citations

Citations to this article as recorded by

Prognostic value of star-shaped intense uptake of 131I in thyroid cancer patients
Liu Xiao, Wen Jie Zhang, Yue Qi Wang, Lin Li
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition).2021; 40(1): 30. CrossRef
Valores pronósticos de la captación en estrella de 131I en pacientes con cáncer diferenciado de tiroides
L. Xiao, W.J. Zhang, Y.Q. Wang, L. Li
Revista Española de Medicina Nuclear e Imagen Molecular.2021; 40(1): 30. CrossRef
Comparison between planar and single-photon computed tomography images for radiation intensity quantification in iodine-131 scintigraphy
Yusuke Iizuka, Tomohiro Katagiri, Minoru Inoue, Kiyonao Nakamura, Takashi Mizowaki
Scientific Reports.2021;[Epub] CrossRef

Endocrine Research
Thyroid Hormone Regulates the mRNA Expression of Small Heterodimer Partner through Liver Receptor Homolog-1: Hwa Young Ahn, Hwan Hee Kim, Ye An Kim, Min Kim, Jung Hun Ohn, Sung Soo Chung, Yoon-Kwang Lee, Do Joon Park, Kyong Soo Park, David D. Moore, Young Joo Park; Endocrinol Metab. 2015;30(4):584-592. Published online December 31, 2015; DOI: https://doi.org/10.3803/EnM.2015.30.4.584

2,977 View
31 Download
3 Citations

Abstract PDF PubReader Crossref - TDM

Background

Expression of hepatic cholesterol 7α-hydroxylase (CYP7A1) is negatively regulated by orphan nuclear receptor small heterodimer partner (SHP). In this study, we aimed to find whether thyroid hormone regulates SHP expression by modulating the transcriptional activities of liver receptor homolog-1 (LRH-1).

Methods

We injected thyroid hormone (triiodothyronine, T3) to C57BL/6J wild type. RNA was isolated from mouse liver and used for microarray analysis and quantitative real-time polymerase chain reaction (PCR). Human hepatoma cell and primary hepatocytes from mouse liver were used to confirm the effect of T3 in vitro. Promoter assay and electrophoretic mobility-shift assay (EMSA) were also performed using human hepatoma cell line

Results

Initial microarray results indicated that SHP expression is markedly decreased in livers of T3 treated mice. We confirmed that T3 repressed SHP expression in the liver of mice as well as in mouse primary hepatocytes and human hepatoma cells by real-time PCR analysis. LRH-1 increased the promoter activity of SHP; however, this increased activity was markedly decreased after thyroid hormone receptor β/retinoid X receptor α/T3 administration. EMSA revealed that T3 inhibits specific LRH-1 DNA binding.

Conclusion

We found that thyroid hormone regulates the expression of SHP mRNA through interference with the transcription factor, LRH-1.

Citations

Citations to this article as recorded by

Bile acid and receptors: biology and drug discovery for nonalcoholic fatty liver disease
Ting-ying Jiao, Yuan-di Ma, Xiao-zhen Guo, Yun-fei Ye, Cen Xie
Acta Pharmacologica Sinica.2022; 43(5): 1103. CrossRef
Loperamide induces excessive accumulation of bile acids in the liver of mice with different diets
Zili Lei, Hedong Rong, Yanhong Yang, Siping Yu, Tianle Zhang, Lei Chen, Ya Nie, Qi Song, Qing Hu, Jiao Guo
Toxicology.2022; 477: 153278. CrossRef
Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms
Giuseppe Ferrandino, Rachel R. Kaspari, Olga Spadaro, Andrea Reyna-Neyra, Rachel J. Perry, Rebecca Cardone, Richard G. Kibbey, Gerald I. Shulman, Vishwa Deep Dixit, Nancy Carrasco
Proceedings of the National Academy of Sciences.2017;[Epub] CrossRef

Prevalence and Risk Factors of Subclinical Thyroid Disease: Ye An Kim, Young Joo Park; Endocrinol Metab. 2014;29(1):20-29. Published online March 14, 2014; DOI: https://doi.org/10.3803/EnM.2014.29.1.20

4,965 View
47 Download
59 Citations

Abstract PDF PubReader Crossref - TDM

Subclinical thyroid disease is defined biochemically by an abnormal thyrotropin (TSH) level and normal serum-free thyroxine level. The prevalence of this condition varies according to the reference range for TSH and geographic or demographic factors. Recently, several studies, including our community-based cohort studies, have reported on the incidence of subclinical thyroid disease in Korea. Using these studies, we reviewed the prevalence and risk factors of subclinical thyroid disease, focusing on subclinical hypothyroidism.

