Skip Navigation
Skip to contents

Endocrinol Metab : Endocrinology and Metabolism

clarivate
OPEN ACCESS
SEARCH
Search

Previous issues

Page Path
HOME > BROWSE ARTICLES > Previous issues
16 Previous issues
Filter
Filter
Article type
Keywords
Authors
Volume 28(4); December 2013
Prev issue Next issue
Review Articles
Adrenal gland
The Molecular Pathogenesis of Pituitary Adenomas: An Update
Xiaobing Jiang, Xun Zhang
Endocrinol Metab. 2013;28(4):245-254.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.245
  • 4,934 View
  • 49 Download
  • 41 Crossref
AbstractAbstract PDFPubReader   

Pituitary tumors represent the most common intracranial neoplasms accompanying serious morbidity through mass effects and inappropriate secretion of pituitary hormones. Understanding the etiology of pituitary tumorigenesis will facilitate the development of satisfactory treatment for pituitary adenomas. Although the pathogenesis of pituitary adenomas is largely unknown, considerable evidence indicates that the pituitary tumorigenesis is a complex process involving multiple factors, including genetic and epigenetic changes. This review summarized the recent progress in the study of pituitary tumorigenesis, focusing on the role of tumor suppressor genes, oncogenes and microRNAs.

Citations

Citations to this article as recorded by  
  • Plurihormonal Pituitary Neuroendocrine Tumors: Clinical Relevance of Immunohistochemical Analysis
    Roxana-Ioana Dumitriu-Stan, Iulia-Florentina Burcea, Ramona Dobre, Valeria Nicoleta Nastase, Raluca Amalia Ceausu, Marius Raica, Catalina Poiana
    Diagnostics.2024; 14(2): 170.     CrossRef
  • Pituitary Adenoma: SSTR2 rs2236750, SSTR5 rs34037914, and AIP rs267606574 Genetic Variants, Serum Levels, and Ki-67 Labeling Index Associations
    Greta Gedvilaite-Vaicechauskiene, Loresa Kriauciuniene, Arimantas Tamasauskas, Vita Rovite, Ilona Mandrika, Sheng-Nan Wu, Chin-Wei Huang, Lina Poskiene, Rasa Liutkeviciene
    Medicina.2024; 60(8): 1252.     CrossRef
  • Single-Cell RNA Sequencing and Its Applications in Pituitary Research
    Shuangjian Yang, Congcong Deng, Changqin Pu, Xuexue Bai, Chenxin Tian, Mengqi Chang, Ming Feng
    Neuroendocrinology.2024; 114(10): 875.     CrossRef
  • The expression of VDACs and Bcl2 family genes in pituitary adenomas: clinical correlations and postsurgical outcomes
    AN Facundo, M Magalhães, GC Nascimento, RS Azulay, RM Santos, LA Freitas, AGPAC Nascimento, VP Rodrigues, WC Santos, AMGS Beckman, JMF Abreu, RP Silva, EL Carneiro, CP Oliveira Neto, RM Gil da Costa, R Corcoy, E Mato, MS Faria
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • Signal Transducer and Activator of Transcription 4 (STAT4) Association with Pituitary Adenoma
    Greta Gedvilaite-Vaicechauskiene, Loresa Kriauciuniene, Rasa Liutkeviciene
    Medicina.2024; 60(11): 1871.     CrossRef
  • LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p
    Tuo Wang, Ping Mao, Yan Zhang, Bo Cui, Mao-De Wang, Ya Li, Ke Gao
    Anti-Cancer Drugs.2022; 33(10): 1058.     CrossRef
  • Transcriptomic Profiles of Normal Pituitary Cells and Pituitary Neuroendocrine Tumor Cells
    Jun Y. Oh, Robert C. Osorio, Jangham Jung, Luis Carrete, Nikita Choudhary, Meeki Lad, Atul Saha, Manish K. Aghi
    Cancers.2022; 15(1): 110.     CrossRef
  • EMT-Related Markers in Serum Exosomes are Potential Diagnostic Biomarkers for Invasive Pituitary Adenomas
    Kelin Chen, Guoge Li, Xixiong Kang, Pinan Liu, Lingye Qian, Yijun Shi, Rasha Alsamani Osman, Zhijun Yang, Guojun Zhang
    Neuropsychiatric Disease and Treatment.2021; Volume 17: 3769.     CrossRef
  • The Role of Long Noncoding RNAs in the Biology of Pituitary Adenomas
    Ozal Beylerli, Ilgiz Gareev, Valentin Pavlov, Xin Chen, Shiguang Zhao
    World Neurosurgery.2020; 137: 252.     CrossRef
  • Sellar Tumors
    Katherine E. Schwetye, Sonika M. Dahiya
    Surgical Pathology Clinics.2020; 13(2): 305.     CrossRef
  • Genomic and molecular characterization of pituitary adenoma pathogenesis: review and translational opportunities
    Mazin Elsarrag, Parantap D. Patel, Ajay Chatrath, Davis Taylor, John A. Jane
    Neurosurgical Focus.2020; 48(6): E11.     CrossRef
  • Metabolic profiling reveals distinct metabolic alterations in different subtypes of pituitary adenomas and confers therapeutic targets
    Jie Feng, Hua Gao, Qi Zhang, Yang Zhou, Chuzhong Li, Sida Zhao, Lichuan Hong, Jinjin Yang, Shuyu Hao, Wan Hong, Zhengping Zhuang, Guowang Xu, Yazhuo Zhang
    Journal of Translational Medicine.2019;[Epub]     CrossRef
  • Quantitative Analysis of Proteome in Non-functional Pituitary Adenomas: Clinical Relevance and Potential Benefits for the Patients
    Tingting Cheng, Ya Wang, Miaolong Lu, Xiaohan Zhan, Tian Zhou, Biao Li, Xianquan Zhan
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • circOMA1-Mediated miR-145-5p Suppresses Tumor Growth of Nonfunctioning Pituitary Adenomas by Targeting TPT1
    Qiu Du, Bin Hu, Yajuan Feng, Zongming Wang, Xin Wang, Dimin Zhu, Yonghong Zhu, Xiaobing Jiang, Haijun Wang
    The Journal of Clinical Endocrinology & Metabolism.2019; 104(6): 2419.     CrossRef
  • Differential Expression of HMGA1 and HMGA2 in pituitary neuroendocrine tumors
    Sérgio Portovedo, Nadja Gaido, Bruno de Almeida Nunes, Ana Giselia Nascimento, Allysson Rocha, Marcelo Magalhães, Gilvan Cortes Nascimento, Denise Pires de Carvalho, Paula Soares, Christina Takiya, Manuel dos Santos Faria, Leandro Miranda-Alves
    Molecular and Cellular Endocrinology.2019; 490: 80.     CrossRef
  • Double Pituitary Adenomas with Synchronous Somatotroph and Corticotroph Clinical Presentation of Acromegaly and Cushing's Disease
    Naomi Collazo-Gutiérrez, Orlando de Jesús, Maria Villamil-Jarauta, Milliette Alvarado, Loida González, Margarita Ramírez, Victor J. Carlo-Chevere
    World Neurosurgery.2019; 132: 161.     CrossRef
  • Association of ApoE haplotype with clinical evidence of pituitary adenoma
    Agne Sidaraite, Alvita Vilkeviciute, Brigita Glebauskiene, Loresa Kriauciuniene, Dalia Zaliuniene, Rasa Liutkeviciene
    Gene.2019; 706: 154.     CrossRef
  • Next-generation sequencing of microRNAs reveals a unique expression pattern in different types of pituitary adenomas
    Zongze He, Longyi Chen, Xiao Hu, Jian Tang, Linfu He, Junting Hu, Fan Fei, Qi Wang
    Endocrine Journal.2019; 66(8): 709.     CrossRef
  • Growth hormone and prolactin-staining tumors causing acromegaly: a retrospective review of clinical presentations and surgical outcomes
    Jonathan Rick, Arman Jahangiri, Patrick M. Flanigan, Ankush Chandra, Sandeep Kunwar, Lewis Blevins, Manish K. Aghi
    Journal of Neurosurgery.2019; 131(1): 147.     CrossRef
  • Study of major genetic factors involved in pituitary tumorigenesis and their impact on clinical and biological characteristics of sporadic somatotropinomas and non-functioning pituitary adenomas
    R.K. Foltran, P.V.G.H. Amorim, F.H. Duarte, I.P.P. Grande, A.C.T.B. Freire, F.P. Frassetto, J.B. Dettoni, V.A. Alves, I. Castro, E.B. Trarbach, M.D. Bronstein, R.S. Jallad
    Brazilian Journal of Medical and Biological Research.2018;[Epub]     CrossRef
  • Detection of circulating tumor cells in patients with pituitary tumors
    Gao Hua, He Yanjiao, Liu Qian, Wang Jichao, Zhang Yazhuo
    BMC Cancer.2018;[Epub]     CrossRef
  • Plurihormonal ACTH-GH Pituitary Adenoma: Case Report and Systematic Literature Review
    Elena Roca, Pier Paolo Mattogno, Teresa Porcelli, Luigi Poliani, Francesco Belotti, Alberto Schreiber, Filippo Maffezzoni, Marco Maria Fontanella, Francesco Doglietto
    World Neurosurgery.2018; 114: e158.     CrossRef
  • The role of galectin-3 in the tumorigenesis and progression of pituitary tumors
    Bo Diao, Ying Liu, Guo‑Zheng Xu, Yi Zhang, Jun Xie, Jie Gong
    Oncology Letters.2018;[Epub]     CrossRef
  • Programmed cell senescence: role of IL-6 in the pituitary
    Melanie Sapochnik, Mariana Fuertes, Eduardo Arzt
    Journal of Molecular Endocrinology.2017; 58(4): R241.     CrossRef
  • Selective molecular biomarkers to predict biologic behavior in pituitary tumors
    Aydin Sav, Fabio Rotondo, Luis V. Syro, Meric A. Altinoz, Kalman Kovacs
    Expert Review of Endocrinology & Metabolism.2017; 12(3): 177.     CrossRef
  • MicroRNA-200b inhibits pituitary tumor cell proliferation and invasion by targeting PKCα
    Yuanchuan Wang, Xiaohong Yin, Long Zhao, Shun Li, Jie Duan, Renzhao Kuang, Junwei Duan
    Experimental and Therapeutic Medicine.2017; 14(2): 1706.     CrossRef
  • Increased expression of the microRNA 106b~25 cluster and its host gene MCM7 in corticotroph pituitary adenomas is associated with tumor invasion and Crooke’s cell morphology
    Filip Garbicz, Dawid Mehlich, Beata Rak, Emir Sajjad, Maria Maksymowicz, Wiktor Paskal, Grzegorz Zieliński, Paweł K. Włodarski
    Pituitary.2017; 20(4): 450.     CrossRef
  • Bromocriptine Induces Autophagy-Dependent Cell Death in Pituitary Adenomas
    Xin Geng, Lixin Ma, Zefu Li, Zhenzhu Li, Jianmin Li, Meng Li, Qingbo Wang, Zheng Chen, Qikai Sun
    World Neurosurgery.2017; 100: 407.     CrossRef
  • Biomarkers of pituitary carcinomas
    Aydin Sav, Fabio Rotondo, Luis V. Syro, Antonio Di Ieva, Michael D. Cusimano, Kalman Kovacs
    Expert Review of Endocrinology & Metabolism.2016; 11(3): 253.     CrossRef
  • MicroRNAs in the pituitary
    Erica Gentilin, Ettore degli Uberti, Maria Chiara Zatelli
    Best Practice & Research Clinical Endocrinology & Metabolism.2016; 30(5): 629.     CrossRef
  • Molecular markers in pituitary tumors
    Asha M. Robertson, Anthony P. Heaney
    Current Opinion in Endocrinology, Diabetes & Obesity.2016; 23(4): 324.     CrossRef
  • MicroRNA-106b promotes pituitary tumor cell proliferation and invasion through PI3K/AKT signaling pathway by targeting PTEN
    Kai Zhou, Tingrong Zhang, YanDong Fan, Serick, Guojia Du, Pengfei Wu, Dangmurenjiafu Geng
    Tumor Biology.2016; 37(10): 13469.     CrossRef
  • Isolated double adrenocorticotropic hormone-secreting pituitary adenomas: A case report and review of the literature
    JIUJUN PU, ZHIMING WANG, HUI ZHOU, AILING ZHONG, KAI JIN, LUNLIANG RUAN, GANG YANG
    Oncology Letters.2016; 12(1): 585.     CrossRef
  • Progress in Endocrine Neoplasia
    Samuel A. Wells
    Clinical Cancer Research.2016; 22(20): 4981.     CrossRef
  • Pituitary adenomas: historical perspective, surgical management and future directions
    Debebe Theodros, Mira Patel, Jacob Ruzevick, Michael Lim, Chetan Bettegowda
    CNS Oncology.2015; 4(6): 411.     CrossRef
  • Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells
    Mark O. Kitchen, Kiren Yacqub-Usman, Richard D. Emes, Alan Richardson, Richard N. Clayton, William E. Farrell
    Pituitary.2015; 18(5): 674.     CrossRef
  • Pituitary Adenoma and the Chemokine Network: A Systemic View
    Fabio Grizzi, Elena Monica Borroni, Alessandro Vacchini, Dorina Qehajaj, Manuela Liguori, Sanja Stifter, Maurizio Chiriva-Internati, Antonio Di Ieva
    Frontiers in Endocrinology.2015;[Epub]     CrossRef
  • MiR-132, miR-15a and miR-16 synergistically inhibit pituitary tumor cell proliferation, invasion and migration by targeting Sox5
    Wang Renjie, Liang Haiqian
    Cancer Letters.2015; 356(2): 568.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Epigenetics of pituitary tumours
    William E. Farrell
    Current Opinion in Endocrinology, Diabetes & Obesity.2014; 21(4): 299.     CrossRef
  • The Role of Genetic and Epigenetic Changes in Pituitary Tumorigenesis
    Hidenori FUKUOKA, Yutaka TAKAHASHI
    Neurologia medico-chirurgica.2014; 54(12): 943.     CrossRef
Close layer
Bone Metabolism
Recent Progress in Osteocyte Research
Paola Divieti Pajevic
Endocrinol Metab. 2013;28(4):255-261.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.255
  • 4,268 View
  • 27 Download
  • 11 Crossref
AbstractAbstract PDFPubReader   

The last decade has seen an exponential increase in our understanding of osteocytes function and biology. These cells, once considered inert by-standers trapped into the mineralized bone, has now risen to be key regulators of skeletal metabolism, mineral homeostasis, and hematopoiesis. As tools and techniques to study osteocytes improved and expanded, it has become evident that there is more to these cells than initially thought. Osteocytes are now recognized not only as the key responders to mechanical forces but also as orchestrators of bone remodeling and mineral homeostasis. These cells are the primary source of several important proteins, such as sclerostin and fibroblast growth factor 23, that are currently target as novel therapies for bone loss (as the case for antisclerostin antibodies) or phosphate disorders. Better understanding of the intricate cellular and molecular mechanisms that govern osteocyte biology will open new avenue of research and ultimately indentify novel therapeutics to treat bone and mineral disorders. This review summarizes novel findings and discusses future avenues of research.

Citations

Citations to this article as recorded by  
  • Study on the influence of scaffold morphology and structure on osteogenic performance
    Jingyu Zhou, Shilang Xiong, Min Liu, Hao Yang, Peng Wei, Feng Yi, Min Ouyang, Hanrui Xi, Zhisheng Long, Yayun Liu, Jingtang Li, Linghua Ding, Long Xiong
    Frontiers in Bioengineering and Biotechnology.2023;[Epub]     CrossRef
  • New Insights Into Monogenic Causes of Osteoporosis
    Riikka E. Mäkitie, Alice Costantini, Anders Kämpe, Jessica J. Alm, Outi Mäkitie
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Calcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytes
    Christopher Dedic, Tin Shing Hung, Alan M. Shipley, Akira Maeda, Thomas Gardella, Andrew L. Miller, Paola Divieti Pajevic, Joseph G. Kunkel, Alessandro Rubinacci
    Bone.2018; 116: 135.     CrossRef
  • Ex vivo replication of phenotypic functions of osteocytes through biomimetic 3D bone tissue construction
    Qiaoling Sun, Saba Choudhary, Ciaran Mannion, Yair Kissin, Jenny Zilberberg, Woo Y. Lee
    Bone.2018; 106: 148.     CrossRef
  • Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS
    Natalia Campos‐Obando, W Nadia H Koek, Elizabeth R Hooker, Bram CJ van der Eerden, Huibert A Pols, Albert Hofman, Johannes PTM van Leeuwen, Andre G Uitterlinden, Carrie M Nielson, M. Carola Zillikens
    Journal of Bone and Mineral Research.2017; 32(6): 1182.     CrossRef
  • Intermittent PTH treatment can delay the transformation of mature osteoblasts into lining cells on the periosteal surfaces
    Mi-Gyeong Jang, Ji Yeon Lee, Jae-Yeon Yang, Hyojung Park, Jung Hee Kim, Jung-Eun Kim, Chan Soo Shin, Seong Yeon Kim, Sang Wan Kim
    Journal of Bone and Mineral Metabolism.2016; 34(5): 532.     CrossRef
  • The osteoclasts attach to the bone surface where the extracellular calcium concentration decreases
    Bilu Xiang, Yang Liu, Lu Xie, Qian Zhao, Ling Zhang, Xueqi Gan, Haiyang Yu
    Cell Biochemistry and Biophysics.2016; 74(4): 553.     CrossRef
  • The Effect of Discontinuing Treatment With Blosozumab: Follow-up Results of a Phase 2 Randomized Clinical Trial in Postmenopausal Women With Low Bone Mineral Density
    Christopher P Recknor, Robert R Recker, Charles T Benson, Deborah A Robins, Alan Y Chiang, Jahangir Alam, Leijun Hu, Toshio Matsumoto, Hideaki Sowa, John H Sloan, Robert J Konrad, Bruce H Mitlak, Adrien A Sipos
    Journal of Bone and Mineral Research.2015; 30(9): 1717.     CrossRef
  • Promoting effect of 1,25(OH) 2 vitamin D 3 in osteogenic differentiation from induced pluripotent stem cells to osteocyte-like cells
    Hiroshi Kato, Hiromi Ochiai-Shino, Shoko Onodera, Akiko Saito, Takahiko Shibahara, Toshifumi Azuma
    Open Biology.2015; 5(2): 140201.     CrossRef
  • From mechanical stimulus to bone formation: A review
    Natacha Rosa, Ricardo Simoes, Fernão D. Magalhães, Antonio Torres Marques
    Medical Engineering & Physics.2015; 37(8): 719.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
Close layer
Obesity and Metabolism
Clinical Application of Glucagon-Like Peptide 1 Receptor Agonists for the Treatment of Type 2 Diabetes Mellitus
Young Min Cho, Rhonda D. Wideman, Timothy J. Kieffer
Endocrinol Metab. 2013;28(4):262-274.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.262
  • 6,558 View
  • 88 Download
  • 38 Crossref
AbstractAbstract PDFPubReader   

Glucagon-like peptide 1 (GLP-1) is secreted from enteroendocrine L-cells in response to oral nutrient intake and elicits glucose-stimulated insulin secretion while suppressing glucagon secretion. It also slows gastric emptying, which contributes to decreased postprandial glycemic excursions. In the 1990s, chronic subcutaneous infusion of GLP-1 was found to lower blood glucose levels in patients with type 2 diabetes. However, GLP-1's very short half-life, arising from cleavage by the enzyme dipeptidyl peptidase 4 (DPP-4) and glomerular filtration by the kidneys, presented challenges for clinical use. Hence, DPP-4 inhibitors were developed, as well as several GLP-1 analogs engineered to circumvent DPP-4-mediated breakdown and/or rapid renal elimination. Three categories of GLP-1 analogs, are being developed and/or are in clinical use: short-acting, long-acting, and prolonged-acting GLP-1 analogs. Each class has different plasma half-lives, molecular size, and homology to native GLP-1, and consequently different characteristic effects on glucose metabolism. In this article, we review current clinical data derived from each class of GLP-1 analogs, and consider the clinical effects reported for each category in recent head to head comparison studies. Given the relatively brief clinical history of these compounds, we also highlight several important efficacy and safety issues which will require further investigation.

