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1 "Neutrophil-to-lymphocyte ratio"
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Original Article
Clinical Study
Association of the Preoperative Neutrophil-to-ymphocyte Count Ratio and Platelet-to-Lymphocyte Count Ratio with Clinicopathological Characteristics in Patients with Papillary Thyroid Cancer
Sang Mi Kim, Eun Heui Kim, Bo Hyun Kim, Jong Ho Kim, Su Bin Park, Yoon Jeong Nam, Kang Hee Ahn, Min Young Oh, Won Jin Kim, Yun Kyung Jeon, Sang Soo Kim, Yong Ki Kim, In Ju Kim
Endocrinol Metab. 2015;30(4):494-501.   Published online December 31, 2015
DOI: https://doi.org/10.3803/EnM.2015.30.4.494
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  • 34 Web of Science
  • 34 Crossref
AbstractAbstract PDFPubReader   
Background

Several inflammatory biomarkers, especially a high preoperative neutrophil-to-lymphocyte count ratio (NLR) and platelet-to-lymphocyte count ratio (PLR), are known to be indicator of poor prognosis in several cancers. However, very few studies have evaluated the significance of the NLR and PLR in papillary thyroid cancer (PTC). We evaluated the association of the preoperative NLR and PLR with clinicopathological characteristics in patients with PTC.

Methods

This study included 1,066 female patients who underwent total thyroidectomy for PTC. Patients were stratified into 4 quartiles by preoperative NLR and PLR. And the combination of preoperative NLR and PLR was calculated on the basis of data obtained value of tertile as follows: patients with both an elevated PLR and an elevated NLR were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively.

Results

The preoperative NLR and PLR were significantly lower in patients aged ≥45 years and in patients with Hashimoto's thyroiditis. The PLR was significantly higher in patients with tumor size >1 cm (P=0.021).When the patients were categorized into the aforementioned four groups, the group with the higher preoperative PLR was found to have a significantly increased incidence of lateral lymph node metastasis (LNM) (P=0.018). However, there are no significant association between the combination of preoperative NLR and PLR and prognostic factors in PTC patients.

Conclusion

These results suggest that a preoperative high PLR were significant associated with lateral LNM in female patients with PTC.

