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- Obesity and Metabolism
- Testosterone Deficiency Associated with Poor Glycemic Control in Korean Male Diabetics
- Joo-Sung Kim, Bong Sun Kim, Ja Young Jeon, Yong Jun Choi, Yoon-Sok Chung
- Endocrinol Metab. 2014;29(3):300-306. Published online September 25, 2014
- DOI: https://doi.org/10.3803/EnM.2014.29.3.300
- 3,517 View
- 31 Download
- 8 Web of Science
- 4 Crossref
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Abstract
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PubReader Background Recent studies have shown that men with diabetes have lower testosterone levels than healthy men. However, studies on the correlation between testosterone and diabetes are rare in Korea. We examined the relationship between testosterone deficiency and markers related to diabetes in adult Korean men.
Methods A total 464 men with diabetes who visited an outpatient clinic at Ajou University Hospital and had serum total testosterone and serum insulin levels measured between January 2000 and September 2013 were selected. Blood samples were collected after the subjects had fasted overnight. We divided the participants into testosterone deficient and normal groups. Testosterone deficiency was defined as having a serum total testosterone level <3.5 ng/mL.
Results Of 464 subjects, 34.9% had a testosterone deficiency. The mean levels of fasting plasma glucose (
P =0.007) and glycated hemoglobin (HbA1c;P =0.038) were significantly higher in the testosterone deficiency group than in the normal group. To clarify the relationship between serum total testosterone level and fasting plasma glucose or HbA1c values, Pearson's correlation test was performed. Fasting plasma glucose levels (r =-0.142,P =0.002) and HbA1c values (r =-0.097,P =0.040) showed a significant negative correlation with serum testosterone levels in men with diabetes.Conclusion Major markers of diabetes that are associated with testosterone deficiency are fasting plasma glucose and HbA1c values. Poor glycemic control appears to be associated with testosterone deficiency in Korean men with diabetes.
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Citations
Citations to this article as recorded by
- Association between T2DM and the lowering of testosterone levels among Kashmiri males
Rabia Farooq, Mohammad Hayat Bhat, Sabhiya Majid, Mohammad Muzaffar Mir
Archives of Endocrinology and Metabolism.2020;[Epub] CrossRef - Hypogonadism and associated risk factors in male patients with type 2 diabetes mellitus attending the diabetic clinic of Tikur Anbessa Specialized Teaching Hospital, Addis Ababa, Ethiopia
Sisay Teka, Samuel Kinde, Gobena Dedefo, Kissi Mudi, Getahun Tarekegn
Journal of Endocrinology, Metabolism and Diabetes of South Africa.2019; 24(1): 16. CrossRef - Hypogonadism in Nigerian men with type 2 diabetes mellitus
S. I. Onung, E. E. Young, T. E. Ugwu, O. A. Fasanmade
International Journal of Diabetes in Developing Countries.2017; 37(3): 254. CrossRef - Articles in 'Endocrinology and Metabolism' in 2014
Won-Young Lee
Endocrinology and Metabolism.2015; 30(1): 47. CrossRef
- Association between T2DM and the lowering of testosterone levels among Kashmiri males
- Obesity and Metabolism
- Hemoglobin A1c Is Positively Correlated with Framingham Risk Score in Older, Apparently Healthy Nondiabetic Korean Adults
- Ji Hye Shin, Ji In Kang, Yun Jung, Young Min Choi, Hyun Jung Park, Jung Hae So, Jin Hwa Kim, Sang Yong Kim, Hak Yeon Bae
- Endocrinol Metab. 2013;28(2):103-109. Published online June 18, 2013
- DOI: https://doi.org/10.3803/EnM.2013.28.2.103
- 3,832 View
- 32 Download
- 7 Web of Science
- 9 Crossref
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Abstract
PDFPubReader
Background Several studies have suggested that elevated levels of hemoglobin A1c (HbA1c) are associated with cardiovascular disease (CVD) in nondiabetic individuals. However, it is unclear whether HbA1c levels can serve as a simple screening marker for increased CVD risk in nondiabetic individuals. Our objective was to evaluate the relationship between HbA1c levels and CVD risk using the Framingham risk score (FRS) in older, apparently healthy nondiabetic Korean adults.