Citations

Citations to this article as recorded by  
  • Poly(l-threonine-co-l-threonine Succinate) Thermogels for Sustained Release of Lixisenatide
    Jin Kyung Park, Zhengyu Piao, Hyun Jung Lee, Byeongmoon Jeong
    Biomacromolecules.2024; 25(8): 4946.     CrossRef
  • The efficacy and safety of combined GLP-1RA and basal insulin therapy among inadequately controlled T2D with premixed insulin therapy
    Jhih-Syuan Liu, Sheng-Chiang Su, Feng-Chih Kuo, Peng-Fei Li, Chia-Luen Huang, Li-Ju Ho, Kuan-Chan Chen, Yi-Chen Liu, Chih-Ping Lin, An-Che Cheng, Chien-Hsing Lee, Fu-Huang Lin, Yi-Jen Hung, Hsin-Ya Liu, Chieh-Hua Lu, Chang-Hsun Hsieh
    Medicine.2023; 102(10): e33167.     CrossRef
  • Pharmacogenetics of Glucagon-like-peptide-1 receptor in diabetes management
    Mariya Kalinkova, Tanya Kadiyska, Teodora Handjieva-Darlenska
    Pharmacia.2023; 70(2): 383.     CrossRef
  • Anti-inflammatory potential of liraglutide, a glucagon-like peptide-1 receptor agonist, in rats with peripheral acute inflammation
    Irem Mert, Ayhan Cetinkaya, Mujgan Gurler, Canan Akünal Turel, Humeyra Celik, Ibrahim Ethem Torun, Idris Turel
    Inflammopharmacology.2022; 30(3): 1093.     CrossRef
  • Exenatide improves hepatocyte insulin resistance induced by different regional adipose tissue
    Chuanmin Bai, Yujun Wang, Zhi Niu, Yaxin Guan, Jingshan Huang, Xin Nian, Fan Zuo, Juan Zhao, Tsutomu Kazumi, Bin Wu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Peptidyl and Non-Peptidyl Oral Glucagon-Like Peptide-1 Receptor Agonists
    Hun Jee Choe, Young Min Cho
    Endocrinology and Metabolism.2021; 36(1): 22.     CrossRef
  • Glucagon-like Peptide-1 Improves Fatty Liver and Enhances Thermogenesis in Brown Adipose Tissue via Inhibiting BMP4-Related Signaling Pathway in High-Fat-Diet-Induced Obese Mice
    Xingchun Wang, Bingwei Ma, Jiaqi Chen, Hui You, Chunjun Sheng, Peng Yang, Shen Qu, Vito Angelo Giagulli
    International Journal of Endocrinology.2021; 2021: 1.     CrossRef
  • Exenatide ameliorates experimental non-alcoholic fatty liver in rats via suppression of toll-like receptor 4/NFκB signaling: Comparison to metformin
    Zeinab A. Saad, Dina M. Khodeer, Sawsan A. Zaitone, Amal A.M. Ahmed, Yasser M. Moustafa
    Life Sciences.2020; 253: 117725.     CrossRef
  • Exenatide ameliorates hepatic steatosis and attenuates fat mass and FTO gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease
    Shan Li, Xiaoman Wang, Jielei Zhang, Jingyi Li, Xiaogang Liu, Yuanyuan Ma, Chao Han, Lixia Zhang, Lili Zheng
    Brazilian Journal of Medical and Biological Research.2018;[Epub]     CrossRef
  • Efficacy and safety of combination therapy with an α‐glucosidase inhibitor and a dipeptidyl peptidase‐4 inhibitor in patients with type 2 diabetes mellitus: A systematic review with meta‐analysis
    Se Hee Min, Jeong‐Hwa Yoon, Seokyung Hahn, Young Min Cho
    Journal of Diabetes Investigation.2018; 9(4): 893.     CrossRef
  • Glucagon-like peptide-1 affects human umbilical vein endothelial cells in high glucose by the PI3K/Akt/eNOS signaling pathway
    Jie Wu, Pingfan Guo, Tianmin He, Fanggang Cai
    Turkish Journal of Biochemistry.2018; 43(2): 119.     CrossRef
  • What next after basal insulin? Treatment intensification with lixisenatide in Asian patients with type 2 diabetes mellitus
    Wing B. Chan, Andrea Luk, Wing S. Chow, Vincent T.F. Yeung
    Journal of Diabetes.2017; 9(6): 562.     CrossRef
  • Treatment potential of the GLP-1 receptor agonists in type 2 diabetes mellitus: a review
    L. Østergaard, Christian S. Frandsen, S. Madsbad
    Expert Review of Clinical Pharmacology.2016; 9(2): 241.     CrossRef
  • Efficacy and safety of dulaglutide in the treatment of type 2 diabetes: a comprehensive review of the dulaglutide clinical data focusing on the AWARD phase 3 clinical trial program
    Johan Jendle, George Grunberger, Thomas Blevins, Francesco Giorgino, Ryan T. Hietpas, Fady T. Botros
    Diabetes/Metabolism Research and Reviews.2016; 32(8): 776.     CrossRef
  • Glucagon‐like peptide‐1(GLP‐1) receptor agonists: potential to reduce fracture risk in diabetic patients?
    Guojing Luo, Hong Liu, Hongyun Lu
    British Journal of Clinical Pharmacology.2016; 81(1): 78.     CrossRef
  • Impact of postprandial glucose control on diabetes-related complications: How is the evidence evolving?
    Sten Madsbad
    Journal of Diabetes and its Complications.2016; 30(2): 374.     CrossRef
  • Risk assessment and management of post-transplant diabetes mellitus
    Eugene Han, Myoung Soo Kim, Yu Seun Kim, Eun Seok Kang
    Metabolism.2016; 65(10): 1559.     CrossRef
  • Recent advances in oral delivery of peptide hormones
    Pegah Varamini, Istvan Toth
    Expert Opinion on Drug Delivery.2016; 13(4): 507.     CrossRef
  • Exendin-4 Inhibits Hepatic Lipogenesis by Increasing β-Catenin Signaling
    Mi Hae Seo, Jinmi Lee, Seok-Woo Hong, Eun-Jung Rhee, Se Eun Park, Cheol Young Park, Ki Won Oh, Sung Woo Park, Won-Young Lee, Catherine Mounier
    PLOS ONE.2016; 11(12): e0166913.     CrossRef
  • Review of head‐to‐head comparisons of glucagon‐like peptide‐1 receptor agonists
    Sten Madsbad
    Diabetes, Obesity and Metabolism.2016; 18(4): 317.     CrossRef
  • Does Bosentan Protect Diabetic Brain Alterations in Rats? The Role of Endothelin‐1 in the Diabetic Brain
    Recep Demir, Elif Cadirci, Erol Akpinar, Yasemin Cayir, Hasan Tarik Atmaca, Harun Un, Celalettin Semih Kunak, Muhammed Yayla, Zafer Bayraktutan, Ilknur Demir
    Basic & Clinical Pharmacology & Toxicology.2015; 116(3): 236.     CrossRef
  • Efficacy and tolerability of albiglutide versus placebo or pioglitazone over 1 year in people with type 2 diabetes currently taking metformin and glimepiride: HARMONY 5
    P. D. Home, P. Shamanna, M. Stewart, F. Yang, M. Miller, C. Perry, M. C. Carr
    Diabetes, Obesity and Metabolism.2015; 17(2): 179.     CrossRef
  • Differential effects of prandial and non-prandial GLP-1 receptor agonists in type 2 diabetes therapy
    Jaime A. Davidson
    Postgraduate Medicine.2015; 127(8): 827.     CrossRef
  • GLP‐1 receptor agonists: effects on the progression of non‐alcoholic fatty liver disease
    Jia Liu, Guang Wang, Yumei Jia, Yuan Xu
    Diabetes/Metabolism Research and Reviews.2015; 31(4): 329.     CrossRef
  • Efficacy and safety of teneligliptin, a dipeptidyl peptidase‐4 inhibitor, combined with metformin in Korean patients with type 2 diabetes mellitus: a 16‐week, randomized, double‐blind, placebo‐controlled phase III trial
    M. K. Kim, E.‐J. Rhee, K. A. Han, A. C. Woo, M.‐K. Lee, B. J. Ku, C. H. Chung, K.‐A. Kim, H. W. Lee, I. B. Park, J. Y. Park, H. C. Chul Jang, K. S. Park, W. I. Jang, B. Y. Cha
    Diabetes, Obesity and Metabolism.2015; 17(3): 309.     CrossRef
  • Incretin physiology and pathophysiology from an Asian perspective
    Young Min Cho
    Journal of Diabetes Investigation.2015; 6(5): 495.     CrossRef
  • Response: Economic Impact of Combining Metformin with Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients with Renal Impairment in Spanish Patients (Diabetes Metab J2015;39:74-81)
    Antoni Sicras-Mainar, Ruth Navarro-Artieda
    Diabetes & Metabolism Journal.2015; 39(2): 173.     CrossRef
  • Clinical Application of Glucagon-Like Peptide-1 Receptor Agonists
    Se Hee Min, Young Min Cho
    The Journal of Korean Diabetes.2015; 16(4): 252.     CrossRef
  • Autophagy deficiency in β cells blunts incretin-induced suppression of glucagon release from α cells
    Min Joo Kim, Ok Kyong Choi, Kyung Sil Chae, Hakmo Lee, Sung Soo Chung, Dong-Sik Ham, Ji-Won Kim, Kun-Ho Yoon, Kyong Soo Park, Hye Seung Jung
    Islets.2015; 7(5): e1129096.     CrossRef
  • Glucagon-Like Peptide-1 Increases Mitochondrial Biogenesis and Function in INS-1 Rat Insulinoma Cells
    Mi Yeon Kang, Tae Jung Oh, Young Min Cho
    Endocrinology and Metabolism.2015; 30(2): 216.     CrossRef
  • Interleukin-6 CpG Methylation and Body Weight Correlate Differently in Type 2 Diabetes Patients Compared to Obese and Lean Controls
    Eva Aumueller, Marlene Remely, Hanna Baeck, Berit Hippe, Helmut Brath, Alexander G. Haslberger
    Lifestyle Genomics.2015; 8(1): 26.     CrossRef
  • The glucagon-like peptide 1 receptor agonist enhances intrinsic peroxisome proliferator-activated receptor γ activity in endothelial cells
    Hirohisa Onuma, Kouichi Inukai, Atsuko Kitahara, Rie Moriya, Susumu Nishida, Toshiaki Tanaka, Hidenori Katsuta, Kazuto Takahashi, Yoshikazu Sumitani, Toshio Hosaka, Hitoshi Ishida
    Biochemical and Biophysical Research Communications.2014; 451(2): 339.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Cytokines and Hormones That Contribute to the Positive Association between Fat and Bone
    Dorit Naot, Jillian Cornish
    Frontiers in Endocrinology.2014;[Epub]     CrossRef
  • Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide
    Maria Voukali, Irene Kastrinelli, Sapfo Stragalinou, Dimitra Tasiopoulou, Pinelopi Paraskevopoulou, Nicholas Katsilambros, Alexandros Kokkinos, Nicholas Tentolouris, Ioannis Ioannidis
    Journal of Diabetes Research.2014; 2014: 1.     CrossRef
  • The cardiometabolic benefits of glycine: Is glycine an ‘antidote’ to dietary fructose?
    Mark F McCarty, James J DiNicolantonio
    Open Heart.2014; 1(1): e000103.     CrossRef
  • Nuevos fármacos antidiabéticos: avanzando hacia el control integral de la diabesidad
    J.J. Gorgojo-Martínez
    Hipertensión y Riesgo Vascular.2014; 31(2): 45.     CrossRef
  • Managing Loss of Glycemic Control in Middle-Aged Patients With Diabetes: The Role of GLP-1 Receptor Agonists in Combination-Therapy Regimens
    Thomas B. Repas
    Journal of Osteopathic Medicine.2014; 114(s52): 14.     CrossRef
Close layer
Thyroid
The Diagnosis and Management of Hyperthyroidism in Korea: Consensus Report of the Korean Thyroid Association
Jae Hoon Moon, Ka Hee Yi
Endocrinol Metab. 2013;28(4):275-279.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.275
  • 6,484 View
  • 78 Download
  • 54 Crossref
AbstractAbstract PDFPubReader   

Hyperthyroidism is one of the causes of thyrotoxicosis and the most common cause of hyperthyroidism in Korea is Graves disease. The diagnosis and treatment of Graves disease are different according to geographical area. Recently, the American Thyroid Association and the American Association of Clinical Endocrinologists suggested new management guidelines for hyperthyroidism. However, these guidelines are different from clinical practice in Korea and are difficult to apply. Therefore, the Korean Thyroid Association (KTA) conducted a survey of KTA members regarding the diagnosis and treatment of hyperthyroidism, and reported the consensus on the management of hyperthyroidism. In this review, we summarized the KTA report on the contemporary practice patterns in the diagnosis and management of hyperthyroidism, and compared this report with guidelines from other countries.

