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Volume 33(3); September 2018
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Review Articles
Diabetes
Therapeutic Role of Yoga in Type 2 Diabetes
Arkiath Veettil Raveendran, Anjali Deshpandae, Shashank R. Joshi
Endocrinol Metab. 2018;33(3):307-317.   Published online August 14, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.307
  • 14,175 View
  • 342 Download
  • 53 Web of Science
  • 81 Crossref
AbstractAbstract PDFPubReader   ePub   

Yoga originated in India more than 5,000 years ago and is a means of balancing and harmonizing the body, mind, and emotions. Yoga practice is useful in the management of various lifestyle diseases, including type 2 diabetes. Psycho-neuro-endocrine and immune mechanisms are involved in the beneficial effects of yoga on diabetes. Incorporation of yoga practice in daily life helps to attain glycaemic control and reduces the risk of complications in people with diabetes. In this review, we briefly describe the role of various yoga practices in the management of diabetes based on evidence from various clinical studies.

Citations

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Close layer
Bone Metabolism
Regulation of Osteoblast Metabolism by Wnt Signaling
Megan C. Moorer, Ryan C. Riddle
Endocrinol Metab. 2018;33(3):318-330.   Published online August 14, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.318
  • 7,561 View
  • 127 Download
  • 45 Web of Science
  • 44 Crossref
AbstractAbstract PDFPubReader   ePub   

Wnt/β-catenin signaling plays a critical role in the achievement of peak bone mass, affecting the commitment of mesenchymal progenitors to the osteoblast lineage and the anabolic capacity of osteoblasts depositing bone matrix. Recent studies suggest that this evolutionarily-conserved, developmental pathway exerts its anabolic effects in part by coordinating osteoblast activity with intermediary metabolism. These findings are compatible with the cloning of the gene encoding the low-density lipoprotein related receptor-5 (LRP5) Wnt co-receptor from a diabetes-susceptibility locus and the now well-established linkage between Wnt signaling and metabolism. In this article, we provide an overview of the role of Wnt signaling in whole-body metabolism and review the literature regarding the impact of Wnt signaling on the osteoblast's utilization of three different energy sources: fatty acids, glucose, and glutamine. Special attention is devoted to the net effect of nutrient utilization and the mode of regulation by Wnt signaling. Mechanistic studies indicate that the utilization of each substrate is governed by a unique mechanism of control with β-catenin-dependent signaling regulating fatty acid β-oxidation, while glucose and glutamine utilization are β-catenin-independent and downstream of mammalian target of rapamycin complex 2 (mTORC2) and mammalian target of rapamycin complex 1 (mTORC1) activation, respectively. The emergence of these data has provided a new context for the mechanisms by which Wnt signaling influences bone development.

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Close layer
Bone Metabolism
Recent Topics in Fibrodysplasia Ossificans Progressiva
Takenobu Katagiri, Sho Tsukamoto, Yutaka Nakachi, Mai Kuratani
Endocrinol Metab. 2018;33(3):331-338.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.331
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AbstractAbstract PDFPubReader   ePub   

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease that is characterized by the formation of heterotopic bone tissues in soft tissues, such as skeletal muscle, ligament, and tendon. It is difficult to remove such heterotopic bones via internal medicine or invasive procedures. The identification of activin A receptor, type I (ACVR1)/ALK2 gene mutations associated with FOP has allowed the genetic diagnosis of FOP. The ACVR1/ALK2 gene encodes the ALK2 protein, which is a transmembrane kinase receptor in the transforming growth factor-β family. The relevant mutations activate intracellular signaling in vitro and induce heterotopic bone formation in vivo. Activin A is a potential ligand that activates mutant ALK2 but not wild-type ALK2. Various types of small chemical and biological inhibitors of ALK2 signaling have been developed to establish treatments for FOP. Some of these are in clinical trials in patients with FOP.

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Close layer
Bone Metabolism
Skeletal Fragility in Type 2 Diabetes Mellitus
Jakob Starup-Linde, Katrine Hygum, Bente Lomholt Langdahl
Endocrinol Metab. 2018;33(3):339-351.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.339
  • 6,454 View
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AbstractAbstract PDFPubReader   ePub   

Type 2 diabetes (T2D) is associated with an increased risk of fracture, which has been reported in several epidemiological studies. However, bone mineral density in T2D is increased and underestimates the fracture risk. Common risk factors for fracture do not fully explain the increased fracture risk observed in patients with T2D. We propose that the pathogenesis of increased fracture risk in T2D is due to low bone turnover caused by osteocyte dysfunction resulting in bone microcracks and fractures. Increased levels of sclerostin may mediate the low bone turnover and may be a novel marker of increased fracture risk, although further research is needed. An impaired incretin response in T2D may also affect bone turnover. Accumulation of advanced glycosylation endproducts may also impair bone strength. Concerning antidiabetic medication, the glitazones are detrimental to bone health and associated with increased fracture risk, and the sulphonylureas may increase fracture risk by causing hypoglycemia. So far, the results on the effect of other antidiabetics are ambiguous. No specific guideline for the management of bone disease in T2D is available and current evidence on the effects of antiosteoporotic medication in T2D is sparse. The aim of this review is to collate current evidence of the pathogenesis, detection and treatment of diabetic bone disease.

