Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Previous issues

Page Path
HOME > BROWSE ARTICLES > Previous issues
17 Previous issues
Filter
Filter
Article type
Keywords
Authors
Volume 33(3); September 2018
Prev issue Next issue
Review Articles
Diabetes
Therapeutic Role of Yoga in Type 2 Diabetes
Arkiath Veettil Raveendran, Anjali Deshpandae, Shashank R. Joshi
Endocrinol Metab. 2018;33(3):307-317.   Published online August 14, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.307
  • 11,241 View
  • 278 Download
  • 44 Web of Science
  • 59 Crossref
AbstractAbstract PDFPubReader   ePub   

Yoga originated in India more than 5,000 years ago and is a means of balancing and harmonizing the body, mind, and emotions. Yoga practice is useful in the management of various lifestyle diseases, including type 2 diabetes. Psycho-neuro-endocrine and immune mechanisms are involved in the beneficial effects of yoga on diabetes. Incorporation of yoga practice in daily life helps to attain glycaemic control and reduces the risk of complications in people with diabetes. In this review, we briefly describe the role of various yoga practices in the management of diabetes based on evidence from various clinical studies.

Citations

Citations to this article as recorded by  
  • Yoga practice can reduce metabolic syndrome and cardiovascular risk in climacteric women
    Laura Alves Cota e Souza, Thiago Magalhães Gouvea, Francielle Caroline Fernandes, Maria Ruth Gonçalves Gaede Carrillo, Vanja Maria Veloso, Ariosvaldo Figueiredo Santos Filho, Angélica Alves Lima
    Journal of Behavioral Medicine.2024; 47(1): 94.     CrossRef
  • Clinical Practice Guidelines for mental health and well-being in patients with chronic medical illnesses
    Sandeep Grover, Ajit Avasthi, Abdul Majid
    Indian Journal of Psychiatry.2024; 66(Suppl 2): S338.     CrossRef
  • Complementary and alternative system of medicine for type 2 diabetes mellitus and its complications: A scoping review
    Shradha S Parsekar, Nachiket Gudi, Sujata Chodankar Walke, Prabhu Dutta Shaw, Aditi Hombali, Anupama V Nayak, Basavaraj S Hadapad
    F1000Research.2024; 11: 526.     CrossRef
  • CLINICAL STUDY OF YOGASANA AND PATHYAAHARA IN MANAGEMENT OF MADHUMEHA (DIABETES MELLITUS-2)
    Jyoti Prajapati, Pramod Kumar Mishra, Brahmanand Sharma
    International Ayurvedic Medical Journal.2024; 12(02): 346.     CrossRef
  • Therapeutic role of yoga in hypertension
    Anjali Mangesh Joshi, Arkiath Veettil Raveendran, Muruganathan Arumugam
    World Journal of Methodology.2024;[Epub]     CrossRef
  • The effect of yoga practices on health parameters: A review
    Gökhan Çetinoğlu, Emirhan Pehlivan
    Turkish Journal of Kinesiology.2024; 10(1): 41.     CrossRef
  • Managing Diabetic Complications with Alternative Therapeutic Strategies
    Shobhit Prakash Srivastava, Pawan Upadhyay, Shibu Das, Neha Tiwari, Sudhanshu Mishra, Shivendra Mani Tripathi
    Current Diabetes Reviews.2024;[Epub]     CrossRef
  • Novel Approaches to Control Diabetes
    Malissa Mathew Dmello, Geeta Bhagwat
    Current Diabetes Reviews.2024;[Epub]     CrossRef
  • A self-management plus mind body intervention for adolescents and young adults with type 2 diabetes: Trial design and methodological report
    Molly McVoy, David Miller, Irina Bransteter, Rose Gubitosi-Klug, Tracy Segal, Jessica Surdam, Martha Sajatovic, Jeffery A. Dusek
    Contemporary Clinical Trials.2023; 133: 107317.     CrossRef
  • Epidemiology of type 2 diabetes mellitus and treatment utilization patterns among the elderly from the first wave of Longitudinal Aging study in India (2017-18)using a Heckman selection model
    Papai Barman, Milan Das, Madhur Verma
    BMC Public Health.2023;[Epub]     CrossRef
  • Is Type 2 Diabetes Mellitus a Behavioural Disorder? An Evidence Review for Type 2 Diabetes Mellitus Prevention and Remission through Lifestyle Modification
    Matthias Li, Mohammad Sadiq Jeeyavudeen, Ganesan Arunagirinathan, Joseph Pappachan
    European Endocrinology.2023; 19(1): 7.     CrossRef
  • Yogic practices for dyslipidemia in type 2 diabetes mellitus: A systematic review of randomized-controlled trials
    Bandana Sairem, Khushbu Jain
    BLDE University Journal of Health Sciences.2023; 8(1): 20.     CrossRef
  • Effect of yoga protocol in primary snoring: A pilot study
    JojanJ Jerone, Ashok Patil, SavitaS Angadi, AmalS Chandran
    Journal of Ayurveda.2023; 17(2): 114.     CrossRef
  • Effects of different mind-body exercises on glucose and lipid metabolism in patients with type 2 diabetes: A network meta-analysis
    Sijun Wu, Lin Wang, Yuxuan He, Fengrui Shi, Huiqi Zhuang, Linqi Mei, Youling Qian
    Complementary Therapies in Clinical Practice.2023; 53: 101802.     CrossRef
  • Mechanisms of improved body composition among perimenopausal women practicing Meditative Movement: a proposed biobehavioral model
    Dara L. James, Linda K. Larkey, Bronwynne Evans, Ann Sebren, Kimberley Goldsmith, Erica Ahlich, Nanako A. Hawley, Afton Kechter, Dorothy D. Sears
    Menopause.2023; 30(11): 1114.     CrossRef
  • A comparative analysis of Vamana and Shamana Chikitsa in prediabetes management: A randomized clinical trial
    Uttamram Yadav, Santosh Kumar Bhatted
    Journal of Ayurveda and Integrative Medicine.2023; 14(5): 100764.     CrossRef
  • Siddha Therapeutic Approach to Diabetic Nephropathy – A Review
    P. Parvathy, G. S. Lekha, S. Aparna, A. Kanagarajan
    Journal of Natural Remedies.2023; : 1359.     CrossRef
  • Enhancing Type 2 Diabetes Management: Exploring the Synergistic Impact of Vestibular Exercise and Yoga
    Athira MS, Sheela Joice P P, Mohan Varughese, Suresh Babu Sayana
    Cureus.2023;[Epub]     CrossRef
  • Dynamic In Silico Model of Type 2 Diabetes Treated With Metformin Combined With Exercise: A Sobol Sensitivity Analysis
    Darshna M. Joshi
    Avicenna Journal of Pharmaceutical Research.2023; 3(2): 91.     CrossRef
  • Complementary and alternative system of medicine for type 2 diabetes mellitus and its complications: A scoping review
    Shradha S Parsekar, Nachiket Gudi, Sujata Chodankar Walke, Prabhu Dutta Shaw, Aditi Hombali, Anupama V Nayak, Basavaraj S Hadapad
    F1000Research.2023; 11: 526.     CrossRef
  • Exploring the Impact of Combined Thai Yoga and Elastic Band Exercise on Physical Fitness and Exercise Capacity in Older Patients with Type 2 Diabetes
    Nattha Muangritdech, Tichanon Promsrisuk, Ratchaniporn Kongsui, Napatr Sriraksa, Sitthisak Thongrong, Arunrat Srithawong
    Physical Education Theory and Methodology.2023; 23(6): 894.     CrossRef
  • Role of Yoga and Its Plausible Mechanism in the Mitigation of DNA Damage in Type-2 Diabetes: A Randomized Clinical Trial
    Rajesh G Nair, Mithila M Vasudev, Ramesh Mavathur
    Annals of Behavioral Medicine.2022; 56(3): 235.     CrossRef
  • Efficacy of Integrated Ayurveda treatment protocol in type 2 Diabetes Mellitus – A case report
    Suketha Kumari, Laxmikant S.D, Sonika B, Suman Khanal
    Journal of Ayurveda and Integrative Medicine.2022; 13(1): 100512.     CrossRef
  • Role of structured exercise therapy on cognitive markers and stress parameters in young patients with Type 2 diabetes mellitus
    Harpreet Kour, VA Kothiwale, ShivaprasadS Goudar
    Indian Journal of Health Sciences and Biomedical Research (KLEU).2022; 15(1): 70.     CrossRef
  • The Influence of Amateur Sports on Health Quality
    M. M. Vovchenko
    Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2022; 7(1): 8.     CrossRef
  • Complementary and alternative system of medicine for type 2 diabetes mellitus and its complications: A scoping review
    Shradha S Parsekar, Nachiket Gudi, Sujata Chodankar Walke, Prabhu Dutta Shaw, Aditi Hombali, Anupama V Nayak, Basavaraj S Hadapad
    F1000Research.2022; 11: 526.     CrossRef
  • Neuroimaging perspective in targeted treatment for type 2 diabetes melitus and sleep disorders
    Karen M. von Deneen, Malgorzata A. Garstka
    Intelligent Medicine.2022; 2(4): 209.     CrossRef
  • Efficacy of yoga practices on emotion regulation and mindfulness in type 2 diabetes mellitus patients
    Amit Kanthi, Singh Deepeshwar, Chidananda Kaligal, Mahadevappa Vidyashree, Dwivedi Krishna
    Yoga Mimamsa.2022; 54(1): 12.     CrossRef
  • Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies
    Bhaskar Jyoti Dutta, Shamsher Singh, Sanket Seksaria, Ghanshyam Das Gupta, Amrita Singh
    Pharmacological Research.2022; 182: 106358.     CrossRef
  • LINKAGE OF YOGA TO OXIDATIVE STRESS IN PATIENTS WITH DIABETES MELLITUS, TYPE 2
    Deepika Khatri, Yuliya Tyravska
    InterConf.2022; (15(117)): 215.     CrossRef
  • An Observational Study on the Effect of Yoga and Sudarshan Kriya in Type 2 Diabetes Mellitus Patients
    Meenakshi R Verma, Deepakkumar G Langade, Rahul D Rao, Shreya Shivangi, Sonali Khedkar, Divya Kanchibhotla
    Cureus.2022;[Epub]     CrossRef
  • The most effective exercise to prevent obesity: A longitudinal study of 33,731 Taiwan biobank participants
    Wan-Yu Lin
    Frontiers in Nutrition.2022;[Epub]     CrossRef
  • Type 2 diabetes mellitus, its impact on quality of life and how the disease can be managed-a review
    Priyanka Garg, Navneet Duggal
    Obesity Medicine.2022; 35: 100459.     CrossRef
  • Effect of om chanting and yoga nidra on blood pressure and lipid profile in hypertension – A randomized controlled trial
    K. Anjana, R. Archana, J.K. Mukkadan
    Journal of Ayurveda and Integrative Medicine.2022; 13(4): 100657.     CrossRef
  • Effect of yoga intervention on skeletal muscle linked glucose homeostasis in pre-diabetic individuals: Study protocol for a randomized controlled trial
    Supriya Bhalerao, Jayshree Kharche, Shubhangi Harke
    Advances in Integrative Medicine.2022; 9(4): 230.     CrossRef
  • Popular Complementary and Alternative Therapy Methods in Different Conditions
    Akın SÜZER, Nevriye ÜNAL SÜZER, Raziye ŞAVKIN, Nihal BÜKER
    International Journal of Traditional and Complementary Medicine Research.2022; 3(3): 201.     CrossRef
  • Add on Hypoglycemic effect of customized Yoga module in diabetes mellitus: A case report
    KK Resmi, MB Kavita, Gurubasavaraj Yalagachin
    Journal of Ayurveda Case Reports.2022; 5(4): 163.     CrossRef
  • Modern Postural Yoga and the Health-Spirituality-Neoliberalism Nexus
    Matteo Di Placido, Anna Strhan, Stefania Palmisano
    Fieldwork in Religion.2022;[Epub]     CrossRef
  • Metabolic syndrome and possible treatments (consecutive therapies): a literature review
    Jitender Sorout, Sudhanshu Kacker, Neha Saboo
    INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2022; 18(6): 351.     CrossRef
  • Umbilical Cord-Mesenchymal Stem Cell-Conditioned Medium Improves Insulin Resistance in C2C12 Cell
    Kyung-Soo Kim, Yeon Kyung Choi, Mi Jin Kim, Jung Wook Hwang, Kyunghoon Min, Sang Youn Jung, Soo-Kyung Kim, Yong-Soo Choi, Yong-Wook Cho
    Diabetes & Metabolism Journal.2021; 45(2): 260.     CrossRef
  • Yoga as a complementary therapy for metabolic syndrome: A narrative review
    Dastan M. Khoshnaw, Abhijit A. Ghadge
    Journal of Integrative Medicine.2021; 19(1): 6.     CrossRef
  • Effect of yoga on glycemia and lipid parameters in type-2 diabetes: a meta-analysis
    Deep Dutta, Saptarshi Bhattacharya, Meha Sharma, Deepak Khandelwal, Vineet Surana, Sanjay Kalra
    Journal of Diabetes & Metabolic Disorders.2021; 20(1): 349.     CrossRef
  • Effect of Yoga on Glucose Control and Quality of Life in Patients of Prediabetes
    Rajesh Rajput, Karamvir Yadav, Meena Rajput, Jyoti Yadav, Neharika Saini
    Metabolic Syndrome and Related Disorders.2021; 19(8): 417.     CrossRef
  • Effect of long-term Yogic practices in type 2 diabetes mellitus: a single case study
    KetakiH Patil, Vidya Wasnik (Thatere), VijayG Patrikar
    Journal of Indian System of Medicine.2021; 9(2): 135.     CrossRef
  • Effectiveness of Yoga Lifestyle on Lipid Metabolism in a Vulnerable Population—A Community Based Multicenter Randomized Controlled Trial
    Raghuram Nagarathna, Saurabh Kumar, Akshay Anand, Ishwara N. Acharya, Amit Kumar Singh, Suchitra S. Patil, Ramesh H Latha, Purnima Datey, Hongasandra Ramarao Nagendra
    Medicines.2021; 8(7): 37.     CrossRef
  • Yoga for Healthy Aging: Science or Hype?