Citations

Citations to this article as recorded by

Relationship Between Thyroid Hormonal Status in Patients with a Hypothyroid Form of Hashimoto’s Thyroiditis and Iodine Concentrations in Drinking Water
Olha Kasiyan, Halyna Tkachenko, Natalia Kurhaluk, Svitlana Yurchenko, Alek Manenko
Biological Trace Element Research.2022; 200(1): 59. CrossRef
Androgen deprivation therapy for prostate cancer and the risk of thyroid diseases
Jui‐Ming Liu, Yu‐Tang Chen, Chun‐Te Wu, Wen‐Lin Hsu, Ren‐Jun Hsu
The Prostate.2022; 82(7): 809. CrossRef
Subclinical hypothyroidism in women’s health: from pre- to post-menopause
Anna Capozzi, Giovanni Scambia, Stefano Lello
Gynecological Endocrinology.2022; 38(5): 357. CrossRef
Subclinical Hypothyroidism and Cognitive Impairment
Jung-Min Pyun, Young Ho Park, SangYun Kim
Journal of Alzheimer's Disease.2022; 88(2): 757. CrossRef
Rosuvastatin potentiates the thyrotropin‐lowering effect of metformin in men with non‐autoimmune subclinical hypothyroidism and prediabetes
Robert Krysiak, Karolina Kowalcze, Bogusław Okopień
Journal of Clinical Pharmacy and Therapeutics.2022; 47(12): 2030. CrossRef
Natural history of subclinical hypothyroidism and prognostic factors for the development of overt hypothyroidism: Tehran Thyroid Study (TTS)
A. Amouzegar, M. Dehghani, H. Abdi, L. Mehran, S. Masoumi, F. Azizi
Journal of Endocrinological Investigation.2022; 45(12): 2353. CrossRef
Interplay between cardiovascular and thyroid dysfunctions: A review of clinical implications and management strategies
Sanyal Debmalya, Ray Saumitra, Malhi Harshveer Singh
Endocrine Regulations.2022; 56(4): 311. CrossRef
Routine Measurement of Thyroid Stimulating Hormone in Patients Presenting With Third-Degree Atrioventricular Block: Do We Really Need It?
Muhammad Faisal, Zubair Mumtaz, Abdul Mueed, Sajid Ali, Haseeb H Raza, Samra Khan, Sayeda Salma, Mustajab Mujtaba, Musa Karim, Faisal Qadir
Cureus.2021;[Epub] CrossRef
Update of hypothyroidism and its management in Unani medicine
Md. Anzar Alam, Mohd Aleemuddin Quamri, Ghulamuddin Sofi, Shabnam Ansari
Journal of Basic and Clinical Physiology and Pharmacology.2021; 32(2): 1. CrossRef
Past, present and future of endemic goiter
Yılmaz SEZGİN
Turkish Journal of Family Medicine and Primary Care.2021;[Epub] CrossRef
Prognosis of papillary thyroid carcinoma in relation to preoperative subclinical hypothyroidism
SY Kang, HR Ahn, HJ Youn, SH Jung
The Annals of The Royal College of Surgeons of England.2021; 103(5): 367. CrossRef
Stroke in SARS-CoV-2 Infection: A Pictorial Overview of the Pathoetiology
Saeideh Aghayari Sheikh Neshin, Shima Shahjouei, Eric Koza, Isabel Friedenberg, Faezeh Khodadadi, Mirna Sabra, Firas Kobeissy, Saeed Ansari, Georgios Tsivgoulis, Jiang Li, Vida Abedi, Donna M. Wolk, Ramin Zand
Frontiers in Cardiovascular Medicine.2021;[Epub] CrossRef
Higher hepatic sterol-binding protein-2 gene expression and serum triglyceride level in methimazole induced subclinical hypothyroid animal model
Marie Saghaeian Jazi, Mohammad Mostakhdem Hashemi, Abbas Nezhadebrahimi, Azadreza Mansourian
Comparative Clinical Pathology.2021; 30(4): 627. CrossRef
Subclinical Hypothyroidism: Prevalence, Health Impact, and Treatment Landscape
Won Sang Yoo, Hyun Kyung Chung
Endocrinology and Metabolism.2021; 36(3): 500. CrossRef
Thyroid Function and Nutrient Status in the Athlete
D. Enette Larson-Meyer, Demetre E. Gostas
Current Sports Medicine Reports.2020; 19(2): 84. CrossRef
Seasonal effects on resting energy expenditure are dependent on age and percent body fat
