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1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
2Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea
3Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
4Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
5Department of Radiology, National Cancer Center, Goyang, Korea
6Department of Surgery, Thyroid Cancer Center, Gangnam Severance Hospital, Institute of Refractory Thyroid Cancer, Yonsei University College of Medicine, Seoul, Korea
7Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
8Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
9Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
10Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea
11Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea
Copyright © 2021 Korean Endocrine Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Adult patients (aged 19 to 80) with a thyroid nodule which fulfils all of the following criteria:
A maximum diameter of between 6.0 mm and 10.0 mm measured by US.
Diagnosed as suspicious for malignancy (Bethesda category V [18]) or as a malignancy (Bethesda category VI) by either fine needle aspiration or core needle biopsy.
In cases of Bethesda category V lesions, the nodule should show highly suspicious US features in accordance with the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) [19] or should harbor a BRAF V600E mutation.
Patients who can’t understand or don’t agree to the study protocol.
Pregnant women.
Patients with a history of head and neck cancer, actively receiving treatment for other cancers, or with any uncontrolled chronic disease.
Patients with multiple thyroid nodules or another thyroid disease requiring a total thyroidectomy.
PTMC with a suspicion of a cervical LN metastasis determined by either US or thyroid protocol CT [6].
PTMC with a suspicion of distant metastasis, with clinical symptoms/signs of extra-thyroidal extension of the tumor, or showing invasion to recurrent laryngeal nerve [6].
CONFLICTS OF INTEREST
No potential conflict of interest relevant to this article was reported.
AUTHOR CONTRIBUTIONS
Conception or design: M.J.J., J.H.M., D.J.L.,C.Y.L., Y.S.L., S.W.K., M.H.K., B.H.K., H.C.K., M.S. Drafting the work or revising: M.J.J., Y.E.K. Final approval of the manuscript: S.W.C., W.B.K.