    Advances in Geriatric Medicine and Research.2021;[Epub]     CrossRef
  • A Prospective Study on Type-2 Diabetic Complications and Efficacy of Integrated Yoga: A Pan India 2017
    Suchitra S. Patil, Nagarathna Raghuram, Amit Singh, S. K. Rajesh, Sabzar Ahmed, Nagendra Hongasandra
    Annals of Neurosciences.2021; 28(1-2): 21.     CrossRef
  • Effects of Yoga Therapy and Walking Therapy in Reducing Blood Sugar Levels on Diabetes Mellitus Patients in the Community
    Wachidah Yuniartika, Agus Sudaryanto, Abi Muhlisin, Dian Hudiyawati, Dimas Ria Angga Pribadi
    Open Access Macedonian Journal of Medical Sciences.2021; 9(E): 906.     CrossRef
  • Yoga nidra practice shows improvement in sleep in patients with chronic insomnia: A randomized controlled trial
    KARUNA DATTA, MANJARI TRIPATHI, MANSI VERMA, DEEPIKA MASIWAL, HRUDA NANDA MALLICK
    The National Medical Journal of India.2021; 34: 143.     CrossRef
  • MANAGEMENT THROUGH AYURVEDIC MEDICATIONS AND LIFESTYLE MODIFICATION (PATHYASEVANA AND YOGASANA) IN A CASE OF POST-COVID COMPLICATION DIABETES MELLITUS (TYPE 2 DM): A SINGLE CASE STUDY
    Prajakta D. Nimje, Vidya Wasnik (Thatere), Sumeeta Jain
    International Ayurvedic Medical Journal.2021; 9(10): 2619.     CrossRef
  • Efficacy of palliative herbal decoction (Darvyadi Kwatha) with lifestyle modification in the management of prediabetes (Prameha): a single-arm clinical trial
    Uttamram Yadav, SantoshK Bhatted
    Journal of Indian System of Medicine.2021; 9(4): 265.     CrossRef
  • Role of yoga as an adjuvant therapy in the management of metabolic syndrome – A randomized control pilot study
    Rajasekaran Balaji, Meena Ramanathan, AnandaBalayogi Bhavanani
    Yoga Mimamsa.2021; 53(2): 116.     CrossRef
  • Effect of an 8-Week Yoga-Based Lifestyle Intervention on Psycho-Neuro-Immune Axis, Disease Activity, and Perceived Quality of Life in Rheumatoid Arthritis Patients: A Randomized Controlled Trial
    Surabhi Gautam, Manoj Kumar, Uma Kumar, Rima Dada
    Frontiers in Psychology.2020;[Epub]     CrossRef
  • Type 2 diabetes mellitus: pathogenesis and genetic diagnosis
    D. Himanshu, Wahid Ali, Mohd Wamique
    Journal of Diabetes & Metabolic Disorders.2020; 19(2): 1959.     CrossRef
  • Prevalence and Awareness of Stroke and Other Comorbidities Associated with Diabetes in Northwest India
    Vivek Podder, Vinod Srivastava, Saurabh Kumar, Raghuram Nagarathna, Madhava Sai Sivapuram, Navneet Kaur, Kanupriya Sharma, Amit Kumar Singh, Neeru Malik, Akshay Anand, Hongasandra R. Nagendra
    Journal of Neurosciences in Rural Practice.2020; 11: 467.     CrossRef
  • Patterns of concomitant use of Ayurveda and conventional anti-diabetic formulations - Experiences at a tertiary care Ayurveda hospital, India
    R Galib, Poonam Dang, Vijay Kumar, Rakesh Rana, Pramod Yadav, PK Prajapati
    AYU (An international quarterly journal of research in Ayurveda).2020; 41(2): 72.     CrossRef
  • A perspective on yoga as a preventive strategy for coronavirus disease 2019
    R Nagarathna, HR Nagendra, Vijaya Majumdar
    International Journal of Yoga.2020; 13(2): 89.     CrossRef
  • Effect of Ayurveda intervention, lifestyle modification and Yoga in prediabetic and type 2 diabetes under the National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS)–AYUSH integration project
    Ramavtar Sharma, VinodKumar Shahi, Shruti Khanduri, Arun Goyal, Suhas Chaudhary, RakeshKumar Rana, Richa Singhal, Narayanam Srikanth, KartarSingh Dhiman
    AYU (An international quarterly journal of research in Ayurveda).2019; 40(1): 8.     CrossRef
  • Type 2 diabetes mellitus, physical activity, yoga and telomere length: A literature review
    Reepa A. Ughreja, Reena A. Ughreja
    Journal of Metabolic Health.2019;[Epub]     CrossRef
Close layer
Bone Metabolism
Regulation of Osteoblast Metabolism by Wnt Signaling
Megan C. Moorer, Ryan C. Riddle
Endocrinol Metab. 2018;33(3):318-330.   Published online August 14, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.318
  • 6,317 View
  • 115 Download
  • 39 Web of Science
  • 38 Crossref
AbstractAbstract PDFPubReader   ePub   

Wnt/β-catenin signaling plays a critical role in the achievement of peak bone mass, affecting the commitment of mesenchymal progenitors to the osteoblast lineage and the anabolic capacity of osteoblasts depositing bone matrix. Recent studies suggest that this evolutionarily-conserved, developmental pathway exerts its anabolic effects in part by coordinating osteoblast activity with intermediary metabolism. These findings are compatible with the cloning of the gene encoding the low-density lipoprotein related receptor-5 (LRP5) Wnt co-receptor from a diabetes-susceptibility locus and the now well-established linkage between Wnt signaling and metabolism. In this article, we provide an overview of the role of Wnt signaling in whole-body metabolism and review the literature regarding the impact of Wnt signaling on the osteoblast's utilization of three different energy sources: fatty acids, glucose, and glutamine. Special attention is devoted to the net effect of nutrient utilization and the mode of regulation by Wnt signaling. Mechanistic studies indicate that the utilization of each substrate is governed by a unique mechanism of control with β-catenin-dependent signaling regulating fatty acid β-oxidation, while glucose and glutamine utilization are β-catenin-independent and downstream of mammalian target of rapamycin complex 2 (mTORC2) and mammalian target of rapamycin complex 1 (mTORC1) activation, respectively. The emergence of these data has provided a new context for the mechanisms by which Wnt signaling influences bone development.

