Clinical Differences between Classic Papillary Thyroid Carcinoma and Variants.

Ji Young Park; Ji In Lee; Alice Hyun Kyung Tan; Hye Won Jang; Hyun Won Shin; Young Lyun Oh; Jung Hee Shin; Jung Han Kim; Ji Soo Kim; Young Ik Son; Sun Wook Kim; Jae Hoon Chung

doi:10.3803/jkes.2009.24.3.165

Articles

Page Path: HOME > Endocrinol Metab > Volume 24(3); 2009 > Article

Original Article Clinical Differences between Classic Papillary Thyroid Carcinoma and Variants.: Ji Young Park, Ji In Lee, Alice Hyun Kyung Tan, Hye Won Jang, Hyun Won Shin, Young Lyun Oh, Jung Hee Shin, Jung Han Kim, Ji Soo Kim, Young Ik Son, Sun Wook Kim, Jae Hoon Chung; Endocrinology and Metabolism 2009;24(3):165-173
DOI: https://doi.org/10.3803/jkes.2009.24.3.165
Published online: September 1, 2009

2,048 Views
22 Download
2 Crossref
0 Scopus

¹Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.
²Department of Medicine, Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.
³Department of Medicine, Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.
⁴Department of Medicine, Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.
⁵Department of Medicine, Otorhinolaryngology-Head & Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea.

Full Article

Download PDF

Abstract

BACKGROUND
The outcomes of papillary thyroid carcinoma (PTC) variants have been described in a limited number of studies. The purpose of this study was to compare patient outcomes of PTC variants with those of patients with classic PTC. METHODS: A single-institution retrospective analysis was performed to review 2,366 patients with classic PTC and 159 patients with PTC variants diagnosed between 1994 and 2004. PTC variant patients were divided into two groups, favorable (n = 119, 119 follicular variants including 14 encapsulated follicular variants) and aggressive (n = 40, including 13 diffuse sclerosing, 11 tall cell, six solid, six oncocytic, and four columnar cell variants). RESULTS: Compared with classic PTC, the favorable and aggressive variants had a significantly larger tumor size (P<0.001). The favorable variants had significantly lower rates of bilaterality, multifocality, extrathyroidal invasion, cervical lymph node metastasis, stage III and IV disease, and greater male to female ratio (P<0.05). In particular, the encapsulated follicular variant showed no bilaterality, multifocality, extrathyroidal invasion, lymph node metastasis, and distant metastasis. However, the disease-specific survival and recurrence-free survival of patients with favorable PTC were not different from the patients with classic PTC. The aggressive variants had significantly higher rates of bilaterality and cervical lymph node metastasis compared to the classic PTC (P<0.05). They had significantly reduced disease-specific survival and recurrence-free survival rates (P<0.01). CONCLUSIONS: Knowledge of the nature of PTC variants, especially aggressive types, is important in predicting patient outcome and providing appropriate treatment. Further study is needed to better understand PTC variants.

Keywords: papillary thyroid carcinoma;recurrence;survival;variant;

Figure & Data

References

Citations

Citations to this article as recorded by

Ultrasonographic Characteristics of the Follicular Variant Papillary Thyroid Cancer According to the Tumor Size
Eon Ju Jeon, Young Ju Jeong, Sung Hwan Park, Chang Ho Cho, Ho Sang Shon, Eui Dal Jung
Journal of Korean Medical Science.2016; 31(3): 397. CrossRef
Follicular Variant of Papillary Thyroid Carcinoma: Distinct Biologic Behavior Based on Ultrasonographic Features
Sun Jung Rhee, Soo Yeon Hahn, Eun Sook Ko, Jae Wook Ryu, Eun Young Ko, Jung Hee Shin
Thyroid.2014; 24(4): 683. CrossRef

Cite

Related articles