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Original Article
Clinical Study Protocol for a Korean Multicenter Prospective Cohort Study of Active Surveillance or Surgery (KoMPASS) in Papillary Thyroid Microcarcinoma
Min Ji Jeon1*orcid, Yea Eun Kang2*orcid, Jae Hoon Moon3, Dong Jun Lim4, Chang Yoon Lee5, Yong Sang Lee6, Sun Wook Kim7, Min-Hee Kim8, Bo Hyun Kim9, Ho-Cheol Kang10, Minho Shong2, Sun Wook Cho11orcid, Won Bae Kim1orcid
Endocrinology and Metabolism 2021;36(2):359-364.
DOI: https://doi.org/10.3803/EnM.2020.890
Published online: March 23, 2021
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  • 12 Crossref
  • 11 Scopus

1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

2Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea

3Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea

4Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

5Department of Radiology, National Cancer Center, Goyang, Korea

6Department of Surgery, Thyroid Cancer Center, Gangnam Severance Hospital, Institute of Refractory Thyroid Cancer, Yonsei University College of Medicine, Seoul, Korea

7Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

8Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

9Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea

10Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea

11Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea

Corresponding authors: Won Bae Kim. Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea, Tel: +82-2-3010-3913, Fax: +82-2-3010-6962, E-mail: kimwb@amc.seoul.kr.
Sun Wook Cho. Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea, Tel: +82-2-2072-4761, Fax: +82-2-762-2292, E-mail: swchomd@snu.ac.kr
* These authors contributed equally to this work.
• Received: October 27, 2020   • Revised: December 9, 2020   • Accepted: January 12, 2021