Citations

Citations to this article as recorded by  
  • Aseptic loosening around total joint replacement in humans is regulated by miR-1246 and miR-6089 via the Wnt signalling pathway
    Yi Deng, Kate Phillips, Zhi-Ping Feng, Paul N. Smith, Rachel W. Li
    Journal of Orthopaedic Surgery and Research.2024;[Epub]     CrossRef
  • Cardamonin inhibits osteogenic differentiation by downregulating Wnt/beta‐catenin signaling and alleviates subchondral osteosclerosis in osteoarthritic mice
    Fanding Meng, Pengchong Zhu, Xiaoli Ren, Limei Wang, Dong Ding, Jiangbo Yan, Ying Zhang, Shang‐You Yang, Bin Ning
    Journal of Orthopaedic Research.2024;[Epub]     CrossRef
  • Common Regulators of Lipid Metabolism and Bone Marrow Adiposity in Postmenopausal Women
    Dae-Yong Kim, Seong-Hee Ko
    Pharmaceuticals.2023; 16(2): 322.     CrossRef
  • Novel mutation in LRP5 gene cause rare osteosclerosis: cases studies and literature review
    Dichen Zhao, Lei Sun, Wenbin Zheng, Jing Hu, Bingna Zhou, Ou Wang, Yan Jiang, Weibo Xia, Xiaoping Xing, Mei Li
    Molecular Genetics and Genomics.2023; 298(3): 683.     CrossRef
  • RUNX Family as a Promising Biomarker and a Therapeutic Target in Bone Cancers: A Review on Its Molecular Mechanism(s) behind Tumorigenesis
    Selvaraj Vimalraj, Saravanan Sekaran
    Cancers.2023; 15(12): 3247.     CrossRef
  • FGF19 protects against obesity-induced bone loss by promoting osteogenic differentiation
    Ai Guo, Kai Li, Hong-Chuan Tian, Bai-Long Tao, Qian Xiao, Dian-Ming Jiang
    Biomedicine & Pharmacotherapy.2022; 146: 112524.     CrossRef
  • Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts
    Sarocha Suthon, Jianjian Lin, Rachel S. Perkins, John R. Crockarell, Gustavo A. Miranda-Carboni, Susan A. Krum
    The American Journal of Human Genetics.2022; 109(1): 97.     CrossRef
  • Exposure of primary osteoblasts to combined magnetic and electric fields induced spatiotemporal endochondral ossification characteristic gene- and protein expression profiles
    Klaus H. Dittmann, Claus Mayer, Heribert Stephan, Christin Mieth, Michael Bonin, Beat Lechmann, H. Peter Rodemann
    Journal of Experimental Orthopaedics.2022;[Epub]     CrossRef
  • Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway
    Luyao Li, Afang Li, Li Zhu, Liangying Gan, Li Zuo
    Journal of Orthopaedic Surgery and Research.2022;[Epub]     CrossRef
  • T-cell factor 7L2 is a novel regulator of osteoblast functions that acts in part by modulation of hypoxia signaling
    Subburaman Mohan, Chandrasekhar Kesavan
    American Journal of Physiology-Endocrinology and Metabolism.2022; 322(6): E528.     CrossRef
  • Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications
    Ioannis Akoumianakis, Murray Polkinghorne, Charalambos Antoniades
    Nature Reviews Cardiology.2022; 19(12): 783.     CrossRef
  • Osteoporosis pathogenesis and treatment: existing and emerging avenues
    Bo Liang, George Burley, Shu Lin, Yan-Chuan Shi
    Cellular & Molecular Biology Letters.2022;[Epub]     CrossRef
  • QingreHuoxue decoction protects joint and toe bone morphology and structure in rats with active RA through bidirectional regulation of bone metabolism
    Hui Yang, Zhenyu Wu, Xun Gong, Bo Li, Guangjun Wu, Quan Jiang
    Pharmacological Research - Modern Chinese Medicine.2022; 4: 100156.     CrossRef
  • Regulation of Wnt signaling by non-coding RNAs during osteoblast differentiation
    I. Saranya, R.L. Akshaya, N. Selvamurugan
    Differentiation.2022; 128: 57.     CrossRef
  • Looking at Mountains: Role of Sustained Hypoxia in Regulating Bone Mineral Homeostasis in Relation to Wnt Pathway and Estrogen
    Lijy K. Babu, Dishari Ghosh
    Clinical Reviews in Bone and Mineral Metabolism.2022; 20(1-4): 18.     CrossRef
  • Effect of the Pulsed Electromagnetic Field Treatment in a Rat Model of Senile Osteoporosis In Vivo
    Jun Zhou, Jinling Wang, Mengjian Qu, Xiarong Huang, Linwei Yin, Yang Liao, Fujin Huang, Pengyun Ning, Peirui Zhong, Yahua Zeng
    Bioelectromagnetics.2022; 43(7): 438.     CrossRef
  • Arm race between Rift Valley fever virus and host
    Xiao Wang, Yupei Yuan, Yihan Liu, Leiliang Zhang
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Differential bone metabolism and protein expression in mice fed a high-fat diet versus Daurian ground squirrels following natural pre-hibernation fattening
    Xuli Gao, Shenyang Shen, Qiaohua Niu, Weilan Miao, Yuting Han, Ziwei Hao, Ning An, Yingyu Yang, Yu Zhang, Han Zhang, Kenneth B. Storey, Hui Chang
    Journal of Zhejiang University-SCIENCE B.2022; 23(12): 1042.     CrossRef
  • miR‐142a‐5p promoted osteoblast differentiation via targeting nuclear factor IA
    Hairui Yuan, Mengyue Li, Xue Feng, Endong Zhu, Baoli Wang
    Journal of Cellular Physiology.2021; 236(3): 1810.     CrossRef
  • Serum sclerostin and glucose homeostasis: No association in healthy men. Cross-sectional and prospective data from the EGIR-RISC study
    Jens-Jacob L. Lauterlein, Pernille Hermann, Thomas Konrad, Peter Wolf, Peter Nilsson, Rafael Gabriel Sánchez, Ele Ferrannini, Beverley Balkau, Kurt Højlund, Morten Frost
    Bone.2021; 143: 115681.     CrossRef
  • Energy Metabolism and Ketogenic Diets: What about the Skeletal Health? A Narrative Review and a Prospective Vision for Planning Clinical Trials on this Issue
    Daniela Merlotti, Roberta Cosso, Cristina Eller-Vainicher, Fabio Vescini, Iacopo Chiodini, Luigi Gennari, Alberto Falchetti
    International Journal of Molecular Sciences.2021; 22(1): 435.     CrossRef
  • Therapeutic potential of iron chelators on osteoporosis and their cellular mechanisms
    Jian Zhang, Hai Zhao, Gang Yao, Penghai Qiao, Longfei Li, Shuguang Wu
    Biomedicine & Pharmacotherapy.2021; 137: 111380.     CrossRef
  • Insertion of gallic acid onto chitosan promotes the differentiation of osteoblasts from murine bone marrow-derived mesenchymal stem cells
    Yunok Oh, Chang-Bum Ahn, M.P.C.K. Marasinghe, Jae-Young Je
    International Journal of Biological Macromolecules.2021; 183: 1410.     CrossRef
  • Biological Mechanisms of Paeonoside in the Differentiation of Pre-Osteoblasts and the Formation of Mineralized Nodules
    Kyung-Ran Park, Joon Yeop Lee, Myounglae Cho, Jin Tae Hong, Hyung-Mun Yun
    International Journal of Molecular Sciences.2021; 22(13): 6899.     CrossRef
  • Enamel matrix derivative (EMD) enhances the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs)
    Lu Cheng, Ying Li, Qian Xia, MaoHua Meng, ZhaoYang Ye, ZhengLong Tang, HongChao Feng, Xin Chen, HeLin Chen, Xiao Zeng, Yi Luo, Qiang Dong
    Bioengineered.2021; 12(1): 7033.     CrossRef
  • Synthesized Nanorods Hydroxyapatite by Microwave-Assisted Technology for In Vitro Osteoporotic Bone Regeneration through Wnt/β-Catenin Pathway
    Nadia Z. Shaban, Marwa Y. Kenawy, Nahla A. Taha, Mona M. Abd El-Latif, Doaa A. Ghareeb
    Materials.2021; 14(19): 5823.     CrossRef
  • Chlorogenic Acids Inhibit Adipogenesis: Implications of Wnt/β-Catenin Signaling Pathway
    Mengting Liu, Jian Qin, Jing Cong, Yubin Yang, Muhittin Yurekli
    International Journal of Endocrinology.2021; 2021: 1.     CrossRef
  • Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation
    Jelena Krstić, Slavko Mojsilović, Sonja S Mojsilović, Juan F Santibanez
    World Journal of Stem Cells.2021; 13(11): 1699.     CrossRef
  • Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation
    Jelena Krstić, Slavko Mojsilović, Sonja S Mojsilović, Juan F Santibanez
    World Journal of Stem Cells.2021; 13(11): 1696.     CrossRef
  • The Skeletal Cellular and Molecular Underpinning of the Murine Hindlimb Unloading Model
    Priyanka Garg, Maura Strigini, Laura Peurière, Laurence Vico, Donata Iandolo
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • Changes in Serum Dickkopf-1, RANK Ligand, Osteoprotegerin, and Bone Mineral Density after Allogeneic Hematopoietic Stem Cell Transplantation Treatment
    Eunhee Jang, Jeonghoon Ha, Ki-Hyun Baek, Moo Il Kang
    Endocrinology and Metabolism.2021; 36(6): 1211.     CrossRef
  • Amyloid β peptide promotes bone formation by regulating Wnt/β‐catenin signaling and the OPG/RANKL/RANK system
    Bu Yang, Shangfu Li, Zheng Chen, Feng Feng, Lei He, Bin Liu, Tianwei He, Xuan Wang, Ruiqiang Chen, Zihao Chen, Peigen Xie, Limin Rong
    The FASEB Journal.2020; 34(3): 3583.     CrossRef
  • Evaluation of chondrogenesis and osteogenesis via Wnt/β-Catenin, S100 immunoexpression and histomorphometry in fetal rats following maternal uterine artery ligation
    Serap USLU, Gülperi ÖKTEM, Fatih OLTULU, Kenan DEMİR, Arzu İRBAN, Gülçin BAŞDEMİR, Ümit İNCE, Ayşegül UYSAL
    Ege Tıp Dergisi.2020; 59(1): 39.     CrossRef
  • Dual Effects of Lipid Metabolism on Osteoblast Function
    Nathalie S. Alekos, Megan C. Moorer, Ryan C. Riddle
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Mesenchymal stem cells: amazing remedies for bone and cartilage defects
    Parisa Kangari, Tahereh Talaei-Khozani, Iman Razeghian-Jahromi, Mahboobeh Razmkhah
    Stem Cell Research & Therapy.2020;[Epub]     CrossRef
  • Blue Mussel-Derived Peptides PIISVYWK and FSVVPSPK Trigger Wnt/β-Catenin Signaling-Mediated Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells
    Yunok Oh, Chang-Bum Ahn, Jae-Young Je
    Marine Drugs.2020; 18(10): 510.     CrossRef
  • Interleukin-35 stimulates tumor necrosis factor-α activated osteoblasts differentiation through Wnt/β-catenin signaling pathway in rheumatoid arthritis
    Yuxuan Li, Lin Yuan, Shenyi Jiang, Siyan Liu, Liping Xia, Hui Shen, Jing Lu
    International Immunopharmacology.2019; 75: 105810.     CrossRef
  • The roles of Orai and Stim in bone health and disease
    Lisa J. Robinson, Harry C. Blair, John B. Barnett, Jonathan Soboloff
    Cell Calcium.2019; 81: 51.     CrossRef
Close layer
Bone Metabolism
Recent Topics in Fibrodysplasia Ossificans Progressiva
Takenobu Katagiri, Sho Tsukamoto, Yutaka Nakachi, Mai Kuratani
Endocrinol Metab. 2018;33(3):331-338.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.331
  • 4,909 View
  • 77 Download
  • 19 Web of Science
  • 22 Crossref
AbstractAbstract PDFPubReader   ePub   

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease that is characterized by the formation of heterotopic bone tissues in soft tissues, such as skeletal muscle, ligament, and tendon. It is difficult to remove such heterotopic bones via internal medicine or invasive procedures. The identification of activin A receptor, type I (ACVR1)/ALK2 gene mutations associated with FOP has allowed the genetic diagnosis of FOP. The ACVR1/ALK2 gene encodes the ALK2 protein, which is a transmembrane kinase receptor in the transforming growth factor-β family. The relevant mutations activate intracellular signaling in vitro and induce heterotopic bone formation in vivo. Activin A is a potential ligand that activates mutant ALK2 but not wild-type ALK2. Various types of small chemical and biological inhibitors of ALK2 signaling have been developed to establish treatments for FOP. Some of these are in clinical trials in patients with FOP.