Methods We retrospectively studied 2,879 Korean adults between the ages of 40 and 79 who underwent voluntary health check-ups at the Health Promotion Center of our hospital from July 2009 to June 2011. Subjects were subdivided based on their HbA1c levels into four groups: tertiles within the HbA1c normal tolerance range and a group for subjects with an increased risk for diabetes (IRD).
Results The mean FRS for the upper tertile (9.6±3.8) group was significantly higher than that of the middle tertile (8.4±4.0) and lower tertile (7.6±3.8) groups. In addition, FRS was highest in the IRD group (10.5±3.7). Multiple linear regression analysis demonstrated that HbA1c levels exhibited a significant positive correlation with FRS when adjusted for confounding variables in all subjects (β±standard error [SE], 0.018±0.002;
R 2, 0.131), women (β±SE, 0.023±0.003;R 2, 0.170), and men (β±SE, 0.016±0.004;R 2, 0.109).Conclusion HbA1c levels were positively correlated with FRS in older, apparently healthy nondiabetic Korean adults. We propose that HbA1c levels may reflect CVD risk in nondiabetic individuals.
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Citations
Citations to this article as recorded by- Correlation between cardiovascular risk and glycemic control among patients with diabetes
Naomi Niari Dalimunthe, Herwindo Ahmad, Dina Arwina Dalimunthe
MGM Journal of Medical Sciences.2024; 11(1): 44. CrossRef - Framingham Risk Score Assessment in Subjects with Pre-diabetes and Diabetes: A Cross-Sectional Study in Korea
Hyuk Sang Kwon, Kee Ho Song, Jae Myung Yu, Dong Sun Kim, Ho Sang Shon, Kyu Jeung Ahn, Sung Hee Choi, Seung Hyun Ko, Won Kim, Kyoung Hwa Lee, Il Seong Nam-Goong, Tae Sun Park
Journal of Obesity & Metabolic Syndrome.2021; 30(3): 261. CrossRef - Physician-Directed Diabetes Education without a Medication Change and Associated Patient Outcomes
Hun-Sung Kim, Hyunah Kim, Hae-Kyung Yang, Eun Young Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Seo Yeon Baik, Seung-Hwan Lee, Jae Hyoung Cho, In Young Choi, Hyeon Woo Yim, Bong-Yun Cha
Diabetes & Metabolism Journal.2017; 41(3): 187. CrossRef - Randomized, Open-Label, Parallel Group Study to Evaluate the Effect of Internet-Based Glucose Management System on Subjects with Diabetes in China
Hun-Sung Kim, Chenglin Sun, So Jung Yang, Lin Sun, Fei Li, In Young Choi, Jae-Hyoung Cho, Guixia Wang, Kun-Ho Yoon
Telemedicine and e-Health.2016; 22(8): 666. CrossRef - GA to HbA1C ratio, but not HbA1C is associated with cognition in Chinese nondiabetic old adults
Yuan Zhong, Jun Jin, Chan Chan Xu, Guo Xiang Fu
Aging & Mental Health.2015; 19(9): 853. CrossRef - Relationship of Glycated Hemoglobin A1c, Coronary Artery Calcification and Insulin Resistance in Males Without Diabetes
Chan-Hee Jung, Eun-Jung Rhee, Kyu-Jin Kim, Bo-Yeon Kim, Se Eun Park, Yoosoo Chang, Seungho Ryu, Cheol-Young Park, Ji-Oh Mok, Ki-Won Oh, Chul-Hee Kim, Sung-Woo Park, Sung-Koo Kang, Won-Young Lee
Archives of Medical Research.2015; 46(1): 71. CrossRef - Evaluation of Nutrient Intake and Food Variety in Korean Male Adults according to Framingham Risk Score
Mi-Kyeong Choi, Yun-Jung Bae
The Korean Journal of Food And Nutrition.2014; 27(3): 484. CrossRef - Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
Won-Young Lee
Endocrinology and Metabolism.2014; 29(3): 251. CrossRef - Suicidal ideation and suicide attempts among diabetes mellitus: The Korea National Health and Nutrition Examination Survey (KNHANES IV, V) from 2007 to 2012
Jae Ho Chung, Kitae Moon, Do Hyung Kim, Joo-Won Min, Tae Ho Kim, Hee-Jin Hwang
Journal of Psychosomatic Research.2014; 77(6): 457. CrossRef
- Correlation between cardiovascular risk and glycemic control among patients with diabetes
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