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    Orit Ofir, Assaf Buch, Vanessa Rouach, Rebecca Goldsmith, Naftali Stern, Efrat Monsonego-Ornan
    Aging Clinical and Experimental Research.2020; 32(8): 1459.     CrossRef
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    N.H. Rasmussen, J. Dal, F. de Vries, J.P. van den Bergh, M.H. Jensen, P. Vestergaard
    Osteoporosis International.2020; 31(3): 447.     CrossRef
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    B. Depczynski, P. Y. Liew, C. White
    Diabetic Medicine.2020; 37(9): 1545.     CrossRef
  • Understanding Bone Disease in Patients with Diabetic Kidney Disease: a Narrative Review
    Sabina Chaudhary Hauge, Morten Frost, Ditte Hansen
    Current Osteoporosis Reports.2020; 18(6): 727.     CrossRef
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    Nicklas Højgaard Rasmussen, Jakob Dal
    Current Osteoporosis Reports.2019; 17(3): 147.     CrossRef
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    Lin Jiating, Ji Buyun, Zhang Yinchang
    BioMed Research International.2019; 2019: 1.     CrossRef
  • An update on therapies for the treatment of diabetes-induced osteoporosis
    Sahar Mohsin, May MYH Baniyas, Reem SMH AlDarmaki, Kornélia Tekes, Huba Kalász, Ernest A. Adeghate
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Close layer
Editorial
Adrenal gland
Update on the Aldosterone Resolution Score and Lateralization in Patients with Primary Aldosteronism
Eun-Hee Cho
Endocrinol Metab. 2018;33(3):352-354.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.352
  • 3,566 View
  • 33 Download
PDFPubReader   ePub   
Close layer
Original Articles
Clinical Study
Factors Associated with Resolution of Hypertension after Adrenalectomy in Patients with Primary Aldosteronism
Wann Jia Loh, Dawn Shao Ting Lim, Lih Ming Loh, Peng Chin Kek
Endocrinol Metab. 2018;33(3):355-363.   Published online August 14, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.355
  • 4,742 View
  • 53 Download
  • 8 Web of Science
  • 8 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

The aim of this study was to investigate the factors associated with resolution of hypertension after adrenalectomy in patients with primary aldosteronism. A secondary aim was to describe our use of the contralateral ratio in adrenal venous sampling (AVS) in the setting of suboptimal successful cannulation rates.

Methods

A retrospective review of patients who underwent AVS followed by unilateral adrenalectomy for primary aldosteronism was performed.

Results

Complete resolution of hypertension and hypokalemia was seen in 17 of 40 patients (42.5%), while a clinical improvement in hypertension was seen in 38 of 40 (95%). Shorter duration of hypertension, mean aldosteronoma resolution score (ARS), and a high ARS of 3 to 5 were associated with resolution of hypertension after adrenalectomy (P=0.02, P=0.02, and P=0.004, respectively). Of the individual components of ARS, only a duration of hypertension of ≤6 years was associated with resolution of hypertension after adrenalectomy (P=0.03).

Conclusion

A shorter duration of hypertension was significantly associated with resolution of hypertension after adrenalectomy in patients with primary aldosteronism.