Citations

Citations to this article as recorded by  
  • How Activin A Became a Therapeutic Target in Fibrodysplasia Ossificans Progressiva
    Dushyanth Srinivasan, Martin Arostegui, Erich J. Goebel, Kaitlin N. Hart, Senem Aykul, John B. Lees-Shepard, Vincent Idone, Sarah J. Hatsell, Aris N. Economides
    Biomolecules.2024; 14(1): 101.     CrossRef
  • Fibrodysplasia Ossificans Progressiva Mimics Generalized Dystonia Disorder: A Case Report
    Seraj Makkawi, Osama Khojah, Reema Abualnaja, Abdulaziz Qashqari, Nawaf A Alahmadi, Abdullatif G Bshnaq, Abdulrahman Alharthi, Hashem H Al-Hashemi, Aiman M Shawli
    Cureus.2023;[Epub]     CrossRef
  • Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites
    Hiroyuki Yamazaki
    Journal of Natural Medicines.2022; 76(1): 1.     CrossRef
  • A Novel De Novo Frameshift Pathogenic Variant in the FAM111B Resulting in Progressive Osseous Heteroplasia Phenotype
    Anna Ryabets-Lienhard, Panadeekarn Panjawatanan, Kyle Vogt, Jianling Ji, Senta Georgia, Pisit Pitukcheewanont
    Calcified Tissue International.2022; 112(4): 518.     CrossRef
  • Inhibitory effects of sesquiterpene lactones from the Indonesian marine sponge Lamellodysidea cf. herbacea on bone morphogenetic protein-induced osteoblastic differentiation
    Satoshi Ohte, Hiroyuki Yamazaki, Ohgi Takahashi, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Delfly B. Abdjul, Wilmar Maarisit, Magie M. Kapojos, Huiping Zhang, Fumiaki Hayashi, Michio Namikoshi, Takenobu Katagiri, Hiroshi Tomoda, Ryuji Uchid
    Bioorganic & Medicinal Chemistry Letters.2021; 35: 127783.     CrossRef
  • Genomic Context and Mechanisms of the ACVR1 Mutation in Fibrodysplasia Ossificans Progressiva
    Roberto Ravazzolo, Renata Bocciardi
    Biomedicines.2021; 9(2): 154.     CrossRef
  • New insights on fibrodysplasia ossificans progressiva: discussion of an autoptic case report and brief literature review
    Vittorio Bolcato, Claudia Carelli, Silvia Damiana Visonà, Marcella Reguzzoni, Maja Di Rocco, Alessandra Radogna, Livio Pietro Tronconi, Matteo Moretti
    Intractable & Rare Diseases Research.2021; 10(2): 136.     CrossRef
  • Accumulated Knowledge of Activin Receptor-Like Kinase 2 (ALK2)/Activin A Receptor, Type 1 (ACVR1) as a Target for Human Disorders
    Takenobu Katagiri, Sho Tsukamoto, Mai Kuratani
    Biomedicines.2021; 9(7): 736.     CrossRef
  • Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases
    Wojciech Michał Ciszewski, Marta Ewelina Wawro, Izabela Sacewicz-Hofman, Katarzyna Sobierajska
    International Journal of Molecular Sciences.2021; 22(21): 11607.     CrossRef
  • Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate
    Juliana Souza Vieira, Emanuelle Juliana Cunha, Juliana Feltrin de Souza, Luis Henrique Koeler Chaves, Jessica Lakes de Souza, Allan Fernando Giovanini
    World Journal of Experimental Medicine.2020; 10(1): 1.     CrossRef
  • ALK2: A Therapeutic Target for Fibrodysplasia Ossificans Progressiva and Diffuse Intrinsic Pontine Glioma
    Katsuhiko Sekimata, Tomohiro Sato, Naoki Sakai
    Chemical and Pharmaceutical Bulletin.2020; 68(3): 194.     CrossRef
  • Role of Signal Transduction Pathways and Transcription Factors in Cartilage and Joint Diseases
    Riko Nishimura, Kenji Hata, Yoshifumi Takahata, Tomohiko Murakami, Eriko Nakamura, Maki Ohkawa, Lerdluck Ruengsinpinya
    International Journal of Molecular Sciences.2020; 21(4): 1340.     CrossRef
  • Design of primers for direct sequencing of nine coding exons in the human ACVR1 gene
    Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
    Bone.2020; 138: 115469.     CrossRef
  • A new diketopiperazine-like inhibitor of bone morphogenetic protein-induced osteoblastic differentiation produced by marine-derived Aspergillus sp. BFM-0085
    Satoshi Ohte, Takehiro Shiokawa, Nobuhiro Koyama, Takenobu Katagiri, Chiaki Imada, Hiroshi Tomoda
    The Journal of Antibiotics.2020; 73(8): 554.     CrossRef
  • Penicillic Acid Congener, a New Inhibitor of BMP-Induced Alkaline Phosphatase Activity in Myoblasts, Produced by the Fungus Penicillium sp. BF-0343
    Nobuhiro Koyama, Yasuhiro Otoguro, Satoshi Ohte, Takenobu Katagiri, Hiroshi Tomoda
    Natural Product Communications.2020; 15(9): 1934578X2094265.     CrossRef
  • Fibrodysplasia ossificans progressiva: current concepts from bench to bedside
    Arun-Kumar Kaliya-Perumal, Tom J. Carney, Philip W. Ingham
    Disease Models & Mechanisms.2020;[Epub]     CrossRef
  • Clinical Aspects and Current Therapeutic Approaches for FOP
    Hiroshi Kitoh
    Biomedicines.2020; 8(9): 325.     CrossRef
  • Screening for Small Molecule Inhibitors of BMP-Induced Osteoblastic Differentiation from Indonesian Marine Invertebrates
    Hiroyuki Yamazaki, Satoshi Ohte, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Delfly B. Abdjul, Wilmar Maarisit, Magie M. Kapojos, Michio Namikoshi, Takenobu Katagiri, Hiroshi Tomoda, Ryuji Uchida
    Marine Drugs.2020; 18(12): 606.     CrossRef
  • Propranolol and ascorbic acid in control of fibrodysplasia ossificans progressiva flare-ups due to accidental falls
    Durval Batista Palhares, Deborah Ribeiro Nascimento, Marilene Garcia Palhares, Suzana Lopes Bomfim Balaniuc, Liane de Rosso Giuliani, Paula Cristhina Niz Xavier, José Mauro Goulart Brum, Fabiana Alves, Francisco Oliveira Vieira, Elaine Maria Souza-Fagunde
    Intractable & Rare Diseases Research.2019; 8(1): 24.     CrossRef
  • Late-onset fibrodysplasia ossificans progressiva with atypical presentation: A case report
    Conor M. Cunningham, J. Matthew Royeca, Samuel W. King, Hemant Pandit
    Case Reports in Women's Health.2019; 23: e00134.     CrossRef
  • Fibrodysplasia ossificans progressiva: lessons learned from a rare disease
    Gulseren Akyuz, Kardelen Gencer-Atalay, Pinar Ata
    Current Opinion in Pediatrics.2019; 31(6): 716.     CrossRef
  • Discovery of Heterotopic Bone-Inducing Activity in Hard Tissues and the TGF-β Superfamily
    Takenobu Katagiri, Sho Tsukamoto, Yutaka Nakachi, Mai Kuratani
    International Journal of Molecular Sciences.2018; 19(11): 3586.     CrossRef
Close layer
Bone Metabolism
Skeletal Fragility in Type 2 Diabetes Mellitus
Jakob Starup-Linde, Katrine Hygum, Bente Lomholt Langdahl
Endocrinol Metab. 2018;33(3):339-351.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.339
  • 5,669 View
  • 100 Download
  • 26 Web of Science
  • 23 Crossref
AbstractAbstract PDFPubReader   ePub   

Type 2 diabetes (T2D) is associated with an increased risk of fracture, which has been reported in several epidemiological studies. However, bone mineral density in T2D is increased and underestimates the fracture risk. Common risk factors for fracture do not fully explain the increased fracture risk observed in patients with T2D. We propose that the pathogenesis of increased fracture risk in T2D is due to low bone turnover caused by osteocyte dysfunction resulting in bone microcracks and fractures. Increased levels of sclerostin may mediate the low bone turnover and may be a novel marker of increased fracture risk, although further research is needed. An impaired incretin response in T2D may also affect bone turnover. Accumulation of advanced glycosylation endproducts may also impair bone strength. Concerning antidiabetic medication, the glitazones are detrimental to bone health and associated with increased fracture risk, and the sulphonylureas may increase fracture risk by causing hypoglycemia. So far, the results on the effect of other antidiabetics are ambiguous. No specific guideline for the management of bone disease in T2D is available and current evidence on the effects of antiosteoporotic medication in T2D is sparse. The aim of this review is to collate current evidence of the pathogenesis, detection and treatment of diabetic bone disease.

