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Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Copyright © 2015 Korean Endocrine Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.
Variable | Sheehan's syndrome (n=78) |
---|---|
Age at diagnosis, yr | 54.0 (42.8-63.3) |
Body mass index, kg/m2 | 22.0 (20.0-24.0) |
Mental status on initial visit, normal/confusion/coma | 61 (78.2)/14 (17.9)/3 (3.8) |
Loss of lactation | 73 (93.6) |
Age at menopause, yr | 33 (29.0-40.0) |
Hypoglycemia (glucose<55 mg/dL) on initial visit | 3 (3.8) |
Diabetes mellitus | 8 (10.3) |
Hypertension | 8 (10.3) |
Infection | 10 (12.8) |
Diabetes insipidus | 0 |
MRI scan of sella: empty sella, total/partial | 47 (60.3)/31 (39.7) |
Characteristic | Sheehan's syndrome (n=78) | Controls (n=95) | P value |
---|---|---|---|
Age at diagnosis, yr | 54.0 (42.8-63.3) | 49.5 (43.3-54.8) | 0.105 |
Body mass index, kg/m2 | 22.0 (20.0-24.0) | 25.1 (22.6-27.0) | <0.001 |
Hemoglobin, g/dL | 11.0 (10.0-12.0) | 12.8 (11.9-13.5) | <0.001 |
Sodium, mEq/L | 131.0 (117.5-139.0) | 140.0 (139.0-142.0) | <0.001 |
Potassium, mEq/L | 3.8 (3.4-4.1) | 4.0 (3.7-4.3) | 0.002 |
Total calcium, mg/dL | 8.8 (8.6-9.2) | 9.1 (8.8-9.3) | 0.204 |
Ionized calcium, mEq/L | 2.2 (2.1-2.3) | 2.4 (2.3-2.5) | <0.001 |
Magnesium, mg/dL | 1.9 (1.7-2.0) | 2.2 (2.1-2.4) | 0.002 |
Inorganic phosphorus, mg/dL | 3.1 (2.6-3.6) | 3.7 (3.2-4.0) | 0.004 |
Creatinine, mg/dL | 0.8 (0.6-1.0) | 0.6 (0.5-0.7) | <0.001 |
HbA1c, % | 5.8 (5.5-6.6) | 5.8 (5.4-8.3) | 0.967 |
Total cholesterol, mg/dL | 220.0 (180.5-260.5) | 196.0 (162.0-234.8) | 0.140 |
Triglyceride, mg/dL | 137.0 (101.0-191.5) | 132.5 (70.0-182.3) | 0.449 |
HDL-C, mg/dL | 52.0 (36.5-63.0) | 51.0 (40.0-63.0) | 0.703 |
LDL-C, mg/dL | 145.0 (111.0-177.0) | 134.0 (98.0-164.5) | <0.001 |
Serum osmolality, mOsm/kg | 268.0 (243.0-291.8) | 302.5 (283.3-309.8) | <0.001 |
Urine osmolality, mOsm/kg | 386.0 (300.0-586.0) | 306.5 (161.3-485.0) | 0.216 |
Variable | Na | K | Ca (i) | P | Mg |
---|---|---|---|---|---|
TSH | |||||
Basal | -0.091 | -0.021 | 0.296a | 0.034 | -0.020 |
Peak | 0.263b | 0.046 | 0.290b | 0.220a | 0.229 |
Delta | 0.344c | 0.094 | 0.323b | 0.259a | 0.185 |
FT4 | 0.425c | 0.106 | 0.264a | 0.123 | 0.161 |
ACTH | |||||
Basal | -0.002 | -0.042 | 0.175 | 0.010 | 0.046 |
Peak | 0.305c | 0.182a | 0.352b | 0.058 | 0.139 |
Delta | 0.310c | 0.262b | 0.428c | 0.116 | 0.384b |
Cortisol | |||||
Basal | 0.332c | 0.209b | 0.226a | 0.073 | 0.198 |
Peak | 0.455c | 0.248b | 0.304b | 0.156 | 0.254 |
Delta | 0.425c | 0.263b | 0.282b | 0.109 | 0.276a |
GH | |||||
Basal | 0.287c | 0.147 | 0.255a | 0.185 | 0.201 |
Peak | 0.461c | 0.182a | 0.315b | 0.278a | 0.213 |
Delta | 0.442c | 0.174a | 0.344b | 0.258a | 0.228 |
PRL | |||||
Basal | 0.312c | 0.01 | 0.270a | 0.212a | 0.169 |
Peak | 0.463c | 0.11 | 0.415c | 0.270a | 0.282 |
Delta | 0.458c | 0.14 | 0.455c | 0.252a | 0.277 |
LH | |||||
Basal | 0.211b | 0.069 | 0.317b | -0.035 | 0.110 |
Peak | 0.330c | 0.069 | 0.257a | 0.061 | 0.177 |
Delta | 0.341c | 0.070 | 0.226a | 0.155 | 0.062 |
FSH | |||||
Basal | 0.202a | 0.042 | 0.230a | 0.019 | 0.250 |
Peak | 0.354c | 0.078 | 0.297b | 0.076 | 0.262 |
Delta | 0.323c | 0.039 | 0.246a | 0.196 | 0.173 |
Values are expressed as median (interquartile range) or number (%). MRI, magnetic resonance imaging.
Values are expressed as median (interquartile range). HbA1c, hemoglobin A1c; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol.
ρ indicates the Spearman's rank correlation coefficient. Ca (i), ionized calcium; TSH, thyroid-stimulating hormone; FT4, free thyroxine; ACTH, adrenocorticotrophic hormone; GH, growth hormone; PRL, prolactin; LH, luteinizing hormone; FSH, follicle-stimulating hormone. a