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1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
2Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Korea.
Copyright © 2018 Korean Endocrine Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.
AUTHOR CONTRIBUTIONS: Conception or design: J.W.H., C.W.A. Acquisition, analysis, or interpretation of data: J.S.N., J.W.H., M.J.K., S.K., J.S.P. Drafting the work or revising: J.S.N., S.B.L., J.H.Y. Final approval of the manuscript: C.W.A.
Values are expressed as mean±SD.
NS, not significant; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; TC, total cholesterol; TG, triglyceride; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance; HOMA-β, homeostasis model assessment of β-cell function.
Characteristic | Diabetic | Control | P value |
---|---|---|---|
No. of subjects (male/female) | 249 (158/91) | 131 (61/70) | NS |
Age, yr | 56.03±6.73 | 54.52±6.39 | NS |
BMI, kg/m2 | 24.67±3.64 | 23.73±2.53 | 0.009 |
SBP, mm Hg | 124.00±10.37 | 123.39±12.57 | NS |
DBP, mm Hg | 77.57±6.95 | 75.82±9.29 | 0.038 |
FPG, mmol/L | 7.75±2.19 | 5.00±0.33 | <0.001 |
TC, mmol/L | 4.84±1.00 | 5.04±0.96 | 0.060 |
TG, mmol/L | 1.71±0.95 | 1.23±0.64 | <0.001 |
LDL-C, mmol/L | 2.73±0.85 | 2.96±0.83 | 0.010 |
HDL-C, mmol/L | 0.28±0.31 | 1.40±0.32 | 0.001 |
Adiponectin, μg/mL | 7.34±4.85 | 8.47±6.17 | 0.040 |
Fasting insulin, μU/L | 3.92±4.88 | 3.34±2.68 | NS |
HOMA-IR | 2.52±4.06 | 1.35±1.05 | <0.001 |
HOMA-β, % | 60.48±65.84 | 77.42±65.48 | 0.017 |
Gene | Genotype | No. of case (%) | No. of control (%) | OR (95% CI) | P value |
---|---|---|---|---|---|
ACDC 276G/T | TT | 121 (48.6) | 60 (45.8) | 1.00 | |
TG | 102 (41.0) | 54 (41.2) | 0.91 (0.57–1.45) | 0.69 | |
GG | 26 (10.4) | 17 (13.0) | 0.84 (0.41–1.71) | 0.63 | |
ACDC 45T/G | GG | 119 (47.8) | 61 (46.6) | 1.00 | |
GT | 108 (43.4) | 60 (45.8) | 0.96 (0.61–1.51) | 0.86 | |
TT | 22 (8.8) | 10 (7.6) | 1.12 (0.49–2.58) | 0.79 | |
CAPN10 43G/A | GG | 202 (81.1) | 101 (77.1) | 1.00 | |
GA | 44 (17.7) | 29 (22.1) | 0.76 (0.44–1.31) | 0.32 | |
AA | 3 (1.2) | 1 (0.8) | 1.04 (0.10–10.5) | 0.97 | |
CAPN10 63C/T | CC | 132 (53.4) | 77 (59.2) | 1.00 | |
CT | 93 (37.7) | 49 (37.7) | 1.11 (0.70–1.77) | 0.65 | |
TT | 22 (8.9) | 4 (3.1) | 3.38 (1.10–10.4) | 0.03 |
Gene | Additive model | Dominant model OR (95% CI) | Recessive model OR (95% CI) | ||||||
---|---|---|---|---|---|---|---|---|---|
Genotype | OR (95% CI) | P value | Genotype | Dominant model OR (95% CI) | P value | Genotype | Recessive model OR (95% CI) | P value | |
ACDC 276G/T | TT | 0.91 (0.66–1.26) | 0.58 | TT | 1.00 | TT+TG | 1.00 | ||
TG+GG | 1.00 | TG+GG | 0.89 (0.58–1.39) | 0.61 | GG | 0.88 (0.45–1.72) | 0.71 | ||
ACDC 45T/G | GG | 1.02 (0.72–1.43) | 0.93 | GG | 1.00 | GG+GT | 1.00 | ||
GT+TT | 1.00 | GT+TT | 0.99 (0.64–1.52) | 0.94 | TT | 1.14 (0.51–2.55) | 0.74 | ||
CAPN10 43G/A | GG | 0.80 (0.49–1.31) | 0.38 | GG | 1.00 | GG+GA | 1.00 | ||
GA+AA | 1.00 | GA+AA | 0.77 (0.45–1.31) | 0.34 | AA | 1.10 (0.11–11.1) | 0.94 | ||
CAPN10 63C/T | CC | 1.39 (0.96–2.00) | 0.08 | CC | 1.00 | CC+CT | 1.00 | ||
CT+TT | 1.00 | CT+TT | 1.28 (0.82–3.01) | 0.27 | TT | 3.23 (1.06–9.79) | 0.04 |
Values are expressed as mean±SD. NS, not significant; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; TC, total cholesterol; TG, triglyceride; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance; HOMA-β, homeostasis model assessment of β-cell function.
Adjusted for age and gender.
Adjusted for age and gender. OR, odds ratio; CI, confidence interval;