Preparation for radioactive iodine (RAI) therapy includes an increased serum thyroid stimulating hormone level and a low iodine diet (LID). Because of extremely high iodine intake, some physicians have advocated a more stringent LID for greater than 2 weeks in Korean patients with thyroid cancer prior to RAI therapy; however, it is very difficult to maintain a stringent LID for a longer period of time. According to recent reports in Korea, a nonstringent, simple LID for only 1 week might be enough prior to RAI therapy, if the patients can be educated intensively by specially trained staff. The measurement of simple urinary iodine concentration (UIC; µg/L) may underestimate daily iodine excretion in patients with a urinary volume of more than 1 L/day and can also be affected by dilution status. Simple UIC had a weaker correlation than the iodine/creatinine (I/Cr) ratio. Therefore, the urinary I/Cr ratio can replace 24-hour urine iodine excretion instead of simple UIC, although it may overestimate iodine intake in patients with malnutrition or poor muscle mass. The measurement of serum iodine level might be useful as an adjunct parameter for assessing LID preparation, but its sensitivity and specificity were relatively low compared to the urinary I/Cr ratio.

Citations

Citations to this article as recorded by  

• Theranostics of Thyroid Cancer
  Luca Giovanella, Murat Tuncel, Atena Aghaee, Alfredo Campenni, Armando De Virgilio, Petra Petranović Ovčariček
  Seminars in Nuclear Medicine.2024;[Epub]     CrossRef
• Patient Preparation and Radiation Protection Guidance for Adult Patients Undergoing Radioiodine Treatment for Thyroid Cancer in the UK
  J. Wadsley, N. Armstrong, V. Bassett-Smith, M. Beasley, R. Chandler, L. Cluny, A.J. Craig, K. Farnell, K. Garcez, N. Garnham, K. Graham, A. Hallam, S. Hill, H. Hobrough, F. McKiddie, M.W.J. Strachan
  Clinical Oncology.2023; 35(1): 42.     CrossRef
• Nomogram Model Based on Iodine Nutrition and Clinical Characteristics of Papillary Thyroid Carcinoma to Predict Lateral Lymph Node Metastasis
  Junrong Wang, Yuzhang Gao, Yuxuan Zong, Weitong Gao, Xueying Wang, Ji Sun, Susheng Miao
  Cancer Control.2023;[Epub]     CrossRef
• Is a 4-Day Low-Iodine Diet Sufficient for Radioactive Iodine Ablation in Differentiated Thyroid Cancer Treatment?
  Alex Tessnow
  Clinical Thyroidology.2022; 34(3): 123.     CrossRef
• The Role of the Nurse in Patients on Low Iodine Diet Period
  Nedıme KOSGEROGLU, Dilek GÜMÜŞ, Handan KOYUNCU
  OSMANGAZİ JOURNAL OF MEDICINE.2022;[Epub]     CrossRef
• The Interplay Between Thyroid Dysfunction and Kidney Disease
  Yoko Narasaki, Peter Sohn, Connie M. Rhee
  Seminars in Nephrology.2021; 41(2): 133.     CrossRef
• Urinary iodine concentration and radioactive iodine therapeutic response in patients with differentiated thyroid cancer
  Yuyan Jiang, Jiahui Jin, Jingzheng Fan, Chao Huang, Qiang Jia, Jian Tan, Xianghui He, Xiangqian Zheng, Yue Zhao, Qing Zhang, Zhaowei Meng, Yan Wang
  Biomarkers in Medicine.2021; 15(11): 879.     CrossRef
• Update on Thyroid Hormone Levels and Thyroid Dysfunction in the Korean Population Based on Data from the Korea National Health and Nutrition Examination Survey VI (2013 to 2015)
  Jae Hoon Chung
  Endocrinology and Metabolism.2020; 35(1): 7.     CrossRef
• Contemporary considerations in adjuvant radioiodine treatment of adults with differentiated thyroid cancer
  Malik E. Juweid, Mark Tulchinsky, Ayman Mismar, Munther Momani, Ayman A. Zayed, Hussam Al Hawari, Nader Albsoul, Felix M. Mottaghy
  International Journal of Cancer.2020; 147(9): 2345.     CrossRef
• Personalized management of differentiated thyroid cancer in real life – practical guidance from a multidisciplinary panel of experts
  Alfredo Campennì, Daniele Barbaro, Marco Guzzo, Francesca Capoccetti, Luca Giovanella
  Endocrine.2020; 70(2): 280.     CrossRef
• Urinary iodine concentration and thyroid hormones: Korea National Health and Nutrition Examination Survey 2013–2015
  Hye In Kim, Hyun-Kyung Oh, So Young Park, Hye Won Jang, Myung-Hee Shin, Sun Wook Kim, Tae Hyuk Kim, Jae Hoon Chung
  European Journal of Nutrition.2019; 58(1): 233.     CrossRef
• Analysis of Iodine Content in Salts and Korean Sauces for Low-Iodine Diet Education in Korean Patients with Thyroid Cancer Preparing for Radioiodine Therapy
  Soo Young Kim, Jung Mi Park, Jae Pil Hwang
  Nuclear Medicine and Molecular Imaging.2018; 52(3): 229.     CrossRef
• Evaluation of Thyroid Hormone Levels and Urinary Iodine Concentrations in Koreans Based on the Data from Korea National Health and Nutrition Examination Survey VI (2013 to 2015)
  Jae Hoon Chung
  Endocrinology and Metabolism.2018; 33(2): 160.     CrossRef
• The application of serum iodine in assessing individual iodine status
  Xing Jin, Peng Jiang, Lixiang Liu, Qingzhen Jia, Peng Liu, Fangang Meng, Xiaoye Zhang, Yunfeng Guan, Yi Pang, Zheng Lu, Hongmei Shen
  Clinical Endocrinology.2017; 87(6): 807.     CrossRef
• Dietary evaluation of a low-iodine diet in Korean thyroid cancer patients preparing for radioactive iodine therapy in an iodine-rich region
  Dal Lae Ju, Young Joo Park, Hee-Young Paik, Min-Ji Kim, Seonyeong Park, Kyong Yeun Jung, Tae Hyuk Kim, Hun Sung Choi, Yoon Ju Song
  Nutrition Research and Practice.2016; 10(2): 167.     CrossRef
• Experiences with a low-iodine diet: A qualitative study of patients with thyroid cancer receiving radioactive iodine therapy
  Kyem Ju Lee, Sung Ok Chang, Kwang Yoon Jung
  European Journal of Oncology Nursing.2016; 23: 43.     CrossRef
• The Impact of Low Adherence to the Low-iodine Diet on the Efficacy of the Radioactive Iodine Ablation Therapy
  Dal Lae Ju, Young Joo Park, Hee-Young Paik, YoonJu Song
  Clinical Nutrition Research.2015; 4(4): 267.     CrossRef
• Effect of Iodine Restriction on Thyroid Function in Subclinical Hypothyroid Patients in an Iodine-Replete Area: A Long Period Observation in a Large-Scale Cohort
  Ji Young Joung, Yoon Young Cho, Sun-Mi Park, Tae Hun Kim, Na Kyung Kim, Seo Young Sohn, Sun Wook Kim, Jae Hoon Chung
  Thyroid.2014; 24(9): 1361.     CrossRef
• Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
  Won-Young Lee
  Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef