Endocrinology and Metabolism

Review Articles

Thyroid
Thyroid Function across the Lifespan: Do Age-Related Changes Matter?: John P. Walsh; Endocrinol Metab. 2022;37(2):208-219. Published online April 14, 2022; DOI: https://doi.org/10.3803/EnM.2022.1463

6,055 View
339 Download
12 Web of Science
15 Crossref

Circulating concentrations of thyrotropin (TSH) and thyroxine (T4) are tightly regulated. Each individual has setpoints for TSH and free T4 which are genetically determined, and subject to environmental and epigenetic influence. Pituitary-thyroid axis setpoints are probably established in utero, with maturation of thyroid function continuing until late gestation. From neonatal life (characterized by a surge of TSH and T4 secretion) through childhood and adolescence (when free triiodothyronine levels are higher than in adults), thyroid function tests display complex, dynamic patterns which are sexually dimorphic. In later life, TSH increases with age in healthy older adults without an accompanying fall in free T4, indicating alteration in TSH setpoint. In view of this, and evidence that mild subclinical hypothyroidism in older people has no health impact, a strong case can be made for implementation of age-related TSH reference ranges in adults, as is routine in children.

Citations

Citations to this article as recorded by

The ageing thyroid: implications for longevity and patient care
Diana van Heemst
Nature Reviews Endocrinology.2024; 20(1): 5. CrossRef
Incidence and Determinants of Spontaneous Normalization of Subclinical Hypothyroidism in Older Adults
Evie van der Spoel, Nicolien A van Vliet, Rosalinde K E Poortvliet, Robert S Du Puy, Wendy P J den Elzen, Terence J Quinn, David J Stott, Naveed Sattar, Patricia M Kearney, Manuel R Blum, Heba Alwan, Nicolas Rodondi, Tinh-Hai Collet, Rudi G J Westendorp,
The Journal of Clinical Endocrinology & Metabolism.2024; 109(3): e1167. CrossRef
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
Rosalie B. T. M. Sterenborg, Inga Steinbrenner, Yong Li, Melissa N. Bujnis, Tatsuhiko Naito, Eirini Marouli, Tessel E. Galesloot, Oladapo Babajide, Laura Andreasen, Arne Astrup, Bjørn Olav Åsvold, Stefania Bandinelli, Marian Beekman, John P. Beilby, Jette
Nature Communications.2024;[Epub] CrossRef
Evaluation of multiple organophosphate insecticide exposure in relation to altered thyroid hormones in NHANES 2007‐2008 adult population
Massira Ousseni Diawara, Songtao Li, Mingzhi Zhang, Francis Manyori Bigambo, Xu Yang, Xu Wang, Tianyu Dong, Di Wu, Chenghao Yan, Yankai Xia
Ecotoxicology and Environmental Safety.2024; 273: 116139. CrossRef
Thyroid-function reference ranges in the diagnosis of thyroid dysfunction in adults
Salman Razvi
Nature Reviews Endocrinology.2024; 20(5): 253. CrossRef
Association between exposure to chemical mixtures and epigenetic ageing biomarkers: Modifying effects of thyroid hormones and physical activity
Wanying Shi, Jianlong Fang, Huimin Ren, Peijie Sun, Juan Liu, Fuchang Deng, Shuyi Zhang, Qiong Wang, Jiaonan Wang, Shilu Tong, Song Tang, Xiaoming Shi
Journal of Hazardous Materials.2024; 469: 134009. CrossRef
DNA Methylation in Autoimmune Thyroid Disease
Nicole Lafontaine, Scott G Wilson, John P Walsh
The Journal of Clinical Endocrinology & Metabolism.2023; 108(3): 604. CrossRef
A Causality between Thyroid Function and Bone Mineral Density in Childhood: Abnormal Thyrotropin May Be Another Pediatric Predictor of Bone Fragility
Dongjin Lee, Moon Ahn
Metabolites.2023; 13(3): 372. CrossRef
Serum Lipidomic Analysis Reveals Biomarkers and Metabolic Pathways of Thyroid Dysfunction
Hua Dong, Wenjie Zhou, Xingxu Yan, Huan Zhao, Honggang Zhao, Yan Jiao, Guijiang Sun, Yubo Li, Zuncheng Zhang
ACS Omega.2023; 8(11): 10355. CrossRef
Developmental and environmental modulation of fecal thyroid hormone levels in wild Assamese macaques (Macaca assamensis)
Verena Behringer, Michael Heistermann, Suchinda Malaivijitnond, Oliver Schülke, Julia Ostner
American Journal of Primatology.2023;[Epub] CrossRef
Prevalence of Functional Alterations and the Effects of Thyroid Autoimmunity on the Levels of TSH in an Urban Population of Colombia: A Population-Based Study
Hernando Vargas-Uricoechea, Valentina Agredo-Delgado, Hernando David Vargas-Sierra, María V. Pinzón-Fernández
Endocrine, Metabolic & Immune Disorders - Drug Targets.2023; 23(6): 857. CrossRef
Genetic determinants of thyroid function in children
Tessa A Mulder, Purdey J Campbell, Peter N Taylor, Robin P Peeters, Scott G Wilson, Marco Medici, Colin Dayan, Vincent V W Jaddoe, John P Walsh, Nicholas G Martin, Henning Tiemeier, Tim I M Korevaar
European Journal of Endocrinology.2023; 189(2): 164. CrossRef
Relationship between Thyroid CT Density, Volume, and Future TSH Elevation: A 5-Year Follow-Up Study
Tomohiro Kikuchi, Shouhei Hanaoka, Takahiro Nakao, Yukihiro Nomura, Takeharu Yoshikawa, Md Ashraful Alam, Harushi Mori, Naoto Hayashi
Life.2023; 13(12): 2303. CrossRef
Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status
Katleen Van Uytfanghe, Joel Ehrenkranz, David Halsall, Kelly Hoff, Tze Ping Loh, Carole A. Spencer, Josef Köhrle
Thyroid®.2023; 33(9): 1013. CrossRef
Blood hormones and suicidal behaviour: A systematic review and meta-analysis
Xue-Lei Fu, Xia Li, Jia-Mei Ji, Hua Wu, Hong-Lin Chen
Neuroscience & Biobehavioral Reviews.2022; 139: 104725. CrossRef