Duong Duc Pham, Jeong Hun Lee, Ki Hwan Hong, Youn Joo Jung, Sung Jin Kim, Chae Hun Leem
Clinical Nutrition.2020; 39(4): 1276. CrossRef
Subclinical hypothyroidism
Chelsea Simon, Emily Weidman-Evans, Sarah Allen
Journal of the American Academy of Physician Assistants.2020; 33(5): 21. CrossRef
Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition
Alice Batistuzzo, Miriam Oliveira Ribeiro
Archives of Endocrinology and Metabolism.2020; 64(1): 89. CrossRef
Protective effect of a polyherbal bioactive fraction in propylthiouracil-induced thyroid toxicity in ratsby modulation of the hypothalamic–pituitary–thyroid and hypothalamic–pituitary–adrenal axes
Sneha Singh, Vandana Panda, Sudhamani S., Payal Dande
Toxicology Reports.2020; 7: 730. CrossRef
Subclinical Hypothyroidism Affects the Long-Term Outcomes of Patients Who Undergo Coronary Artery Bypass Grafting Surgery but Not Heart Valve Surgery
Hana Kim, Sung Hye Kong, Jae Hoon Moon, Sang Yoon Kim, Kay-Hyun Park, Jun Sung Kim, Joong Haeng Choh, Young Joo Park, Cheong Lim
Endocrinology and Metabolism.2020; 35(2): 308. CrossRef
Serum FT4 / FT3 Ratio, a Predictive Biochemical Marker for Subclinical Hypothyroidism in Patients with Chronic Kidney Disease
Venkat Siddarth Chagamreddy, Malligai Elancheran, Murugavel K
Journal of Evolution of Medical and Dental Sciences.2020; 9(33): 2319. CrossRef
Importance of thyroid-stimulating hormone levels in liver disease
Hyun Jin Kim
Journal of Pediatric Endocrinology and Metabolism.2020; 33(9): 1133. CrossRef
Does Hypothyroidism Increase Complications, Lengths of Stay, Readmissions, and Costs Following Primary 1- to 2-Level Lumbar Fusion?
Rushabh M. Vakharia, Joseph O. Ehiorobo, Bilal Mahmood, Martin W. Roche, Michael A. Mont, Afshin E. Razi
Clinical Spine Surgery: A Spine Publication.2020; 33(10): E559. CrossRef
Acute psychosis in patients with subclinical hyperthyroidism
Sohei Kimoto, Kazuhiko Yamamuro, Toshifumi Kishimoto
Psychiatry and Clinical Neurosciences.2019; 73(6): 348. CrossRef
Screening for thyroid dysfunction and treatment of screen-detected thyroid dysfunction in asymptomatic, community-dwelling adults: a systematic review
Francesca Reyes Domingo, Marc T. Avey, Marion Doull
Systematic Reviews.2019;[Epub] CrossRef
Association between subclinical hypothyroidism and metabolic disorders: A retrospective chart review study in an emerging university hospital
Khaled Aldossari, Sameer Al‐Ghamdi, Jamaan Al‐Zahrani, Anwar Al Jammah, Bader Alanazi, Abdulilah Al‐Briek, Mohammad Alanazi
Journal of Clinical Laboratory Analysis.2019;[Epub] CrossRef
Investigation of Vitamin D Levels and Metabolic Parameters in Patients With Subclinical Hyperthyroidism
Müge Keskin, Esra Ademoğlu, Arzu Or Koca, Derun Taner Ertugrul
Ankara Medical Journal.2019;[Epub] CrossRef
Reference Range and Sociodemographic Characteristics of TSH among Reproductive Age Women in Rural China
Qiang Su, Shikun Zhang, Mei Hu, Qiaomei Wang, Na Liu, Haiping Shen, Yiping Zhang, Man Zhang
Biological Trace Element Research.2019; 189(2): 336. CrossRef
Subklinik Hipotiroiditli Çocuklarda Ağız Sağlığı Durumunun Değerlendirilmesi
Nuray TÜLOĞLU, Tuğçe KALİÇOĞLU, Birgül KIREL
JOURNAL OF BIOTECHNOLOGY AND STRATEGIC HEALTH RESEARCH.2019;[Epub] CrossRef
Association High-Iodine-Containing Seaweed Soup Consumption after Birth and Subclinical Hypothyroidism in Korean Women: Korea National Health and Nutrition Examination Survey IV (2013–2015)
Hyunsam Kim, Ha Ni Lee, Jeonghoon Ha
International Journal of Thyroidology.2019; 12(2): 105. CrossRef