Citations

Citations to this article as recorded by  
  • Effect of previous administration of potassium iodine and different durations of low iodine diets for radioiodine therapy on the treatment of Graves' disease in iodine-rich areas
    Mika Tamura, Kunihiro Nakada, Haruna Iwanaga, Naotoshi Fujita, Katsuhiko Kato
    European Journal of Nuclear Medicine and Molecular Imaging.2024; 51(4): 1060.     CrossRef
  • Effects of altitude on thyroid disorders according to Chinese three-rung, ladder-like topography: national cross-sectional study
    Boshen Gong, Youmin Wang, Jin-an Zhang, Qiao Zhang, Jiajun Zhao, Jiashu Li, Xichang Wang, Yutong Han, Ziwei Yu, Chenyu Zhang, Bingcong Peng, Yumin Xing, Qiuxian Li, Ping Wang, Yongze Li, Weiping Teng, Zhongyan Shan
    BMC Public Health.2024;[Epub]     CrossRef
  • MACE and Hyperthyroidism Treated With Medication, Radioactive Iodine, or Thyroidectomy
    Carol Chiung-Hui Peng, Yu-Jie Lin, Sun Y. Lee, Shu-Man Lin, Cheng Han, Ching-Hui Loh, Huei-Kai Huang, Elizabeth N. Pearce
    JAMA Network Open.2024; 7(3): e240904.     CrossRef
  • Increased risk of incident gout in patients with hyperthyroidism: a nationwide retrospective cohort study
    Ju-Yeun Lee, So-Yeon Park, Seo Young Sohn
    Rheumatology International.2023; 44(3): 451.     CrossRef
  • The Current Status of Hyperthyroidism in Korea
    Hyemi Kwon
    Endocrinology and Metabolism.2023; 38(4): 392.     CrossRef
  • A machine learning-assisted system to predict thyrotoxicosis using patients’ heart rate monitoring data: a retrospective cohort study
    Kyubo Shin, Jongchan Kim, Jaemin Park, Tae Jung Oh, Sung Hye Kong, Chang Ho Ahn, Joon Ho Moon, Min Joo Kim, Jae Hoon Moon
    Scientific Reports.2023;[Epub]     CrossRef
  • Immunometabolic signatures predict recovery from thyrotoxic myopathy in patients with Graves' disease
    Daiki Setoyama, Ho Yeop Lee, Ji Sun Moon, Jingwen Tian, Yea Eun Kang, Ju Hee Lee, Minho Shong, Dongchon Kang, Hyon‐Seung Yi
    Journal of Cachexia, Sarcopenia and Muscle.2022; 13(1): 355.     CrossRef
  • Comparison of 99mTc Pertechnetate Thyroid Uptake Rates by Gamma Probe and Gamma Camera Methods for Differentiating Graves’ Disease and Thyroiditis
    Meihua Jin, Jonghwa Ahn, Seong-gil Jo, Jangwon Park, Min Ji Jeon, Won Gu Kim, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Jin-Sook Ryu
    Nuclear Medicine and Molecular Imaging.2022; 56(1): 42.     CrossRef
  • KSNM60 in Nuclear Endocrinology: from the Beginning to the Future
    Chae Moon Hong, Young Jin Jeong, Hae Won Kim, Byeong-Cheol Ahn
    Nuclear Medicine and Molecular Imaging.2022; 56(1): 17.     CrossRef
  • Graves’ disease and the risk of Parkinson’s disease: a Korean population-based study
    Yoon Young Cho, Bongseong Kim, Dong Wook Shin, Jinyoung Youn, Ji Oh Mok, Chul-Hee Kim, Sun Wook Kim, Jae Hoon Chung, Kyungdo Han, Tae Hyuk Kim
    Brain Communications.2022;[Epub]     CrossRef
  • Graves’ Disease and the Risk of End-Stage Renal Disease: A Korean Population-Based Study
    Yoon Young Cho, Bongseong Kim, Dong Wook Shin, Hye Ryoun Jang, Bo-Yeon Kim, Chan-Hee Jung, Jae Hyeon Kim, Sun Wook Kim, Jae Hoon Chung, Kyungdo Han, Tae Hyuk Kim
    Endocrinology and Metabolism.2022; 37(2): 281.     CrossRef
  • Evaluation and Management of Bone Health in Patients with Thyroid Diseases: a Position Statement from the Korean Thyroid Association
    A Ram Hong, Hwa Young Ahn, Bu Kyung Kim, Seong Hee Ahn, So Young Park, Min-Hee Kim, Jeongmin Lee, Sun Wook Cho, Ho-Cheol Kang
    International Journal of Thyroidology.2022; 15(1): 1.     CrossRef
  • Patient Population and Test Utilization for Thyroid Function in Local Clinics and Hospitals in Korea
    Rihwa Choi, Sang Gon Lee, Eun Hee Lee
    Diagnostics.2022; 12(7): 1638.     CrossRef
  • 2021 Asia-Pacific Graves’ Disease Consortium Survey of Clinical Practice Patterns in the Management of Graves’ Disease
    Rajeev Parameswaran, Mechteld Christine de Jong, James Lee Wai Kit, Kathleen Sek, Tran Quang Nam, Tran Viet Thang, Nguyen Thy Khue, Than Than Aye, Phone Myint Tun, Timothy Cole, Julie A. Miller, Michael Villa, Benjapa Khiewvan, Sirinart Sirinvaravong, Yon
    Endocrine.2022; 79(1): 135.     CrossRef
  • Graves’ disease, its treatments, and the risk of atrial fibrillation: A Korean population-based study
    Yoon Young Cho, Bongseong Kim, Dughyun Choi, Chul-Hee Kim, Dong Wook Shin, Jee Soo Kim, Seung-Jung Park, Sun Wook Kim, Jae Hoon Chung, Kyungdo Han, Tae Hyuk Kim
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Forty Years Together, New Leap Forward! The 40th Anniversary of the Korean Endocrine Society
    Jong Chul Won, Ki-Hyun Baek
    Endocrinology and Metabolism.2022; 37(6): 851.     CrossRef
  • Evaluation of the role of thyroid scintigraphy in the differential diagnosis of thyrotoxicosis
    Carolina M. Perdomo, Marta García‐Goñi, Lidia Sancho, José J. Paricio, María D. Lozano, Magdalena de la Higuera, María Currás, Javier Arbizu, Juan C. Galofré
    Clinical Endocrinology.2021; 94(3): 466.     CrossRef
  • Treatment of patients with Graves’ disease in Sweden compared to international surveys of an ‘index patient’
    Gabriel Sjölin, Kristina Byström, Mats Holmberg, Ove Törring, Selwan Khamisi, Jan Calissendorff, Mikael Lantz, Bengt Hallengren, Helena Filipsson Nyström, Tereza Planck, Göran Wallin
    Endocrinology, Diabetes & Metabolism.2021;[Epub]     CrossRef
  • Secular Trends in Ablation Therapy for Graves’ Disease: An Analysis of a 15-Year Experience at a Tertiary Hospital in South Korea
    Min Joo Kim, Ye An Kim, Sun Wook Cho, Su-jin Kim, Kyu Eun Lee, Young Joo Park, Do Joon Park, Bo Youn Cho
    Journal of Clinical Medicine.2021; 10(8): 1629.     CrossRef
  • Long-Term Antithyroid Drug Treatment of Graves’ Disease in Children and Adolescents: A 20-Year Single-Center Experience
    Ari Song, Su Jin Kim, Min-Sun Kim, Jiyeon Kim, Insung Kim, Ga Young Bae, Eunseop Seo, Young Seok Cho, Joon Young Choi, Sung Yoon Cho, Dong-Kyu Jin
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Association of Polygenetic Risk Scores Related to Immunity and Inflammation with Hyperthyroidism Risk and Interactions between the Polygenetic Scores and Dietary Factors in a Large Cohort
    Mi Young Song, Sunmin Park, Anjali Mishra
    Journal of Thyroid Research.2021; 2021: 1.     CrossRef
  • Treatment Modality and Risk of Heart Failure in Patients With Long-Standing Graves’ Disease: A Nationwide Population-Based Cohort Study
    Eyun Song, Mina Kim, Sojeong Park, Min Jeong Park, Jung A. Kim, Eun Roh, Ji Hee Yu, Nam Hoon Kim, Ji A. Seo, Sin Gon Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Hye Jin Yoo
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Risk of Diabetes in Patients with Long-Standing Graves’ Disease: A Longitudinal Study
    Eyun Song, Min Ji Koo, Eunjin Noh, Soon Young Hwang, Min Jeong Park, Jung A Kim, Eun Roh, Kyung Mook Choi, Sei Hyun Baik, Geum Joon Cho, Hye Jin Yoo
    Endocrinology and Metabolism.2021; 36(6): 1277.     CrossRef
  • Diabetes and Hyperthyroidism: Is There a Causal Link?
    Sang Yong Kim
    Endocrinology and Metabolism.2021; 36(6): 1175.     CrossRef
  • Incidence and Mortality of Myocardial Infarction and Stroke in Patients with Hyperthyroidism: A Nationwide Cohort Study in Korea
    Hyun Jung Kim, Taeuk Kang, Min Ji Kang, Hyeong Sik Ahn, Seo Young Sohn
    Thyroid.2020; 30(7): 955.     CrossRef
  • Diagnosis and Management of Graves’ Disease in Thailand: A Survey of Current Practice
    Chutintorn Sriphrapradang
    Journal of Thyroid Research.2020; 2020: 1.     CrossRef
  • The success rate of radioactive iodine therapy for Graves’ disease in iodine-replete area and affecting factors: a single-center study
    Hyunju Park, Hye In Kim, Jun Park, So Young Park, Tae Hyuk Kim, Jae Hoon Chung, Joon Young Choi, Sun Wook Kim
    Nuclear Medicine Communications.2020; 41(3): 212.     CrossRef
  • Tirotoksikoz nedenli erektil disfonksiyon üzerine sildenafil etkisinin histopatolojik olarak değerlendirilmesi
    Murat ÖZDEMİR, Canberk TOMRUK, Gürkan YİĞİTTÜRK, Varlık EROL, Emel Öykü ÇETİN, Ilgın YILDIRIM ŞİMŞİR, Çiğdem YENİSEY, Yiğit UYANIKGİL, Adnan ŞİMŞİR, Özer MAKAY
    Ege Tıp Dergisi.2020; 59(3): 215.     CrossRef
  • The Management of Thyroid Disease in COVID-19 Pandemic
    Won Sang Yoo, Hyun-Kyung Chung
    International Journal of Thyroidology.2020; 13(2): 65.     CrossRef
  • Is Hyperthyroidism Diagnosed and Treated Appropriately in the United States?
    Ammar Asban, Sophie Dream, Brenessa Lindeman
    Advances in Surgery.2019; 53: 117.     CrossRef
  • Long-term remission following antithyroid drug withdrawal in patients with Graves’ hyperthyroidism: parameters with prognostic value
    Ricardo V. García-Mayor, Paula Álvarez-Vázquez, Enrique Fluiters, Diana Valverde, Amalia Andrade
    Endocrine.2019; 63(2): 316.     CrossRef
  • Safety of long-term antithyroid drug treatment? A systematic review
    F. Azizi, R. Malboosbaf
    Journal of Endocrinological Investigation.2019; 42(11): 1273.     CrossRef
  • Changes in Thyroid Peroxidase and Thyroglobulin Antibodies Might Be Associated with Graves' Disease Relapse after Antithyroid Drug Therapy
    Yun Mi Choi, Mi Kyung Kwak, Sang Mo Hong, Eun-Gyoung Hong
    Endocrinology and Metabolism.2019; 34(3): 268.     CrossRef
  • Prevalence and Annual Incidence of Thyroid Disease in Korea from 2006 to 2015: A Nationwide Population-Based Cohort Study
    Hyemi Kwon, Jin-hyung Jung, Kyung-Do Han, Yong-Gyu Park, Jung-Hwan Cho, Da Young Lee, Ji Min Han, Se Eun Park, Eun-Jung Rhee, Won-Young Lee
    Endocrinology and Metabolism.2018; 33(2): 260.     CrossRef
  • An update in the treatment preference for hyperthyroidism
    Obin Kwon
    Nature Reviews Endocrinology.2018; 14(7): 438.     CrossRef
  • Clinical Feasibility of Monitoring Resting Heart Rate Using a Wearable Activity Tracker in Patients With Thyrotoxicosis: Prospective Longitudinal Observational Study
    Jie-Eun Lee, Dong Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Sung Hee Choi, Soo Lim, Young Joo Park, Do Joon Park, Hak Chul Jang, Jae Hoon Moon
    JMIR mHealth and uHealth.2018; 6(7): e159.     CrossRef
  • Graves' Disease Patients with Large Goiters Respond Best to Radioactive Iodine Doses of at Least 15 mCi: a Sonographic Volumetric Study
    Yun Ah Jeong, Jee Hee Yoon, Hee Kyung Kim, Ho-Cheol Kang
    International Journal of Thyroidology.2018; 11(2): 137.     CrossRef
  • Chylothorax Associated with Substernal Goiter in Graves’ Disease Treated with Radioactive Iodine
    Seo Young Oh, Bo Hyun Kim, Do Young Kim, Kyu Min Lee, Min Jin Lee, Sung Su Kim, Jong Ho Kim, Yun Kyung Jeon, Sang Soo Kim, Yong Ki Kim, In Joo Kim
    International Journal of Endocrinology and Metabolism.2017;[Epub]     CrossRef
  • Vitiligo and overt thyroid diseases: A nationwide population-based study in Korea
    Jung Min Bae, June Hyunkyung Lee, Jae Seung Yun, Byeol Han, Tae Young Han
    Journal of the American Academy of Dermatology.2017; 76(5): 871.     CrossRef
  • Increased risk of thyroid diseases in patients with systemic lupus erythematosus: A nationwide population-based Study in Korea
    Jae-Seung Yun, Jung Min Bae, Ki-Jo Kim, Yu Seok Jung, Gyong Moon Kim, Hyung-Rae Kim, Jun-Seok Lee, Seung-Hyun Ko, Seon-Ah Cha, Yu-Bae Ahn, Ludmila Prokunina-Olsson
    PLOS ONE.2017; 12(6): e0179088.     CrossRef
  • The Second Antithyroid Drug Treatment Is Effective in Relapsed Graves' Disease Patients: A Median 11-Year Follow-Up Study
    Ye An Kim, Sun Wook Cho, Hoon Sung Choi, Shinje Moon, Jae Hoon Moon, Kyung Won Kim, Do Joon Park, Ka Hee Yi, Young Joo Park, Bo Youn Cho
    Thyroid.2017; 27(4): 491.     CrossRef
  • Free Thyroxine, Anti-Thyroid Stimulating Hormone Receptor Antibody Titers, and Absence of Goiter Were Associated with Responsiveness to Methimazole in Patients with New Onset Graves' Disease
    Hoon Sung Choi, Won Sang Yoo
    Endocrinology and Metabolism.2017; 32(2): 281.     CrossRef
  • Long-Term Antithyroid Drug Treatment: A Systematic Review and Meta-Analysis
    Fereidoun Azizi, Ramin Malboosbaf
    Thyroid.2017; 27(10): 1223.     CrossRef
  • The Recurrence Rate of Graves' Disease among Patients with Subclinical Thyrotoxicosis after Initial Remission with Antithyroid Agents
    Myoung Sook Shim, Soo Min Nam, Jin Sae Yoo, Hae Kyung Kim, Sang Jun Lee, Mi Young Lee
    International Journal of Thyroidology.2017; 10(2): 77.     CrossRef
  • Serum 25-hydroxyvitamin D might be an independent prognostic factor for Graves disease recurrence
    Hwa Young Ahn, Yun Jae Chung, Bo Youn Cho
    Medicine.2017; 96(31): e7700.     CrossRef
  • Recent Advances in Autoimmune Thyroid Diseases
    Won Sang Yoo, Hyun Kyung Chung
    Endocrinology and Metabolism.2016; 31(3): 379.     CrossRef
  • Usefulness of Measuring Thyroid Stimulating Antibody at the Time of Antithyroid Drug Withdrawal for Predicting Relapse of Graves Disease
    Hyemi Kwon, Won Gu Kim, Eun Kyung Jang, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Jin-Sook Ryu, Young Kee Shong, Won Bae Kim
    Endocrinology and Metabolism.2016; 31(2): 300.     CrossRef
  • Hyperthyroidism
    Simone De Leo, Sun Y Lee, Lewis E Braverman
    The Lancet.2016; 388(10047): 906.     CrossRef
  • Differentiating Graves' disease from subacute thyroiditis using ratio of serum free triiodothyronine to free thyroxine
    Chutintorn Sriphrapradang, Adikan Bhasipol
    Annals of Medicine and Surgery.2016; 10: 69.     CrossRef
  • Management of hyperthyroid patients in dental emergencies: a case report
    Kyung-Jin Lee, Wonse Park, Nan-Sim Pang, Jin-Hyung Cho, Kee-Deog Kim, Bock Young Jung, Eun-Jung Kwak
    Journal of Dental Anesthesia and Pain Medicine.2016; 16(2): 147.     CrossRef
  • The Presence of Thyroid-Stimulation Blocking Antibody Prevents High Bone Turnover in Untreated Premenopausal Patients with Graves’ Disease
    Sun Wook Cho, Jae Hyun Bae, Gyeong Woon Noh, Ye An Kim, Min Kyong Moon, Kyoung Un Park, Junghan Song, Ka Hee Yi, Do Joon Park, June-Key Chung, Bo Youn Cho, Young Joo Park, Jung-Eun Kim
    PLOS ONE.2015; 10(12): e0144599.     CrossRef
  • Refractory Graves' Disease Successfully Cured by Adjunctive Cholestyramine and Subsequent Total Thyroidectomy
    Yeoree Yang, Seawon Hwang, Minji Kim, Yejee Lim, Min-Hee Kim, Sohee Lee, Dong-Jun Lim, Moo-Il Kang, Bong-Yun Cha
    Endocrinology and Metabolism.2015; 30(4): 620.     CrossRef
  • Improved quality of life in hyperthyroidism patients after surgery
    Branka Bukvic, Vladan Zivaljevic, Sandra Sipetic, Aleksandar Diklic, Katarina Tausanovic, Dragos Stojanovic, Dejan Stevanovic, Ivan Paunovic
    Journal of Surgical Research.2015; 193(2): 724.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
Close layer
Editorial
Obesity and Metabolism
Noninvasive Markers for the Diagnosis of Nonalcoholic Fatty Liver Disease
Sang Yong Kim
Endocrinol Metab. 2013;28(4):280-282.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.280
  • 3,355 View
  • 27 Download
  • 3 Crossref
PDFPubReader   

Citations

Citations to this article as recorded by  
  • Developmental Programming: Impact of Prenatal Exposure to Bisphenol A on Senescence and Circadian Mediators in the Liver of Sheep
    Giuliana Motta, Soundara Viveka Thangaraj, Vasantha Padmanabhan
    Toxics.2023; 12(1): 15.     CrossRef
  • Lobeglitazone, a Novel Thiazolidinedione, Improves Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes: Its Efficacy and Predictive Factors Related to Responsiveness
    Yong-ho Lee, Jae Hyeon Kim, So Ra Kim, Heung Yong Jin, Eun-Jung Rhee, Young Min Cho, Byung-Wan Lee
    Journal of Korean Medical Science.2017; 32(1): 60.     CrossRef
  • Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease
    Gyuri Kim, Kwang Joon Kim, Yumie Rhee, Sung-Kil Lim, Salvatore Petta
    PLOS ONE.2017; 12(7): e0182202.     CrossRef
Close layer
Original Articles
Obesity and Metabolism
Association of Serum Adipocyte-Specific Fatty Acid Binding Protein with Fatty Liver Index as a Predictive Indicator of Nonalcoholic Fatty Liver Disease
Won Seon Jeon, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
Endocrinol Metab. 2013;28(4):283-287.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.283
  • 4,052 View
  • 34 Download
  • 16 Crossref
AbstractAbstract PDFPubReader   
Background

Adipocyte-specific fatty acid-binding protein (A-FABP) is a cytoplasmic protein expressed in macrophages and adipocytes and it plays a role in insulin resistance and metabolic syndrome. Recently, the fatty liver index (FLI) was introduced as an indicator of nonalcoholic fatty liver disease (NAFLD). In this study, we aimed to investigate the relationship between baseline serum A-FABP levels and FLI after 4 years in apparently healthy subjects.

Methods

A total of 238 subjects without a past history of alcoholism or hepatitis were recruited from a medical check-up program. The NAFLD state was evaluated 4 years later in the same subjects using FLI. Fatty liver disease was diagnosed as diffusely increased echogenicity of the hepatic parenchyma compared to the kidneys, vascular blurring, and deep-echo attenuation. NAFLD was defined as subjects with fatty liver and no history of alcohol consumption (>20 g/day).

Results

Baseline serum A-FABP levels were significantly associated with FLI after adjustment for age and sex (P<0.001). The subjects with higher A-FABP levels had a higher mean FLI (P for trend=0.006). After adjusting for age and sex, serum A-FABP levels at baseline were shown to be significantly associated with FLI as a marker of development of NAFLD after 4 years (odds ratio, 2.68; 95% confidence interval, 1.24 to 5.80 for highest tertile vs. lowest tertile; P=0.012).

Conclusion

This study demonstrated that higher baseline serum A-FABP levels were associated with FLI as a predictive indicator of NAFLD after 4 years of follow-up in healthy Korean adults.