Citations

Citations to this article as recorded by  
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    Medicine.2024; 103(5): e37210.     CrossRef
  • Preoperative serum inflammation-based scores in medullary thyroid cancer
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  • Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis
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    Indian Journal of Nuclear Medicine.2023; 38(4): 313.     CrossRef
  • The predictive value of hematologic parameters in the risk of thyroid malignancy in cases with atypia/follicular lesion of undetermined significance
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    European Archives of Oto-Rhino-Laryngology.2022; 279(8): 4077.     CrossRef
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    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • The role of neutrophil to lymphocyte and platelet to lymphocyte ratios in diagnosing thyroid nodule
    HaiderSalim Mihson, AyadKhani Maikhan, AliRodan Shuwelif
    Mustansiriya Medical Journal.2022; 21(2): 155.     CrossRef
  • Comparison of Mean Platelet Volume, Platelet Distribution Width, Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and Lymphocyte/Monocyte Ratio in Patients with Differentiated Thyroid Cancer According to TSH Levels
    Seher ÇETİNKAYA ALTUNTAŞ, Ömercan TOPALOĞLU
    Batı Karadeniz Tıp Dergisi.2022; 6(3): 302.     CrossRef
  • Delta Neutrophil Index and Neutrophil‐to‐Lymphocyte Ratio in the Differentiation of Thyroid Malignancy and Nodular Goiter
    Mehmet Buğra Bozan, Fatih Mehmet Yazar, İlhami Taner Kale, Mehmet Fatih Yüzbaşıoğlu, Ömer Faruk Boran, Ayşe Azak Bozan
    World Journal of Surgery.2021; 45(2): 507.     CrossRef
  • Factors Affecting Central Node Metastasis and Metastatic Lymph Node Ratio in Papillary Thyroid Cancer
    Jungirl Seok, Chang Hwan Ryu, Seog Yun Park, Chang Yoon Lee, Young Ki Lee, Yul Hwangbo, Eun Kyung Lee, You Jin Lee, Tae Sung Kim, Seok‐ki Kim, Yuh‐Seog Jung, Junsun Ryu
    Otolaryngology–Head and Neck Surgery.2021; 165(4): 519.     CrossRef
  • Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter
    Hakan BÖLÜKBAŞI, Serhan YILMAZ
    Ege Tıp Dergisi.2021; 60(1): 63.     CrossRef
  • Development and Validation of a Nomogram for Preoperative Prediction of Central Compartment Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma and Type 2 Diabetes Mellitus
    Chao He, Yiqiao Lu, Binqi Wang, Jie He, Haiguang Liu, Xiaohua Zhang
    Cancer Management and Research.2021; Volume 13: 2499.     CrossRef
  • The diagnostic predictive value of neutrophil-to-lymphocyte ratio in thyroid cancer adjusted for tumor size
    Taek Yoon Cheong, Sang Duk Hong, Keun-Woo Jung, Yoon Kyoung So, Paula Soares
    PLOS ONE.2021; 16(5): e0251446.     CrossRef
  • Usefulness of pre-thyroidectomy neutrophil–lymphocyte, platelet–lymphocyte, and monocyte–lymphocyte ratios for discriminating lymph node and distant metastases in differentiated thyroid cancer
    Cínthia Minatel Riguetto, Icléia Siqueira Barreto, Frederico Fernandes Ribeiro Maia, Lígia Vera Montali da Assumpção, Denise Engelbrecht Zantut-Wittmann
    Clinics.2021; 76: e3022.     CrossRef
  • Serum Inflammation-based Scores in Endocrine Tumors
    Pedro Marques, Friso de Vries, Olaf M Dekkers, Márta Korbonits, Nienke R Biermasz, Alberto M Pereira
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(10): e3796.     CrossRef
  • Diferansiye Tiroid Kanserli Hastalarda Preoperatif Nötrofil / Lenfosit Oranının Boyun Ultrasonografisi ve Patolojik Bulgularla İlişkisi
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    Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi.2021; 54(2): 243.     CrossRef
  • Platelet Activation and Inflammation in Patients with Papillary Thyroid Cancer
    Sorina Martin, Theodor Mustata, Oana Enache, Oana Ion, Andreea Chifulescu, Anca Sirbu, Carmen Barbu, Adrian Miron, Cosmin Giulea, Florin Andrei, Simona Fica
    Diagnostics.2021; 11(11): 1959.     CrossRef
  • The prognostic and diagnostic use of hematological parameters in subacute thyroiditis patients
    Murat Calapkulu, Muhammed Erkam Sencar, Davut Sakiz, Hakan Duger, Ilknur Ozturk Unsal, Mustafa Ozbek, Erman Cakal
    Endocrine.2020; 68(1): 138.     CrossRef
  • Association of the Preoperative Inflammation-Based Scores with TNM Stage and Recurrence in Patients with Papillary Thyroid Carcinoma: A Retrospective, Multicenter Analysis