Graves Disease in Central Ghana: Clinical Characteristics and Associated Factors
Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Ishmael Kyei
Clinical Medicine Insights: Endocrinology and Diabetes.2018; 11: 117955141875907. CrossRef
Sex differences in risk factors for subclinical hypothyroidism
Jeonghoon Ha, Jeongmin Lee, Kwanhoon Jo, Dong-Jun Lim, Moo Il Kang, Bong Yun Cha, Min-Hee Kim
Endocrine Connections.2018; 7(4): 511. CrossRef
Age-sex disparities and sub-clinical hypothyroidism among patients in Tikur Anbesa Specialized Hospital, Addis Ababa, Ethiopia
Habtamu Azene Tekle, Tesfahun Molla Bobe, Efrata Girma Tufa, Fithamlak Bisetegen Solomon
Journal of Health, Population and Nutrition.2018;[Epub] CrossRef
Subclinical Hypothyroidism and the Risk of Cardiovascular Disease and All-Cause Mortality: A Meta-Analysis of Prospective Cohort Studies
Shinje Moon, Min Joo Kim, Jae Myung Yu, Hyung Joon Yoo, Young Joo Park
Thyroid.2018; 28(9): 1101. CrossRef
Age- and gender-specific reference intervals of TSH and free T4 in an iodine-replete area: Data from Korean National Health and Nutrition Examination Survey IV (2013–2015)
So Young Park, Hae In Kim, Hyun-Kyung Oh, Tae Hyuk Kim, Hye Won Jang, Jae Hoon Chung, Myung-Hee Shin, Sun Wook Kim, Sun Y Lee
PLOS ONE.2018; 13(2): e0190738. CrossRef
Helicobacter pylori-induced autoimmune thyroiditis: is the pathogenic link concluded or still a hypothesis?
Santhanamari Thiyagarajan, Anil M.R. Saini, Jamal Alruwaili
Reviews in Medical Microbiology.2018; 29(2): 64. CrossRef
Evaluation of Thyroid Hormone Levels and Urinary Iodine Concentrations in Koreans Based on the Data from Korea National Health and Nutrition Examination Survey VI (2013 to 2015)
Jae Hoon Chung
Endocrinology and Metabolism.2018; 33(2): 160. CrossRef
Transcriptome Network Analysis Reveals Aging-Related Mitochondrial and Proteasomal Dysfunction and Immune Activation in Human Thyroid
Byuri Angela Cho, Seong-Keun Yoo, Young Shin Song, Su-jin Kim, Kyu Eun Lee, Minho Shong, Young Joo Park, Jeong-Sun Seo
Thyroid.2018; 28(5): 656. CrossRef
Relation of Subclinical Hypothyroidism is Associated With Cardiovascular Events and All-Cause Mortality in Adults With High Cardiovascular Risk
Shinje Moon, Sung Hye Kong, Hoon Sung Choi, Yul Hwangbo, Moon-Kyu Lee, Jae Hoon Moon, Hak Chul Jang, Nam Han Cho, Young Joo Park
The American Journal of Cardiology.2018; 122(4): 571. CrossRef
Subclinical Hypothyroidism and Coronary Revascularization After Coronary Artery Bypass Grafting
Sung Hye Kong, Ji Won Yoon, Sang Yoon Kim, Tae Jung Oh, Kay-Hyun Park, Joong Haeng Choh, Young Joo Park, Cheong Lim
The American Journal of Cardiology.2018; 122(11): 1862. CrossRef
A Case of Subclinical Hyperthyroidism Treatment with Herbal Medicine
Dong-eun Jin, Seok-woo Kim, Hyeon-cheo Shin
The Journal of Internal Korean Medicine.2018; 39(4): 831. CrossRef
Cardiovascular Risk in Subclinical Hypothyroidism
Mariana Dobrescu, Diana Păun, Daniel Grigorie, Cătălina Poiană
Internal Medicine.2018; 15(3): 51. CrossRef
Association between thyroid autoimmunity and Helicobacter pylori infection
Yun Mi Choi, Tae Yong Kim, Eui Young Kim, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
The Korean Journal of Internal Medicine.2017; 32(2): 309. CrossRef
Effect of Marijuana Use on Thyroid Function and Autoimmunity
Sonali Malhotra, Rubina A. Heptulla, Peter Homel, Roja Motaghedi
Thyroid.2017; 27(2): 167. CrossRef
Insidious danger in childhood era's: subclinical hypothyroidism
Ayşegül Alpcan, Ayça Törel Ergür, Serkan Tursun
