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Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
Copyright © 2015 Korean Endocrine Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.
Values are expressed as mean±SD or number (%).
BMI, body mass index; DM, diabetes mellitus; PP2, post-prandial 2 hours blood glucose; HbA1c, hemoglobin A1c; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; uACR, urinary microalbumin-creatinine ratio.
Variable | BB+Bb | bb | P value |
---|---|---|---|
ESRDa | 0 | 4 (9) | 0.580 |
Polyneuropathyb | 33 (48.5) | 233 (49.7) | 0.979 |
Strokec | 5 (7.4) | 50 (10.7) | 0.273 |
MI | 4 (5.9) | 14 (3.0) | 0.183 |
PADd | 0 | 6 (1.3) | 0.442 |
DM foot | 2 (2.9) | 18 (3.8) | 0.524 |
Values are expressed as number (%).
ESRD, end-stage renal disease; MI, myocardiac infarction; PAD, peripheral artery disease; DM, diabetes mellitus. aPatient who have kidney replacement therapy; bPatient who have anti-neuralgia medicine; cCerebral ischemic event including transient ischemic attack; dAbove 50% arterial stenosis confirmed by angiography.
No. (%) | |
---|---|
Total | 537 (100) |
BB | 10 (1.86) |
Bb | 58 (10.80) |
bb | 469 (87.34) |
Characteristic | Total (n=537) | BB+Bb (n=68) | bb (n=469) | P value |
---|---|---|---|---|
Sex, female:male | 255:282 | 34:34 | 221:248 | 0.658 |
Age, yr | 62.44±10.64 | 59.19±10.58 | 62.93±10.59 | 0.007 |
BMI, kg/m2 | 25.02±3.64 | 23.73±4.19 | 25.20±3.52 | 0.002 |
Duration of DM, yr | 13.65±7.39 | 13.09±7.28 | 13.73±7.41 | 0.506 |
Fasting glucose, mg/dL | 145.98±55.89 | 151.59±76.96 | 145.16±52.20 | 0.376 |
PP2, mg/dL | 208.00±78.86 | 206.34±68.00 | 208.25±74.71 | 0.842 |
HbA1c, % | 7.58±1.41 | 7.85±1.74 | 7.54±1.36 | 0.088 |
C-peptide, ng/mL | 2.62±2.07 | 2.56±1.71 | 2.63±2.11 | 0.787 |
Cholesterol, mg/dL | 170.67±34.22 | 171.65±38.24 | 170.53±33.64 | 0.802 |
Triglyceride, mg/dL | 158.47±99.01 | 141.04±71.88 | 161.00±102.17 | 0.120 |
HDL-C, mg/dL | 45.63±11.87 | 47.88±11.73 | 45.30±11.87 | 0.094 |
LDL-C, mg/dL | 96.57±28.09 | 95.53±30.38 | 96.72±27.77 | 0.744 |
BUN, mg/dL | 16.42±8.32 | 15.08±5.90 | 16.62±8.60 | 0.154 |
Cr, mg/dL | 1.14±0.81 | 1.00±0.38 | 1.16±0.85 | 0.125 |
eGFR, mL/min/1.73 m2 | 77.12±26.37 | 82.23±27.05 | 76.38±26.22 | 0.087 |
uACR, µg/mgCr | 98.50±316.32 | 64.60±263.41 | 103.42±323.22 | 0.345 |
Family history of DM | 269 (50) | 32 (47) | 237 (51) | 0.593 |
Hypertension | 355 (66) | 41 (60) | 314 (67) | 0.279 |
Statin | 306 (57) | 40 (59) | 266 (57) | 0.743 |
Variable | BB+Bb | bb | P value |
---|---|---|---|
ESRDa | 0 | 4 (9) | 0.580 |
Polyneuropathyb | 33 (48.5) | 233 (49.7) | 0.979 |
Strokec | 5 (7.4) | 50 (10.7) | 0.273 |
MI | 4 (5.9) | 14 (3.0) | 0.183 |
PADd | 0 | 6 (1.3) | 0.442 |
DM foot | 2 (2.9) | 18 (3.8) | 0.524 |
No. (%) | |
---|---|
Total | 537 (100) |
BB | 10 (1.86) |
Bb | 58 (10.80) |
bb | 469 (87.34) |
Variable | Severe NPDR, PDR | |
---|---|---|
OR (95% CI) | P value | |
Non-B allele | 2.63 (1.03-6.75) | 0.037 |
HbA1c | 2.87 (1.11-7.45) | 0.030 |
Body mass index | 3.23 (1.23-8.48) | 0.017 |
Sex | 3.20 (1.22-8.40) | 0.018 |
Age | 3.05 (1.16-8.03) | 0.024 |
DM duration | 2.86 (1.04-7.87) | 0.042 |
Dyslipidemia | 2.96 (1.08-8.13) | 0.035 |
Hypertension | 2.99 (1.08-8.29) | 0.035 |
Values are expressed as mean±SD or number (%). BMI, body mass index; DM, diabetes mellitus; PP2, post-prandial 2 hours blood glucose; HbA1c, hemoglobin A1c; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; BUN, blood urea nitrogen; eGFR, estimated glomerular filtration rate; uACR, urinary microalbumin-creatinine ratio.
Values are expressed as number (%). ESRD, end-stage renal disease; MI, myocardiac infarction; PAD, peripheral artery disease; DM, diabetes mellitus. aPatient who have kidney replacement therapy; bPatient who have anti-neuralgia medicine; cCerebral ischemic event including transient ischemic attack; dAbove 50% arterial stenosis confirmed by angiography.
NPDR, non-proliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy; OR, odds ratio; CI, confidence interval; HbA1c, hemoglobin A1c; DM, diabetes mellitus.