Endocrinol Metab > Volume 22(5); 2007 > Article
Journal of Korean Endocrine Society 2007;22(5):344-352.
DOI: https://doi.org/10.3803/jkes.2007.22.5.344    Published online October 1, 2007.
A Case of Parathyroid Carcinoma Underwent Radiation Therapy on the Metastatic Bone Lesions.
Jun Ho Lee, Young Min Kim, Dae Seong Hwang, Young Tae Hwang, Jun Bum Eum, Jung Min Seo, Dae Hwa Choi, Byeong Seong Kang, Young Ju Noh, Il Seong Nam-Goong, Young Il Kim, Eun Sook Kim
1Department of Internal Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan.
2Department of Pathology, Ulsan University Hospital, College of Medicine, University of Ulsan.
3Department of Surgery, Ulsan University Hospital, College of Medicine, University of Ulsan.
4Department of Radiology, Ulsan University Hospital, College of Medicine, University of Ulsan.
5Department of Radiation Oncology, Ulsan University Hospital, College of Medicine, University of Ulsan.
Abstract
Parathyroid carcinoma is a rare malignancy that is responsible for only 0.5 to 4% of all cases of primary hyperparathyroidism. Surgery is the only curative treatment. We report a case of a 46-year-old woman referred for a severe osteoporosis with frequent bone fracture associated with hypercalcemia. Initially, though she had multiple osteolytic lesions, we thought that the lesions were brown tumors resulting from hyperparathyroidism. The patient underwent surgery and was diagnosed with parathyroid carcinoma. After surgery, her intact PTH level normalized for brief period of time, but it was again elevated at 6 weeks after surgery. We suggest that the multiple osteolytic lesions were metastases because there was no evidence of local recurrence of parathyroid carcinoma, and the lesions looked like metastases on CT and PET-CT. The patient was treated with radiation therapy on the lumbar vertebra, one a site of the metastatic lesions. After radiotherapy, her serum intact PTH was decreased.
Key Words: Multiple bone metastases, Parathyroid carcinoma, Radiation therapy


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