Ortadoğu Tıp Dergisi.2017; 9(1): 34. CrossRef
Thyroid Stimulating Hormone Reference Range and Prevalence of Thyroid Dysfunction in the Korean Population: Korea National Health and Nutrition Examination Survey 2013 to 2015
Won Gu Kim, Won Bae Kim, Gyeongji Woo, Hyejin Kim, Yumi Cho, Tae Yong Kim, Sun Wook Kim, Myung-Hee Shin, Jin Woo Park, Hai-Lin Park, Kyungwon Oh, Jae Hoon Chung
Endocrinology and Metabolism.2017; 32(1): 106. CrossRef
Thyroid diseases and risk of non-thyroidal pathology
R I Glushakov, E V Kozyrko, I V Sobolev, S A Ermolova, O V Vlaseva, A A Kuzin, N I Tapilskaya
Kazan medical journal.2017; 98(1): 77. CrossRef
Hipertiroidismo
M. Toni, J. Pineda, E. Anda, J.C. Galofré
Medicine - Programa de Formación Médica Continuada Acreditado.2016; 12(13): 731. CrossRef
Subclinical Hypothyroidism in Childhood Cancer Survivors
Hyun Joo Lee, Seung Min Hahn, Song Lee Jin, Yoon Jung Shin, Sun Hee Kim, Yoon Sun Lee, Hyo Sun Kim, Chuhl Joo Lyu, Jung Woo Han
Yonsei Medical Journal.2016; 57(4): 915. CrossRef
Comparison of universal screening with targeted high-risk case finding for diagnosis of thyroid disorders
Sima Nazarpour, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Maryam Tohidi, Hamid AlaviMajd, Fereidoun Azizi
European Journal of Endocrinology.2016; 174(1): 77. CrossRef
Association of low baseline free thyroxin levels with progression of coronary artery calcification over 4 years in euthyroid subjects: the Kangbuk Samsung Health Study
Hye‐Jeong Park, Jihyun Kim, Eun Jin Han, Se Eun Park, Cheol‐Young Park, Won‐Young Lee, Ki‐Won Oh, Sung‐Woo Park, Eun‐Jung Rhee
Clinical Endocrinology.2016; 84(6): 889. CrossRef
Distinct Features of Nonthyroidal Illness in Critically Ill Patients With Infectious Diseases
Woo Kyung Lee, Sena Hwang, Daham Kim, Seul Gi Lee, Seonhyang Jeong, Mi-Youn Seol, Hyunji Kim, Cheol Ryong Ku, Dong Yeop Shin, Woong Youn Chung, Eun Jig Lee, Jandee Lee, Young Suk Jo
Medicine.2016; 95(14): e3346. CrossRef
Articles in 'Endocrinology and Metabolism' in 2014
Won-Young Lee
Endocrinology and Metabolism.2015; 30(1): 47. CrossRef
Reference interval for thyrotropin in a ultrasonography screened Korean population
Mijin Kim, Tae Yong Kim, Soo Han Kim, Yunkyoung Lee, Su-yeon Park, Hyung-don Kim, Hyemi Kwon, Yun Mi Choi, Eun Kyung Jang, Min Ji Jeon, Won Gu Kim, Young Kee Shong, Won Bae Kim
The Korean Journal of Internal Medicine.2015; 30(3): 335. CrossRef
Incidence and Prevalence of Overt Hypothyroidism and Causative Diseases in Korea as Determined Using Claims Data Provided by the Health Insurance Review and Assessment Service
Gi Hyeon Seo, Jae Hoon Chung
Endocrinology and Metabolism.2015; 30(3): 288. CrossRef
Subclinical Hypothyroidism and Cardiovascular Disease
Sunghwan Suh, Duk Kyu Kim
Endocrinology and Metabolism.2015; 30(3): 246. CrossRef
Bone Health and Clinical Results after Hip Fracture Surgery in Patients with Subclinical Hypothyroidism
Ki-Choul Kim, Young-Kyun Lee, You Jin Lee, Yong-Chan Ha, Kyung-Hoi Koo
Journal of Bone Metabolism.2014; 21(3): 213. CrossRef
Subclinical Thyroid Dysfunction in the Elderly
Ki Dong Ko
Journal of the Korean Geriatrics Society.2014; 18(3): 111. CrossRef
Subclinical hypothyroidism in addition to common risk scores for prediction of cardiovascular disease: a 10-year community-based cohort study
Tae Hyuk Kim, Hoon Sung Choi, Ji Cheol Bae, Jae Hoon Moon, Hyung-Kwan Kim, Sung Hee Choi, Soo Lim, Do Joon Park, Kyong Soo Park, Hak Chul Jang, Moon-Kyu Lee, Nam H Cho, Young Joo Park
European Journal of Endocrinology.2014; 171(5): 649. CrossRef