Citations

Citations to this article as recorded by  
  • Clinical and biochemical outcomes after adrenalectomy for primary aldosteronism in tertiary and quaternary referral centers: data from SOPRANO study
    Luigi Marzano, Claudio Ronco
    Hypertension Research.2024; 47(3): 721.     CrossRef
  • Catheter-based adrenal ablation: an alternative therapy for patients with aldosterone-producing adenoma
    Fang Sun, Xiaoli Liu, Hexuan Zhang, Xunmei Zhou, Zhigang Zhao, Hongbo He, Zhencheng Yan, Yingsha Li, Qiang Li, Yaoming Li, Jun Jiang, Zhiming Zhu, Hongyun Miao, Zhiyong Li, Ping Wei, Min Long, Xiaoli Chen, Xiaoyun Fan, Wuquan Deng, Yangjie He, Qingbin Lia
    Hypertension Research.2023; 46(1): 91.     CrossRef
  • Prognostic models to predict complete resolution of hypertension after adrenalectomy in primary aldosteronism: A systematic review and meta‐analysis
    Luigi Marzano, Amir Kazory, Faeq Husain‐Syed, Claudio Ronco
    Clinical Endocrinology.2023; 99(1): 17.     CrossRef
  • Long-term outcome success after operative treatment for primary aldosteronism
    Omar Picado, Bryan W. Whitfield, Zahra F. Khan, Mohammed Jeraq, Josefina C. Farrá, John I. Lew
    Surgery.2021; 169(3): 528.     CrossRef
  • Outcomes of Adrenalectomy and the Aldosteronoma Resolution Score in the Black and Hispanic Population
    Gustavo Romero‐Velez, Amanda M. Laird, Manuel E. Barajas, Mauricio Sierra‐Salazar, Miguel F. Herrera, Steven K. Libutti, Michael K. Parides, Xavier Pereira, John C. McAuliffe
    World Journal of Surgery.2021; 45(5): 1475.     CrossRef
  • Comparison of cystatin C-based and creatinine-based glomerular filtration rate in the prediction of postoperative residual hypertension in aldosterone-producing adenoma patients after adrenalectomy
    Ching-Way Chen, Cheng-Hsuan Tsai, Chi-Sheng Hung, I-Jung Tsai, Yu-Wei Chiu, Chin-Cheng Chang, Kao-Lang Liu, Shih-Cheng Liao, Vin-Cent Wu, Yen-Hung Lin
    Clinica Chimica Acta.2021; 520: 147.     CrossRef
  • Long-term blood pressure outcomes of patients with adrenal venous sampling-proven unilateral primary aldosteronism
    Xu Meng, Wen-Jun Ma, Xiong-Jing Jiang, Pei-Pei Lu, Ying Zhang, Peng Fan, Jun Cai, Hui-Min Zhang, Lei Song, Hai-Ying Wu, Xian-Liang Zhou, Ying Lou
    Journal of Human Hypertension.2020; 34(6): 440.     CrossRef
  • Update on the Aldosterone Resolution Score and Lateralization in Patients with Primary Aldosteronism
    Eun-Hee Cho
    Endocrinology and Metabolism.2018; 33(3): 352.     CrossRef
Close layer
Clinical Study
Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients
Ji Sun Nam, Jung Woo Han, Sang Bae Lee, Ji Hong You, Min Jin Kim, Shinae Kang, Jong Suk Park, Chul Woo Ahn
Endocrinol Metab. 2018;33(3):364-371.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.364
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  • 7 Web of Science
  • 6 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients.

Methods

Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes.

Results

Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion.

Conclusion

Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism.

Citations

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  • Decoding type 2 diabetes mellitus genetic risk variants in Pakistani Pashtun ethnic population using the nascent whole exome sequencing and MassARRAY genotyping: A case-control association study
    Asif Jan, Zakiullah, Sajid Ali, Basir Muhammad, Amina Arshad, Yasar Shah, Haji Bahadur, Hamayun Khan, Fazli Khuda, Rani Akbar, Kiran Ijaz, Giuseppe Novelli
    PLOS ONE.2023; 18(1): e0281070.     CrossRef
  • Silencing LncRNA PVT1 Reverses High Glucose-Induced Regulation of the High Expression of PVT1 in HRMECs by Targeting miR-128-3p
    Xuyang Wang, Wangling Chen, Wei Lao, Yunxin Chen
    Hormone and Metabolic Research.2022; 54(02): 119.     CrossRef
  • Association of CAPN10 (SNP-19) genetic polymorphism and obesity with T2DM: a study on Bengali Hindu caste population
    Pranabesh Sarkar, Diptendu Chatterjee, Arup Ratan Bandyopadhyay
    International Journal of Diabetes in Developing Countries.2021; 41(1): 37.     CrossRef
  • Association of Candidate Gene Polymorphism with Metabolic Syndrome among Mongolian Subjects: A Case-Control Study
    Ariunbold Chuluun-Erdene, Orgil Sengeragchaa, Tsend-Ayush Altangerel, Purevjal Sanjmyatav, Batnaran Dagdan, Solongo Battulga, Lundiamaa Enkhbat, Nyamjav Byambasuren, Munkhzol Malchinkhuu, Munkhtstetseg Janlav
    Medical Sciences.2020; 8(3): 38.     CrossRef
  • Meta-analysis of the association between adiponectin SNP 45, SNP 276, and type 2 diabetes mellitus
    Yuwei Dong, Gongping Huang, Xin Wang, Zhaoming Chu, Jingzhi Miao, Houwen Zhou, Mingqing Xu
    PLOS ONE.2020; 15(10): e0241078.     CrossRef
  • Association of three SNPs in adiponectin gene with lipid traits of Tianzhu Black Muscovy (Cairina moschata)
    Yuan-Yu Qin, Yi-Yu Zhang, Hua-Lun Luo, Lei Wu
    Molecular Biology Reports.2019; 46(1): 325.     CrossRef
Close layer
Clinical Study
Iodine Status in Filipino Women of Childbearing Age
Michael E. Serafico, Joselita Rosario C. Ulanday, Marites V. Alibayan, Glen Melvin P. Gironella, Leah A. Perlas
Endocrinol Metab. 2018;33(3):372-379.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.372
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  • 7 Web of Science
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AbstractAbstract PDFPubReader   ePub   
Background

Iodine deficiency (ID) has become a concern not only among pregnant women, but in women of childbearing age as well. In fact, a recent report suggested that women with moderate to severe ID may experience a significantly longer time to conceive. This study aimed to investigate iodine status in Filipino women of childbearing age.