Citations

Citations to this article as recorded by  
  • Insulin Resistance, Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Clinical and Experimental Perspective
    Inha Jung, Dae-Jeong Koo, Won-Young Lee
    Diabetes & Metabolism Journal.2024; 48(3): 327.     CrossRef
  • FABP4 Expression in Subcutaneous Adipose Tissue Is Independently Associated with Circulating Triglycerides in Obesity
    Óscar Osorio-Conles, Ainitze Ibarzabal, José María Balibrea, Josep Vidal, Emilio Ortega, Ana de Hollanda
    Journal of Clinical Medicine.2023; 12(3): 1013.     CrossRef
  • Unveiling the Role of the Fatty Acid Binding Protein 4 in the Metabolic-Associated Fatty Liver Disease
    Juan Moreno-Vedia, Josefa Girona, Daiana Ibarretxe, Lluís Masana, Ricardo Rodríguez-Calvo
    Biomedicines.2022; 10(1): 197.     CrossRef
  • Circulating level of fatty acid‐binding protein 4 is an independent predictor of metabolic dysfunction‐associated fatty liver disease in middle‐aged and elderly individuals
    Marenao Tanaka, Satoko Takahashi, Yukimura Higashiura, Akiko Sakai, Masayuki Koyama, Shigeyuki Saitoh, Kazuaki Shimamoto, Hirofumi Ohnishi, Masato Furuhashi
    Journal of Diabetes Investigation.2022; 13(5): 878.     CrossRef
  • New Insights into Non-Alcoholic Fatty Liver Disease and Coronary Artery Disease: The Liver-Heart Axis
    Georgiana-Diana Cazac, Cristina-Mihaela Lăcătușu, Cătălina Mihai, Elena-Daniela Grigorescu, Alina Onofriescu, Bogdan-Mircea Mihai
    Life.2022; 12(8): 1189.     CrossRef
  • Association between the liver fat score (LFS) and cardiovascular diseases in the national health and nutrition examination survey 1999–2016
    Chun-On Lee, Hang-Long Li, Man-Fung Tsoi, Ching-Lung Cheung, Bernard Man Yung Cheung
    Annals of Medicine.2021; 53(1): 1067.     CrossRef
  • Relationship Between Fatty Acid Binding Protein 4 and Liver Fat in Individuals at Increased Cardiometabolic Risk
    Ricardo Rodríguez-Calvo, Juan Moreno-Vedia, Josefa Girona, Daiana Ibarretxe, Neus Martínez-Micaelo, Jordi Merino, Nuria Plana, Lluis Masana
    Frontiers in Physiology.2021;[Epub]     CrossRef
  • Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective
    Eun-Jung Rhee
    Endocrinology and Metabolism.2019; 34(3): 226.     CrossRef
  • Serum adipocyte fatty acid‐binding protein levels: An indicator of non‐alcoholic fatty liver disease in Chinese individuals
    Yiting Xu, Xiaojing Ma, Xiaoping Pan, Xingxing He, Yufei Wang, Yuqian Bao
    Liver International.2019; 39(3): 568.     CrossRef
  • Clinical Characteristics of Non-Alcoholic Fatty Liver Disease Based on Analyses from the Kangbuk Samsung Health Study
    Eun-Jung Rhee
    The Journal of Korean Diabetes.2017; 18(2): 81.     CrossRef
  • The relationship between serum fatty-acid binding protein 4 level and lung function in Korean subjects with normal ventilatory function
    Hye-Jeong Park, Se Eun Park, Cheol-Young Park, Seong Yong Lim, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
    BMC Pulmonary Medicine.2016;[Epub]     CrossRef
  • Liver fatty acid-binding protein as a diagnostic marker for non-alcoholic fatty liver disease
    Erdem Akbal, Erdem Koçak, Ömer Akyürek, Seyfettin Köklü, Hikmetullah Batgi, Mehmet Şenes
    Wiener klinische Wochenschrift.2016; 128(1-2): 48.     CrossRef
  • High‐methionine diets accelerate atherosclerosis by HHcy‐mediated FABP4 gene demethylation pathway via DNMT1 in ApoE−/− mice
    An-Ning Yang, Hui-Ping Zhang, Yue Sun, Xiao-Ling Yang, Nan Wang, Guangrong Zhu, Hui Zhang, Hua Xu, Sheng-Chao Ma, Yue Zhang, Gui-Zhong Li, Yue-Xia Jia, Jun Cao, Yi-Deng Jiang
    FEBS Letters.2015; 589(24PartB): 3998.     CrossRef
  • Metabolic Health Is More Important than Obesity in the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Retrospective Study
    Min-Kyung Lee, Eun-Jung Rhee, Min Chul Kim, Byung Sub Moon, Jeong In Lee, Young Seok Song, Eun Na Han, Hyo Sun Lee, Yoonjeong Son, Se Eun Park, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee
    Endocrinology and Metabolism.2015; 30(4): 522.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Noninvasive Markers for the Diagnosis of Nonalcoholic Fatty Liver Disease
    Sang Yong Kim
    Endocrinology and Metabolism.2013; 28(4): 280.     CrossRef
Close layer
Adrenal gland
Effects of Chronic Restraint Stress on Body Weight, Food Intake, and Hypothalamic Gene Expressions in Mice
Joo Yeon Jeong, Dong Hoon Lee, Sang Soo Kang
Endocrinol Metab. 2013;28(4):288-296.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.288
  • 8,568 View
  • 163 Download
  • 144 Crossref
AbstractAbstract PDFPubReader   
Background

Stress affects body weight and food intake, but the underlying mechanisms are not well understood.

Methods

We evaluated the changes in body weight and food intake of ICR male mice subjected to daily 2 hours restraint stress for 15 days. Hypothalamic gene expression profiling was analyzed by cDNA microarray.

Results

Daily body weight and food intake measurements revealed that both parameters decreased rapidly after initiating daily restraint stress. Body weights of stressed mice then remained significantly lower than the control body weights, even though food intake slowly recovered to 90% of the control intake at the end of the experiment. cDNA microarray analysis revealed that chronic restraint stress affects the expression of hypothalamic genes possibly related to body weight control. Since decreases of daily food intake and body weight were remarkable in days 1 to 4 of restraint, we examined the expression of food intake-related genes in the hypothalamus. During these periods, the expressions of ghrelin and pro-opiomelanocortin mRNA were significantly changed in mice undergoing restraint stress. Moreover, daily serum corticosterone levels gradually increased, while leptin levels significantly decreased.

Conclusion

The present study demonstrates that restraint stress affects body weight and food intake by initially modifying canonical food intake-related genes and then later modifying other genes involved in energy metabolism. These genetic changes appear to be mediated, at least in part, by corticosterone.