Adrenocorticotropic Hormone-Independent Cushing Syndrome with Bilateral Cortisol-Secreting Adenomas: Eu Jeong Ku, A Ram Hong, Ye An Kim, Jae Hyun Bae, Mee Soo Chang, Sang Wan Kim; Endocrinol Metab. 2013;28(2):133-137. Published online June 18, 2013; DOI: https://doi.org/10.3803/EnM.2013.28.2.133

2,948 View
37 Download
10 Citations

Abstract PDF PubReader Crossref - TDM

A 48-year-old woman was incidentally found to have bilateral adrenal masses, 2.8 cm in diameter on the right, and 2.3 cm and 1.7 cm in diameter on the left, by abdominal computed tomography. The patient had a medical history of hypertension, which was not being controlled by carvedilol, at a dose of 25 mg daily. She presented with signs and symptoms that suggested Cushing Syndrome. We diagnosed adrenocorticotropic hormone (ACTH)-independent Cushing Syndrome based on the results of basal and dynamic hormone tests. Adrenal vein sampling (AVS) was performed to localize a functioning adrenal cortical mass. AVS results were consistent with hypersecretion of cortisol from both adrenal glands, with a cortisol lateralization ratio of 1.1. Upon bilateral laparoscopic adrenalectomy, bilateral ACTH-independent adrenal adenomas were found. The patient's signs and symptoms of Cushing Syndrome improved after surgery just as the blood pressure was normalized. After surgery, the patient was started on glucocorticoid and mineralocorticoid replacement therapy.

Citations

Citations to this article as recorded by

Recent Advances in the Clinical Application of Adrenal Vein Sampling
Shan Zhong, Tianyue Zhang, Minzhi He, Hanxiao Yu, Zhenjie Liu, Zhongyi Li, Xiaoxiao Song, Xiaohong Xu
Frontiers in Endocrinology.2022;[Epub] CrossRef
The role of adrenal venous sampling (AVS) in primary bilateral macronodular adrenocortical hyperplasia (PBMAH): a study of 16 patients
German Rubinstein, Andrea Osswald, Leah Theresa Braun, Frederick Vogel, Matthias Kroiss, Stefan Pilz, Sinan Deniz, Laura Aigner, Thomas Knösel, Jérôme Bertherat, Lucas Bouys, Roland Ladurner, Anna Riester, Martin Bidlingmaier, Felix Beuschlein, Martin Rei
Endocrine.2022; 76(2): 434. CrossRef
Concomitant coexistence of ACTH‐dependent and independent Cushing syndrome
Ach Taieb, Saad Ghada, Gorchène Asma, Ben Abdelkrim Asma, Kacem Maha, Ach Koussay
Clinical Case Reports.2022;[Epub] CrossRef
The Value of Adrenal Androgens for Correcting Cortisol Lateralization in Adrenal Venous Sampling in Patients with Normal Cortisol Secretion
Wenjing Zhang, Keying Zhu, Hongyun Li, Yan Zhang, Dalong Zhu, Xuebin Zhang, Ping Li
International Journal of Endocrinology.2019; 2019: 1. CrossRef
Adrenal venous sampling in patients with ACTH-independent hypercortisolism
Eleni Papakokkinou, Hugo Jakobsson, Augustinas Sakinis, Andreas Muth, Bo Wängberg, Olof Ehn, Gudmundur Johannsson, Oskar Ragnarsson
Endocrine.2019; 66(2): 338. CrossRef
ACTH-independent Cushing’s syndrome with bilateral cortisol-secreting adrenal adenomas: a case report and review of literatures
Jia Wei, Sheyu Li, Qilin Liu, Yuchun Zhu, Nianwei Wu, Ying Tang, Qianrui Li, Kaiyun Ren, Qianying Zhang, Yerong Yu, Zhenmei An, Jing Chen, Jianwei Li
BMC Endocrine Disorders.2018;[Epub] CrossRef
A case of adrenal Cushing’s syndrome with bilateral adrenal masses
Ya-Wun Guo, Chii-Min Hwu, Justin Ging-Shing Won, Chia-Huei Chu, Liang-Yu Lin
Endocrinology, Diabetes & Metabolism Case Reports.2016;[Epub] CrossRef
Bilateral Adrenocortical Masses Producing Aldosterone and Cortisol Independently
Seung-Eun Lee, Jae Hyeon Kim, You-Bin Lee, Hyeri Seok, In Seub Shin, Yeong Hee Eun, Jung-Han Kim, Young Lyun Oh
Endocrinology and Metabolism.2015; 30(4): 607. CrossRef
Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
Won-Young Lee
Endocrinology and Metabolism.2014; 29(3): 251. CrossRef
A Case of Bilateral ACTH-independent Adrenal Adenomas with Cushing's Syndrome Treated by Ipsilateral Total and Contralateral Partial Laparoscopic Adrenalectomy
Seung Ah Park, Dong min Jung, Soon young Kim, Nan Young Choi, Tae-jun Kim, Yong kyun Kim, Seong kyun Na, Chul Sik Kim, Seong Jin Lee, Sung-Hee Ihm, Jun Goo Kang
The Korean Journal of Obesity.2013; 22(4): 254. CrossRef