Thyroid
Mechanisms of TERT Reactivation and Its Interaction with BRAF^V600E: Young Shin Song, Young Joo Park; Endocrinol Metab. 2020;35(3):515-525. Published online September 22, 2020; DOI: https://doi.org/10.3803/EnM.2020.304

7,944 View
198 Download
9 Web of Science
10 Crossref

Abstract PDF PubReader ePub

The telomerase reverse transcriptase (TERT) gene, which is repressed in most differentiated human cells, can be reactivated by somatic TERT alterations and epigenetic modulations. Moreover, the recruitment, accessibility, and binding of transcription factors also affect the regulation of TERT expression. Reactivated TERT contributes to the development and progression of cancer through telomere lengthening-dependent and independent ways. In particular, because of recent advances in high-throughput sequencing technologies, studies on genomic alterations in various cancers that cause increased TERT transcriptional activity have been actively conducted. TERT reactivation has been reported to be associated with poor prognosis in several cancers, and TERT promoter mutations are among the most potent prognostic markers in thyroid cancer. In particular, when a TERT promoter mutation coexists with the BRAF^V600E mutation, these mutations exert synergistic effects on a poor prognosis. Efforts have been made to uncover the mechanisms of these synergistic interactions. In this review, we discuss the role of TERT reactivation in tumorigenesis, the mechanisms of TERT reactivation across all human cancers and in thyroid cancer, and the mechanisms of interactions between BRAF^V600E and TERT promoter mutations.

