Endocrinol Metab > Volume 23(1); 2008 > Article
Journal of Korean Endocrine Society 2008;23(1):56-61.
DOI: https://doi.org/10.3803/jkes.2008.23.1.56    Published online February 1, 2008.
A Case Report of an Aldosterone-producing Adrenocortical Carcinoma.
You Hong Lee, Tae Jin Park, Hae Jin Kim, Dae Jung Kim, Kwan Woo Lee, Myung Wook Kim, Jang Hee Kim, Tae Hi Lee, Yoon Sok Chung
1Department of Endocrinology and Metabolism, Ajou University School of Medicine, Korea.
2Department of Surgery, Ajou University School of Medicine, Korea.
3Department of Pathology, Ajou University School of Medicine, Korea.
Abstract
Primary aldosteronism is a syndrome characterized by hypokalemic alkalosis and hypertension. Aldosterone-producing adenomas and bilateral adrenal hyperplasia are common causes of this syndrome. An aldosterone-producing adrenocortical carcinoma is a very rare cause of primary aldosteronism. Recently we experienced a case of an aldosterone-producing adrenocortical carcinoma. A 41-year-old female was admitted for evaluation of a retroperitoneal mass. Because of hypokalemia and a history of hypertension, we evaluated the patient for primary aldosteronism. The high ratio of plasma aldosterone to renin activity suggested the possibility of the presence of primary aldosteronism. We performed adrenal vein sampling for differential diagnosis of an aldosterone-producing tumor from a retroperitoneal mass. The adrenal vein sampling showed that the primary aldosteronism was due to an aldosterone-producing tumor from the left adrenal gland. Surgical findings indicated that the retroperitoneal mass originated from the left adrenal gland and the pathological diagnosis for the mass was an adrenocortical carcinoma. In conclusion, the results from the adrenal vein sampling, as well as the surgical and pathological findings demonstrate that this case was an aldosterone-producing adrenocortical carcinoma.
Key Words: adrenocortical carcinoma, aldosteronism, retroperitoneal mass


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