Citations

Citations to this article as recorded by  
  • Potential antimicrobial activity of camel milk as a traditional functional food against foodborne pathogens in vivo and in vitro
    Amro Abdelazez, Sherif Melak, Heba Abdelmotaal, Garsa Alshehry, Huda Al-jumayi, Eman Algarni, Xiang-Chen Meng
    Food Science and Technology International.2024; 30(3): 239.     CrossRef
  • Effects of home‐cage elevation on behavioral tests in mice
    Hiroshi Ueno, Yu Takahashi, Shinji Murakami, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara
    Brain and Behavior.2024;[Epub]     CrossRef
  • Anaesthesia-induced Changes in Genomic Expression Leading to Neurodegeneration
    Khalid Saad Alharbi, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Fahad A. Al-Abbasi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Mohammed Albratty, Asim Najmi, Gaurav Gupta
    CNS & Neurological Disorders - Drug Targets.2024; 23(4): 411.     CrossRef
  • Stress integration by an ascending adrenergic-melanocortin circuit
    Connor Laule, Nilufer Sayar-Atasoy, Iltan Aklan, Hyojin Kim, Tayfun Ates, Debbie Davis, Deniz Atasoy
    Neuropsychopharmacology.2024; 49(9): 1361.     CrossRef
  • Stress-induced changes in cognitive function and intestinal barrier integrity can be ameliorated by venlafaxine and synbiotic supplementations
    Sarawut Lapmanee, Nattapon Supkamonseni, Sakkarin Bhubhanil, Nattakan Treesaksrisakul, Chaiyos Sirithanakorn, Mattaka Khongkow, Katawut Namdee, Piyaporn Surinlert, Chittipong Tipbunjong, Prapimpun Wongchitrat
    PeerJ.2024; 12: e17033.     CrossRef
  • Effects of prenatal THC vapor exposure on body weight, glucose metabolism, and feeding behaviors in chow and high-fat diet fed rats
    Catherine Hume, Samantha L. Baglot, Lucia Javorcikova, Savannah H. M. Lightfoot, Jessica Scheufen, Matthew N. Hill
    International Journal of Obesity.2024; 48(7): 981.     CrossRef
  • The inhalation effect of Osmanthus fragrans var. Aurantiacus on physiological parameters in chronically stressed rats
    Moon Yeon Youn, Jin-Ju Cho, Seong Jun Hong, Seong Min Jo, Hyangyeon Jeong, Sojeong Yoon, Younglan Ban, Hyeonjin Park, Jae Kyeom Kim, Young Jun Kim, Eui-Cheol Shin
    Food Chemistry: X.2024; 22: 101304.     CrossRef
  • Intranasal delivery of paroxetine: A preclinical study on pharmacokinetics, depressive-like behaviour, and neurochemical sex differences
    Soraia Silva, Joana Bicker, S. Fialho, Susana Cunha, Amílcar Falcão, Ana Fortuna
    Biochemical Pharmacology.2024; 223: 116184.     CrossRef
  • Translational models of stress and resilience: An applied neuroscience methodology review
    Zeynep Seda Albayrak, Andreia Vaz, Joeri Bordes, Selen Ünlü, Milou S.C. Sep, Christiaan H. Vinkers, Luisa Pinto, Hale Yapici-Eser
    Neuroscience Applied.2024; 3: 104064.     CrossRef
  • Prenatal restraint stress affects early neurobehavioral response and oxidative stress in mice pups.
    Oumaima Essaidi, Meriem Laaroussi, Hafsa Malqui, Laila Berroug, Hammou Anarghou, Hamadi Fetoui, Fatiha Chigr
    Behavioural Brain Research.2024; 468: 115025.     CrossRef
  • Cerebrovascular dysfunction and depressive symptoms in preclinical models: insights from a scoping review
    Nithin J. Menon, Clara Sun, Jashnoor Chhina, Brayden D. Halvorson, Jefferson C. Frisbee, Stephanie J. Frisbee
    Journal of Applied Physiology.2024; 136(6): 1352.     CrossRef
  • Improved Memory and Lower Stress Levels in Male Mice Co-Housed with Ovariectomized Female Mice
    Layung Sekar Sih Wikanthi, Johan Forsström, Birgit Ewaldsson, Vilborg Palsdottir, Therése Admyre
    Animals.2024; 14(10): 1503.     CrossRef
  • The effects of Gastrodia elata on anxiety-like behavior in mice
    Lan-Qiao He, Jia-Yu Lin, Ming-Zhi Yu, Peng-Yu Fan, Cen-Jie He, Ting-Ting Zhao
    All Life.2024;[Epub]     CrossRef
  • Chronic stress intensify PTZ-induced seizures by triggering neuroinflammation and oxidative stress
    Jehan Zeb Khan, Syeda Rida Zainab, Mujeeb Ur Rehman, Muhammad Abid, Muhammad Usama Mazhar, Fawad Ali Shah, Muhammad Khalid Tipu
    Biochemical and Biophysical Research Communications.2024; 729: 150333.     CrossRef
  • Subregion-specific transcriptomic profiling of rat brain reveals sex-distinct gene expression impacted by adolescent stress
    Kristen N. Krolick, Jingyi Cao, Evelyn M. Gulla, Meeta Bhardwaj, Samantha J. Marshall, Ethan Y. Zhou, Andor J. Kiss, Fouad Choueiry, Jiangjiang Zhu, Haifei Shi
    Neuroscience.2024; 553: 19.     CrossRef
  • Sex-dependent astrocyte reactivity: Unveiling chronic stress-induced morphological changes across multiple brain regions
    Ariel Y. Zhang, Elias Elias, Melissa T. Manners
    Neurobiology of Disease.2024; 200: 106610.     CrossRef
  • A Light-Responsive Neural Circuit Suppresses Feeding
    Hailan Liu, Na Qu, Natalia Valdez Gonzalez, Marco A. Palma, Huamin Chen, Jiani Xiong, Abhinav Choubey, Yongxiang Li, Xin Li, Meng Yu, Hesong Liu, Longlong Tu, Nan Zhang, Na Yin, Kristine Marie Conde, Mengjie Wang, Jonathan Carter Bean, Junying Han, Nikola
    The Journal of Neuroscience.2024; 44(30): e2192232024.     CrossRef
  • Pharmacological inhibition of histone deacetylase alleviates chronic unpredictable stress induced atherosclerosis and endothelial dysfunction via upregulation of BDNF
    Mujeeba Rehman, Vipul Agarwal, Rishabh Chaudhary, Arjun Singh Kaushik, Siddhi Srivastava, Sukriti Srivastava, Anand Kumar, Sanjay Singh, Vikas Mishra
    Biochemical and Biophysical Research Communications.2024; 735: 150485.     CrossRef
  • Plasma leptin levels are lower in females, but not males, with ketamine use disorder
    Ming-Chyi Huang, Li-Jung Chiang, Wan-Hsi Chien, Tung-Hsia Liu, Chun-Hsin Chen, Yu-Li Liu
    The American Journal of Drug and Alcohol Abuse.2024; : 1.     CrossRef
  • Acyl-CoA binding protein for the experimental treatment of anorexia
    Hui Chen, Stéphanie Moriceau, Adrien Joseph, Francois Mailliet, Sijing Li, Virginie Tolle, Philibert Duriez, Roland Dardennes, Sylvère Durand, Vincent Carbonnier, Gautier Stoll, Allan Sauvat, Sylvie Lachkar, Fanny Aprahamian, Carolina Alves Costa Silva, H
    Science Translational Medicine.2024;[Epub]     CrossRef
  • Feedforward inhibition of stress by brainstem neuropeptide Y neurons
    Yan Zhang, Jiayi Shen, Famin Xie, Zhiwei Liu, Fangfang Yin, Mingxiu Cheng, Liang Wang, Meiting Cai, Herbert Herzog, Ping Wu, Zhi Zhang, Cheng Zhan, Tiemin Liu
    Nature Communications.2024;[Epub]     CrossRef
  • Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus
    Mario Sánchez-Rubio, Lorena Abarzúa-Catalán, Ana del Valle, Maxs Méndez-Ruette, Natalia Salazar, Jacinta Sigala, Soledad Sandoval, María Inés Godoy, Alejandro Luarte, Lara J. Monteiro, Roberto Romero, Mahesh A. Choolani, Úrsula Wyneken, Sebastián E. Illan
    Biological Research.2024;[Epub]     CrossRef
  • Chronic stress-mediated dysregulations in inflammatory, immune and oxidative circuitry impairs the therapeutic response of methotrexate in experimental autoimmune disease models
    Rishabh Chaudhary, Mohd Akhtar Azam, Bhavana Dowand, Alpana Singh, Mujeeba Rehman, Vipul Agarwal, Anand Kumar, Arjun Singh Kaushik, Sukriti Srivastava, Siddhi Srivastava, Vikas Mishra
    Naunyn-Schmiedeberg's Archives of Pharmacology.2024;[Epub]     CrossRef
  • Stress exacerbates pancreatic cancer both directly and indirectly by creating an immunosuppressive environment
    Takahiro Ikeda, Tomohiko Adachi, Takayuki Tanaka, Daisuke Miyamoto, Hajime Imamura, Hajime Matsushima, Kazuo Yamamoto, Masaaki Hidaka, Kengo Kanetaka, Susumu Eguchi
    Journal of Hepato-Biliary-Pancreatic Sciences.2023; 30(7): 935.     CrossRef
  • Up-regulation of BDNF/TrkB signaling by δ opioid receptor agonist SNC80 modulates depressive-like behaviors in chronic restraint-stressed mice
    Shuo Wu, Kuan Ning, Yujun Wang, Lesha Zhang, Jinggen Liu
    European Journal of Pharmacology.2023; 942: 175532.     CrossRef
  • Assessment of Stress Caused by Environmental Changes for Improving the Welfare of Laboratory Beagle Dogs
    Gwang-Hoon Lee, Woori Jo, Tae-Ku Kang, Taeho Oh, KilSoo Kim
    Animals.2023; 13(6): 1095.     CrossRef
  • Butein ameliorates chronic stress induced atherosclerosis via targeting anti-inflammatory, anti-fibrotic and BDNF pathways
    Mujeeba Rehman, Rishabh Chaudhary, Sonu Rajput, Vipul Agarwal, Arjun Singh Kaushik, Siddhi Srivastava, Sukriti Srivastava, Rohit Singh, Irfan Aziz, Sanjay Singh, Vikas Mishra
    Physiology & Behavior.2023; 267: 114207.     CrossRef
  • Impact of exercise on brain-bone marrow interactions in chronic stress: potential mechanisms preventing stress-induced hypertension
    Thu Van Nguyen, Ko Yamanaka, Keisuke Tomita, Jasenka Zubcevic, Sabine S. S. Gouraud, Hidefumi Waki
    Physiological Genomics.2023; 55(5): 222.     CrossRef
  • Effect of mobile phone radiofrequency electromagnetic radiations on oxidative stress and feeding behaviour in Sprague Dawley (SD) rats
    Pravallika Pagadala, Vinutha Shankar M S, Sumathi M E
    Indian Journal of Physiology and Pharmacology.2023; 67: 131.     CrossRef
  • Mechanical loading and autophagy: A study on the BoNT-A injection-induced condylar cartilage degeneration
    Siyu Hou, Sisi Peng, Hongwei Dai, Jinlin Song, Ling Xu, Jianping Zhou, Lingjie Li
    Archives of Biochemistry and Biophysics.2023; 749: 109788.     CrossRef
  • Continuous deep brain stimulation of the nucleus accumbens reduces food intake but does not affect body weight in mice fed a high-fat diet
    Harold F. Hounchonou, Hui Tang, Raik Paulat, Andrea Kühn, Joachim Spranger, Christoph van Riesen, Lukas Maurer
    Scientific Reports.2023;[Epub]     CrossRef
  • Chronic stress predisposes to the aggravation of inflammation in autoimmune diseases with focus on rheumatoid arthritis and psoriasis
    Rishabh Chaudhary, Ajay Prasad, Vipul Agarwal, Mujeeba Rehman, Anand Kumar, Arjun Singh Kaushik, Siddhi Srivastava, Sukriti Srivastava, Vikas Mishra
    International Immunopharmacology.2023; 125: 111046.     CrossRef
  • Venlafaxine and synbiotic attenuated learned fear-like behavior and recognition memory impairment in immobilized-stressed rats
    Sarawut Lapmanee, Sakkarin Bhubhanil, Siriwan Sriwong, Mattaka Khongkow, Katawut Namdee, Prapimpun Wongchitrat, Pawin Pongkorpsakol
    Physiology and Pharmacology.2023; 27(2): 171.     CrossRef
  • Gonadotropin levels reduced in seven days immobilization stress-induced depressive-like behavior in female rats
    Zafer Sahin, Alpaslan Ozkurkculer, Omer Faruk Kalkan, Funda Gulcu Bulmus, Ozgur Bulmus, Selim Kutlu
    Journal of Basic and Clinical Physiology and Pharmacology.2022; 33(2): 199.     CrossRef
  • Impact of the Sound of Magnetic Resonance Imaging Pulse Sequences in Awake Mice
    Joana Almeida, Frederico Severo, Daniel Nunes
    Journal of Applied Animal Welfare Science.2022; 25(1): 75.     CrossRef
  • Virgin coconut oil abrogates depression-associated cognitive deficits by modulating hippocampal antioxidant balance, GABAergic and glutamatergic receptors in mice
    Edem Ekpenyong Edem, Blessing Eghosa Ihaza, Adedamola Adediran Fafure, Azeez Olakunle Ishola, Kate Eberechukwu Nebo, Linus Anderson Enye, Elizabeth Toyin Akinluyi
    Drug Metabolism and Personalized Therapy.2022; 37(2): 177.     CrossRef
  • Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress
    Dalia Murra, Kathryn L. Hilde, Anne Fitzpatrick, Pamela M. Maras, Stanley J. Watson, Huda Akil
    Neurobiology of Stress.2022; 17: 100437.     CrossRef
  • VTA-projecting cerebellar neurons mediate stress-dependent depression-like behaviors
    Soo Ji Baek, Jin Sung Park, Jinhyun Kim, Yukio Yamamoto, Keiko Tanaka-Yamamoto
    eLife.2022;[Epub]     CrossRef
  • Repeated Restraint Stress and Binge Alcohol during Adolescence Induce Long-Term Effects on Anxiety-like Behavior and the Expression of the Endocannabinoid System in Male Rats
    Laura Sánchez-Marín, María Flores-López, Ana L. Gavito, Juan Suárez, Francisco Javier Pavón-Morón, Fernando Rodríguez de Fonseca, Antonia Serrano
    Biomedicines.2022; 10(3): 593.     CrossRef
  • “Sibling” battle or harmony: crosstalk between nesfatin-1 and ghrelin
    Xi Chen, Jing Dong, Qian Jiao, Xixun Du, Mingxia Bi, Hong Jiang
    Cellular and Molecular Life Sciences.2022;[Epub]     CrossRef
  • Pharmacological Enhancement of Extinction Retention in Non-stressed Adolescent Rats but Not Those Exposed to Chronic Corticosterone
    Anthea A. Stylianakis, Kathryn D. Baker, Rick Richardson
    Frontiers in Neuroscience.2022;[Epub]     CrossRef
  • The effect of choline alphoscerate on non spatial memory and neuronal differentiation in a rat model of dual stress
    Hyo Jeong Yu, Ye Lin Kim, Min Jung Kim, Jung Mee Park, So Young Park, Shi Nae Park, Dong Won Yang
    Brain Research.2022; 1786: 147900.     CrossRef
  • Stress and the brain transcriptome: Identifying commonalities and clusters in standardized data from published experiments
    Adrian M. Stankiewicz, Aneta Jaszczyk, Joanna Goscik, Grzegorz R. Juszczak
    Progress in Neuro-Psychopharmacology and Biological Psychiatry.2022; 119: 110558.     CrossRef
  • Repeated restraint stress modifies fatty acid and amino acid metabolism in the mouse skin
    Yume KITAGAWA, Kaho HAYAKAWA, Daichi OIKAWA, Kazuki IKEDA, Maki IKEDA, Daiki HARADA, Mitsuhiro FURUSE
    Journal of Veterinary Medical Science.2022; 84(4): 511.     CrossRef
  • Antidiabetic Properties and Toxicological Assessment of Antidesma celebicum Miq: Ethanolic Leaves Extract in Sprague–Dawley Rats
    Raysa Y. Pratiwi, Berna Elya, Heri Setiawan, Roshamur C. Forestrania, Rizna T. Dewi, Kim Wei Chan
    Advances in Pharmacological and Pharmaceutical Sciences.2022; 2022: 1.     CrossRef
  • Proteomic and microbiota analyses of the oral cavity during psychological stress
    Durga Paudel, Yasuhiro Kuramitsu, Osamu Uehara, Tetsuro Morikawa, Koki Yoshida, Sarita Giri, Syed Taufiqul Islam, Takao Kitagawa, Tadashi Kondo, Kazuki Sasaki, Hirofumi Matsuoka, Hiroko Miura, Yoshihiro Abiko, Jon M. Jacobs
    PLOS ONE.2022; 17(5): e0268155.     CrossRef
  • Long-lasting effects of postweaning sleep deprivation on cognitive function and social behaviors in adult mice
    Boya Huang, Binhuang Sun, Rui Yang, Shihao Liang, Xinrui Li, Yi Guo, Qian Meng, Yaling Fu, Wenshuya Li, Penghui Zhao, Miao Gong, Yun Shi, Li Song, Sheng Wang, Fang Yuan, Haishui Shi
    Neuropharmacology.2022; 215: 109164.     CrossRef
  • High Housing Density-Induced Chronic Stress Diminishes Ovarian Reserve via Granulosa Cell Apoptosis by Angiotensin II Overexpression in Mice
    Jihyun Kim, Sooseong You
    International Journal of Molecular Sciences.2022; 23(15): 8614.     CrossRef
  • The effect of chronic stress and its preconditioning on spatial memory as well as hippocampal LRP1 and RAGE expression in a streptozotocin-induced rat model of Alzheimer’s disease
    Zohreh Taghadosi, Asadollah Zarifkar, Vahid Razban, Hadi Aligholi
    Metabolic Brain Disease.2022; 37(8): 2699.     CrossRef
  • Validity of the peak velocity to detect physical training improvements in athymic mice
    Maurício Beitia Kraemer, Karen Christine Silva, Camila Cunha França Kraemer, Juliana Silva Pereira, Ivan Gustavo Masseli dos Reis, Denise Gonçalves Priolli, Leonardo Henrique Dalcheco Messias
    Frontiers in Physiology.2022;[Epub]     CrossRef
  • Nicotine exposure through breastfeeding affects brain‐derived neurotrophic factor and synaptic proteins levels in the brain of stressed adult female mice
    Antonio Alves Pereira Júnior, Gabriel Estevam Santos de Amorim, Raphael Caio Tamborelli Garcia, Jéssyca Milene Ribeiro, Alessandra Oliveira Silva, Carolina Aparecida de Faria Almeida, Carla Speroni Ceron, Silvia Graciela Ruginsk, José Antunes‐Rodrigues, L
    International Journal of Developmental Neuroscience.2022; 82(8): 758.     CrossRef
  • Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy
    Tamás Gaszner, József Farkas, Dániel Kun, Balázs Ujvári, Gergely Berta, Valér Csernus, Nóra Füredi, László Ákos Kovács, Hitoshi Hashimoto, Dóra Reglődi, Viktória Kormos, Balázs Gaszner
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Abnormal expression of cortical cell cycle regulators underlying anxiety and depressive-like behavior in mice exposed to chronic stress
    Ana Paula Mendes-Silva, Thomas Damien Prevot, Mounira Banasr, Etienne Sibille, Breno Satler Diniz
    Frontiers in Cellular Neuroscience.2022;[Epub]     CrossRef
  • Chronic Inhibition of Aggressive Behavior Induces Behavioral Change in Mice
    Hiroshi Ueno, Yu Takahashi, Shinji Murakami, Kenta Wani, Tetsuji Miyazaki, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara, Enzo Emanuele
    Behavioural Neurology.2022; 2022: 1.     CrossRef
  • Korean Red Ginseng reduces chronic social defeat stress-induced mood disorders via N-methyl-D-aspartate receptor modulation in mice
    Bo-Ram Lee, Ju-Hyun Lee, Yong-Hyun Ko, Jee-Yeon Seo, Kwang-Hyun Hur, Young-Jung Kim, Seon-Kyung Kim, Seong-Eon Kim, Seok-Yong Lee, Choon-Gon Jang
    Journal of Ginseng Research.2021; 45(2): 254.     CrossRef
  • The Rap1 small GTPase is a critical mediator of the effects of stress on prefrontal cortical dysfunction
    B. A. Kermath, A. M. Vanderplow, K. J. Bjornson, E. N. Seablom, A. M. Novak, C. R. Bernhardt, M. E. Cahill
    Molecular Psychiatry.2021; 26(7): 3223.     CrossRef
  • Anxiolytic activity of Psidium guajava in mice subjected to chronic restraint stress and effect on neurotransmitters in brain
    Swati Sahoo, Prashant S. Kharkar, Niteshkumar U. Sahu, Brijesh S.
    Phytotherapy Research.2021; 35(3): 1399.     CrossRef
  • Changes in nitric oxide, carbon monoxide, hydrogen sulfide and male reproductive hormones in response to chronic restraint stress in rats
    Amira Moustafa
    Free Radical Biology and Medicine.2021; 162: 353.     CrossRef
  • Behavioral and neurological improvement by Cydonia oblonga fruit extract in chronic immobilization stress rats
    Fatma Z. Sakhri, Naoki Adachi, Sakina Zerizer, Yusuke Ohashi, Hideshi Ikemoto, Mana Tsukada, Zahia Kabouche, Tadashi Hisamitsu, Masataka Sunagawa
    Phytotherapy Research.2021; 35(4): 2074.     CrossRef
  • Restraint stress induces uterine microenvironment disorder in mice during early pregnancy through the β2-AR/cAMP/PKA pathway
    Jiayin Lu, Guanhui Liu, Zixu Wang, Jing Cao, Yaoxing Chen, Yulan Dong
    Stress.2021; 24(5): 514.     CrossRef
  • A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling
    Gavin M. Meade, Lily S. Charron, Lantz W. Kilburn, Zhe Pei, Hoau-Yan Wang, Siobhan Robinson
    Physiology & Behavior.2021; 234: 113286.     CrossRef
  • Chronic stress promotes acute myeloid leukemia progression through HMGB1/NLRP3/IL-1β signaling pathway
    Na Liu, Yifan Wu, Xin Wen, Peng Li, Fei Lu, Hong Shang
    Journal of Molecular Medicine.2021; 99(3): 403.     CrossRef
  • Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice
    Jinho Kim, Yoo-Hun Suh, Keun-A Chang
    Molecular Brain.2021;[Epub]     CrossRef
  • Amelioration on oxidative stress, testosterone, and cortisol levels after administration of Vitamins C and E in albino rats with chronic variable stress
    Nanik Hidayatik, Agus Purnomo, Faisal Fikri, Muhammad Thohawi Elziyad Purnama
    Veterinary World.2021; 14(1): 137.     CrossRef
  • Decreased expression of AKAP4 and TyrPho proteins in testis, epididymis, and spermatozoa with low sexual performance of mice induced by modified CUMS
    Pannawat Choowong‐in, Jintana Sattayasai, Chanasorn Poodendaen, Sitthichai Iamsaard
    Andrologia.2021;[Epub]     CrossRef
  • Chronic Mild Unpredictable Stress and High-Fat Diet Given during Adolescence Impact Both Cognitive and Noncognitive Behaviors in Young Adult Mice
    Stephen L. P. Lippi
    Brain Sciences.2021; 11(2): 260.     CrossRef
  • Additional Assessment of Fecal Corticosterone Metabolites Improves Visual Rating in the Evaluation of Stress Responses of Laboratory Rats
    Tina Kroll, Nikola Kornadt-Beck, Angela Oskamp, David Elmenhorst, Chadi Touma, Rupert Palme, Andreas Bauer
    Animals.2021; 11(3): 710.     CrossRef
  • COVID-19 Stress and Food Intake: Protective and Risk Factors for Stress-Related Palatable Food Intake in U.S. Adults
    Jennifer R. Sadler, Gita Thapaliya, Elena Jansen, Anahys H. Aghababian, Kimberly R. Smith, Susan Carnell
    Nutrients.2021; 13(3): 901.     CrossRef
  • Effects of Long‐Term Exposure of Intermediate Frequency Magnetic Fields (20 kHz, 360 µT) on the Development, Pathological Findings, and Behavior of Female Mice
    Alexander Lerchl, Karen Drees (née Grote), Isabel Gronau, Dirk Fischer, Julia Bauch, Axel Hoppe
    Bioelectromagnetics.2021; 42(4): 309.     CrossRef
  • Impact of whole‐body versus nose‐only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2‐month cigarette smoke exposure study in the ApoE−/− mouse model
    Ulrike Kogel, Ee Tsin Wong, Justyna Szostak, Wei Teck Tan, Francesco Lucci, Patrice Leroy, Bjoern Titz, Yang Xiang, Tiffany Low, Sin Kei Wong, Emmanuel Guedj, Nikolai V. Ivanov, Walter K. Schlage, Manuel C. Peitsch, Arkadiusz Kuczaj, Patrick Vanscheeuwijc
    Journal of Applied Toxicology.2021; 41(10): 1598.     CrossRef
  • Neuroprotective Effects of Acrocomia aculeata Pulp Oil Microcapsules on Rats Subjected to Chronic Stress
    Ana Cristina Jacobowski, Eduardo Benedetti Parisotto, Leonardo Recena Aydos, Roberta Serafim de Souza, Sandra Viveros, Ana Laura Colín-Gonzalez, Iandara Schettert Silva, Eliana Janet Sanjinez-Argandoña, Danilo Wilhelm Filho, Abel Santamaría-Del Angel, Mar
    Journal of Medicinal Food.2021; 24(10): 1068.     CrossRef
  • Chronic Sulfasalazine Treatment in Mice Induces System xc− - Independent Adverse Effects
    Lise Verbruggen, Lindsay Sprimont, Eduard Bentea, Pauline Janssen, Azzedine Gharib, Lauren Deneyer, Laura De Pauw, Olaya Lara, Hideyo Sato, Charles Nicaise, Ann Massie
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Effects of Achillea tenuifolia Lam. hydro-alcoholic extract on anxiety-like behavior and reproductive parameters in rat model of chronic restraint stress
    Y Bagheri, E Fathi, A Maghoul, S Moshtagh, K Mokhtari, A Abdollahpour, S Montazersaheb, A Bagheri
    Human & Experimental Toxicology.2021; 40(11): 1852.     CrossRef
  • Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
    Junhel Dalanon, Sachiko Chikahisa, Tetsuya Shiuchi, Noriyuki Shimizu, Parimal Chavan, Yoshitaka Suzuki, Kazuo Okura, Hiroyoshi Séi, Yoshizo Matsuka
    Scientific Reports.2021;[Epub]     CrossRef
  • Stress Diminishes BDNF-stimulated TrkB Signaling, TrkB-NMDA Receptor Linkage and Neuronal Activity in the Rat Brain
    Siobhan Robinson, Allison S. Mogul, Elisa M. Taylor-Yeremeeva, Amber Khan, Anthony D. Tirabassi, Hoau-Yan Wang
    Neuroscience.2021; 473: 142.     CrossRef
  • Improved Training and Semen Collection Outcomes Using the Closed Box Chair for Macaques
    Lisa A. Houser, Cathy Ramsey, Fernanda M. de Carvalho, Breanna Kolwitz, Chelsey Naito, Kristine Coleman, Carol B. Hanna
    Animals.2021; 11(8): 2384.     CrossRef
  • Ethologically relevant repeated acute social stress induces maternal neglect in the lactating female mouse
    Zachary J. Rosinger, Heather S. Mayer, Jacqueline I. Geyfen, Mable K. Orser, Danielle S. Stolzenberg
    Developmental Psychobiology.2021;[Epub]     CrossRef
  • Sperm epigenetic alterations contribute to inter- and transgenerational effects of paternal exposure to long-term psychological stress via evading offspring embryonic reprogramming
    Xiaoguo Zheng, Zhenhua Li, Guishuan Wang, Hanshu Wang, Yuchuan Zhou, Xinzhi Zhao, C. Yan Cheng, Yunbo Qiao, Fei Sun
    Cell Discovery.2021;[Epub]     CrossRef
  • Involvement of Ghrelin Dynamics in Stress-Induced Eating Disorder: Effects of Sex and Aging
    Chihiro Yamada
    International Journal of Molecular Sciences.2021; 22(21): 11695.     CrossRef
  • Voluntary wheel running behaviour as a tool to assess the severity in a mouse pancreatic cancer model
    Nora Weegh, Eva Zentrich, Dietmar Zechner, Birgitta Struve, Laura Wassermann, Steven Roger Talbot, Simone Kumstel, Miriam Heider, Brigitte Vollmar, André Bleich, Christine Häger, Dragan Hrncic
    PLOS ONE.2021; 16(12): e0261662.     CrossRef
  • Chronic Restraint Stress Decreases the Excitability of Hypothalamic POMC Neuron and Increases Food Intake
    Go Eun Ha, Eunji Cheong
    Experimental Neurobiology.2021; 30(6): 375.     CrossRef
  • Protective Effect of Sphaerococcus coronopifolius Crude Extract in Combination with Bacillus Calmette-Guerin on Ligature-Induced Depression in Female Wistar Rats
    Fahima Fellah, Rédha Djenidi, Imen Chebout
    Psychiatry Investigation.2020; 17(2): 130.     CrossRef
  • Physical and Physiological Indicators of Welfare in Guinea Pigs (Cavia porcellus) Serving as Ambassador Animals
    David M. Powell, Corinne P. Kozlowski, John Clark, Alice Seyfried, Eli Baskir, Ashley D. Franklin
    Animals.2020; 10(5): 815.     CrossRef
  • 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-glucoside Restores BDNF-TrkB and FGF2-Akt Signaling Axis to Attenuate Stress-induced Depression
    Xi-Xi Li, Yun Yu, Xiu-Yuan Lang, Cheng-Yong Jiang, Rongfeng Lan, Xiao-Yan Qin
    Neuroscience.2020; 430: 25.     CrossRef
  • Anxiolytic activity of Coriandrum sativum seeds aqueous extract on chronic restraint stressed mice and effect on brain neurotransmitters
    Swati Sahoo, S. Brijesh
    Journal of Functional Foods.2020; 68: 103884.     CrossRef
  • Vitamin C supplementation during chronic variable stress exposure modulates contractile functions of testicular artery and sperm parameters in male Wistar rats
    Shakiru Ademola Salami, Hussein Mofomosara Salahdeen, Oyinlola Toluwani Moronkola, Babatunde Adekunle Murtala, Yinusa Raji
    Middle East Fertility Society Journal.2020;[Epub]     CrossRef
  • A POMC-originated circuit regulates stress-induced hypophagia, depression, and anhedonia
    Na Qu, Yanlin He, Chunmei Wang, Pingwen Xu, Yongjie Yang, Xing Cai, Hesong Liu, Kaifan Yu, Zhou Pei, Ilirjana Hyseni, Zheng Sun, Makoto Fukuda, Yi Li, Qing Tian, Yong Xu
    Molecular Psychiatry.2020; 25(5): 1006.     CrossRef
  • Mirogabalin prevents repeated restraint stress-induced dysfunction in mice
    Takashi Iwai, Akinori Kikuchi, Misa Oyama, Shun Watanabe, Mitsuo Tanabe
    Behavioural Brain Research.2020; 383: 112506.     CrossRef
  • A Systematic Review of In Vitro and In Vivo Radio Frequency Exposure Methods
    Jared W. Hansen, Ellen M. Swartz, Jerika D. Cleveland, Sajid M. Asif, Benjamin Brooks, Benjamin D. Braaten, Daniel L. Ewert
    IEEE Reviews in Biomedical Engineering.2020; 13: 340.     CrossRef
  • Diminished ovarian reserve induced by chronic unpredictable stress in C57BL/6 mice
    Lingyun Gao, Fangui Zhao, Yang Zhang, Wenjun Wang, Qi Cao
    Gynecological Endocrinology.2020; 36(1): 49.     CrossRef
  • Stress-induced blood brain barrier disruption: Molecular mechanisms and signaling pathways
    Menizibeya O. Welcome, Nikos E. Mastorakis
    Pharmacological Research.2020; 157: 104769.     CrossRef
  • Anaesthetic-dependent changes in gene expression following acute and chronic exposure in the rodent brain
    Dannielle H. Upton, Kata Popovic, Roger Fulton, Michael Kassiou
    Scientific Reports.2020;[Epub]     CrossRef
  • Comparative analysis of acute and chronic stress-induced neurobehavioral alteration and liver injury in mice
    Tae Woo Oh, Kwang-Youn Kim, Hyun Ju Do, Young-Woo Kim, Kwang-Il Park
    Molecular & Cellular Toxicology.2020; 16(4): 367.     CrossRef
  • The impact of chronic stress on energy metabolism
    Michael A. van der Kooij
    Molecular and Cellular Neuroscience.2020; 107: 103525.     CrossRef
  • In vitro and in vivo studies of nanoparticles of chitosan-Pandanus tectorius fruit extract as new alternative treatment for hypercholesterolemia via Scavenger Receptor Class B type 1 pathway
    Efriyana Oksal, Inten Pangestika, Tengku Sifzizul Tengku Muhammad, Habsah Mohamad, Hermansyah Amir, Murni Nur Islamiah Kassim, Yosie Andriani
    Saudi Pharmaceutical Journal.2020; 28(10): 1263.     CrossRef
  • Behavioral, metabolic, and renal outcomes of 1-month isolation in adolescent male Dahl salt-sensitive rats
    Oksana Nikolaienko, Elena Isaeva, Vladislav Levchenko, Oleg Palygin, Alexander Staruschenko
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2020; 319(6): R684.     CrossRef
  • The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders
    Eva Maria Fritz, Nicolas Singewald, Dimitri De Bundel
    Frontiers in Synaptic Neuroscience.2020;[Epub]     CrossRef
  • Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology


    Lingyun Gao, Yang Zhang, Huangfang Xu, Fangui Zhao, Wenjun Wang
    Drug Design, Development and Therapy.2020; Volume 14: 4975.     CrossRef
  • Vitamin C protects against chronic social isolation stress-induced weight gain and depressive-like behavior in adult male rats
    Alireza Najaf Dulabi, Zeinab Shakerin, Nasrin Mehranfard, Maedeh Ghasemi
    Endocrine Regulations.2020; 54(4): 266.     CrossRef
  • Intermittent restraint-induced sympathetic activation attenuates hepatic steatosis and inflammation in a high-fat diet-fed mouse model
    Sung Bae Lee, Hyeong Geug Kim, Jin Seok Lee, Won Yong Kim, Myong Min Lee, Yun Hee Kim, Jung Ok Lee, Hyeon Soo Kim, Chang Gue Son
    American Journal of Physiology-Gastrointestinal and Liver Physiology.2019; 317(6): G811.     CrossRef
  • Involvement of Hepatic SHIP2 and PI3K/Akt Signalling in the Regulation of Plasma Insulin by Xiaoyaosan in Chronic Immobilization-Stressed Rats
    Qiuxia Pan, Jiajia Wu, Yueyun Liu, Xiaojuan Li, Jiaxu Chen
    Molecules.2019; 24(3): 480.     CrossRef
  • miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior
    Sydney Aten, Chloe E. Page, Anisha Kalidindi, Kelin Wheaton, Anzela Niraula, Jon P. Godbout, Kari R. Hoyt, Karl Obrietan
    Neuropharmacology.2019; 144: 256.     CrossRef
  • Oxytocin involves in chronic stress-evoked melanoma metastasis via β-arrestin 2-mediated ERK signaling pathway
    Haoyi Ji, Na Liu, Jing Li, Dawei Chen, Dan Luo, Qian Sun, Yingchun Yin, Yanli Liu, Bing Bu, Xiaoyang Chen, Jingxin Li
    Carcinogenesis.2019; 40(11): 1395.     CrossRef
  • Anxiolytic effects of γ-oryzanol in chronically- stressed mice are related to monoamine levels in the brain
    Salina Akter, Hiroyuki Sasaki, Kazi Rasel Uddin, Yuko Ikeda, Hiroki Miyakawa, Shigenobu Shibata
    Life Sciences.2019; 216: 119.     CrossRef
  • Resveratrol and dimethyl fumarate ameliorate testicular dysfunction caused by chronic unpredictable mild stress-induced depression in rats
    Atef Tadros Fahim, Amal Ahmed Abd El-Fattah, Nermin Abdel Hamid Sadik, Bassam Mohamed Ali
    Archives of Biochemistry and Biophysics.2019; 665: 152.     CrossRef
  • Centella asiaticaPrevents Increase of Hippocampal Tumor Necrosis Factor-αIndependently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic Stress
    Mawaddah Ar Rochmah, Ika Murti Harini, Dian Eurike Septyaningtrias, Dwi Cahyani Ratna Sari, Rina Susilowati
    BioMed Research International.2019; 2019: 1.     CrossRef
  • Stress-related over-enhancement of the hypothalamic-pituitary-adrenal axis causes experimental neurolathyrism in rats
    Kimino Minagawa, Shin-ichi Yamada, Ayano Suzuki, Saeko Ta, Toshio Kumai, Fernand Lambein, Kuniko Kusama-Eguchi
    Environmental Toxicology and Pharmacology.2019; 72: 103245.     CrossRef
  • Chronic Stress Combined with a Fructose Diet Reduces Hypothalamic Insulin Signaling and Antioxidative Defense in Female Rats
    Sanja Kovačević, Jelena Nestorov, Gordana Matić, Ivana Elaković
    Neuroendocrinology.2019; 108(4): 278.     CrossRef
  • Gut-Brain Neuroendocrine Signaling Under Conditions of Stress—Focus on Food Intake-Regulatory Mediators
    Andreas Stengel, Yvette Taché
    Frontiers in Endocrinology.2018;[Epub]     CrossRef
  • Chronic unpredictable mild stress-induced depressive-like behavior and dysregulation of brain levels of biogenic amines in Drosophila melanogaster
    Stífani Machado Araujo, Marcia Rósula Poetini, Vandreza Cardoso Bortolotto, Shanda de Freitas Couto, Franciane Cabral Pinheiro, Luana Barreto Meichtry, Francielli Polet de Almeida, Elize Aparecida Santos Musachio, Mariane Trindade de Paula, Marina Prigol
    Behavioural Brain Research.2018; 351: 104.     CrossRef
  • Melatonin attenuates chronic immobilization stress-induced muscle atrophy in rats: Influence on lactate-to-pyruvate ratios and Na+/K+ ATPase activity
    Eman S.H. Abd Allah, Ahmed M. Mahmoud
    Pathophysiology.2018; 25(4): 353.     CrossRef
  • Chronic stress effects and their reversibility on the Fallopian tubes and uterus in rats
    S. Divyashree, H. N. Yajurvedi
    Reproduction, Fertility and Development.2018; 30(2): 380.     CrossRef
  • Evidence-based severity assessment: Impact of repeated versus single open-field testing on welfare in C57BL/6J mice
    Carina Bodden, Sophie Siestrup, Rupert Palme, Sylvia Kaiser, Norbert Sachser, S. Helene Richter
    Behavioural Brain Research.2018; 336: 261.     CrossRef
  • Repeated Neck Restraint Stress Bidirectionally Modulates Excitatory Transmission in the Dentate Gyrus and Performance in a Hippocampus-dependent Memory Task
    Jadwiga Spyrka, Grzegorz Hess
    Neuroscience.2018; 379: 32.     CrossRef
  • Stress-induced strain and brain region-specific activation of LINE-1 transposons in adult mice
    Ugo Cappucci, Giulia Torromino, Assunta Maria Casale, Jeremy Camon, Fabrizio Capitano, Maria Berloco, Andrea Mele, Sergio Pimpinelli, Arianna Rinaldi, Lucia Piacentini
    Stress.2018; 21(6): 575.     CrossRef
  • The involvement of Rhopr-CRF/DH in feeding and reproduction in the blood-gorging insect Rhodnius prolixus
    Shirin Mollayeva, Ian Orchard, Angela B. Lange
    General and Comparative Endocrinology.2018; 258: 79.     CrossRef
  • Ghrelin is a persistent biomarker for chronic stress exposure in adolescent rats and humans
    Muhammad I. ul Akbar Yousufzai, Elia S. Harmatz, Mohsin Shah, Muhammad O. Malik, Ki A. Goosens
    Translational Psychiatry.2018;[Epub]     CrossRef
  • Sub-Chronic Stress Exacerbates the Pro-Thrombotic Phenotype in BDNFVal/Met Mice: Gene-Environment Interaction in the Modulation of Arterial Thrombosis
    Leonardo Sandrini, Alessandro Ieraci, Patrizia Amadio, Fabrizio Veglia, Maurizio Popoli, Francis S. Lee, Elena Tremoli, Silvia Stella Barbieri
    International Journal of Molecular Sciences.2018; 19(10): 3235.     CrossRef
  • Juvenile stress induces behavioral change and affects perineuronal net formation in juvenile mice
    Hiroshi Ueno, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Shozo Aoki, Takeshi Ishihara
    BMC Neuroscience.2018;[Epub]     CrossRef
  • Chronic stress induced duration dependent alterations in immune system and their reversibility in rats
    H.N. Sarjan, H.N. Yajurvedi
    Immunology Letters.2018; 197: 31.     CrossRef
  • Chronic stress alters adrenal clock function in a sexually dimorphic manner
    Matthew Stagl, Mary Bozsik, Christopher Karow, David Wertz, Ian Kloehn, Savin Pillai, Paul J Gasser, Marieke R Gilmartin, Jennifer A Evans
    Journal of Molecular Endocrinology.2018; 60(2): 55.     CrossRef
  • Impaired Growth Performance and Testicular Cells Apoptosis Following Restraint Stress in Adult Hypothyroid Mice
    Asif Mehfooz, Quanwei Wei, Mohamed Babo Fadlalla, Farman Ali Siyal, Kuldeep Dhama, Dagan Mao, Fangxiong Shi
    International Journal of Pharmacology.2017; 13(6): 541.     CrossRef
  • Chronic stress induced disruption of the peri-infarct neurovascular unit following experimentally induced photothrombotic stroke
    Zidan Zhao, Lin Kooi Ong, Sarah Johnson, Michael Nilsson, Frederick R Walker
    Journal of Cerebral Blood Flow & Metabolism.2017; 37(12): 3709.     CrossRef
  • Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis
    Leonie Stolz, Amin Derouiche, Kavi Devraj, Frank Weber, Robert Brunkhorst, Christian Foerch
    Journal of Neuroinflammation.2017;[Epub]     CrossRef
  • Maternal high-fat diet intensifies the metabolic response to stress in male rat offspring
    Roxana Karbaschi, Homeira Zardooz, Fariba Khodagholi, Leila Dargahi, Mina Salimi, FatemehSadat Rashidi
    Nutrition & Metabolism.2017;[Epub]     CrossRef
  • The effect of chronic noise stress on serum levels of cortisol, gonadotropins, and sexual hormones at implantation time of mice
    Alireza Shafiei, Hassan Ehteram, Hossein Akbari, Masoud Motalebi Kashani, Mandana Beigi, Javad Amini Mahabadi, Tahere Mazoochi
    Comparative Clinical Pathology.2017; 26(4): 779.     CrossRef
  • Aging rather than stress strongly influences amino acid metabolisms in the brain and genital organs of female mice
    Momoko Kodaira, Mao Nagasawa, Takeshi Yamaguchi, Hiromi Ikeda, Kimie Minaminaka, Vishwajit S. Chowdhury, Shinobu Yasuo, Mitsuhiro Furuse
    Mechanisms of Ageing and Development.2017; 162: 72.     CrossRef
  • Histone deacetylase-2 is involved in stress-induced cognitive impairment via histone deacetylation and PI3K/AKT signaling pathway modification
    Jie Wu, Cui Liu, Ling Zhang, Chun-Hui Qu, Xiao-Long Sui, Hua Zhu, Lan Huang, Yan-Feng Xu, Yun-Lin Han, Chuan Qin
    Molecular Medicine Reports.2017; 16(2): 1846.     CrossRef
  • High Hydrostatic Pressure Extract of Ginger Exerts Antistress Effects in Immobilization-Stressed Rats
    Sohee Moon, Mak-Soon Lee, Sunyoon Jung, Bori Kang, Seog-Young Kim, Seonyoung Park, Hye-Yeon Son, Chong-Tai Kim, Young-Hee Jo, In-Hwan Kim, Young Soon Kim, Yangha Kim
    Journal of Medicinal Food.2017; 20(9): 864.     CrossRef
  • Insulin, not glutamine dipeptide, reduces lipases expression and prevents fat wasting and weight loss in Walker 256 tumor-bearing rats
    Hely de Morais, Flaviane de Fatima Silva, Francemilson Goulart da Silva, Milene Ortiz Silva, Maria Fernanda Rodrigues Graciano, Maria Isabel Lovo Martins, Ângelo Rafael Carpinelli, Tânia Longo Mazucco, Roberto Barbosa Bazotte, Helenir Medri de Souza
    European Journal of Pharmacology.2017; 806: 67.     CrossRef
  • HBK-15 protects mice from stress-induced behavioral disturbances and changes in corticosterone, BDNF, and NGF levels
    Karolina Pytka, Monika Głuch-Lutwin, Magdalena Kotańska, Elżbieta Żmudzka, Magdalena Jakubczyk, Anna Waszkielewicz, Paulina Janiszewska, Maria Walczak
    Behavioural Brain Research.2017; 333: 54.     CrossRef
  • The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels
    Chong Chen, Shin Nakagawa, Yan An, Koki Ito, Yuji Kitaichi, Ichiro Kusumi
    Frontiers in Neuroendocrinology.2017; 44: 83.     CrossRef
  • Long-term chronic stress exposure induces PCO phenotype in rat
    S Divyashree, H N Yajurvedi
    Reproduction.2016; 152(6): 765.     CrossRef
  • Vasculoprotective Effects of 3-Hydroxybenzaldehyde against VSMCs Proliferation and ECs Inflammation
    Byung Soo Kong, Soo Jung Im, Yang Jong Lee, Yoon Hee Cho, Yu Ri Do, Jung Woo Byun, Cheol Ryong Ku, Eun Jig Lee, Maria Cristina Vinci
    PLOS ONE.2016; 11(3): e0149394.     CrossRef
  • Effects of long-term chronic stress on the lymphoid organs and blood leukocytes of the rat (Rattus norvegicus)
    S. Divyashree, H.N. Sarjan, H.N. Yajurvedi
    Canadian Journal of Zoology.2016; 94(2): 137.     CrossRef
  • Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe
    Keitaro Yoshida, Yu Mimura, Ryosuke Ishihara, Hiroshi Nishida, Yuji Komaki, Tomohito Minakuchi, Tomokazu Tsurugizawa, Masaru Mimura, Hideyuki Okano, Kenji F. Tanaka, Norio Takata
    Journal of Neuroscience Methods.2016; 274: 38.     CrossRef
  • Integrated circuits and molecular components for stress and feeding: implications for eating disorders
    J. A. Hardaway, N. A. Crowley, C. M. Bulik, T. L. Kash
    Genes, Brain and Behavior.2015; 14(1): 85.     CrossRef
  • The Use of Animal Models to Decipher Physiological and Neurobiological Alterations of Anorexia Nervosa Patients
    Mathieu Méquinion, Christophe Chauveau, Odile Viltart
    Frontiers in Endocrinology.2015;[Epub]     CrossRef
  • Kososan, but not milnacipran, elicits antidepressant‐like effects in a novel psychological stress‐induced mouse model of depression
    Atsushi Hori, Naoki Ito, Tetsuro Oikawa, Toshihiko Hanawa
    Traditional & Kampo Medicine.2015; 2(1): 1.     CrossRef
  • Electroconvulsive stimulation, but not chronic restraint stress, causes structural alterations in adult rat hippocampus—A stereological study
    Mikkel V. Olesen, Gitta Wörtwein, Bente Pakkenberg
    Hippocampus.2015; 25(1): 72.     CrossRef
  • Dopamine release in the lateral hypothalamus is stimulated by α-MSH in both the anticipatory and consummatory phases of feeding
    Romain Legrand, Nicolas Lucas, Jonathan Breton, Pierre Déchelotte, Sergueï O. Fetissov
    Psychoneuroendocrinology.2015; 56: 79.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Contrasting mechanisms by which social isolation and restraint impair healing in male mice
    Leah M. Pyter, Linglan Yang, Cassandra McKenzie, José M. da Rocha, C. Sue Carter, Bin Cheng, Christopher G. Engeland
    Stress.2014; 17(3): 256.     CrossRef
  • G Protein-Coupled Estrogen Receptor-1 Is Involved in the Protective Effect of Protocatechuic Aldehyde against Endothelial Dysfunction
    Byung Soo Kong, Yoon Hee Cho, Eun Jig Lee, Rajesh Mohanraj
    PLoS ONE.2014; 9(11): e113242.     CrossRef
Close layer
Obesity and Metabolism
Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells
You-Mie Kim, Insun Song, Yong-Hak Seo, Gyesoon Yoon
Endocrinol Metab. 2013;28(4):297-308.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.297
  • 5,015 View
  • 41 Download
  • 17 Crossref
AbstractAbstract PDFPubReader   
Background

Enhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an increase in organellar mass, one of the indicators of senescence. We investigated the molecular mechanisms by which signaling molecules control SREBP1-mediated lipogenesis and senescence.