Citations

Citations to this article as recorded by  
  • Effects of Exogenous GIP and GLP-2 on Bone Turnover in Individuals With Type 2 Diabetes
    Kirsa Skov-Jeppesen, Charlotte B Christiansen, Laura S Hansen, Johanne A Windeløv, Nora Hedbäck, Lærke S Gasbjerg, Morten Hindsø, Maria S Svane, Sten Madsbad, Jens J Holst, Mette M Rosenkilde, Bolette Hartmann
    The Journal of Clinical Endocrinology & Metabolism.2024;[Epub]     CrossRef
  • The association between type 2 diabetes mellitus/prediabetes status and femoral neck bone mineral density in old adults
    Bo Wang, Chenhao Shi, Zhongxin Zhu
    Journal of Orthopaedic Surgery.2024;[Epub]     CrossRef
  • Bone parameters in T1D and T2D assessed by DXA and HR-pQCT – A cross-sectional study: The DIAFALL study
    Nicklas Højgaard-hessellund Rasmussen, Jakob Dal, Annika Vestergaard Kvist, Joop P. van den Bergh, Morten Hasselstrøm Jensen, Peter Vestergaard
    Bone.2023; 172: 116753.     CrossRef
  • Clinical risk factors analysis and prevention of osteoporosis as a complication of diabetes
    Jiaojiao Wang, Hang Li, Haihong Zhu, Xinyan Xie, Qiyue Zheng, Jian Qu, Haiyan Yuan, Ting Liu, Qiong Lu
    International Journal of Diabetes in Developing Countries.2023;[Epub]     CrossRef
  • Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A Post Hoc Analysis of the U-TURN Trial
    JULIE ABILDGAARD, METTE YUN JOHANSEN, KIRSA SKOV-JEPPESEN, LARS BO ANDERSEN, KRISTIAN KARSTOFT, KATRINE BAGGE HANSEN, BOLETTE HARTMANN, JENS JUUL HOLST, BENTE KLARLUND PEDERSEN, MATHIAS RIED-LARSEN
    Medicine & Science in Sports & Exercise.2022; 54(1): 38.     CrossRef
  • The Effects of 12-Weeks Whey Protein Supplements on Markers of Bone Turnover in Adults With Abdominal Obesity – A Post Hoc Analysis
    Rasmus Fuglsang-Nielsen, Elin Rakvaag, Peter Vestergaard, Kjeld Hermansen, Søren Gregersen, Jakob Starup-Linde
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Diabetes and osteoporosis – Treating two entities: A challenge or cause for concern?
    Nicklas H. Rasmussen, Peter Vestergaard
    Best Practice & Research Clinical Rheumatology.2022; 36(3): 101779.     CrossRef
  • Do proximal hip geometry, trabecular microarchitecture, and prevalent vertebral fractures differ in postmenopausal women with type 2 diabetes mellitus? A cross-sectional study from a teaching hospital in southern India
    J. Paul, V. Devarapalli, J. T. Johnson, K. E. Cherian, F. K. Jebasingh, H. S. Asha, N. Kapoor, N. Thomas, T. V. Paul
    Osteoporosis International.2021; 32(8): 1585.     CrossRef
  • Investigation of Mechanical, Material, and Compositional Determinants of Human Trabecular Bone Quality in Type 2 Diabetes
    Praveer Sihota, Ram Naresh Yadav, Ruban Dhaliwal, Jagadeesh Chandra Bose, Vandana Dhiman, Deepak Neradi, Shailesh Karn, Sidhartha Sharma, Sameer Aggarwal, Vijay G Goni, Vishwajeet Mehandia, Deepak Vashishth, Sanjay Kumar Bhadada, Navin Kumar
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(5): e2271.     CrossRef
  • The clinical application of high-resolution peripheral computed tomography (HR-pQCT) in adults: state of the art and future directions
    J.P. van den Bergh, P. Szulc, A.M. Cheung, M. Bouxsein, K. Engelke, R. Chapurlat
    Osteoporosis International.2021; 32(8): 1465.     CrossRef
  • Characteristics of bone metabolism in postmenopausal women with newly diagnosed type 2 diabetes mellitus
    Huijuan Li, Yuhua Wen, Peipei Liu, Liya Zhang, Xiaoya Zhang, Yichen Liu, Bin Ma, Haidong Kuang, Jianxin Wang, Lige Song
    Clinical Endocrinology.2021; 95(3): 430.     CrossRef
  • Associations between markers of glucose metabolism and bone measures among diabetic and non-diabetic adults
    Kelly Virecoulon Giudici, Natasha Aparecida Grande de França, Bárbara Santarosa Emo Peters, Regina Mara Fisberg, Lígia Araújo Martini
    Journal of Diabetes & Metabolic Disorders.2021; 20(2): 1247.     CrossRef
  • Diabetes increases the risk of bone fractures in patients on kidney replacement therapy: A Danish national cohort study
    Sabina Chaudhary Hauge, Bo Abrahamsen, Gunnar Gislason, Jonas Bjerring Olesen, Kristine Hommel, Ditte Hansen
    Bone.2021; 153: 116158.     CrossRef
  • Comparison of the Effects of Various Antidiabetic Medication on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus
    Jeonghoon Ha, Yejee Lim, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Ho Song, Seung Hyun Ko, Moo Il Kang, Sung Dae Moon, Ki-Hyun Baek
    Endocrinology and Metabolism.2021; 36(4): 895.     CrossRef
  • Can fingernail quality predict bone damage in Type 2 diabetes mellitus? a pilot study
    Praveer Sihota, Rimesh Pal, Ram Naresh Yadav, Deepak Neradi, Shailesh Karn, Vijay G. Goni, Siddhartha Sharma, Vishwajeet Mehandia, Sanjay Kumar Bhadada, Navin Kumar, Sudhaker D. Rao, Subburaman Mohan
    PLOS ONE.2021; 16(9): e0257955.     CrossRef
  • Do patients with diabetes have an increased risk of impaired fracture healing? A systematic review and meta‐analysis
    Zi‐chuan Ding, Wei‐nan Zeng, Xiao Rong, Zhi‐min Liang, Zong‐ke Zhou
    ANZ Journal of Surgery.2020; 90(7-8): 1259.     CrossRef
  • Association between abdominal obesity and fragility fractures among elderly Israeli women
    Orit Ofir, Assaf Buch, Vanessa Rouach, Rebecca Goldsmith, Naftali Stern, Efrat Monsonego-Ornan
    Aging Clinical and Experimental Research.2020; 32(8): 1459.     CrossRef
  • Diabetes and fractures: new evidence of atypical femoral fractures?
    N.H. Rasmussen, J. Dal, F. de Vries, J.P. van den Bergh, M.H. Jensen, P. Vestergaard
    Osteoporosis International.2020; 31(3): 447.     CrossRef
  • Association of glycaemic variables with trabecular bone score in post‐menopausal women with type 2 diabetes mellitus
    B. Depczynski, P. Y. Liew, C. White
    Diabetic Medicine.2020; 37(9): 1545.     CrossRef
  • Understanding Bone Disease in Patients with Diabetic Kidney Disease: a Narrative Review
    Sabina Chaudhary Hauge, Morten Frost, Ditte Hansen
    Current Osteoporosis Reports.2020; 18(6): 727.     CrossRef
  • Falls and Fractures in Diabetes—More than Bone Fragility
    Nicklas Højgaard Rasmussen, Jakob Dal
    Current Osteoporosis Reports.2019; 17(3): 147.     CrossRef
  • Role of Metformin on Osteoblast Differentiation in Type 2 Diabetes
    Lin Jiating, Ji Buyun, Zhang Yinchang
    BioMed Research International.2019; 2019: 1.     CrossRef
  • An update on therapies for the treatment of diabetes-induced osteoporosis
    Sahar Mohsin, May MYH Baniyas, Reem SMH AlDarmaki, Kornélia Tekes, Huba Kalász, Ernest A. Adeghate
    Expert Opinion on Biological Therapy.2019; 19(9): 937.     CrossRef
Close layer
Editorial
Adrenal gland
Update on the Aldosterone Resolution Score and Lateralization in Patients with Primary Aldosteronism
Eun-Hee Cho
Endocrinol Metab. 2018;33(3):352-354.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.352
  • 3,125 View
  • 32 Download
PDFPubReader   ePub   
Close layer
Original Articles
Clinical Study
Factors Associated with Resolution of Hypertension after Adrenalectomy in Patients with Primary Aldosteronism
Wann Jia Loh, Dawn Shao Ting Lim, Lih Ming Loh, Peng Chin Kek
Endocrinol Metab. 2018;33(3):355-363.   Published online August 14, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.355
  • 3,899 View
  • 48 Download
  • 8 Web of Science
  • 8 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

The aim of this study was to investigate the factors associated with resolution of hypertension after adrenalectomy in patients with primary aldosteronism. A secondary aim was to describe our use of the contralateral ratio in adrenal venous sampling (AVS) in the setting of suboptimal successful cannulation rates.

Methods

A retrospective review of patients who underwent AVS followed by unilateral adrenalectomy for primary aldosteronism was performed.

Results

Complete resolution of hypertension and hypokalemia was seen in 17 of 40 patients (42.5%), while a clinical improvement in hypertension was seen in 38 of 40 (95%). Shorter duration of hypertension, mean aldosteronoma resolution score (ARS), and a high ARS of 3 to 5 were associated with resolution of hypertension after adrenalectomy (P=0.02, P=0.02, and P=0.004, respectively). Of the individual components of ARS, only a duration of hypertension of ≤6 years was associated with resolution of hypertension after adrenalectomy (P=0.03).

Conclusion

A shorter duration of hypertension was significantly associated with resolution of hypertension after adrenalectomy in patients with primary aldosteronism.

Citations

Citations to this article as recorded by  
  • Clinical and biochemical outcomes after adrenalectomy for primary aldosteronism in tertiary and quaternary referral centers: data from SOPRANO study
    Luigi Marzano, Claudio Ronco
    Hypertension Research.2024; 47(3): 721.     CrossRef
  • Catheter-based adrenal ablation: an alternative therapy for patients with aldosterone-producing adenoma
    Fang Sun, Xiaoli Liu, Hexuan Zhang, Xunmei Zhou, Zhigang Zhao, Hongbo He, Zhencheng Yan, Yingsha Li, Qiang Li, Yaoming Li, Jun Jiang, Zhiming Zhu, Hongyun Miao, Zhiyong Li, Ping Wei, Min Long, Xiaoli Chen, Xiaoyun Fan, Wuquan Deng, Yangjie He, Qingbin Lia
    Hypertension Research.2023; 46(1): 91.     CrossRef
  • Prognostic models to predict complete resolution of hypertension after adrenalectomy in primary aldosteronism: A systematic review and meta‐analysis
    Luigi Marzano, Amir Kazory, Faeq Husain‐Syed, Claudio Ronco
    Clinical Endocrinology.2023; 99(1): 17.     CrossRef
  • Long-term outcome success after operative treatment for primary aldosteronism
    Omar Picado, Bryan W. Whitfield, Zahra F. Khan, Mohammed Jeraq, Josefina C. Farrá, John I. Lew
    Surgery.2021; 169(3): 528.     CrossRef
  • Outcomes of Adrenalectomy and the Aldosteronoma Resolution Score in the Black and Hispanic Population
    Gustavo Romero‐Velez, Amanda M. Laird, Manuel E. Barajas, Mauricio Sierra‐Salazar, Miguel F. Herrera, Steven K. Libutti, Michael K. Parides, Xavier Pereira, John C. McAuliffe
    World Journal of Surgery.2021; 45(5): 1475.     CrossRef
  • Comparison of cystatin C-based and creatinine-based glomerular filtration rate in the prediction of postoperative residual hypertension in aldosterone-producing adenoma patients after adrenalectomy
    Ching-Way Chen, Cheng-Hsuan Tsai, Chi-Sheng Hung, I-Jung Tsai, Yu-Wei Chiu, Chin-Cheng Chang, Kao-Lang Liu, Shih-Cheng Liao, Vin-Cent Wu, Yen-Hung Lin
    Clinica Chimica Acta.2021; 520: 147.     CrossRef
  • Long-term blood pressure outcomes of patients with adrenal venous sampling-proven unilateral primary aldosteronism
    Xu Meng, Wen-Jun Ma, Xiong-Jing Jiang, Pei-Pei Lu, Ying Zhang, Peng Fan, Jun Cai, Hui-Min Zhang, Lei Song, Hai-Ying Wu, Xian-Liang Zhou, Ying Lou
    Journal of Human Hypertension.2020; 34(6): 440.     CrossRef
  • Update on the Aldosterone Resolution Score and Lateralization in Patients with Primary Aldosteronism
    Eun-Hee Cho
    Endocrinology and Metabolism.2018; 33(3): 352.     CrossRef
Close layer
Clinical Study
Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients
Ji Sun Nam, Jung Woo Han, Sang Bae Lee, Ji Hong You, Min Jin Kim, Shinae Kang, Jong Suk Park, Chul Woo Ahn
Endocrinol Metab. 2018;33(3):364-371.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.364
  • 3,480 View
  • 49 Download
  • 7 Web of Science
  • 6 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients.

Methods

Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes.

Results

Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion.

Conclusion

Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism.

Citations

Citations to this article as recorded by  
  • Decoding type 2 diabetes mellitus genetic risk variants in Pakistani Pashtun ethnic population using the nascent whole exome sequencing and MassARRAY genotyping: A case-control association study
    Asif Jan, Zakiullah, Sajid Ali, Basir Muhammad, Amina Arshad, Yasar Shah, Haji Bahadur, Hamayun Khan, Fazli Khuda, Rani Akbar, Kiran Ijaz, Giuseppe Novelli
    PLOS ONE.2023; 18(1): e0281070.     CrossRef
  • Silencing LncRNA PVT1 Reverses High Glucose-Induced Regulation of the High Expression of PVT1 in HRMECs by Targeting miR-128-3p
    Xuyang Wang, Wangling Chen, Wei Lao, Yunxin Chen
    Hormone and Metabolic Research.2022; 54(02): 119.     CrossRef
  • Association of CAPN10 (SNP-19) genetic polymorphism and obesity with T2DM: a study on Bengali Hindu caste population
    Pranabesh Sarkar, Diptendu Chatterjee, Arup Ratan Bandyopadhyay
    International Journal of Diabetes in Developing Countries.2021; 41(1): 37.     CrossRef
  • Association of Candidate Gene Polymorphism with Metabolic Syndrome among Mongolian Subjects: A Case-Control Study
    Ariunbold Chuluun-Erdene, Orgil Sengeragchaa, Tsend-Ayush Altangerel, Purevjal Sanjmyatav, Batnaran Dagdan, Solongo Battulga, Lundiamaa Enkhbat, Nyamjav Byambasuren, Munkhzol Malchinkhuu, Munkhtstetseg Janlav
    Medical Sciences.2020; 8(3): 38.     CrossRef
  • Meta-analysis of the association between adiponectin SNP 45, SNP 276, and type 2 diabetes mellitus
    Yuwei Dong, Gongping Huang, Xin Wang, Zhaoming Chu, Jingzhi Miao, Houwen Zhou, Mingqing Xu
    PLOS ONE.2020; 15(10): e0241078.     CrossRef
  • Association of three SNPs in adiponectin gene with lipid traits of Tianzhu Black Muscovy (Cairina moschata)
    Yuan-Yu Qin, Yi-Yu Zhang, Hua-Lun Luo, Lei Wu
    Molecular Biology Reports.2019; 46(1): 325.     CrossRef
Close layer
Clinical Study
Iodine Status in Filipino Women of Childbearing Age
Michael E. Serafico, Joselita Rosario C. Ulanday, Marites V. Alibayan, Glen Melvin P. Gironella, Leah A. Perlas
Endocrinol Metab. 2018;33(3):372-379.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.372
  • 4,193 View
  • 57 Download
  • 6 Web of Science
  • 7 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Iodine deficiency (ID) has become a concern not only among pregnant women, but in women of childbearing age as well. In fact, a recent report suggested that women with moderate to severe ID may experience a significantly longer time to conceive. This study aimed to investigate iodine status in Filipino women of childbearing age.