Methods

The iodine status of 6,194 Filipino women aged 15 to 45 years old was assessed through urinary iodine analysis. A casual spot urine sample was collected from women in households participating in the eighth National Nutrition Survey conducted by the Food and Nutrition Research Institute. The sample was analyzed using ammonium persulfate digestion followed by the Sandell-Kolthoff colorimetric reaction. A median urinary iodine concentration (UIC) of less than 100 µg/L was used to define ID.

Results

The median UIC was 123 µg/L, indicative of adequate iodine nutrition; however, 21.5% of participants had a UIC below 50 µg/L. The median UIC of women who lived in urban areas (142 µg/L), belonged to the middle to richest class (>124 µg/L), had reached a college education (136 µg/L), and used iodized salt (15 ppm and above; 148 to 179 µg/L) reflected adequate iodine nutrition. ID was found to have been eliminated in the regions of Central Luzon, Eastern Visayas, Calabarzon, Mimaropa, and the National Capital, while mild ID was identified in Western Visayas, Southern and Western Mindanao, and in the Autonomous Region in Muslim Mindanao.

Conclusion

Pockets of ID among women of childbearing age exist in the Philippines. Proper information through education and the use of adequately iodized salt are key measures for improving the iodine status of the studied population.

Citations

Citations to this article as recorded by  
  • Adequate iodine nutrition and higher salt intake in Chinese adults aged 18–59 years recommended by international organizations
    Diqun Chen, Ying Ye, Ying Lan, Meng He, Jiani Wu, Lijin Wang, Zhihui Chen
    Scientific Reports.2024;[Epub]     CrossRef
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    R. Wei, Z. Wang, X. Zhang, X. Wang, Y. Xu, Q. Li
    Public Health.2023; 222: 75.     CrossRef
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    Yongze Li, Zhongyan Shan, Weiping Teng
    Endocrine Practice.2021; 27(10): 1028.     CrossRef
  • Female Fertility and the Nutritional Approach: The Most Essential Aspects
    Kinga Skoracka, Alicja Ewa Ratajczak, Anna Maria Rychter, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
    Advances in Nutrition.2021; 12(6): 2372.     CrossRef
  • Establishing reference intervals for urine and serum iodine levels: A nationwide multicenter study of a euthyroid Chinese population
    Songlin Yu, Danchen Wang, Xinqi Cheng, Qiong Zhang, Mingxue Wang, Haipeng Guo, Benzhang Yu, Xiuming Zhang, Liangyu Xia, Dandan Sun, Qian Cheng, Pengchang Li, Yicong Yin, Chaochao Ma, Li'an Hou, Yutong Zou, Honglei Li, Dandan Li, Ling Qiu, Kiyoshi Ichihara
    Clinica Chimica Acta.2020; 502: 34.     CrossRef
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    Michael E. Serafico
    Endocrinology and Metabolism.2018; 33(4): 495.     CrossRef
  • Letter: Iodine Status in Filipino Women of Childbearing Age (Endocrinol Metab 2018;33:372-9, Michael E. Serafico et al.)
    Zheng Feei Ma
    Endocrinology and Metabolism.2018; 33(4): 493.     CrossRef
Close layer
Clinical Study
Genetic Analysis of CLCN7 in an Old Female Patient with Type II Autosomal Dominant Osteopetrosis
Seon Young Kim, Younghak Lee, Yea Eun Kang, Ji Min Kim, Kyong Hye Joung, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Bon Jeong Ku, Minho Shong, Hyon-Seung Yi
Endocrinol Metab. 2018;33(3):380-386.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.380
  • 4,978 View
  • 62 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Type II autosomal dominant osteopetrosis (ADO II) is a rare genetically heterogeneous disorder characterized by osteosclerosis and increased bone mass, predominantly involving spine, pelvis, and skull. It is closely related to functional defect of osteoclasts caused by chloride voltage-gated channel 7 (CLCN7) gene mutations. In this study, we aimed to identify the pathogenic mutation in a Korean patient with ADO II using whole exome sequencing.

Methods

We evaluated the clinical, biochemical, and radiographic analysis of a 68-year-old woman with ADO II. We also performed whole exome sequencing to identify pathogenic mutation of a rare genetic disorder of the skeleton. Moreover, a polymorphism phenotyping program, Polymorphism Phenotyping v2 (PolyPhen-2), was used to assess the effect of the identified mutation on protein function.

