Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis. It is known that kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone (GnRH). Loss of kisspeptin signaling causes hypogonadotrophic hypogonadism in humans and other mammals. Kisspeptin interacts with other neuropeptides such as neurokinin B and dynorphin, to regulate GnRH pulse generation. In addition, a growing body of evidence suggests that kisspeptin signaling be regulated by nutritional status and stress. Kisspeptin may also represent a novel potential therapeutic target in the treatment of fertility disorders. Early human studies suggest that peripheral exogenous kisspeptin administration stimulates gonadotrophin release in healthy adults and in patients with certain forms of infertility. This review aims to concisely summarize what is known about kisspeptin as a regulator of reproductive function, and provide an update on recent advances within this field.

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• An update on the prevention of ovarian hyperstimulation syndrome
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• Expression of Tachykinins and Tachykinin Receptors and Interaction with Kisspeptin in Human Granulosa and Cumulus Cells1
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  Biology of Reproduction.2016;[Epub]     CrossRef
• Kisspeptin Regulation of Neuronal Activity throughout the Central Nervous System
  Xinhuai Liu, Allan E. Herbison
  Endocrinology and Metabolism.2016; 31(2): 193.     CrossRef
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  Raphaëlle Quillet, Safia Ayachi, Frédéric Bihel, Khadija Elhabazi, Brigitte Ilien, Frédéric Simonin
  Pharmacology & Therapeutics.2016; 160: 84.     CrossRef
• Kisspeptin-mediated regulation of the morpho-functional state of the rat testicles under the effect of silver nanoparticles
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  Bulletin of Taras Shevchenko National University of Kyiv. Series: Problems of Physiological Functions Regulation.2016; 20(1): 8.     CrossRef
• Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin may alter LH release patterns by abolishing sex differences in GABA/glutamate cell number and modifying the transcriptome of the male anteroventral periventricular nucleus
  Javier Del Pino Sans, Kelsey J. Clements, Alexander Suvorov, Sudha Krishnan, Hillary L. Adams, Sandra L. Petersen
  Neuroscience.2016; 329: 239.     CrossRef
• Control of puberty onset and fertility by gonadotropin-releasing hormone neurons
  Allan E. Herbison
  Nature Reviews Endocrinology.2016; 12(8): 452.     CrossRef
• Patent Highlights June–July 2015
  Hermann AM Mucke
  Pharmaceutical Patent Analyst.2015; 4(6): 423.     CrossRef