Methods

The iodine status of 6,194 Filipino women aged 15 to 45 years old was assessed through urinary iodine analysis. A casual spot urine sample was collected from women in households participating in the eighth National Nutrition Survey conducted by the Food and Nutrition Research Institute. The sample was analyzed using ammonium persulfate digestion followed by the Sandell-Kolthoff colorimetric reaction. A median urinary iodine concentration (UIC) of less than 100 µg/L was used to define ID.

Results

The median UIC was 123 µg/L, indicative of adequate iodine nutrition; however, 21.5% of participants had a UIC below 50 µg/L. The median UIC of women who lived in urban areas (142 µg/L), belonged to the middle to richest class (>124 µg/L), had reached a college education (136 µg/L), and used iodized salt (15 ppm and above; 148 to 179 µg/L) reflected adequate iodine nutrition. ID was found to have been eliminated in the regions of Central Luzon, Eastern Visayas, Calabarzon, Mimaropa, and the National Capital, while mild ID was identified in Western Visayas, Southern and Western Mindanao, and in the Autonomous Region in Muslim Mindanao.

Conclusion

Pockets of ID among women of childbearing age exist in the Philippines. Proper information through education and the use of adequately iodized salt are key measures for improving the iodine status of the studied population.

Citations

Citations to this article as recorded by  
  • Adequate iodine nutrition and higher salt intake in Chinese adults aged 18–59 years recommended by international organizations
    Diqun Chen, Ying Ye, Ying Lan, Meng He, Jiani Wu, Lijin Wang, Zhihui Chen
    Scientific Reports.2024;[Epub]     CrossRef
  • Burden and trends of iodine deficiency in Asia from 1990 to 2019
    R. Wei, Z. Wang, X. Zhang, X. Wang, Y. Xu, Q. Li
    Public Health.2023; 222: 75.     CrossRef
  • The Iodine Status and Prevalence of Thyroid Disorders Among Women of Childbearing Age in China: National Cross-sectional Study
    Yongze Li, Zhongyan Shan, Weiping Teng
    Endocrine Practice.2021; 27(10): 1028.     CrossRef
  • Female Fertility and the Nutritional Approach: The Most Essential Aspects
    Kinga Skoracka, Alicja Ewa Ratajczak, Anna Maria Rychter, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
    Advances in Nutrition.2021; 12(6): 2372.     CrossRef
  • Establishing reference intervals for urine and serum iodine levels: A nationwide multicenter study of a euthyroid Chinese population
    Songlin Yu, Danchen Wang, Xinqi Cheng, Qiong Zhang, Mingxue Wang, Haipeng Guo, Benzhang Yu, Xiuming Zhang, Liangyu Xia, Dandan Sun, Qian Cheng, Pengchang Li, Yicong Yin, Chaochao Ma, Li'an Hou, Yutong Zou, Honglei Li, Dandan Li, Ling Qiu, Kiyoshi Ichihara
    Clinica Chimica Acta.2020; 502: 34.     CrossRef
  • Response: Iodine Status in Filipino Women of Childbearing Age (Endocrinol Metab 2018;33:372-9, Michael E. Serafico et al.)
    Michael E. Serafico
    Endocrinology and Metabolism.2018; 33(4): 495.     CrossRef
  • Letter: Iodine Status in Filipino Women of Childbearing Age (Endocrinol Metab 2018;33:372-9, Michael E. Serafico et al.)
    Zheng Feei Ma
    Endocrinology and Metabolism.2018; 33(4): 493.     CrossRef
Close layer
Clinical Study
Genetic Analysis of CLCN7 in an Old Female Patient with Type II Autosomal Dominant Osteopetrosis
Seon Young Kim, Younghak Lee, Yea Eun Kang, Ji Min Kim, Kyong Hye Joung, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Bon Jeong Ku, Minho Shong, Hyon-Seung Yi
Endocrinol Metab. 2018;33(3):380-386.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.380
  • 4,097 View
  • 57 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Type II autosomal dominant osteopetrosis (ADO II) is a rare genetically heterogeneous disorder characterized by osteosclerosis and increased bone mass, predominantly involving spine, pelvis, and skull. It is closely related to functional defect of osteoclasts caused by chloride voltage-gated channel 7 (CLCN7) gene mutations. In this study, we aimed to identify the pathogenic mutation in a Korean patient with ADO II using whole exome sequencing.

Methods

We evaluated the clinical, biochemical, and radiographic analysis of a 68-year-old woman with ADO II. We also performed whole exome sequencing to identify pathogenic mutation of a rare genetic disorder of the skeleton. Moreover, a polymorphism phenotyping program, Polymorphism Phenotyping v2 (PolyPhen-2), was used to assess the effect of the identified mutation on protein function.

Results

Whole exome sequencing using peripheral leukocytes revealed a heterozygous c.296A>G missense mutation in the CLCN7 gene. The mutation was also confirmed using Sanger sequencing. The mutation c.296A>G was regarded to have a pathogenic effect by PolyPhen-2 software.

Conclusion

We detect a heterozygous mutation in CLCN7 gene of a patient with ADO II, which is the first report in Korea. Our present findings suggest that symptoms and signs of ADO II patient having a c.296A>G mutation in CLCN7 may appear at a very late age. The present study would also enrich the database of CLCN7 mutations and improve our understanding of ADO II.

Citations

Citations to this article as recorded by  
  • Autosomal dominant osteopetrosis type II resulting from a de novo mutation in the CLCN7 gene: A case report
    Xiu-Li Song, Li-Yuan Peng, Dao-Wen Wang, Hong Wang
    World Journal of Clinical Cases.2022; 10(20): 6936.     CrossRef
  • Magnetic resonance findings in a Cavalier King Charles spaniel with osteopetrosis, Chiari‐like malformation and syringomyelia
    Ricardo Fernandes, C J Jordan, Colin Driver
    Veterinary Record Case Reports.2019;[Epub]     CrossRef
Close layer
Clinical Study
Effect of Dapagliflozin on Alanine Aminotransferase Improvement in Type 2 Diabetes Mellitus with Non-alcoholic Fatty Liver Disease
Dug-Hyun Choi, Chan-Hee Jung, Ji-Oh Mok, Chul-Hee Kim, Sung-Koo Kang, Bo-Yeon Kim
Endocrinol Metab. 2018;33(3):387-394.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.387
  • 5,238 View
  • 105 Download
  • 36 Web of Science
  • 34 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are expected to improve the liver function of patients with non-alcoholic fatty liver disease (NAFLD) combined type 2 diabetes mellitus (T2DM) by its characteristic mechanism. This study was designed to investigate the effect of dapagliflozin, one of the SGLT2i, on the liver function of T2DM with NAFLD when combined with metformin.

Methods

Among patients who received dual oral hypoglycemic agents within the 3 months of diagnosing NAFLD, patients who had abnormal alanine aminotransferase (ALT) level (>40 IU/L) were included. Patients were divided into two groups: metformin+dapagliflozin group and metformin+dipeptidyl peptidase-4 inhibitors (DPP4i) group. Demographic data, biochemical data and the clinical and treatment histories of all patients were reviewed.

Results

A total of 102 patients were included (dapagliflozin group, n=50; DPP4i group, n=52). Dapagliflozin group showed more weight loss and more ALT decline than DPP4i group (−2.9 kg vs. −0.4 kg, P=0.005; −21.1 U/L vs. −9.5 U/L, P=0.008, respectively) and the proportion of patients with ALT normalization after treatment was also significantly higher in the dapagliflozin group (80.0% vs. 61.5%, P=0.041). The effect of dapagliflozin with metformin on ALT normalization remained significant after adjustment for confounding variables including body weight loss (odds ratio, 3.489; P=0.046).

Conclusion

ALT improvement was statistically significant in the dapagliflozin than the DPP4i when combined with metformin and the result was consistent after adjustment for confounding variables including body weight loss.