Copyright © 2021 Korean Endocrine Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article has been corrected. See "Corrigendum: Correction of Acknowledgments. Protocol for a Korean Multicenter Prospective Cohort Study of Active Surveillance or Surgery (KoMPASS) in Papillary Thyroid Microcarcinoma" in Volume 37 on page 181.
  • Background
    A Korean Multicenter Prospective cohort study of Active Surveillance or Surgery (KoMPASS) for papillary thyroid microcarcinomas (PTMCs) has been initiated. The aim is to compare clinical outcomes between active surveillance (AS) and an immediate lobectomy for low-risk PTMCs. We here outline the detailed protocol for this study.
  • Methods
    Adult patients with a cytopathologically confirmed PTMC sized 6.0 to 10.0 mm by ultrasound (US) will be included. Patients will be excluded if they have a suspicious extra-thyroidal extension or metastasis of a PTMC or multiple thyroid nodules or other thyroid diseases which require a total thyroidectomy. Printed material describing the prognosis of PTMCs, and the pros and cons of each management option, will be provided to eligible patients to select their preferred intervention. For the AS group, thyroid US, thyroid function, and quality of life (QoL) parameters will be monitored every 6 months during the first year, and then annually thereafter. Disease progression will be defined as a ≥3 mm increase in maximal diameter of a PTMC, or the development of new thyroid cancers or metastases. If progression is detected, patients should undergo appropriate surgery. For the lobectomy group, a lobectomy with prophylactic central neck dissection will be done within 6 months. After initial surgery, thyroid US, thyroid function, serum thyroglobulin (Tg), anti-Tg antibody, and QoL parameters will be monitored every 6 months during the first year and annually thereafter. Disease progression will be defined in these cases as the development of new thyroid cancers or metastases.
  • Conclusion
    KoMPASS findings will help to confirm the role of AS, and develop individualized management strategies, for low-risk PTMCs.
A significant increase in the incidence of papillary thyroid cancer, especially papillary thyroid microcarcinoma (PTMC), has been reported worldwide [1]. Excellent clinical outcomes have been reported for PTMC patients due to the indolent nature [2]. As a result, active surveillance (AS) instead of immediate surgery has been suggested as an alternative management approach for low-risk PTMCs [3]. AS involves a life-long regular follow-up of the PTMC status with appropriate surgical treatment provided only when disease progression becomes apparent [46]. Since the introduction of AS for PTMCs by Japanese surgeons [3], many retrospective observational studies have suggested that this is a safe and effective approach for the management of low-risk PTMCs [79]. In a prior meta-analysis of PTMC patients, the pooled proportion of 5-year tumor size enlargements ≥3 mm was found to be only 5.3%, and that of 5-year lymph node (LN) metastasis only 1.6% during AS [10].
Recent American Thyroid Association guidelines recommend a lobectomy as a standard surgical treatment for low-risk PTMCs unless there are clear indications to remove the contralateral lobe [11]. A lobectomy does not pose a significantly higher risk of recurrence than a total thyroidectomy according to a previous retrospective study of PTMCs [12]. Furthermore, the incidence of postoperative complications following a lobectomy is very low by high-volume surgeons [12,13], and the incidence of postoperative hypothyroidism in patients who have undergone a lobectomy is only approximately 20% [14]. These findings have suggested that a lobectomy may be safer and more effective than AS in PTMC patients [15]. However, only single-arm retrospective studies of AS have been conducted so far, and no prior reports have compared the clinical outcomes of AS with those of lobectomy in PTMC populations.
To address this issue and compare the clinical outcomes of AS with those of an immediate lobectomy in PTMC, a Korean Multicenter Prospective cohort study of Active Surveillance or Surgery (KoMPASS) in low-risk PTMC cases has been initiated. KoMPASS aims to compare the disease progression rate, quality of life (QoL), and cost-effectiveness between AS and lobectomy to confirm the efficacy of the AS approach in the management of low-risk PTMCs. Factors associated with disease progression during AS, socioeconomic and QoL parameters affecting the informed decision-making in terms of intervention with their changes during follow-up, appropriate imaging follow-up strategies during AS, and differences in surgery-related factors such as the surgical extent, postoperative staging and postoperative complications between immediate and delayed surgery will also be evaluated. We hear introduce the details of the KoMPASS protocol.
Study design
KoMPASS will be a nationwide prospective observational cohort study of low-risk PTMCs. Eleven referral hospitals in Korea are participating and the study protocol was approved by the ethics committee of each institution: Asan Medical Center (2019-1541), Seoul National University Bundang Hospital (B-1912/583-304), Seoul St. Mary’s Hospital (XC20ONDE-0053K), the National Cancer Center (NCC2020-0123), Gangnam Severance Hospital (3-2020-0077), Seoul National University Hospital (1911-149-1083), Samsung Medical Center (2019-11-140), Eunpyeong St. Mary’s Hospital (XC20ONDE0053P), Pusan National University Hospital (2004-03-089), Chonnam National University Hwasun Hospital (CNUHH-2020-086), and Chungnam National University Hospital (2019-11-054). The protocol of this study is registered at the Clinical Research Information Service of Korea Centers for Disease Control and Prevention (KCT0004935). Patients will be included from August 2020 to August 2023, and follow-up data will be collected until August 2024.
Study population and enrollment
Low-risk PTMCs which can be treated by lobectomy are considered eligible. Patients with an eligible PTMC will be offered the printed material containing a detailed description of the clinical outcomes associated with a low-risk PTMC, and the pros and cons of AS and lobectomy. After careful consideration, patients will be asked to select their preferred treatment approach. Up to 3 months will be given to patients to make this decision (i.e., an informed decision process). When patients decide upon their treatment option, the physicians will explain the KoMPASS protocol and informed consent to participate will be obtained. The clinical and socioeconomic characteristics of the study patients, their initial PTMC status including ultrasound (US) and computed tomography (CT) results, laboratory findings including thyroid function, and QoL parameters assessed by two questionnaires will be collected at the time of enrollment (Fig. 1). The Korean versions of the questionnaires to be used in KoMPASS have been validated in previous studies [16,17].
Inclusion criteria
  • - Adult patients (aged 19 to 80) with a thyroid nodule which fulfils all of the following criteria:

  • A maximum diameter of between 6.0 mm and 10.0 mm measured by US.

  • Diagnosed as suspicious for malignancy (Bethesda category V [18]) or as a malignancy (Bethesda category VI) by either fine needle aspiration or core needle biopsy.

  • In cases of Bethesda category V lesions, the nodule should show highly suspicious US features in accordance with the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) [19] or should harbor a BRAF V600E mutation.

Exclusion criteria
  • Patients who can’t understand or don’t agree to the study protocol.

  • Pregnant women.