Two Cases of Methimazole-Induced Insulin Autoimmune Syndrome in Graves' Disease: Eun Roh, Ye An Kim, Eu Jeong Ku, Jae Hyun Bae, Hye Mi Kim, Young Min Cho, Young Joo Park, Kyong Soo Park, Seong Yeon Kim, Soo Heon Kwak; Endocrinol Metab. 2013;28(1):55-60. Published online March 25, 2013; DOI: https://doi.org/10.3803/EnM.2013.28.1.55

4,921 View
50 Download
14 Citations

Abstract PDF PubReader Crossref - TDM

We report here the cases of two females with Graves' disease who developed insulin autoimmune syndrome after treatment with methimazole. The patients exhibited a sudden altered mental state after treatment with methimazole for approximately 4 weeks. Patients had hypoglycemia with serum glucose below 70 mg/dL, and laboratory findings showed both high levels of serum insulin and high titers of insulin autoantibodies. The two women had never been exposed to insulin or oral antidiabetic agents, and there was no evidence of insulinoma in imaging studies. After glucose loading, serum glucose, and total insulin levels increased abnormally. One of the patient was found to have HLA-DRB1*0406, which is known to be strongly associated with methimazole-induced insulin autoimmune syndrome. After discontinuation of methimazole, hypoglycemic events disappeared within 1 month. Insulin autoantibody titer and insulin levels decreased within 5 months and there was no further development of hypoglycemic events. We present these cases with a review of the relevant literature.

Citations

Citations to this article as recorded by

Insulin Autoimmune Syndrome: A Systematic Review
MingXu Lin, YuHua Chen, Jie Ning, Tatsuya Kin
International Journal of Endocrinology.2023; 2023: 1. CrossRef
Case report: hypoglycemia secondary to methimazole-induced insulin autoimmune syndrome in young Taiwanese woman with Graves’ disease
Hsuan-Yu Wu, I-Hua Chen, Mei-Yueh Lee
Medicine.2022; 101(25): e29337. CrossRef
Analysis of the clinical characteristics of insulin autoimmune syndrome induced by methimazole
Linli Sun, Weijin Fang, Dan Yi, Wei Sun, Chunjiang Wang
Journal of Clinical Pharmacy and Therapeutics.2021; 46(2): 470. CrossRef
Preoperative plasmapheresis experience in Graves’ disease patients with anti-thyroid drug-induced hepatotoxicity
Tugce Apaydın, Onur Elbasan, Dilek Gogas Yavuz
Transfusion and Apheresis Science.2020; 59(5): 102826. CrossRef
Glycemic variation in uncontrolled Graves’ disease patients with normal glucose metabolism: Assessment by continuous glucose monitoring
Gu Gao, Feng-fei Li, Yun Hu, Reng-na Yan, Bing-li Liu, Xiao-mei Liu, Xiao-fei Su, Jian-hua Ma, Gang Hu
Endocrine.2019; 64(2): 265. CrossRef
Insulin autoimmune syndrome induced by exogenous insulin injection: a four-case series
Yimin Shen, Xiaoxiao Song, Yuezhong Ren
BMC Endocrine Disorders.2019;[Epub] CrossRef
Assessment and Management of Anti-Insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome
David Church, Luís Cardoso, Richard G Kay, Claire L Williams, Bernard Freudenthal, Catriona Clarke, Julie Harris, Myuri Moorthy, Efthmia Karra, Fiona M Gribble, Frank Reimann, Keith Burling, Alistair J K Williams, Alia Munir, T Hugh Jones, Dagmar Führer,
The Journal of Clinical Endocrinology & Metabolism.2018; 103(10): 3845. CrossRef
MANAGEMENT OF ENDOCRINE DISEASE: Pathogenesis and management of hypoglycemia
Nana Esi Kittah, Adrian Vella
European Journal of Endocrinology.2017; 177(1): R37. CrossRef
Insulin autoimmune syndrome during the administration of clopidogrel
Eijiro Yamada, Shuichi Okada, Tsugumichi Saito, Aya Osaki, Atushi Ozawa, Masanobu Yamada
Journal of Diabetes.2016; 8(4): 588. CrossRef
Hyperinsulinemic hypoglycemia associated with insulin antibodies caused by exogenous insulin analog
Chih-Ting Su, Yi-Chun Lin
Endocrinology, Diabetes & Metabolism Case Reports.2016;[Epub] CrossRef
Anti-tuberculosis Treatment-Induced Insulin Autoimmune Syndrome
Jung Suk Han, Han Ju Moon, Jin Seo Kim, Hong Il Kim, Cheol Hyeon Kim, Min Joo Kim
The Ewha Medical Journal.2016; 39(4): 122. CrossRef
2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis
Douglas S. Ross, Henry B. Burch, David S. Cooper, M. Carol Greenlee, Peter Laurberg, Ana Luiza Maia, Scott A. Rivkees, Mary Samuels, Julie Ann Sosa, Marius N. Stan, Martin A. Walter
Thyroid.2016; 26(10): 1343. CrossRef
Insulin Autoimmune Syndrome in a Patient with Hashimoto's Thyroiditis
In Wook Song, Eugene Han, Nan Hee Cho, Ho Chan Cho
Journal of Korean Thyroid Association.2014; 7(2): 180. CrossRef
Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
Won-Young Lee
Endocrinology and Metabolism.2014; 29(3): 251. CrossRef