Citations

Citations to this article as recorded by  
  • The role of anti-diabetic drugs in NAFLD. Have we found the Holy Grail? A narrative review
    Maria Zachou, Pagona Flevari, Narjes Nasiri-Ansari, Constantinos Varytimiadis, Evangelos Kalaitzakis, Eva Kassi, Theodoros Androutsakos
    European Journal of Clinical Pharmacology.2024; 80(1): 127.     CrossRef
  • Comparative effectiveness of sodium‐glucose co‐transporter‐2 inhibitors and dipeptidyl peptidase‐4 inhibitors on liver function in patients with type 2 diabetes in Japan: A real‐world data analysis
    Hirokazu Takahashi, Keiko Asakawa, Yoshinori Kosakai, Takumi Lee, Mitsuhiro Rokuda
    Diabetes, Obesity and Metabolism.2024; 26(3): 997.     CrossRef
  • Effects of a Combination of Empagliflozin Plus Metformin vs. Metformin Monotherapy on NAFLD Progression in Type 2 Diabetes: The IMAGIN Pilot Study
    Alfredo Caturano, Raffaele Galiero, Giuseppe Loffredo, Erica Vetrano, Giulia Medicamento, Carlo Acierno, Luca Rinaldi, Aldo Marrone, Teresa Salvatore, Marcellino Monda, Celestino Sardu, Raffaele Marfella, Ferdinando Carlo Sasso
    Biomedicines.2023; 11(2): 322.     CrossRef
  • Swimming exercise ameliorates insulin resistance and nonalcoholic fatty liver by negatively regulating PPARγ transcriptional network in mice fed high fat diet
    Yong Zhang, Jie Xu, Di Zhou, Tingting Ye, Puqing Zhou, Zuofeng Liu, Xinyuan Liu, Zinan Wang, Tianmiao Hua, Zhenghao Zhang, Qingyan Sun
    Molecular Medicine.2023;[Epub]     CrossRef
  • Association between Obstructive Sleep Apnea and Heart Failure in Adults—A Systematic Review
    Agnieszka Polecka, Natalia Olszewska, Łukasz Danielski, Ewa Olszewska
    Journal of Clinical Medicine.2023; 12(19): 6139.     CrossRef
  • Prospects of using sodium-glucose co-transporter-2 (SGLT-2) inhibitors in patients with metabolic-associated fatty liver disease (MAFLD)
    Iryna Kostitska, Nadia Protas, Liliia Petrovska
    Diabetes Obesity Metabolic Syndrome.2023; (5): 8.     CrossRef
  • Therapeutic outcome of dapagliflozin on various parameters in non-alcoholic fatty liver disease (NAFLD) patients
    Mazhar Hussain, Muhammad Zafar Majeed Babar, Saba Tariq, Muhammad Irfan Ahmad, Lubna Akhtar
    International Journal of Diabetes in Developing Countries.2022; 42(2): 290.     CrossRef
  • The safety and efficacy evaluation of sodium-glucose co-transporter 2 inhibitors for patients with non-alcoholic fatty liver disease: An updated meta-analysis
    Manqiu Mo, Zichun Huang, Yuzhen Liang, Yunhua Liao, Ning Xia
    Digestive and Liver Disease.2022; 54(4): 461.     CrossRef
  • Dapagliflozin improves steatohepatitis in diabetic rats via inhibition of oxidative stress and inflammation
    Reem M. Hazem, Ahmed Z. Ibrahim, Dina A. Ali, Yasser M. Moustafa
    International Immunopharmacology.2022; 104: 108503.     CrossRef
  • SGLT-2 Inhibitors in NAFLD: Expanding Their Role beyond Diabetes and Cardioprotection
    Theodoros Androutsakos, Narjes Nasiri-Ansari, Athanasios-Dimitrios Bakasis, Ioannis Kyrou, Efstathios Efstathopoulos, Harpal S. Randeva, Eva Kassi
    International Journal of Molecular Sciences.2022; 23(6): 3107.     CrossRef
  • Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice
    Panshuang Qiao, Yingli Jia, Ang Ma, Jinzhao He, Chen Shao, Xiaowei Li, Shuyuan Wang, Baoxue Yang, Hong Zhou
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Comparison of Tofogliflozin and Glimepiride Effects on Nonalcoholic Fatty Liver Disease in Participants With Type 2 Diabetes: A Randomized, 48-Week, Open-Label, Active-Controlled Trial
    Yumie Takeshita, Masao Honda, Kenichi Harada, Yuki Kita, Noboru Takata, Hiromasa Tsujiguchi, Takeo Tanaka, Hisanori Goto, Yujiro Nakano, Noriho Iida, Kuniaki Arai, Tatsuya Yamashita, Eishiro Mizukoshi, Hiroyuki Nakamura, Shuichi Kaneko, Toshinari Takamura
    Diabetes Care.2022; 45(9): 2064.     CrossRef
  • Heart Failure with Preserved Ejection Fraction and Obstructive Sleep Apnea: A Novel Paradigm for Additional Cardiovascular Benefit of SGLT2 Inhibitors in Subjects With or Without Type 2 Diabetes
    Vincenzo Maria Monda, Sandro Gentile, Francesca Porcellati, Ersilia Satta, Alessandro Fucili, Marcello Monesi, Felice Strollo
    Advances in Therapy.2022; 39(11): 4837.     CrossRef
  • Metformin, pioglitazone, dapagliflozin and their combinations ameliorate manifestations associated with NAFLD in rats via anti-inflammatory, anti-fibrotic, anti-oxidant and anti-apoptotic mechanisms
    Hager H. Shaaban, Ibrahim Alzaim, Ahmed El-Mallah, Rania G. Aly, Ahmed F. El-Yazbi, Ahmed Wahid
    Life Sciences.2022; 308: 120956.     CrossRef
  • The impact of sodium glucose co‐transporter 2 inhibitors on non‐alcoholic fatty liver disease
    Lampros Chrysavgis, Alkistis‐Maria Papatheodoridi, Antonios Chatzigeorgiou, Evangelos Cholongitas
    Journal of Gastroenterology and Hepatology.2021; 36(4): 893.     CrossRef
  • Sodium-Glucose Co-Transporter 2 Inhibitors for Non-Alcoholic Fatty Liver Disease in Asian Patients With Type 2 Diabetes: A Meta-Analysis
    Chloe Wong, Clyve Yu Leon Yaow, Cheng Han Ng, Yip Han Chin, Yi Fen Low, Amanda Yuan Ling Lim, Mark Dhinesh Muthiah, Chin Meng Khoo
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Effects of sodium‐glucose co‐transporter 2 inhibitors on liver parameters and steatosis: A meta‐analysis of randomized clinical trials
    Francisca dos Santos Coelho, Marta Borges‐Canha, Madalena von Hafe, João Sérgio Neves, Catarina Vale, Ana Rita Leite, Davide Carvalho, Adelino Leite‐Moreira
    Diabetes/Metabolism Research and Reviews.2021;[Epub]     CrossRef
  • Effects of anti-diabetic treatments in type 2 diabetes and fatty liver disease
    Elizabeth M. Lamos, Megan Kristan, Maka Siamashvili, Stephen N. Davis
    Expert Review of Clinical Pharmacology.2021; 14(7): 837.     CrossRef
  • Sodium-Glucose Cotransporter-2 Inhibitors Ameliorate Liver Enzyme Abnormalities in Korean Patients With Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease
    Won Euh, Soo Lim, Jin-Wook Kim
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Dapagliflozin attenuates steatosis in livers of high-fat diet-induced mice and oleic acid-treated L02 cells via regulating AMPK/mTOR pathway
    Jingyi Luo, Pengbo Sun, Yangyang Wang, Yang Chen, Yaoyun Niu, Yipei Ding, Naihan Xu, Yaou Zhang, Weidong Xie
    European Journal of Pharmacology.2021; 907: 174304.     CrossRef
  • The effects of dapagliflozin on hepatic and visceral fat in type 2 diabetes patients with non‐alcoholic fatty liver disease
    Susrichit Phrueksotsai, Kanokwan Pinyopornpanish, Juntima Euathrongchit, Apinya Leerapun, Arintaya Phrommintikul, Supawan Buranapin, Nipon Chattipakorn, Satawat Thongsawat
    Journal of Gastroenterology and Hepatology.2021; 36(10): 2952.     CrossRef
  • Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A Systematic Literature Review-Based Hypothesis
    Vincenzo Maria Monda, Francesca Porcellati, Felice Strollo, Alessandro Fucili, Marcello Monesi, Ersilia Satta, Sandro Gentile
    Advances in Therapy.2021; 38(8): 4195.     CrossRef
  • Sodium‐glucose co‐transporter 2 inhibitors reduce hepatic events in diabetic patients with chronic hepatitis B
    Lilian Yan Liang, Vincent Wai‐Sun Wong, Vicki Wing‐Ki Hui, Terry Cheuk‐Fung Yip, Yee‐Kit Tse, Grace Chung‐Yan Lui, Henry Lik‐Yuen Chan, Grace Lai‐Hung Wong
    GastroHep.2021; 3(4): 261.     CrossRef
  • Effects of Metformin on Hepatic Steatosis in Adults with Nonalcoholic Fatty Liver Disease and Diabetes: Insights from the Cellular to Patient Levels
    Kanokwan Pinyopornpanish, Apinya Leerapun, Kanokporn Pinyopornpanish, Nipon Chattipakorn
    Gut and Liver.2021; 15(6): 827.     CrossRef
  • The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease
    F. Anthony Romero, Christopher T. Jones, Yingzi Xu, Martijn Fenaux, Randall L. Halcomb
    Journal of Medicinal Chemistry.2020; 63(10): 5031.     CrossRef
  • SGLT2 Inhibitors in Liver Patients
    John Chen Hsiang, Vincent Wai-Sun Wong
    Clinical Gastroenterology and Hepatology.2020; 18(10): 2168.     CrossRef
  • Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
    Kyung-Soo Kim, Byung-Wan Lee
    Clinical and Molecular Hepatology.2020; 26(4): 430.     CrossRef
  • Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics
    Stergios A. Polyzos, Jannis Kountouras, Christos S. Mantzoros
    Metabolism.2019; 92: 82.     CrossRef
  • Nonalcoholic Fatty Liver Disease and Diabetes: Part II: Treatment
    Kyung-Soo Kim, Byung-Wan Lee, Yong Jin Kim, Dae Ho Lee, Bong-Soo Cha, Cheol-Young Park
    Diabetes & Metabolism Journal.2019; 43(2): 127.     CrossRef
  • Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-γ and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet
    Fan Zheng, Ying Cai
    Lipids in Health and Disease.2019;[Epub]     CrossRef
  • The Effects of Hypoglycemic Agents on Non-alcoholic Fatty Liver Disease: Focused on Sodium-Glucose Cotransporter 2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists
    Chan-Hee Jung, Ji-Oh Mok
    Journal of Obesity & Metabolic Syndrome.2019; 28(1): 18.     CrossRef
  • Effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Ex quo et quo vadimus?
    Niki Katsiki, Nikolaos Perakakis, Christos Mantzoros
    Metabolism.2019; 98: iii.     CrossRef
  • Empaglifozin mitigates NAFLD in high-fat-fed mice by alleviating insulin resistance, lipogenesis and ER stress
    Tamiris Ingrid Petito-da-Silva, Vanessa Souza-Mello, Sandra Barbosa-da-Silva
    Molecular and Cellular Endocrinology.2019; 498: 110539.     CrossRef
  • Beneficial effects of SGLT2 inhibitors on fatty liver in type 2 diabetes: A common comorbidity associated with severe complications
    A.J. Scheen
    Diabetes & Metabolism.2019; 45(3): 213.     CrossRef
Close layer
Clinical Study
Effects of Maternal Iodine Status during Pregnancy and Lactation on Maternal Thyroid Function and Offspring Growth and Development: A Prospective Study Protocol for the Ideal Breast Milk Cohort
Young Ah Lee, Sun Wook Cho, Ho Kyung Sung, Kyungsik Kim, Young Shin Song, Sin Je Moon, Jung Won Oh, Dal Lae Ju, Sooyeon Choi, Sang Hoon Song, Gi Jeong Cheon, Young Joo Park, Choong Ho Shin, Sue K. Park, Jong Kwan Jun, June-Key Chung
Endocrinol Metab. 2018;33(3):395-402.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.395
  • 4,819 View
  • 83 Download
  • 1 Web of Science
  • 2 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Iodine is an intrinsic element of thyroid hormone, which is essential for childhood growth and development. The Ideal Breast Milk (IBM) cohort study aims to evaluate the effects of maternal iodine status during pregnancy and lactation on maternal thyroid function, offspring growth and development, and offspring thyroid function.

Methods

The IBM cohort study recruited pregnant women from Seoul National University Hospital between June 2016 and August 2017, followed by enrollment of their offspring after delivery. For the maternal participants, iodine status is evaluated by urinary iodine concentration (UIC) and dietary records in the third trimester and at 3 to 4 weeks and 12 to 15 months postpartum. For the child participants, cord blood sampling and UIC measurements are performed at birth. At 3 to 4 weeks of age, UIC and breastmilk iodine concentrations are measured. At 12 to 15 months of age, growth and development are assessed and measurements of UIC, a thyroid function test, and ultrasonography are performed.

Results

A total of 198 pregnant women in their third trimester were recruited. Their mean age was 35.1±3.5 years, and 78 (39.4%) of them were pregnant with twins. Thirty-three (16.7%) of them had a previous history of thyroid disease.

Conclusion

Korea is an iodine-replete area. In particular, lactating women in Korea are commonly exposed to excess iodine due to the traditional practice of consuming brown seaweed soup postpartum. The study of the IBM cohort is expected to contribute to developing guidelines for optimal iodine nutrition in pregnant or lactating women.