  • Patients with a history of head and neck cancer, actively receiving treatment for other cancers, or with any uncontrolled chronic disease.

  • Patients with multiple thyroid nodules or another thyroid disease requiring a total thyroidectomy.

  • PTMC with a suspicion of a cervical LN metastasis determined by either US or thyroid protocol CT [6].

  • PTMC with a suspicion of distant metastasis, with clinical symptoms/signs of extra-thyroidal extension of the tumor, or showing invasion to recurrent laryngeal nerve [6].

Follow-up protocol
For the PTMC patients undergoing AS, thyroid US, thyroid function, and QoL parameters will be monitored every 6 months during the first year, and then annually thereafter [3]. If disease progression is detected, patients should undergo the appropriate surgery. For patients deciding to undergo a lobectomy, a lobectomy with prophylactic central neck dissection will be done within 6 months of this decision. After the initial surgery, thyroid US, thyroid function, serum thyroglobulin (Tg), anti-Tg antibody, and QoL parameters will be monitored every 6 months during the first year, and then annually thereafter. During follow-up, thyroid function needs to be maintained in an euthyroid status.
Patients undergoing AS will be allowed to change their treatment option at any time during follow-up, i.e., they can elect to undergo surgery. However, any patient that changes their treatment option within 6 months of the initial enrollment will be excluded from the study.
Study outcomes
The primary outcome of the KoMPASS study is progression-free survival. Disease progression in the study patients undergoing AS will be defined by any of the following criteria: (1) a maximum PTMC size increase of ≥3 mm [3]; (2) a cytopathological diagnosis of a new thyroid cancer lesion; (3) a cytopathological diagnosis of a cervical LN metastasis; or (4) clinical or radiological suspicion of a distant metastasis. Disease progression after a lobectomy will be defined by any of the following: (1) a cytopathological diagnosis of a new lesion in the remnant thyroid; (2) a cytopathological diagnosis of a cervical LN metastasis; or (3) a clinical or radiological suspicion of a distant metastasis.
For secondary outcomes, we aim to evaluate overall survival, socioeconomic status and the QoL parameters of the enrolled patients. We will also examine the cost-effectiveness of the two different management approaches, the risk factors for disease progression during AS (i.e., the age and sex of the patients, US features of nodules, the tumor volume [TV], and the TV doubling time [20]), any reasons for a delayed surgery, appropriate imaging follow-up strategies during AS, and differences in surgery-related factors such as the surgical extent, postoperative staging and postoperative complications between immediate surgery and delayed surgery.
Sample size calculation
According to previous retrospective studies and meta-analyses of PTMCs, the disease progression rate associated with AS is about 6.9% [10] and that for an immediate lobectomy is around 1.6% [21]. We used inequality hypothesis for two survival curves using a Cox’s proportional hazards model. The hazard ratio for the surgery group will be set to 0.54 based on our prior experience. The expected enrollment ratio for AS and surgery group is estimated to be about 1:1. The alpha-error will be set to 0.05 based on a two-sided effect and the power will be set to 80%. With these assumptions, the sample size per group has been estimated at 973 (total 1,946) via the Power Analysis Sample Size function of PASS 15 software (NCSS LCC., Kaysville, UT, USA). We aim therefore to recruit a total of 2,000 PTMC patients into the KoMPASS trial.
Data analysis
Continuous data will be presented as a mean±standard deviation or median with interquartile range. Categorical data will be presented as numbers with percentages. A Cox proportional hazard models will be used to evaluate survival outcomes. Both intent to treat and per protocol analysis will be conducted. To reduce possible biases, propensity score matching or inverse probability of treatment weighting methods will be used. Variables measured multiple times during follow-up will be compared with the paired t test in accordance with the clinical management used. A significant level will be set at 0.05 and R version 3.1.0 and R libraries survival, car, prodlim, and Cairo software will be used to analyze the data (R Foundation for Statistical Computing, http://www.R-project.org).
Dissemination policy
The scientific integrity of this project requires that data from all centers should be analyzed and reported. Thus, an individual center is not expected to report the data collected from its center alone. Topics suggested for publication will be circulated to the principal investigators of all centers. The lead author of the study should be the person who suggested the topic and co-authors should be decided according to the authorship guidelines.