Characterization of Incidentally Detected Adrenal Pheochromocytoma.: Ye An Kim, Yul Hwangbo, Min Joo Kim, Hyung Jin Choi, Je Hyun Seo, Yenna Lee, Soo Heun Kwak, Eu Jeong Ku, Tae Jung Oh, Eun Roh, Jae Hyun Bae, Jung Hee Kim, Kyoung Soo Park, Seong Yeon Kim; Endocrinol Metab. 2012;27(2):132-137. Published online June 20, 2012; DOI: https://doi.org/10.3803/EnM.2012.27.2.132

1,737 View
23 Download
3 Citations

Abstract PDF

BACKGROUND
In approach to an adrenal incidentaloma, early exclusion of pheochromocytoma is clinically important, due to the risk of catecholamine crisis. The aims of this study are to investigate the characteristics of incidentally detected pheochromocytomas, compared with that of the other adrenal incidentalomas, and to compare these characteristics with those of symptomatic pheochromocytomas. METHODS: In this retrospective study, we reviewed the medical records of 198 patients with adrenal incidentaloma from 2001 to 2010. We analyzed the clinical, laboratory and radiological data of pheochromocytomas, in comparison with those of the other adrenal incidentalomas. We also compared the characteristics of these incidentally detected pheochromocytomas with the medical records of 28 pathologically proven pheochromocytomas, diagnosed based on typical symptoms. RESULTS: Among the 198 patients with adrenal incidentaloma, nineteen patients were diagnosed with pheochromocytoma. Pheochromocytomas showed larger size and higher Hounsfield unit at precontrast computed tomography (CT) than did non-pheochromocytomas. All pheochromocytomas were larger than 2.0 cm, and the Hounsfield units were 19 or higher in precontrast CT. When both criteria of size > 2.0 cm and Hounsfield unit > 19 were met, the sensitivity and specificity for the diagnosis of pheochromocytoma were 100% and 79.3%, respectively. Compared with patients with pheochromocytoma, diagnosed based on typical symptoms, patients with incidentally detected pheochromocytoma were older, presented less often with hypertension, and showed lower levels of 24-hour urine metanephrine. CONCLUSION: Adrenal incidentaloma with < 2.0 cm in size or < or = 19 Hounsfield units in precontrast CT imaging was less likely to be a pheochromocytoma. Patients with incidentally discovered pheochromocytoma showed lower catecholamine metabolites, compared with those patients with symptomatic pheochromocytoma.

Citations

Citations to this article as recorded by

Guidelines for the Management of Adrenal Incidentaloma: the Korean Endocrine Society, Committee of Clinical Practice Guidelines
Jung-Min Lee, Mee Kyoung Kim, Seung-Hyun Ko, Jung-Min Koh, Bo-Yeon Kim, Sang-Wan Kim, Soo-Kyung Kim, Hae-Jin Kim, Ohk-Hyun Ryu, Juri Park, Jung-Soo Lim, Seong Yeon Kim, Young Kee Shong, Soon Jib Yoo
The Korean Journal of Medicine.2017; 92(1): 4. CrossRef
Clinical Guidelines for the Management of Adrenal Incidentaloma
Jung-Min Lee, Mee Kyoung Kim, Seung-Hyun Ko, Jung-Min Koh, Bo-Yeon Kim, Sang Wan Kim, Soo-Kyung Kim, Hae Jin Kim, Ohk-Hyun Ryu, Juri Park, Jung Soo Lim, Seong Yeon Kim, Young Kee Shong, Soon Jib Yoo
Endocrinology and Metabolism.2017; 32(2): 200. CrossRef
Characterization of Incidentally Detected Adrenal Pheochromocytoma
Soon Jib Yoo, Woohyeon Kim
Endocrinology and Metabolism.2012; 27(2): 116. CrossRef

Author index