Table 1Clinical Characteristics of the Study Population
Characteristic |
Diabetic |
Control |
P value |
No. of subjects (male/female) |
249 (158/91) |
131 (61/70) |
NS |
Age, yr |
56.03±6.73 |
54.52±6.39 |
NS |
BMI, kg/m2
|
24.67±3.64 |
23.73±2.53 |
0.009 |
SBP, mm Hg |
124.00±10.37 |
123.39±12.57 |
NS |
DBP, mm Hg |
77.57±6.95 |
75.82±9.29 |
0.038 |
FPG, mmol/L |
7.75±2.19 |
5.00±0.33 |
<0.001 |
TC, mmol/L |
4.84±1.00 |
5.04±0.96 |
0.060 |
TG, mmol/L |
1.71±0.95 |
1.23±0.64 |
<0.001 |
LDL-C, mmol/L |
2.73±0.85 |
2.96±0.83 |
0.010 |
HDL-C, mmol/L |
0.28±0.31 |
1.40±0.32 |
0.001 |
Adiponectin, μg/mL |
7.34±4.85 |
8.47±6.17 |
0.040 |
Fasting insulin, μU/L |
3.92±4.88 |
3.34±2.68 |
NS |
HOMA-IR |
2.52±4.06 |
1.35±1.05 |
<0.001 |
HOMA-β, % |
60.48±65.84 |
77.42±65.48 |
0.017 |
Table 2Association between Adiponectin and CAPN10 Gene Polymorphisms and Type 2 Diabetes
Gene |
Genotype |
No. of case (%) |
No. of control (%) |
OR (95% CI) |
P value |
ACDC 276G/T |
TT |
121 (48.6) |
60 (45.8) |
1.00 |
|
TG |
102 (41.0) |
54 (41.2) |
0.91 (0.57–1.45) |
0.69 |
GG |
26 (10.4) |
17 (13.0) |
0.84 (0.41–1.71) |
0.63 |
ACDC 45T/G |
GG |
119 (47.8) |
61 (46.6) |
1.00 |
|
GT |
108 (43.4) |
60 (45.8) |
0.96 (0.61–1.51) |
0.86 |
TT |
22 (8.8) |
10 (7.6) |
1.12 (0.49–2.58) |
0.79 |
CAPN10 43G/A |
GG |
202 (81.1) |
101 (77.1) |
1.00 |
|
GA |
44 (17.7) |
29 (22.1) |
0.76 (0.44–1.31) |
0.32 |
AA |
3 (1.2) |
1 (0.8) |
1.04 (0.10–10.5) |
0.97 |
CAPN10 63C/T |
CC |
132 (53.4) |
77 (59.2) |
1.00 |
|
CT |
93 (37.7) |
49 (37.7) |
1.11 (0.70–1.77) |
0.65 |
TT |
22 (8.9) |
4 (3.1) |
3.38 (1.10–10.4) |
0.03 |
Table 3Association between Dominant, Recessive Polymorphisms Model and Type 2 Diabetes
Gene |
Additive model |
Dominant model OR (95% CI) |
Recessive model OR (95% CI) |
Genotype |
OR (95% CI) |
P value |
Genotype |
Dominant model OR (95% CI) |
P value |
Genotype |
Recessive model OR (95% CI) |
P value |
ACDC 276G/T |
TT |
0.91 (0.66–1.26) |
0.58 |
TT |
1.00 |
|
TT+TG |
1.00 |
|
TG+GG |
1.00 |
|
TG+GG |
0.89 (0.58–1.39) |
0.61 |
GG |
0.88 (0.45–1.72) |
0.71 |
ACDC 45T/G |
GG |
1.02 (0.72–1.43) |
0.93 |
GG |
1.00 |
|
GG+GT |
1.00 |
|
GT+TT |
1.00 |
|
GT+TT |
0.99 (0.64–1.52) |
0.94 |
TT |
1.14 (0.51–2.55) |
0.74 |
CAPN10 43G/A |
GG |
0.80 (0.49–1.31) |
0.38 |
GG |
1.00 |
|
GG+GA |
1.00 |
|
GA+AA |
1.00 |
|
GA+AA |
0.77 (0.45–1.31) |
0.34 |
AA |
1.10 (0.11–11.1) |
0.94 |
CAPN10 63C/T |
CC |
1.39 (0.96–2.00) |
0.08 |
CC |
1.00 |
|
CC+CT |
1.00 |
|
CT+TT |
1.00 |
|
CT+TT |
1.28 (0.82–3.01) |
0.27 |
TT |
3.23 (1.06–9.79) |
0.04 |