AS has only been introduced recently for the management of PTMC cases, and most of the evidence to date for the effectiveness of this approach has come from single-arm, short-term, retrospective studies [3,8,9,22]. Some prospective comparative studies have been conducted for AS interventions in PTMC patients, but the results have not been reported yet [6,23]. The strengths of the KoMPASS protocol are that it follows the recent guidelines and protocols of some of the seminal reports on PTMC [3,11,19,24] and will be a head-to-head comparison of AS and lobectomy, which is the standard surgical intervention used for low-risk PTMCs. We aim over the next 4 years to compare various effects of AS and lobectomy on the clinical outcomes of PTMC patients, including the oncologic and surgical outcomes, QoL, and cost-effectiveness. We will also evaluate the appropriateness of different imaging follow-up strategies during AS.
The KoMPASS protocol is primarily characterized by its inclusion and exclusion criteria, which limit the enrollment eligibility to subjects that can be treated by lobectomy, its use of routine CT examinations to confirm the PTMC status of the patients at the time of enrollment [25], and its requirement that patients receive detailed and adequate information to enable informed decision-making regarding their study participation and choice of treatment. The PTMC patients select their preferred clinical management approach, i.e., AS or immediate lobectomy, by themselves after careful consideration of this relevant information. We will evaluate the socioeconomic characteristics and QoL parameters of our enrolled patients, as this can potentially affect their informed decision-making, and assess any QoL changes during follow-up in accordance with the selected management option. Cost-effectiveness is also an important issue in relation to AS management of PTMC and has been reported to be dependent on the patient-specific QoL in a previous study [26]. The KoMPASS protocol thus includes appropriate questionnaires for analyzing the cost-effectiveness of AS in comparison with a lobectomy.
A potential limitation of this study protocol is the possibility of a selection bias. The patients will select the management option for the PTMC, and this process cannot be controlled by the investigators. We will however statistically adjust for possible bias using propensity score matching or weighting methods. Patients who subsequently change to the surgery option, even without evidence of disease progression, during AS could also affect the study findings. A previous meta-analysis of PTMC cases has reported that disease progression was not the reason for delayed surgery in two-thirds of the patients who had initially been undergoing AS [10]. Notably however, a recent report has indicated that the 5-year cumulative surgery conversion rates during AS have been significantly decreased from 12.3% prior to November 2009 to 4.2% after December 2009 [27].
Notwithstanding the aforementioned limitations, KoMPASS will be the first nationwide large-scale prospective study of patients with low-risk PTMCs in Korea. Eleven referral hospitals in various regions of Korea will be participating, which will enable a large patient population with various characteristics to be recruited. The aim is to enroll 2,000 PTMC patients within the next 3 years and collect detailed follow-up data for this cohort. Furthermore, a multidisciplinary team of thyroid cancer specialists including endocrinologists, thyroid surgeons and thyroid radiologists will be participating as investigators and can perform optimal management and follow-ups for the PTMC patients in the study. The findings from KoMPASS will help us to develop more optimal management options for PTMC that accord with the clinical, socioeconomic, and radiologic characteristics of the affected patients and will provide definitive evidence that may validate the role of AS in the management of low-risk PTMCs.
In conclusion, we have commenced a nationwide multicenter prospective cohort study for low-risk PTMCs in Korea that compares AS and surgery (lobectomy) and will be known as KoMPASS. The results of this prospective investigation will confirm the role of AS and help to develop individualized management strategies for low-risk PTMC patients.
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant numbers: HC19C0481, HC19C0215).
The part of the manuscript was reported as an abstract of the symposium at the 2020 annual congress of Korean Surgical Society.


No potential conflict of interest relevant to this article was reported.


Conception or design: M.J.J., J.H.M., D.J.L.,C.Y.L., Y.S.L., S.W.K., M.H.K., B.H.K., H.C.K., M.S. Drafting the work or revising: M.J.J., Y.E.K. Final approval of the manuscript: S.W.C., W.B.K.

Fig. 1
Flow diagram of the study process. PTMC, papillary thyroid microcarcinoma; US, ultrasound; CT, computed tomography; AS, active surveillance; QoL, quality of life; CND, central neck dissection; Tg, thyroglobulin; TgAb, anti-Tg antibody.
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