Citations

Citations to this article as recorded by  
  • High intakes of iodine among women during pregnancy and the postpartum period has no adverse effect on thyroid function
    Dal Lae Ju, Sun Wook Cho, Chae Won Chung, Young Ah Lee, Gi Jeong Cheon, Young Joo Park, Choong Ho Shin, Jong Kwan Jun, June-Key Chung, Sue K. Park, YoonJu Song
    European Journal of Nutrition.2023; 62(1): 239.     CrossRef
  • Associations between maternal thyroid function in pregnancy and child neurodevelopmental outcomes at 20 months in the Seychelles Child Development Study, Nutrition Cohort 2 (SCDS NC2)
    Anna M. Monaghan, Maria S. Mulhern, Emeir M. Mc Sorley, J.J. Strain, Theresa Winter, Edwin van Wijngaarden, Gary J. Myers, Philip W. Davidson, Conrad Shamlaye, Jude Gedeon, Alison J. Yeates
    Journal of Nutritional Science.2021;[Epub]     CrossRef
Close layer
Endocrine Research
Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes β-Cell Impairment via Mitochondrial Dysregulation
Seok-Woo Hong, Jinmi Lee, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
Endocrinol Metab. 2018;33(3):403-412.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.403
  • 4,145 View
  • 49 Download
  • 16 Web of Science
  • 16 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Emerging evidence suggests that sphingolipids may be involved in type 2 diabetes. However, the exact signaling defect through which disordered sphingolipid metabolism induces β-cell dysfunction remains unknown. The current study demonstrated that sphingosine-1-phosphate (S1P), the product of sphingosine kinase (SphK), is an essential factor for maintaining β-cell function and survival via regulation of mitochondrial action, as mediated by prohibitin (PHB).

Methods

We examined β-cell function and viability, as measured by mitochondrial function, in mouse insulinoma 6 (MIN6) cells in response to manipulation of cellular S1P and PHB levels.

Results

Lack of S1P induced by sphingosine kinase inhibitor (SphKi) treatment caused β-cell dysfunction and apoptosis, with repression of mitochondrial function shown by decreases in cellular adenosine triphosphate content, the oxygen consumption rate, the expression of oxidative phosphorylation complexes, the mitochondrial membrane potential, and the expression of key regulators of mitochondrial dynamics (mitochondrial dynamin-like GTPase [OPA1] and mitofusin 1 [MFN1]). Supplementation of S1P led to the recovery of mitochondrial function and greatly improved β-cell function and viability. Knockdown of SphK2 using small interfering RNA induced mitochondrial dysfunction, decreased glucose-stimulated insulin secretion (GSIS), and reduced the expression of PHB, an essential regulator of mitochondrial metabolism. PHB deficiency significantly reduced GSIS and induced mitochondrial dysfunction, and co-treatment with S1P did not reverse these trends.

Conclusion

Altogether, these data suggest that S1P is an essential factor in the maintenance of β-cell function and survival through its regulation of mitochondrial action and PHB expression.

Citations

Citations to this article as recorded by  
  • Mitochondrial Cristae Morphology Reflecting Metabolism, Superoxide Formation, Redox Homeostasis, and Pathology
    Petr Ježek, Martin Jabůrek, Blanka Holendová, Hana Engstová, Andrea Dlasková
    Antioxidants & Redox Signaling.2023; 39(10-12): 635.     CrossRef
  • Sphingolipids in mitochondria—from function to disease
    Maryam Jamil, Lauren Ashley Cowart
    Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
  • Sphingosine‐1‐phosphate in mitochondrial function and metabolic diseases
    Meng Duan, Pan Gao, Sheng‐xi Chen, Petr Novák, Kai Yin, Xiao Zhu
    Obesity Reviews.2022;[Epub]     CrossRef
  • Involvement of miR‐27a‐3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress
    Lina Wu, Qingzhu Wang, Feng Guo, Xiaojun Ma, Jiao Wang, Yanyan Zhao, Yushan Yan, Guijun Qin
    Journal of Cellular Physiology.2021; 236(2): 1454.     CrossRef
  • Sphingosine‐1‐phosphate in acute exercise and training
    Katarzyna Hodun, Adrian Chabowski, Marcin Baranowski
    Scandinavian Journal of Medicine & Science in Sports.2021; 31(5): 945.     CrossRef
  • The Ethyl Acetate Extract From Celastrus orbiculatus Promotes Apoptosis of Gastric Cancer Cells Through Mitochondria Regulation by PHB
    Lide Tao, Zixin Yin, Tengyang Ni, Zewen Chu, Shihua Hao, Zeyu Wang, Masataka Sunagawa, Haibo Wang, Yanqing Liu
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Sphingosine 1-phosphate Stimulates Insulin Secretion and Improves Cell Survival by Blocking Voltage-dependent K+ Channels in β Cells
    Zhihong Liu, Huanhuan Yang, Linping Zhi, Huan Xue, Zhihong Lu, Yanli Zhao, Lijuan Cui, Tao Liu, Shouan Ren, Peifeng He, Yunfeng Liu, Yi Zhang
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Sphingosine-1 Phosphate Lyase Regulates Sensitivity of Pancreatic Beta-Cells to Lipotoxicity
    Yadi Tang, Thomas Plötz, Markus H. Gräler, Ewa Gurgul-Convey
    International Journal of Molecular Sciences.2021; 22(19): 10893.     CrossRef
  • Sphingolipids and Mitochondrial Dynamic
    Lais Brigliadori Fugio, Fernanda B. Coeli-Lacchini, Andréia Machado Leopoldino
    Cells.2020; 9(3): 581.     CrossRef
  • Diminished Sphingolipid Metabolism, a Hallmark of Future Type 2 Diabetes Pathogenesis, Is Linked to Pancreatic β Cell Dysfunction
    Saifur R. Khan, Yousef Manialawy, Andreea Obersterescu, Brian J. Cox, Erica P. Gunderson, Michael B. Wheeler
    iScience.2020; 23(10): 101566.     CrossRef
  • Neuronal Metabolism and Neuroprotection: Neuroprotective Effect of Fingolimod on Menadione-Induced Mitochondrial Damage
    Antonio Gil, Elisa Martín-Montañez, Nadia Valverde, Estrella Lara, Federica Boraldi, Silvia Claros, Silvana-Yanina Romero-Zerbo, Oscar Fernández, Jose Pavia, Maria Garcia-Fernandez
    Cells.2020; 10(1): 34.     CrossRef
  • WITHDRAWN: Ceramide and Sphingosine 1-Phosphate in adipose dysfunction
    Zijian Fang, Susan Pyne, Nigel J. Pyne
    Progress in Lipid Research.2019; : 100991.     CrossRef
  • Dynamic of mitochondrial network, cristae, and mitochondrial nucleoids in pancreatic β-cells
    Petr Ježek, Andrea Dlasková
    Mitochondrion.2019; 49: 245.     CrossRef
  • Sphingosine kinase 1 overexpression induces MFN2 fragmentation and alters mitochondrial matrix Ca2+ handling in HeLa cells
    I. Pulli, C. Löf, T. Blom, M.Y. Asghar, T. Lassila, N. Bäck, K.-L. Lin, J.H. Nyström, K. Kemppainen, D.M. Toivola, E. Dufour, A. Sanz, H.M. Cooper, J.B. Parys, K. Törnquist
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2019; 1866(9): 1475.     CrossRef
  • Ceramide and sphingosine 1-phosphate in adipose dysfunction
    Zijian Fang, Susan Pyne, Nigel J. Pyne
    Progress in Lipid Research.2019; 74: 145.     CrossRef
  • S1P/S1P Receptor Signaling in Neuromuscolar Disorders
    Elisabetta Meacci, Mercedes Garcia-Gil
    International Journal of Molecular Sciences.2019; 20(24): 6364.     CrossRef
Close layer
Endocrine Research
Functional Identification of Compound Heterozygous Mutations in the CYP17A1 Gene Resulting in Combined 17α-Hydroxylase/17,20-Lyase Deficiency
Eun Yeong Mo, Ji-young Lee, Su Yeon Kim, Min Ji Kim, Eun Sook Kim, Seungok Lee, Je Ho Han, Sung-dae Moon
Endocrinol Metab. 2018;33(3):413-422.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.413
  • 3,684 View
  • 61 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

We previously reported a patient with congenital adrenal hyperplasia (CAH) with compound heterozygous mutations in the cytochrome P450 17A1 (CYP17A1) gene. One allele had a p.His373Leu and the other a new p.Glu383fsX36 mutation. The aim of this study was to investigate the functional properties of a new allele present in a compound heterozygote of CYP17A1.

Methods

To understand how p.His373Leu and p.Glu383fsX36 affect P450c17 enzymatic activity, wild type and mutant CYP17A1 cDNAs were cloned into flag-tagged pcDNA3 vector and introduced into human embryonic kidney cells 293T (HEK293T) cells. Protein expression levels of CYP17A1 were then analyzed. And the activities of 17α-hydroxylase and 17,20-lyase of CYP17A1 were evaluated by measuring the conversion of progesterone to 17α-hydroxyprogesterone and of 17α-hydroxypregnenolone to dehydroepiandrosterone, respectively. In addition a computer model was used to create the three-dimensional structure of the mutant CYP17A1 enzymes.

Results

Production of the p.His373Leu mutant protein was significantly lower than that of the wild type protein, and the p.Glu383fsX36 protein was hardly produced. Similarly the enzymatic activity derived from the p.His373Leu mutant vector was significantly lower than that obtained from the wild type vector, and little activity was obtained from the p.Glu383fsX36 vector. Three-dimensional modeling of the enzyme showed that p.His373 was located in region important for heme-binding and proper folding. Neither the p.His373Leu nor the p.Glu383fsX36 mutant protein formed a heme-binding structure.

Conclusion

Enzyme activity measured in both mutants disappeared completely in both 17α-hydroxylase and 17,20-lyase. This result accounts for the clinical manifestations of the patient with the compound heterozygous CYP17A1 mutations.

Citations

Citations to this article as recorded by  
  • A rare case of 17α-hydroxylase/17, 20-lyase deficiency: Clinical and genetic findings and follow-up outcomes
    Li-Zhen Dai, Hong Ma, Jian-Fang Ke, Chen-Shi Lin, Yanling Huang, Yuan Tian, Danling Chen
    Women's Health.2022; 18: 174550572211225.     CrossRef
  • Novel mutations of the CYP17A1 gene in four Chinese 46,XX cases with partial 17a-hydroxylase/17,20-lyase deficiency
    Yanjie Xia, Panlai Shi, Junke Xia, Huijuan Zhang, Lijun Xu, Xiangdong Kong
    Steroids.2021; 173: 108873.     CrossRef
Close layer
Letter
Adrenal gland
An Ectopic Cortisol-Producing Adrenocortical Adenoma Masquerading as a Liposarcoma in the Pararenal Space
Sunyoung Kang, Seung Shin Park, Jae Hyun Bae, Kyu Eun Lee, Jung Hee Kim, Chan Soo Shin
Endocrinol Metab. 2018;33(3):423-424.   Published online August 14, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.423
  • 2,806 View
  • 42 Download
PDFPubReader   ePub   
Close layer
Response
Diabetes
Response: The Association between Persistent Hypertriglyceridemia and the Risk of Diabetes Development: The Kangbuk Samsung Health Study (Endocrinol Metab 2018;33:55–61, Yu Hyun Kwon et al.)
Eun-Jung Rhee, Yu Hyun Kwon
Endocrinol Metab. 2018;33(3):425-426.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.425
[Original]
  • 3,097 View
  • 59 Download
PDFPubReader   ePub   
Close layer

Endocrinol Metab : Endocrinology and Metabolism