Results

Whole exome sequencing using peripheral leukocytes revealed a heterozygous c.296A>G missense mutation in the CLCN7 gene. The mutation was also confirmed using Sanger sequencing. The mutation c.296A>G was regarded to have a pathogenic effect by PolyPhen-2 software.

Conclusion

We detect a heterozygous mutation in CLCN7 gene of a patient with ADO II, which is the first report in Korea. Our present findings suggest that symptoms and signs of ADO II patient having a c.296A>G mutation in CLCN7 may appear at a very late age. The present study would also enrich the database of CLCN7 mutations and improve our understanding of ADO II.

Citations

Citations to this article as recorded by  
  • Autosomal dominant osteopetrosis type II resulting from a de novo mutation in the CLCN7 gene: A case report
    Xiu-Li Song, Li-Yuan Peng, Dao-Wen Wang, Hong Wang
    World Journal of Clinical Cases.2022; 10(20): 6936.     CrossRef
  • Magnetic resonance findings in a Cavalier King Charles spaniel with osteopetrosis, Chiari‐like malformation and syringomyelia
    Ricardo Fernandes, C J Jordan, Colin Driver
    Veterinary Record Case Reports.2019;[Epub]     CrossRef
Close layer
Clinical Study
Effect of Dapagliflozin on Alanine Aminotransferase Improvement in Type 2 Diabetes Mellitus with Non-alcoholic Fatty Liver Disease
Dug-Hyun Choi, Chan-Hee Jung, Ji-Oh Mok, Chul-Hee Kim, Sung-Koo Kang, Bo-Yeon Kim
Endocrinol Metab. 2018;33(3):387-394.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.387
  • 6,058 View
  • 123 Download
  • 36 Web of Science
  • 35 Crossref
AbstractAbstract PDFPubReader   ePub   
Background

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are expected to improve the liver function of patients with non-alcoholic fatty liver disease (NAFLD) combined type 2 diabetes mellitus (T2DM) by its characteristic mechanism. This study was designed to investigate the effect of dapagliflozin, one of the SGLT2i, on the liver function of T2DM with NAFLD when combined with metformin.

Methods

Among patients who received dual oral hypoglycemic agents within the 3 months of diagnosing NAFLD, patients who had abnormal alanine aminotransferase (ALT) level (>40 IU/L) were included. Patients were divided into two groups: metformin+dapagliflozin group and metformin+dipeptidyl peptidase-4 inhibitors (DPP4i) group. Demographic data, biochemical data and the clinical and treatment histories of all patients were reviewed.

Results

A total of 102 patients were included (dapagliflozin group, n=50; DPP4i group, n=52). Dapagliflozin group showed more weight loss and more ALT decline than DPP4i group (−2.9 kg vs. −0.4 kg, P=0.005; −21.1 U/L vs. −9.5 U/L, P=0.008, respectively) and the proportion of patients with ALT normalization after treatment was also significantly higher in the dapagliflozin group (80.0% vs. 61.5%, P=0.041). The effect of dapagliflozin with metformin on ALT normalization remained significant after adjustment for confounding variables including body weight loss (odds ratio, 3.489; P=0.046).

Conclusion

ALT improvement was statistically significant in the dapagliflozin than the DPP4i when combined with metformin and the result was consistent after adjustment for confounding variables including body weight loss.

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    Stergios A. Polyzos, Jannis Kountouras, Christos S. Mantzoros
    Metabolism.2019; 92: 82.     CrossRef
  • Nonalcoholic Fatty Liver Disease and Diabetes: Part II: Treatment
    Kyung-Soo Kim, Byung-Wan Lee, Yong Jin Kim, Dae Ho Lee, Bong-Soo Cha, Cheol-Young Park
    Diabetes & Metabolism Journal.2019; 43(2): 127.     CrossRef
  • Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-γ and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet
    Fan Zheng, Ying Cai
    Lipids in Health and Disease.2019;[Epub]     CrossRef
  • The Effects of Hypoglycemic Agents on Non-alcoholic Fatty Liver Disease: Focused on Sodium-Glucose Cotransporter 2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists
    Chan-Hee Jung, Ji-Oh Mok
    Journal of Obesity & Metabolic Syndrome.2019; 28(1): 18.     CrossRef
  • Effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Ex quo et quo vadimus?
    Niki Katsiki, Nikolaos Perakakis, Christos Mantzoros
    Metabolism.2019; 98: iii.     CrossRef
  • Empaglifozin mitigates NAFLD in high-fat-fed mice by alleviating insulin resistance, lipogenesis and ER stress
    Tamiris Ingrid Petito-da-Silva, Vanessa Souza-Mello, Sandra Barbosa-da-Silva
    Molecular and Cellular Endocrinology.2019; 498: 110539.     CrossRef
  • Beneficial effects of SGLT2 inhibitors on fatty liver in type 2 diabetes: A common comorbidity associated with severe complications
    A.J. Scheen
    Diabetes & Metabolism.2019; 45(3): 213.     CrossRef
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Clinical Study
Effects of Maternal Iodine Status during Pregnancy and Lactation on Maternal Thyroid Function and Offspring Growth and Development: A Prospective Study Protocol for the Ideal Breast Milk Cohort
Young Ah Lee, Sun Wook Cho, Ho Kyung Sung, Kyungsik Kim, Young Shin Song, Sin Je Moon, Jung Won Oh, Dal Lae Ju, Sooyeon Choi, Sang Hoon Song, Gi Jeong Cheon, Young Joo Park, Choong Ho Shin, Sue K. Park, Jong Kwan Jun, June-Key Chung
Endocrinol Metab. 2018;33(3):395-402.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.395
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AbstractAbstract PDFPubReader   ePub   
Background

