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1Department of Biochemistry and Molecular Biology, Integrated Genomic Research Center for Metabolic Regulation, Institute of Genetic Science, Yonsei University College of Medicine, Seoul, Korea.
2Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Korea.
3Department of Integrated OMICS for Biomedical Sciences, Yonsei University Graduate School, Seoul, Korea.
Copyright © 2016 Korean Endocrine Society
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.
GK, glucokinase; PFK, phosphofructokinase; PK, pyruvate kinase; PEPCK, phosphoenol pyruvate carboxykinase; G6Pase, glucose 6-phosphatase; FAS, fatty acid synthase; ACC, acetyl CoA carboxylase; FABP, fatty acid binding protein; FATP, fatty acid transport protein; HK1, hexokinase 1; HK2, hexokinase 2; PDH, pyruvate dehydrogenase; Cyto C, cytochrome C; Glut1, glucose transporter 1; UCP1, uncoupling protein 1; Dio2, deiodinase 2; ELOVL3, elongation of very long chain fatty acid-like 3 (fatty acid elongase 3); Cox8b, cytochrome C oxidase 8b; Prdm16, PR domain containing 16; Ebf2, early B-cell factor 2; Tle3, transducin-like enhancer of split 3; Gsta3, glutathione S-transferase alpha 3; Lyz2, lysozyme C-2 precursor; SREBP, sterol regulatory element-binding protein; PPAR, peroxisome proliferator-activated receptor; PGC, PPAR gamma coactivator; ChREBP, carbohydrate response element-binding protein; LXR, liver X receptor; CREB, cAMP response element-binding protein; 4EBP1, eukaryotic translation initiation factor 4E-binding protein 1; IR, insulin receptor; IRS, insulin receptor substrate; PI3K, phosphoinositol-4,5-bisphosphate 3-kinase; ERK, extracellular signal-regulated kinase; AMPK, 5’ adenosine monophosphate- activated protein kinase; TSC, tuberous sclerosis complex; mTOR, mammalian target of rapamycin; RAPTOR, regulatory-associated protein of mTOR.
RT-PCR, reverse transcriptase-polymerase chain reaction; siRNA, small interfering RNA; shRNA, short hairpin RNA; ELISA, enzyme-linked immunosorbent assay; FACS, fluorescence-activated cell sorting; ChIP, chromatin immunoprecipitation; RNAseq, RNA sequencing; ChIPseq, ChIP sequencing; ATP, adenosine triphosphate; MRI, magnetic resonance imaging; CRISPR/Cas9, clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9; cAMP, cyclic adenosine monophosphate; PER, proboscis extension response; AMPK, 5’ adenosine monophosphate-activated protein kinase.