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    Cancer Management and Research.2020; Volume 12: 1809.     CrossRef
  • Inflammatory biomarkers and dynamics of neutrophil-to-lymphocyte ratio in anaplastic thyroid carcinoma
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    Endocrine.2020; 70(1): 115.     CrossRef
  • Immune Cell Confrontation in the Papillary Thyroid Carcinoma Microenvironment
    Zhenyu Xie, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Yu Lun, Jian Zhang
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  • Hipertiroidi Hastalarında Tedavi Öncesi ve Sonrası Trombosit/Lenfosit ve Nötrofil/Lenfosit Oranlarının Değerlendirilmesi
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    Harran Üniversitesi Tıp Fakültesi Dergisi.2020; 17(1): 104.     CrossRef
  • Comparison of Mean Platelet Volume, Platelet Count, Neutrophil/ Lymphocyte Ratio and Platelet/Lymphocyte Ratio in the Euthyroid, Overt Hypothyroid and Subclinical Hyperthyroid Phases of Papillary Thyroid Carcinoma
    Faruk Kutluturk, Serdar S. Gul, Safak Sahin, Turker Tasliyurt
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2019; 19(6): 859.     CrossRef
  • The Immune Landscape of Thyroid Cancer in the Context of Immune Checkpoint Inhibition
    Gilda Varricchi, Stefania Loffredo, Giancarlo Marone, Luca Modestino, Poupak Fallahi, Silvia Martina Ferrari, Amato de Paulis, Alessandro Antonelli, Maria Rosaria Galdiero
    International Journal of Molecular Sciences.2019; 20(16): 3934.     CrossRef
  • Different prognostic values of individual hematologic parameters in papillary thyroid cancer due to age-related changes in immunity
    Kwan Ho Lee, Eun Young Seok, Eun Young Kim, Ji Sup Yun, Yong Lai Park, Chan Heun Park
    Annals of Surgical Treatment and Research.2019; 96(2): 70.     CrossRef
  • Diagnostic Accuracy of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Detecting Occult Papillary Thyroid Microcarcinomas in Benign Multinodular Goitres
    Dimitrios K. Manatakis, Sophia Tseleni-Balafouta, Lazaros Tzelves, Dimitrios Balalis, Adelais Tzortzopoulou, Dimitrios P. Korkolis, George H. Sakorafas, Emmanouil Gontikakis, Georgios Plataniotis
    Journal of Thyroid Research.2018; 2018: 1.     CrossRef
  • Assessment of clinical and pathological features of patients who underwent thyroid surgery: A retrospective clinical study
    Arif Emre, Sami Akbulut, Mehmet Sertkaya, Muharrem Bitiren, Ilhami Taner Kale, Ertan Bulbuloglu, Cemil Colak
    World Journal of Clinical Cases.2018; 6(3): 20.     CrossRef
  • Trends in white blood cell and platelet indices in a comparison of patients with papillary thyroid carcinoma and multinodular goiter do not permit differentiation between the conditions
    Nikolaos Machairas, Ioannis D. Kostakis, Anastasia Prodromidou, Paraskevas Stamopoulos, Themistoklis Feretis, Zoe Garoufalia, Christos Damaskos, Gerasimos Tsourouflis, Gregory Kouraklis
    Endocrine Research.2017; 42(4): 311.     CrossRef
  • Evaluation of Hemocytometer Parameters as Potential Biomarkers in Benign Multinodular Goiter and Papillary Thyroid Carcinoma
    Erdal Uysal, Seyit Mehmet Ceylan, Efe Sezgin, Hasan Bakir, Ahmet Orhan Gurer, Basar Aksoy, Mehmet Bastemir
    Iranian Red Crescent Medical Journal.2017;[Epub]     CrossRef
  • Clinical Value of Blood Neutrophil to Lymphocyte Ratio in Patients with Papillary Thyroid Carcinoma with Neck Lymph Node Metastasis
    Hwa Bin Kim, Hyoung Shin Lee, Sung Won Kim, Seok Won Jeon, Ji Ah Song, Kang Dae Lee
    International Journal of Thyroidology.2017; 10(2): 89.     CrossRef
  • Association of Baseline Neutrophil-to-Lymphocyte Ratio with Clinicopathological Characteristics of Papillary Thyroid Carcinoma
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    International Journal of Endocrinology.2017; 2017: 1.     CrossRef
  • Association of the preoperative neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with lymph node metastasis and recurrence in patients with medullary thyroid carcinoma
    Ke Jiang, Jianyong Lei, Wenjie Chen, Yanping Gong, Han Luo, Zhihui Li, Rixiang Gong, Jingqiang Zhu
    Medicine.2016; 95(40): e5079.     CrossRef
  • Association between neutrophil-to-lymphocyte ratio and differentiated thyroid cancer: a meta-analysis
    Ji-Feng Liu, Luo Ba, Hong Lv, Dan Lv, Jin-Tao Du, Xiao-Mei Jing, Ning-Jing Yang, Shao-Xin Wang, Chao Li, Xiao-Xia Li
    Scientific Reports.2016;[Epub]     CrossRef
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