Iodine is an intrinsic element of thyroid hormone, which is essential for childhood growth and development. The Ideal Breast Milk (IBM) cohort study aims to evaluate the effects of maternal iodine status during pregnancy and lactation on maternal thyroid function, offspring growth and development, and offspring thyroid function.

Methods

The IBM cohort study recruited pregnant women from Seoul National University Hospital between June 2016 and August 2017, followed by enrollment of their offspring after delivery. For the maternal participants, iodine status is evaluated by urinary iodine concentration (UIC) and dietary records in the third trimester and at 3 to 4 weeks and 12 to 15 months postpartum. For the child participants, cord blood sampling and UIC measurements are performed at birth. At 3 to 4 weeks of age, UIC and breastmilk iodine concentrations are measured. At 12 to 15 months of age, growth and development are assessed and measurements of UIC, a thyroid function test, and ultrasonography are performed.

Results

A total of 198 pregnant women in their third trimester were recruited. Their mean age was 35.1±3.5 years, and 78 (39.4%) of them were pregnant with twins. Thirty-three (16.7%) of them had a previous history of thyroid disease.

Conclusion

Korea is an iodine-replete area. In particular, lactating women in Korea are commonly exposed to excess iodine due to the traditional practice of consuming brown seaweed soup postpartum. The study of the IBM cohort is expected to contribute to developing guidelines for optimal iodine nutrition in pregnant or lactating women.

Citations

Citations to this article as recorded by  
  • Exposure to and Transplacental Transfer of Per- and Polyfluoroalkyl Substances in a Twin Pregnancy Cohort in Korea
    Na-Youn Park, Sun Wook Cho, Ye Eun Seo, Heeyeon Chae, Inae Lee, Young Ah Lee, Jong Kwan Jun, Eun Na Kim, Jeong-Won Oh, Kyungho Choi, Younglim Kho
    Environmental Science & Technology.2024; 58(48): 21120.     CrossRef
  • High intakes of iodine among women during pregnancy and the postpartum period has no adverse effect on thyroid function
    Dal Lae Ju, Sun Wook Cho, Chae Won Chung, Young Ah Lee, Gi Jeong Cheon, Young Joo Park, Choong Ho Shin, Jong Kwan Jun, June-Key Chung, Sue K. Park, YoonJu Song
    European Journal of Nutrition.2023; 62(1): 239.     CrossRef
  • Associations between maternal thyroid function in pregnancy and child neurodevelopmental outcomes at 20 months in the Seychelles Child Development Study, Nutrition Cohort 2 (SCDS NC2)
    Anna M. Monaghan, Maria S. Mulhern, Emeir M. Mc Sorley, J.J. Strain, Theresa Winter, Edwin van Wijngaarden, Gary J. Myers, Philip W. Davidson, Conrad Shamlaye, Jude Gedeon, Alison J. Yeates
    Journal of Nutritional Science.2021;[Epub]     CrossRef
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Endocrine Research
Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes β-Cell Impairment via Mitochondrial Dysregulation
Seok-Woo Hong, Jinmi Lee, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
Endocrinol Metab. 2018;33(3):403-412.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.403
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AbstractAbstract PDFPubReader   ePub   
Background

Emerging evidence suggests that sphingolipids may be involved in type 2 diabetes. However, the exact signaling defect through which disordered sphingolipid metabolism induces β-cell dysfunction remains unknown. The current study demonstrated that sphingosine-1-phosphate (S1P), the product of sphingosine kinase (SphK), is an essential factor for maintaining β-cell function and survival via regulation of mitochondrial action, as mediated by prohibitin (PHB).

Methods

We examined β-cell function and viability, as measured by mitochondrial function, in mouse insulinoma 6 (MIN6) cells in response to manipulation of cellular S1P and PHB levels.