Citations

Citations to this article as recorded by

Adult granulosa cell tumor of the testis with malignant tendency: A case report with genetic analysis using high-throughput sequencing
Lili Deng, Jingjing Zeng, Jin Feng Qiu, Li Hua Yang, Jie Ma
Medicine.2023; 102(32): e34523. CrossRef
Genomic Analysis in the Categorization of Poorly Differentiated Primary Liver Carcinomas
Alexander T. Kikuchi, Sarah Umetsu, Nancy Joseph, Sanjay Kakar
American Journal of Surgical Pathology.2023; 47(11): 1207. CrossRef
Telomerase and hallmarks of cancer: An intricate interplay governing cancer cell evolution
Naveen kumar, Gautam Sethi
Cancer Letters.2023; 578: 216459. CrossRef
Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Tumour Entity with a Short History. A Review on Challenges in Our Microscopes, Molecular and Ultrasonographic Profile
Ivana Kholová, Elina Haaga, Jaroslav Ludvik, David Kalfert, Marie Ludvikova
Diagnostics.2022; 12(2): 250. CrossRef
Does Locally Advanced Thyroid Cancer Have Different Features? Results from a Single Academic Center
Marco Dell’Aquila, Pietro Tralongo, Giuseppe De Ruggieri, Mariangela Curatolo, Luca Revelli, Celestino Pio Lombardi, Alfredo Pontecorvi, Guido Fadda, Luigi Maria Larocca, Marco Raffaelli, Liron Pantanowitz, Esther Diana Rossi
Journal of Personalized Medicine.2022; 12(2): 221. CrossRef
Adult Wilms Tumor
Pedram Argani, Satish K. Tickoo, Andres Matoso, Christine A. Pratilas, Rohit Mehra, Maria Tretiakova, Mathilde Sibony, Alan K. Meeker, Ming-Tseh Lin, Victor E. Reuter, Jonathan I. Epstein, Jeffrey Gagan, Doreen N. Palsgrove
American Journal of Surgical Pathology.2022; 46(7): 988. CrossRef
Prospective Analysis of TERT Promoter Mutations in Papillary Thyroid Carcinoma at a Single Institution
Yun-Suk Choi, Seong-Woon Choi, Jin-Wook Yi
Journal of Clinical Medicine.2021; 10(10): 2179. CrossRef
How limited molecular testing can also offer diagnostic and prognostic evaluation of thyroid nodules processed with liquid‐based cytology: Role of TERT promoter and BRAF V600E mutation analysis
Marco Dell’Aquila, Vincenzo Fiorentino, Maurizio Martini, Sara Capodimonti, Tonia Cenci, Celestino Pio Lombardi, Marco Raffaelli, Alfredo Pontecorvi, Guido Fadda, Liron Pantanowitz, Luigi Maria Larocca, Esther Diana Rossi
Cancer Cytopathology.2021; 129(10): 819. CrossRef
Human telomerase reverse transcriptase and telomeres in cancer
Anurag Mehta, Shrinidhi Nathany
Journal of Current Oncology.2021; 4(1): 1. CrossRef
Mutation in Genes Encoding Key Functional Groups Additively Increase Mortality in Patients with BRAFV600E-Mutant Advanced Papillary Thyroid Carcinoma
Eyun Song, Meihua Jin, Ahreum Jang, Min Ji Jeon, Dong Eun Song, Hye Jin Yoo, Won Bae Kim, Young Kee Shong, Won Gu Kim
Cancers.2021; 13(22): 5846. CrossRef

Epigenetic Modifications: Novel Therapeutic Approach for Thyroid Cancer: Xuguang Zhu, Sheue-yann Cheng; Endocrinol Metab. 2017;32(3):326-331. Published online September 18, 2017; DOI: https://doi.org/10.3803/EnM.2017.32.3.326

3,889 View
39 Download
13 Web of Science
13 Crossref

Abstract PDF PubReader

The incidence of thyroid cancer is growing the fastest among all cancers in the United States, especially in women. The number of patients with thyroid neoplasm is part of an even larger number of patients who often need to undergo an operation to exclude a cancer diagnosis. While differentiated thyroid cancer (papillary thyroid cancer and follicular thyroid cancer) accounts for most cases of thyroid cancer and has a relatively good prognosis, effective treatments for patients with de-differentiated and anaplastic thyroid cancer are still gravely needed. Despite progress in the identification of genetic changes in thyroid cancer, the impact of aberrant epigenetic alterations on thyroid cancer remains to be fully elucidated. Understanding of the roles of epigenetic changes in thyroid cancer could open new opportunities for the identification of innovative molecular targets for novel treatment modalities, especially for anaplastic thyroid cancer for which treatment is very limited. This article briefly reviews the studies that exemplify the potential for and promise of using epigenetic regulators in the treatment of thyroid cancer.