Methods

We developed cellular models for stress-induced senescence, by exposing Chang cells, which are immortalized human liver cells, to subcytotoxic concentrations (200 µM) of deferoxamine (DFO) and H2O2.

Results

In this model of stress-induced cell senescence using DFO and H2O2, the phosphorylation profile of glycogen synthase kinase 3α (GSK3α) and β corresponded closely to the expression profile of the mature form of SREBP-1 protein. Inhibition of GSK3 with a subcytotoxic concentration of the selective GSK3 inhibitor SB415286 significantly increased mature SREBP1 expression, as well as lipogenesis and organellar mass. In addition, GSK3 inhibition was sufficient to induce senescence in Chang cells. Suppression of GSK3 expression with siRNAs specific to GSK3α and β also increased mature SREBP1 expression and induced senescence. Finally, blocking lipogenesis with fatty acid synthase inhibitors (cerulenin and C75) and siRNA-mediated silencing of SREBP1 and ATP citrate lyase (ACL) significantly attenuated GSK3 inhibition-induced senescence.

Conclusion

GSK3 inactivation is an important upstream event that induces SREBP1-mediated lipogenesis and consequent cell senescence.

Citations

Citations to this article as recorded by  
  • Senoinflammation as the underlying mechanism of aging and its modulation by calorie restriction
    Sang Gyun Noh, Hyun Woo Kim, Seungwoo Kim, Ki Wung Chung, Young-Suk Jung, Jeong-Hyun Yoon, Byung Pal Yu, Jaewon Lee, Hae Young Chung
    Ageing Research Reviews.2024; 101: 102503.     CrossRef
  • Mammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia
    Lei Sun, He Yang, Dong He, Jian Chen, Zhiqiang Dong, Shaoxiang Luo, Huiting Liang, Yu Cao, Bingcheng Cai, Min Zhang
    Cell Death & Disease.2022;[Epub]     CrossRef
  • The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products
    Jun-Ping Shiau, Ya-Ting Chuang, Jen-Yang Tang, Kun-Han Yang, Fang-Rong Chang, Ming-Feng Hou, Ching-Yu Yen, Hsueh-Wei Chang
    Antioxidants.2022; 11(9): 1845.     CrossRef
  • Treadmill Exercise Reduces Neuroinflammation, Glial Cell Activation and Improves Synaptic Transmission in the Prefrontal Cortex in 3 × Tg-AD Mice
    Lianwei Mu, Dongdong Xia, Jiajia Cai, Boya Gu, Xiaojie Liu, Vladislav Friedman, Qing-Song Liu, Li Zhao
    International Journal of Molecular Sciences.2022; 23(20): 12655.     CrossRef
  • Lysosomes in T Cell Immunity and Aging
    Jun Jin, Huimin Zhang, Cornelia M. Weyand, Jorg J. Goronzy
    Frontiers in Aging.2021;[Epub]     CrossRef
  • FOXO1 deficiency impairs proteostasis in aged T cells
    Jun Jin, Xuanying Li, Bin Hu, Chulwoo Kim, Wenqiang Cao, Huimin Zhang, Cornelia M. Weyand, Jorg J. Goronzy
    Science Advances.2020;[Epub]     CrossRef
  • Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations
    Kim Cuong Cap, Yeon-Joo Jung, Bo Young Choi, Seung Jae Hyeon, Jae-Gyu Kim, Jung-Ki Min, Rokibul Islam, Abu Jubayer Hossain, Won-Suk Chung, Sang Won Suh, Hoon Ryu, Jae-Bong Park
    Redox Biology.2020; 32: 101446.     CrossRef
  • Metabolic features and regulation in cell senescence
    So Mee Kwon, Sun Mi Hong, Young-Kyoung Lee, Seongki Min, Gyesoon Yoon
    BMB Reports.2019; 52(1): 5.     CrossRef
  • DNA repair deficiency and senescence in concussed professional athletes involved in contact sports
    Nicole Schwab, Karl Grenier, Lili-Naz Hazrati
    Acta Neuropathologica Communications.2019;[Epub]     CrossRef
  • Oxidative stress-induced downregulation of glycogen synthase kinase 3 beta in fetal membranes promotes cellular senescence†
    Narmada Lavu, Lauren Richardson, Enkhtuya Radnaa, Talar Kechichian, Rheanna Urrabaz-Garza, Samantha Sheller-Miller, Elizabeth Bonney, Ramkumar Menon
    Biology of Reproduction.2019; 101(5): 1018.     CrossRef
  • Blocking lysophosphatidic acid receptor 1 signaling inhibits diabetic nephropathy in db/db mice
    Hui Ying Li, Yoon Sin Oh, Ji-Woong Choi, Ji Yong Jung, Hee-Sook Jun
    Kidney International.2017; 91(6): 1362.     CrossRef
  • Expression of senescence-associated genes in multipotent mesenchymal stromal cells during long-term cultivation at various hypoxic levels
    M. V. Lobanova, A. Y. Ratushnyy, L. B. Buravkova
    Doklady Biochemistry and Biophysics.2016; 470(1): 326.     CrossRef
  • The PI3K pathway in B cell metabolism
    Julia Jellusova, Robert C. Rickert
    Critical Reviews in Biochemistry and Molecular Biology.2016; 51(5): 359.     CrossRef
  • Deferoxamine attenuates lipopolysaccharide-induced neuroinflammation and memory impairment in mice
    Xiao-Ying Zhang, Jiang-Bei Cao, Li-Ming Zhang, Yun-Feng Li, Wei-Dong Mi
    Journal of Neuroinflammation.2015;[Epub]     CrossRef
  • Anti-diabetic efficacy of KICG1338, a novel glycogen synthase kinase-3β inhibitor, and its molecular characterization in animal models of type 2 diabetes and insulin resistance
    Kyoung Min Kim, Kuy-Sook Lee, Gha Young Lee, Hyunjin Jin, Eunice Sung Durrance, Ho Seon Park, Sung Hee Choi, Kyong Soo Park, Young-Bum Kim, Hak Chul Jang, Soo Lim
    Molecular and Cellular Endocrinology.2015; 409: 1.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Immunosenescence in monocytes, macrophages, and dendritic cells: Lessons learned from the lung and heart
    Phyllis-Jean Linton, Marilyn L. Thoman
    Immunology Letters.2014; 162(1): 290.     CrossRef
Close layer
Obesity and Metabolism
Association between Cardiac Autonomic Neuropathy, Diabetic Retinopathy and Carotid Atherosclerosis in Patients with Type 2 Diabetes
Chan-Hee Jung, Ae-Rin Baek, Kyu-Jin Kim, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
Endocrinol Metab. 2013;28(4):309-319.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.309
  • 5,032 View
  • 40 Download
  • 22 Crossref
AbstractAbstract PDFPubReader   
Background

It is not clear whether microangiopathies are associated with subclinical atherosclerosis in type 2 diabetes mellitus (T2DM). We investigated the relation of cardiac autonomic neuropathy (CAN) and other microangiopathies with carotid atherosclerosis in T2DM.

Methods

A total of 131 patients with T2DM were stratified by mean carotid intima-media thickness (CIMT) ≥ or <1.0 mm and the number of carotid plaques. CAN was assessed by the five standard cardiovascular reflex tests according to the Ewing's protocol. CAN was defined as the presence of at least two abnormal tests or an autonomic neuropathy points ≥2. Diabetic microangiopathies were assessed.

Results

Patients with CAN comprised 77% of the group with mean CIMT ≥1.0 mm, while they were 29% of the group with CIMT <1.0 mm (P=0.016). Patients with diabetic retinopathy (DR) comprised 68% of the group with CIMT ≥1.0 mm, while they were 28% of the group without CIMT thickening (P=0.003). Patients with CAN comprised 51% of the group with ≥2 carotid plaques, while they were 23% of the group with ≤1 carotid plaque (P=0.014). In multivariable adjusted logistic regression analysis, the patients who presented with CAN showed an odds ratio [OR] of 8.6 (95% confidence interval [CI], 1.6 to 44.8) for CIMT thickening and an OR of 2.9 (95% CI, 1.1 to 7.5) for carotid plaques. Furthermore, patients with DR were 3.8 times (95% CI, 1.4 to 10.2) more likely to have CIMT thickening.

Conclusion

These results suggest that CAN is associated with carotid atherosclerosis, represented as CIMT and plaques, independent of the traditional cardiovascular risk factors in T2DM. CAN or DR may be a determinant of subclinical atherosclerosis in T2DM.

Citations

Citations to this article as recorded by  
  • Common carotid artery intima media thickness (CIMT) in patients with prediabetes and newly diagnosed type 2 diabetes mellitus
    Antoaneta Gateva, Yavor Assyov, Vera Karamfilova, Zdravko Kamenov
    Journal of Diabetes and its Complications.2024; 38(7): 108766.     CrossRef
  • Carotid atherosclerosis: An independent risk factor for small fiber nerve dysfunction in patients with type 2 diabetes mellitus
    Simin Guo, Yali Jing, Chenxi Li, Dalong Zhu, Weimin Wang
    Journal of Diabetes Investigation.2023; 14(2): 289.     CrossRef
  • Evaluating Diagnostic Ultrasound of the Vagus Nerve as a Surrogate Marker for Autonomic Neuropathy in Diabetic Patients
    Bianka Heiling, Adriana Karl, Nadin Fedtke, Nicolle Müller, Christof Kloos, Alexander Grimm, Hubertus Axer
    Medicina.2023; 59(3): 525.     CrossRef
  • Albuminuria but not low eGFR is closely associated with atherosclerosis in patients with type 2 diabetes: an observational study
    Jun-Wei Wang, Jiang-Feng Ke, Zhi-Hui Zhang, Jun-Xi Lu, Lian-Xi Li
    Diabetology & Metabolic Syndrome.2022;[Epub]     CrossRef
  • Predictive Value of the Advanced Lipoprotein Profile and Glycated Proteins on Diabetic Retinopathy
    Josep Julve, Joana Rossell, Eudald Correig, Marina Idalia Rojo-Lopez, Nuria Amigó, Marta Hernández, Alicia Traveset, Marc Carbonell, Nuria Alonso, Didac Mauricio, Esmeralda Castelblanco
    Nutrients.2022; 14(19): 3932.     CrossRef
  • The relationship between carotid disease and retinopathy in diabetes: a systematic review
    Jocelyn J. Drinkwater, Timothy M. E. Davis, Wendy A. Davis
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Carotid Disease and Retinal Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes: The Fremantle Diabetes Study Phase II
    Jocelyn J. Drinkwater, Fred K. Chen, Alison M. Brooks, Brad T. Davis, Angus W. Turner, Timothy M.E. Davis, Wendy A. Davis
    Diabetes Care.2020; 43(12): 3034.     CrossRef
  • Diabetic foot – invalidating complication of diabetes mellitus
    Oana Manuela Spălăţelu, Sergiu Chirila, Leonard Gurgas, Vasile Sârbu
    Medic.ro.2019; 3(129): 40.     CrossRef
  • Clinical factors associated with the recovery of cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus
    Ji Eun Jun, Seung-Eun Lee, Min Sun Choi, Sung Woon Park, You-Cheol Hwang, Jae Hyeon Kim
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Association of carotid intima-media thickness with exercise tolerance test in type 2 diabetic patients
    Ali Momeni, Abdolmajid Taheri, Maryam Mansuri, Ali Bazdar, Morteza Sedehi, Masoud Amiri
    IJC Heart & Vasculature.2018; 21: 74.     CrossRef
  • Cardiac autonomic neuropathy may play a role in pathogenesis of atherosclerosis in type 1 diabetes mellitus
    Sarka Mala, Veronika Potockova, Lucie Hoskovcova, Pavlina Pithova, Marek Brabec, Jaroslava Kulhankova, Radan Keil, Lucie Riedlbauchova, Jan Broz
    Diabetes Research and Clinical Practice.2017; 134: 139.     CrossRef
  • Cardio-Ankle Vascular Index and Indices of Diabetic Polyneuropathy in Patients with Type 2 Diabetes
    Akihiko Ando, Michiaki Miyamoto, Kazuhiko Kotani, Kenta Okada, Shoichiro Nagasaka, Shun Ishibashi
    Journal of Diabetes Research.2017; 2017: 1.     CrossRef
  • Cardiac Involvement in Peripheral Neuropathies
    Ahmet Z. Burakgazi, Soufian AlMahameed
    Journal of Clinical Neuromuscular Disease.2016; 17(3): 120.     CrossRef
  • The relationship between vitamin D status and cardiac autonomic neuropathy in patients with type 2 diabetes mellitus
    Chan-Hee Jung, Sang-Hee Jung, Kyu-Jin Kim, Bo-Yeon Kim, Chul-Hee Kim, Sung-Koo Kang, Ji-Oh Mok
    Diabetes and Vascular Disease Research.2015; 12(5): 342.     CrossRef
  • Atorvastatin Treatment for Carotid Intima-Media Thickness in Chinese Patients With Type 2 Diabetes
    Na Fang, Wei Han, Dandan Gong, Zou Chen, Yu Fan
    Medicine.2015; 94(44): e1920.     CrossRef
  • Cardiovascular complications in patients with autonomic failure
    Valeria Milazzo, Cristina Di Stefano, Alberto Milan, Agnese Ravera, Gabriele Sobrero, Luca Sabia, Franco Veglio, Simona Maule
    Clinical Autonomic Research.2015; 25(3): 133.     CrossRef
  • Association of heart rate with albuminuria in a general adult population: the 2011 Korea National Health and Nutrition Examination Survey
    H. S. Choi, J. W. Hong, J. H. Lee, J. H. Noh, D. J. Kim
    Internal Medicine Journal.2015; 45(4): 428.     CrossRef
  • Type 2 diabetes-associated carotid plaque burden is increased in patients with retinopathy compared to those without retinopathy
    Núria Alonso, Alicia Traveset, Esther Rubinat, Emilio Ortega, Nuria Alcubierre, Jordi Sanahuja, Marta Hernández, Angels Betriu, Carmen Jurjo, Elvira Fernández, Didac Mauricio
    Cardiovascular Diabetology.2015;[Epub]     CrossRef
  • Letter: Association between Cardiac Autonomic Neuropathy, Diabetic Retinopathy and Carotid Atherosclerosis in Patients with Type 2 Diabetes (Endocrinol Metab 2013;28:309-19, Chan-Hee Jung et al.)
    Hyun-Kyung Chung
    Endocrinology and Metabolism.2014; 29(1): 101.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Clinical utility of serum beta-2-microglobulin as a predictor of diabetic complications in patients with type 2 diabetes without renal impairment
    M.K. Kim, K.-J. Yun, H.J. Chun, E.-H. Jang, K.-D. Han, Y.-M. Park, K.-H. Baek, K.-H. Song, B.-Y. Cha, C.S. Park, H.-S. Kwon
    Diabetes & Metabolism.2014; 40(6): 459.     CrossRef
  • Association between Brachial-Ankle pulse wave velocity and cardiac autonomic neuropathy in type 2 diabetes
    Nan Wu, Xiaoling Cai, Kuanping Ye, Yintao Li, Min He, Weiwei Zhao, Renming Hu
    Diabetology & Metabolic Syndrome.2014;[Epub]     CrossRef
Close layer
Obesity and Metabolism
A Novel Mutation in the Von Hippel-Lindau Tumor Suppressor Gene Identified in a Patient Presenting with Gestational Diabetes Mellitus
Yun Hyi Ku, Chang Ho Ahn, Chan-Hyeon Jung, Jie Eun Lee, Lee-Kyung Kim, Soo Heon Kwak, Hye Seung Jung, Kyong Soo Park, Young Min Cho
Endocrinol Metab. 2013;28(4):320-325.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.320
  • 4,180 View
  • 29 Download
  • 4 Crossref
AbstractAbstract PDFPubReader   
Background

Von Hippel-Lindau (VHL) disease is an autosomal dominantly inherited, multisystemic tumor syndrome caused by mutations in the VHL gene. To date, more than 1,000 germline and somatic mutations of the VHL gene have been reported. We present a novel mutation in the VHL tumor suppressor gene that presented with gestational diabetes mellitus.

Methods

A 30-year-old woman presented with gestational diabetes mellitus. She sequentially showed multiple pancreatic cysts, spinal cord hemangioblastoma, cerebellar hemangioblastoma, and clear cell type renal cell carcinomas. Also, her father and brother had brain hemangioblastomas. Each of the three exons of the VHL gene was individually amplified by polymerase chain reaction and direct sequencing was performed using an ABI 3730 DNA analyzer.

Results

DNA sequence analysis to determine the presence of VHL mutation in her family revealed del291C, a novel frameshift mutation.

Conclusion

We found a novel mutation in the VHL tumor suppressor gene that presented with gestational diabetes mellitus.