Results

Lack of S1P induced by sphingosine kinase inhibitor (SphKi) treatment caused β-cell dysfunction and apoptosis, with repression of mitochondrial function shown by decreases in cellular adenosine triphosphate content, the oxygen consumption rate, the expression of oxidative phosphorylation complexes, the mitochondrial membrane potential, and the expression of key regulators of mitochondrial dynamics (mitochondrial dynamin-like GTPase [OPA1] and mitofusin 1 [MFN1]). Supplementation of S1P led to the recovery of mitochondrial function and greatly improved β-cell function and viability. Knockdown of SphK2 using small interfering RNA induced mitochondrial dysfunction, decreased glucose-stimulated insulin secretion (GSIS), and reduced the expression of PHB, an essential regulator of mitochondrial metabolism. PHB deficiency significantly reduced GSIS and induced mitochondrial dysfunction, and co-treatment with S1P did not reverse these trends.

Conclusion

Altogether, these data suggest that S1P is an essential factor in the maintenance of β-cell function and survival through its regulation of mitochondrial action and PHB expression.

Citations

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  • Mitochondrial Cristae Morphology Reflecting Metabolism, Superoxide Formation, Redox Homeostasis, and Pathology
    Petr Ježek, Martin Jabůrek, Blanka Holendová, Hana Engstová, Andrea Dlasková
    Antioxidants & Redox Signaling.2023; 39(10-12): 635.     CrossRef
  • Sphingolipids in mitochondria—from function to disease
    Maryam Jamil, Lauren Ashley Cowart
    Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
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    Meng Duan, Pan Gao, Sheng‐xi Chen, Petr Novák, Kai Yin, Xiao Zhu
    Obesity Reviews.2022;[Epub]     CrossRef
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    Lina Wu, Qingzhu Wang, Feng Guo, Xiaojun Ma, Jiao Wang, Yanyan Zhao, Yushan Yan, Guijun Qin
    Journal of Cellular Physiology.2021; 236(2): 1454.     CrossRef
  • Sphingosine‐1‐phosphate in acute exercise and training
    Katarzyna Hodun, Adrian Chabowski, Marcin Baranowski
    Scandinavian Journal of Medicine & Science in Sports.2021; 31(5): 945.     CrossRef
  • The Ethyl Acetate Extract From Celastrus orbiculatus Promotes Apoptosis of Gastric Cancer Cells Through Mitochondria Regulation by PHB
    Lide Tao, Zixin Yin, Tengyang Ni, Zewen Chu, Shihua Hao, Zeyu Wang, Masataka Sunagawa, Haibo Wang, Yanqing Liu
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Sphingosine 1-phosphate Stimulates Insulin Secretion and Improves Cell Survival by Blocking Voltage-dependent K+ Channels in β Cells
    Zhihong Liu, Huanhuan Yang, Linping Zhi, Huan Xue, Zhihong Lu, Yanli Zhao, Lijuan Cui, Tao Liu, Shouan Ren, Peifeng He, Yunfeng Liu, Yi Zhang
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Sphingosine-1 Phosphate Lyase Regulates Sensitivity of Pancreatic Beta-Cells to Lipotoxicity
    Yadi Tang, Thomas Plötz, Markus H. Gräler, Ewa Gurgul-Convey
    International Journal of Molecular Sciences.2021; 22(19): 10893.     CrossRef
  • Sphingolipids and Mitochondrial Dynamic
    Lais Brigliadori Fugio, Fernanda B. Coeli-Lacchini, Andréia Machado Leopoldino
    Cells.2020; 9(3): 581.     CrossRef
  • Diminished Sphingolipid Metabolism, a Hallmark of Future Type 2 Diabetes Pathogenesis, Is Linked to Pancreatic β Cell Dysfunction
    Saifur R. Khan, Yousef Manialawy, Andreea Obersterescu, Brian J. Cox, Erica P. Gunderson, Michael B. Wheeler
    iScience.2020; 23(10): 101566.     CrossRef
  • Neuronal Metabolism and Neuroprotection: Neuroprotective Effect of Fingolimod on Menadione-Induced Mitochondrial Damage
    Antonio Gil, Elisa Martín-Montañez, Nadia Valverde, Estrella Lara, Federica Boraldi, Silvia Claros, Silvana-Yanina Romero-Zerbo, Oscar Fernández, Jose Pavia, Maria Garcia-Fernandez
    Cells.2020; 10(1): 34.     CrossRef
  • WITHDRAWN: Ceramide and Sphingosine 1-Phosphate in adipose dysfunction
    Zijian Fang, Susan Pyne, Nigel J. Pyne
    Progress in Lipid Research.2019; : 100991.     CrossRef
  • Dynamic of mitochondrial network, cristae, and mitochondrial nucleoids in pancreatic β-cells
    Petr Ježek, Andrea Dlasková
    Mitochondrion.2019; 49: 245.     CrossRef
  • Sphingosine kinase 1 overexpression induces MFN2 fragmentation and alters mitochondrial matrix Ca2+ handling in HeLa cells
    I. Pulli, C. Löf, T. Blom, M.Y. Asghar, T. Lassila, N. Bäck, K.-L. Lin, J.H. Nyström, K. Kemppainen, D.M. Toivola, E. Dufour, A. Sanz, H.M. Cooper, J.B. Parys, K. Törnquist
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2019; 1866(9): 1475.     CrossRef
  • Ceramide and sphingosine 1-phosphate in adipose dysfunction
    Zijian Fang, Susan Pyne, Nigel J. Pyne
    Progress in Lipid Research.2019; 74: 145.     CrossRef
  • S1P/S1P Receptor Signaling in Neuromuscolar Disorders
    Elisabetta Meacci, Mercedes Garcia-Gil
    International Journal of Molecular Sciences.2019; 20(24): 6364.     CrossRef
Close layer
Endocrine Research
Functional Identification of Compound Heterozygous Mutations in the CYP17A1 Gene Resulting in Combined 17α-Hydroxylase/17,20-Lyase Deficiency
Eun Yeong Mo, Ji-young Lee, Su Yeon Kim, Min Ji Kim, Eun Sook Kim, Seungok Lee, Je Ho Han, Sung-dae Moon
Endocrinol Metab. 2018;33(3):413-422.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.413
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AbstractAbstract PDFPubReader   ePub   
Background

