A Case of Hashimoto's Thyroiditis with Transient T3-Thyrotoxicosis Induced by Hydatidiform Mole.

Ji Youn Yoo; Hong Ju Moon; Cheol Young Park; Seong Jin Lee; In Kyung Jeong; Eun Gyung Hong; Gi Weon Oh; Hyeon Kyu Kim; Doo Men Kim; Jae Myung Yoo; Sung Hee Ihm; Moon Gi Choi; Hyung Joon Yoo; Sung Woo Park; Soo Kee Min

doi:10.3803/jkes.2005.20.3.294

Case Report A Case of Hashimoto's Thyroiditis with Transient T3-Thyrotoxicosis Induced by Hydatidiform Mole.: Ji Youn Yoo, Hong Ju Moon, Cheol Young Park, Seong Jin Lee, In Kyung Jeong, Eun Gyung Hong, Gi Weon Oh, Hyeon Kyu Kim, Doo Men Kim, Jae Myung Yoo, Sung Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Sung Woo Park, Soo Kee Min; Endocrinology and Metabolism 2005;20(3):294-298
DOI: https://doi.org/10.3803/jkes.2005.20.3.294
Published online: June 1, 2005

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¹Department of lnternal Medicine, College of Medicine, Hallym University, Chunchon, Korea.
²Department of Pathology, College of Medicine, Hallym University, Chunchon, Korea.

Abstract

Human chorionic gonadotropin(HCG) is a member of the glycoproteins family synthesized by the placenta, which consists of 2 noncovalently joined subunits(alpha(alpha) and beta(beta)). The alpha- and beta-subunits have a structural homology with the alpha- and beta-subunits of TSH and LH. The thyrotropic action of HCG results from its structural similarity to TSH, so beta-HCG can bind to the TSH receptor in the thyroid gland. A high level of HCG accompanied by an increased thyroid hormone level, can be observed in gestational trophoblastic disease (GTD), such as a hydatidiform mole or a choriocarcinoma, but the clinical symptoms of hyperthyroidism are rarely observed. We experienced a case of Hashimoto's thyroiditis, where the patient was diagnosed with T3-thyrotoxicosis, which had initially been induced by excess beta-HCG due to an H-mole; after evacuation of the H-mole, the condition was diagnosed as hypothyroidism. It has been speculated that a patient with Hashimoto's thyroiditis could have hyperthyroidism, induced by beta-HCG, due to an H-mole

Keywords: Hashimoto's thyroiditis;T3-thyrotoxicosis;Hyperthyroidism;GTD(Gestational trophoblastic disease);H-mole;

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Transient T3 toxicosis associated with Hashimoto’s disease
Sarah Jaroudi, Meredith Gavin, Kathryn Boylan, Alan N. Peiris
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