Citations

Citations to this article as recorded by  
  • Diversities of Mechanism in Patients with VHL Syndrome and diabetes: A Report of Two Cases and Literature Review
    Yanlei Wang, Zhaoxiang Liu, Wenhui Zhao, Chenxiang Cao, Luqi Xiao, Jianzhong Xiao
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 1611.     CrossRef
  • Retinal hemangioblastoma in a patient with Von Hippel-Lindau disease: A case report and literature review
    Yikeng Huang, Weiwen Hu, Xionggao Huang
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Updates on the Role of Molecular Alterations and NOTCH Signalling in the Development of Neuroendocrine Neoplasms
    Claudia von Arx, Monica Capozzi, Elena López-Jiménez, Alessandro Ottaiano, Fabiana Tatangelo, Annabella Di Mauro, Guglielmo Nasti, Maria Lina Tornesello, Salvatore Tafuto
    Journal of Clinical Medicine.2019; 8(9): 1277.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
Close layer
Case Reports
Obesity and Metabolism
Recurrent Insulin Autoimmune Syndrome Caused by α-Lipoic Acid in Type 2 Diabetes
Sang Mook Bae, Myoung Nam Bae, Eun Young Kim, Il Kyu Kim, Min Woo Seo, Jin Kyeong Shin, Sung Rae Cho, Gui Hwa Jeong
Endocrinol Metab. 2013;28(4):326-330.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.326
  • 4,626 View
  • 54 Download
  • 18 Crossref
AbstractAbstract PDFPubReader   

Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia caused by insulin autoantibodies in the absence of exogenous insulin administration. Some drugs containing sulfhydryl compounds are known to initiate the onset of IAS. A 67-year-old female who had diabetes for 5 years visited the outpatient clinic at our institution due to diabetic peripheral polyneuropathy. She was prescribed α-lipoic acid (ALA), which contains two sulfur atoms. Two weeks later, she complained of recurrent hypoglycemic symptoms. We detected a high level of insulin and high titers of insulin autoantibodies. Her human leukocyte antigen (HLA) genotype included the DRB1*0406 allele, which indicates a high level of susceptibility to IAS. She was treated with prednisolone. After this episode, she experienced two more hypoglycemic events after taking ALA for diabetic neuropathy in other hospitals. As ALA can be used to treat diabetic peripheral polyneuropathy, physician discretion is advised based on the possibility of IAS due to ALA in diabetic patients.

Citations

Citations to this article as recorded by  
  • HLA Alleles Associate with Insulin Autoimmune Syndrome
    Dan Yao, Jiefeng Jiang, Qianyun Zhou, Caiyun Feng, Jianping Chu, Zhiyan Chen, Jie Yang, Jinying Xia, Yujia Chen
    Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 3463.     CrossRef
  • Long-term follow-up after discharge witnesses a slow decline of insulin autoantibodies in patients with insulin autoimmune syndrome complicated with Grave’s disease: a report of two cases
    Lili Zhao, Jinzhi He, Shandong Ye, Chao Chen, Jie Zhu, Chunchun Xiao, Tingni Wu, Zhicheng Liu
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • Postprandial hyperinsulinemic hypoglycemia
    A. A. Akmedova, F. O. Ushanova
    FOCUS. Endocrinology.2023; 4(3): 74.     CrossRef
  • Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review
    Nahid Najafi, Soghra Mehri, Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
    Phytotherapy Research.2022; 36(6): 2300.     CrossRef
  • Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features
    Umberto Capece, Simona Moffa, Ilaria Improta, Gianfranco Di Giuseppe, Enrico Celestino Nista, Chiara M. A. Cefalo, Francesca Cinti, Alfredo Pontecorvi, Antonio Gasbarrini, Andrea Giaccari, Teresa Mezza
    Nutrients.2022; 15(1): 18.     CrossRef
  • Analysis of the clinical characteristics of insulin autoimmune syndrome induced by alpha‐lipoic acid
    Zuojun Li, Yanhong Su, Dan Yi, Cuifang Wu, Weijin Fang, Chunjiang Wang
    Journal of Clinical Pharmacy and Therapeutics.2021; 46(5): 1295.     CrossRef
  • Scientific opinion on the relationship between intake of alpha‐lipoic acid (thioctic acid) and the risk of insulin autoimmune syndrome
    Dominique Turck, Jacqueline Castenmiller, Stefaan de Henauw, Karen Ildico Hirsch‐Ernst, John Kearney, Helle Katrine Knutsen, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri,
    EFSA Journal.2021;[Epub]     CrossRef
  • Management of Insulin Autoimmune Hypoglycaemia: Single‐centre experience from Western India with systematic review of world literature
    Muniraj Patel, Ravikumar Shah, Swati Ramteke‐Jadhav, Virendra Patil, Shivendra Kumar Patel, Anurag Lila, Nalini Shah, Tushar Bandgar
    Clinical Endocrinology.2020; 92(5): 409.     CrossRef
  • Glucose Changes in a Patient With Insulin Autoimmune Syndrome Demonstrated by Continuous Glucose Monitoring
    Shi-Dou Lin, Shang-Ren Hsu
    AACE Clinical Case Reports.2019; 5(1): e35.     CrossRef
  • Insulin Autoimmune Syndrome in a 25-Year-Old, Previously Healthy Kuwaiti Man
    Einas Alrashidi, Thamer Alessa
    Case Reports in Endocrinology.2019; 2019: 1.     CrossRef
  • Insulin autoimmune syndrome in an Argentine woman taking α-lipoic acid: A case report and review of the literature
    Valentina Izzo, Carla Greco, Diana Corradini, Marco Infante, Maria Teresa Staltari, Maria Romano, Alfonso Bellia, Davide Lauro, Luigi Uccioli
    SAGE Open Medical Case Reports.2018;[Epub]     CrossRef
  • Assessment and Management of Anti-Insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome
    David Church, Luís Cardoso, Richard G Kay, Claire L Williams, Bernard Freudenthal, Catriona Clarke, Julie Harris, Myuri Moorthy, Efthmia Karra, Fiona M Gribble, Frank Reimann, Keith Burling, Alistair J K Williams, Alia Munir, T Hugh Jones, Dagmar Führer,
    The Journal of Clinical Endocrinology & Metabolism.2018; 103(10): 3845.     CrossRef
  • Current Status of Health Foods Including Their Interactions with Drugs and Adverse Events
    Yoshiro Saito
    YAKUGAKU ZASSHI.2018; 138(12): 1511.     CrossRef
  • Autoimmune hypoglycaemia caused by alpha-lipoic acid: a rare condition in Caucasian patients
    A Veltroni, G Zambon, S Cingarlini, M V Davì
    Endocrinology, Diabetes & Metabolism Case Reports.2018;[Epub]     CrossRef
  • GLP‑1R agonists ameliorate peripheral nerve dysfunction and inflammation via p38 MAPK/NF‑κB signaling pathways in streptozotocin‑induced diabetic rats
    Jingjing Ma, Min Shi, Xiangcheng Zhang, Xiaoning Liu, Juan Chen, Ridong Zhang, Xingzhou Wang, Hong Zhang
    International Journal of Molecular Medicine.2018;[Epub]     CrossRef
  • Insulin autoimmune syndrome associated with alpha-lipoic acid in a young woman with no concomitant disease
    Sang Bae Lee, Min Young Lee, Ji Hong You, Seong Han Kim, Ji Sun Nam
    Yeungnam University Journal of Medicine.2017; 34(1): 115.     CrossRef
  • The insulin autoimmune syndrome (IAS) as a cause of hypoglycaemia: an update on the pathophysiology, biochemical investigations and diagnosis
    Adel A.A. Ismail
    Clinical Chemistry and Laboratory Medicine (CCLM).2016; 54(11): 1715.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
Close layer
Thyroid
Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
Pyoung Ahn, Hyun-Jun Min, Sang-Hyun Park, Byoung-Mu Lee, Myung-Jin Choi, Jong-Woo Yoon, Ja-Ryong Koo
Endocrinol Metab. 2013;28(4):331-334.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.331
  • 4,815 View
  • 41 Download
  • 11 Crossref
AbstractAbstract PDFPubReader   

Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.

Citations

Citations to this article as recorded by  
  • Effects of statin use on serum creatinine phosphokinase levels in normal thyroid function
    Jeonghoon Ha, Joonyub Lee, Jin Yu, Hakyoung Park, Jiwon Shinn, Seung-Hwan Lee, Jae-Hyoung Cho, Hun-Sung Kim
    The Korean Journal of Internal Medicine.2024; 39(4): 650.     CrossRef
  • Is Kidney Stone Associated with Thyroid Disease? The United States National Health and Nutrition Examination Survey 2007-2018
    Wenya Xue, Zihan Xue, Yanbing Liu, Pan Yin, Luyu Liu, Shen’ao Qu, Shaobo Wu, Chuance Yang
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2024; 24(11): 1323.     CrossRef
  • Case report: Rhabdomyolysis and kidney injury in a statin-treated hypothyroid patient–kill two birds with one stone
    Wen-Fang Chiang, Jenq-Shyong Chan, Po-Jen Hsiao, Shih-Hua Lin
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Secondary dyslipidemia: its treatments and association with atherosclerosis
    Hidekatsu Yanai, Hiroshi Yoshida
    Global Health & Medicine.2021; 3(1): 15.     CrossRef
  • Hypothyroidism-associated rhabdomyolysis
    Fahmi Yousef Khan, Theeb Osama Sulaiman, Raza Ali Akbar
    Imam Journal of Applied Sciences.2021; 6(2): 31.     CrossRef
  • Phenotyping of Korean patients with better-than-expected efficacy of moderate-intensity statins using tensor factorization
    Jingyun Choi, Yejin Kim, Hun-Sung Kim, In Young Choi, Hwanjo Yu, Katriina Aalto-Setala
    PLOS ONE.2018; 13(6): e0197518.     CrossRef
  • Discovery of potential novel microsomal triglyceride transfer protein inhibitors via virtual screening of pharmacophore modelling and molecular docking
    Ludi Jiang, Yusu He, Ganggang Luo, Yongqiang Yang, Gongyu Li, Yanling Zhang
    Molecular Simulation.2016; 42(15): 1223.     CrossRef
  • Statin‐related aminotransferase elevation according to baseline aminotransferases level in real practice in Korea
    H.‐S. Kim, S. H. Lee, H. Kim, S.‐H. Lee, J. H. Cho, H. Lee, H. W. Yim, S.‐H. Kim, I.‐Y. Choi, K.‐H. Yoon, J. H. Kim
    Journal of Clinical Pharmacy and Therapeutics.2016; 41(3): 266.     CrossRef
  • Creatinine as predictor value of mortality and acute kidney injury in rhabdomyolysis
    R. Baeza‐Trinidad, A. Brea‐Hernando, S. Morera‐Rodriguez, Y. Brito‐Diaz, S. Sanchez‐Hernandez, L. El Bikri, E. Ramalle‐Gomara, J. L. Garcia‐Alvarez
    Internal Medicine Journal.2015; 45(11): 1173.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • The 2013 American College of Cardiology/American Heart Association guidelines for the treatment of dyslipidemia: mind the gaps!
    Vasilios G. Athyros, Niki Katsiki, Asterios Karagiannis, Dimitri P. Mikhailidis
    Current Medical Research and Opinion.2014; 30(9): 1701.     CrossRef
Close layer
Thyroid
Papillary Thyroid Carcinoma: Four Cases Required Caution during Long-Term Follow-Up
Hea Min Yu, Jae Min Lee, Kang Seo Park, Tae Sun Park, Heung Young Jin
Endocrinol Metab. 2013;28(4):335-340.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.335
  • 4,491 View
  • 29 Download
  • 3 Crossref
AbstractAbstract PDFPubReader   

Due to the increased prevalence of papillary thyroid carcinoma (PTC), difficult cases and unexpected events have become more common during long-term follow-up. Herein we reported four cases that exhibited poor progress during long-term follow-up. All the cases were diagnosed with PTC and treated with total thyroidectomy before several years, and the patients had been newly diagnosed with recurrent and metastatic PTC. These four cases included recurred PTC with invasion of large blood vessels, a concomitant second malignancy, malignant transformation, and refractoriness to treatment. Physicians should closely monitor patients to promptly address unforeseen circumstances during PTC follow-up, including PTC recurrence and metastasis. Furthermore, we suggest that the development of a management protocol for refractory or terminal PTC is also warranted.

Citations

Citations to this article as recorded by  
  • Induction of epithelial-mesenchymal transition in thyroid follicular cells is associated with cell adhesion alterations and low-dose hyper-radiosensitivity
    Ankit Mathur, Vijayakumar Chinnadurai, Param Jit Singh Bhalla, Sudhir Chandna
    Tumor Biology.2023; 45(1): 95.     CrossRef
  • Thyroglobulin Level in Fine-Needle Aspirates for Preoperative Diagnosis of Cervical Lymph Node Metastasis in Patients with Papillary Thyroid Carcinoma: Two Different Cutoff Values According to Serum Thyroglobulin Level
    Min Ji Jeon, Won Gu Kim, Eun Kyung Jang, Yun Mi Choi, Yu-Mi Lee, Tae-Yon Sung, Jong Ho Yoon, Ki-Wook Chung, Suck Joon Hong, Jung Hwan Baek, Jeong Hyun Lee, Tae Yong Kim, Young Kee Shong, Won Bae Kim
    Thyroid.2015; 25(4): 410.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
Close layer
Thyroid
Co-Occurrence of Papillary Thyroid Carcinoma and Mucosa-Associated Lymphoid Tissue Lymphoma in a Patient with Long-Standing Hashimoto Thyroiditis
Yoon Jeong Nam, Bo Hyun Kim, Seong Keun Lee, Yun Kyung Jeon, Sang Soo Kim, Woo Jin Jung, Dong Hwahn Kahng, In Ju Kim
Endocrinol Metab. 2013;28(4):341-345.   Published online December 12, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.4.341
  • 5,145 View
  • 64 Download
  • 14 Crossref
AbstractAbstract PDFPubReader   

Papillary thyroid carcinoma (PTC) is a common affliction of the thyroid gland, accounting for 70% to 80% of all thyroid cancers, whereas mucosa-associated lymphoid tissue (MALT) lymphoma of the thyroid gland is uncommon. The simultaneous occurrence of both malignancies is extremely rare. We report the case of a patient with both PTC and MALT lymphoma in the setting of Hashimoto thyroiditis. An 81-year-old female patient was first admitted with goiter and hoarseness, which was attributed to an ultrasonographic thyroid nodule. Subsequent fine-needle aspirate, interpreted as suspicious of papillary thyroid cancer, prompted total thyroidectomy. MALT lymphoma was an incidental postsurgical finding, coexisting with PTC in the setting of Hashimoto thyroiditis. Although the development of MALT lymphoma is very rare, patients with longstanding Hashimoto thyroiditis should undergo careful surveillance for both malignancies.

Citations

Citations to this article as recorded by  
  • Two lymphoma histotypes and papillary thyroid carcinoma coexisting on Hashimoto ground: a case report and review of the literature
    Igor Iskra, Maja Ilić Tomaš, Tatjana Bogović Crnčić, Edvin Kukić, Ita Hadžisejdić, Manuela Avirović, Neva Girotto
    Diagnostic Pathology.2024;[Epub]     CrossRef
  • Thyroid papillary carcinoma combined with primary follicular lymphoma: a case report
    Ting Xu, Li Wu, Hua Ye, Shuai Luo, Jinjing Wang
    Diagnostic Pathology.2024;[Epub]     CrossRef
  • Thyroid Mucosa-associated Lymphoid Tissue Lymphoma Presenting as Intermediate-risk Thyroid Nodule with Positive KRAS Mutation
    Nipith Charoenngam, Mehmet Sercan Marangoz, Simon Lamothe, Benjamin C. James
    AACE Clinical Case Reports.2023; 9(2): 44.     CrossRef
  • Coexistence of tuberculosis and extranodal marginal zone lymphoma of the thyroid gland: Case report and literature review
    Sami Akbulut, Khaled Demyati, Ridvan Yavuz, Nilgun Sogutcu, Emine Turkmen Samdanci, Yusuf Yagmur
    Annals of Medicine and Surgery.2022; 78: 103861.     CrossRef
  • Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation
    Massimo Ralli, Diletta Angeletti, Marco Fiore, Vittorio D'Aguanno, Alessandro Lambiase, Marco Artico, Marco de Vincentiis, Antonio Greco
    Autoimmunity Reviews.2020; 19(10): 102649.     CrossRef
  • Mucosa-Associated Lymphoid Tissue Lymphoma of the Thyroid Gland: A Systematic Review of the Literature
    Evangelos Karvounis, Ioannis Kappas, Anna Angelousi, Georgios-Marios Makris, Eva Kassi
    European Thyroid Journal.2020; 9(1): 11.     CrossRef
  • Primary thyroid MALToma– a rare diagnosis of an unassuming thyroid nodule
    Pragya Shrestha, Kimberly Aderhold, Sharon Swierczynski, Catherine Lin, Ronald Herb
    Journal of Community Hospital Internal Medicine Perspectives.2018; 8(1): 42.     CrossRef
  • Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis
    Maria Trovato, Giuseppe Giuffrida, Antonino Seminara, Simone Fogliani, Vittorio Cavallari, Rosaria Maddalena Ruggeri, Alfredo Campennì
    Archives of Endocrinology and Metabolism.2017; 61(6): 643.     CrossRef
  • Pathology Verified Concomitant Papillary Thyroid Carcinoma in the Sonographically Suspected Thyroid Lymphoma: A Case Report
    Qiong Wu, Yu-xin Jiang, Jun-chao Guo, Yu Xiao, Xiao Yang, Rui-na Zhao, Xing-jian Lai, Shen-ling Zhu, Xiao-yan Zhang, Bo Zhang
    Chinese Medical Sciences Journal.2016; 31(1): 54.     CrossRef
  • Coexistence of papillary thyroid microcarcinoma and mucosa-associated lymphoid tissue lymphoma in a context of Hashimoto's thyroiditis
    Saul Levy-Blitchtein, Stefany Plasencia-Rebata, Domingo Morales Luna, Juana del Valle Mendoza
    Asian Pacific Journal of Tropical Medicine.2016; 9(8): 812.     CrossRef
  • Synchronous Occurrence of Papillary Thyroid Carcinoma and Mucosa-Associated Lymphoid Tissue Lymphoma: a Single Case Report
    Jun Suk Byun, Hye Yoon Lee, Ki Won Chun, Dae Sung Yoon
    International Journal of Thyroidology.2016; 9(2): 195.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
  • Primary mucosa-associated lymphoid tissue lymphoma of the thyroid with concomitant papillary carcinoma
    Shaakir Hasan, Aruna Turaka
    Journal of Radiotherapy in Practice.2014; 13(4): 490.     CrossRef
  • G Protein-Coupled Estrogen Receptor-1 Is Involved in the Protective Effect of Protocatechuic Aldehyde against Endothelial Dysfunction
    Byung Soo Kong, Yoon Hee Cho, Eun Jig Lee, Rajesh Mohanraj
    PLoS ONE.2014; 9(11): e113242.     CrossRef
Close layer
Letter
Close layer

Endocrinol Metab : Endocrinology and Metabolism
TOP