We previously reported a patient with congenital adrenal hyperplasia (CAH) with compound heterozygous mutations in the cytochrome P450 17A1 (CYP17A1) gene. One allele had a p.His373Leu and the other a new p.Glu383fsX36 mutation. The aim of this study was to investigate the functional properties of a new allele present in a compound heterozygote of CYP17A1.

Methods

To understand how p.His373Leu and p.Glu383fsX36 affect P450c17 enzymatic activity, wild type and mutant CYP17A1 cDNAs were cloned into flag-tagged pcDNA3 vector and introduced into human embryonic kidney cells 293T (HEK293T) cells. Protein expression levels of CYP17A1 were then analyzed. And the activities of 17α-hydroxylase and 17,20-lyase of CYP17A1 were evaluated by measuring the conversion of progesterone to 17α-hydroxyprogesterone and of 17α-hydroxypregnenolone to dehydroepiandrosterone, respectively. In addition a computer model was used to create the three-dimensional structure of the mutant CYP17A1 enzymes.

Results

Production of the p.His373Leu mutant protein was significantly lower than that of the wild type protein, and the p.Glu383fsX36 protein was hardly produced. Similarly the enzymatic activity derived from the p.His373Leu mutant vector was significantly lower than that obtained from the wild type vector, and little activity was obtained from the p.Glu383fsX36 vector. Three-dimensional modeling of the enzyme showed that p.His373 was located in region important for heme-binding and proper folding. Neither the p.His373Leu nor the p.Glu383fsX36 mutant protein formed a heme-binding structure.

Conclusion

Enzyme activity measured in both mutants disappeared completely in both 17α-hydroxylase and 17,20-lyase. This result accounts for the clinical manifestations of the patient with the compound heterozygous CYP17A1 mutations.

Citations

Citations to this article as recorded by  
  • A rare case of 17α-hydroxylase/17, 20-lyase deficiency: Clinical and genetic findings and follow-up outcomes
    Li-Zhen Dai, Hong Ma, Jian-Fang Ke, Chen-Shi Lin, Yanling Huang, Yuan Tian, Danling Chen
    Women's Health.2022;[Epub]     CrossRef
  • Novel mutations of the CYP17A1 gene in four Chinese 46,XX cases with partial 17a-hydroxylase/17,20-lyase deficiency
    Yanjie Xia, Panlai Shi, Junke Xia, Huijuan Zhang, Lijun Xu, Xiangdong Kong
    Steroids.2021; 173: 108873.     CrossRef
Close layer
Letter
Adrenal gland
An Ectopic Cortisol-Producing Adrenocortical Adenoma Masquerading as a Liposarcoma in the Pararenal Space
Sunyoung Kang, Seung Shin Park, Jae Hyun Bae, Kyu Eun Lee, Jung Hee Kim, Chan Soo Shin
Endocrinol Metab. 2018;33(3):423-424.   Published online August 14, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.423
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Response
Diabetes
Response: The Association between Persistent Hypertriglyceridemia and the Risk of Diabetes Development: The Kangbuk Samsung Health Study (Endocrinol Metab 2018;33:55–61, Yu Hyun Kwon et al.)
Eun-Jung Rhee, Yu Hyun Kwon
Endocrinol Metab. 2018;33(3):425-426.   Published online September 18, 2018
DOI: https://doi.org/10.3803/EnM.2018.33.3.425
[Original]
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