Citations

Citations to this article as recorded by

Challenges and Coping Strategies of Older Adults in the Aftermath of Kahramanmaraş Earthquake in Türkiye: A Qualitative Research
Nilgun Kuru Alici, Bilge Kalanlar
Journal of Applied Gerontology.2024;[Epub] CrossRef
CircRTN1 stimulates HMGB1 to regulate the malignant progression of papillary thyroid cancer by sponging miR-101-3p
Mei Zheng, Lingli Xu, Cuifeng Wei, Wenzhen Guan
Hormones.2023; 22(2): 281. CrossRef
The expression of HDAC9 and P300 in papillary thyroid carcinoma cell line
Hatice Ozisik, Berrin Ozdil, Aslı Suner, Murat Sipahi, Mehmet Erdogan, Sevki Cetinkalp, Gokhan Ozgen, Fusun Saygili, Gulgun Oktay, Huseyin Aktug
Pathology - Research and Practice.2023; 243: 154385. CrossRef
Dynamic Cancer Cell Heterogeneity: Diagnostic and Therapeutic Implications
Valerie Jacquemin, Mathieu Antoine, Geneviève Dom, Vincent Detours, Carine Maenhaut, Jacques E. Dumont
Cancers.2022; 14(2): 280. CrossRef
Thyroid Carcinoma: A Review for 25 Years of Environmental Risk Factors Studies
Eva Kruger, Eman A. Toraih, Mohammad H. Hussein, Shaimaa A. Shehata, Amani Waheed, Manal S. Fawzy, Emad Kandil
Cancers.2022; 14(24): 6172. CrossRef
Study of Essential and Toxic Metal Imbalances in the Scalp Hair of Thyroid Cancer Patients in Comparison with Healthy Donors
Kalsoom Bibi, Munir H. Shah
Biological Trace Element Research.2021; 199(2): 500. CrossRef
Modern concepts of the molecular pathogenesis of thyroid cancer
A. A. Mikhailova, A. V. Shestakov, K. A. Chubakova, E. V. Kolokolova, V. Yu. Eliseev, M. Ya. Kostyaeva, E. G. Akperov, V. E. Pilipenko, T. V. Saprina, M. R. Mukhamedov, E. L. Choinzonov
Advances in Molecular Oncology.2021; 8(2): 8. CrossRef
Effect of valproic acid on miRNAs affecting histone deacetylase in a model of anaplastic thyroid cancer
Nur Selvi Gunel, Nihal Birden, Cansu Caliskan Kurt, Bakiye Goker Bagca, Behrouz Shademan, Fatma Sogutlu, Neslihan Pinar Ozates, Cigir Biray Avci
Molecular Biology Reports.2021; 48(8): 6085. CrossRef
Histone Deacetylase Inhibitors and Papillary Thyroid Cancer
Eleftherios Spartalis, Konstantinos Kotrotsios, Dimosthenis Chrysikos, Michael Spartalis, Stavroula A. Paschou, Dimitrios Schizas, Konstantinos Tsamakis, Dimitrios Dimitroulis, Theodore Troupis, Nikolaos Nikiteas
Current Pharmaceutical Design.2021; 27(18): 2199. CrossRef
HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer
Ching-Ling Lin, Ming-Lin Tsai, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi, Li-Chi Huang, Chia-Hwa Lee
International Journal of Molecular Sciences.2019; 20(2): 454. CrossRef
Systems Biology Approaches to Investigate Genetic and Epigenetic Molecular Progression Mechanisms for Identifying Gene Expression Signatures in Papillary Thyroid Cancer
Shan-Ju Yeh, Chien-Yu Lin, Cheng-Wei Li, Bor-Sen Chen
International Journal of Molecular Sciences.2019; 20(10): 2536. CrossRef
Human telomerase reverse transcriptase in papillary thyroid cancer: gene expression, effects of silencing and regulation by BET inhibitors in thyroid cancer cells
Valentina Maggisano, Marilena Celano, Saverio Massimo Lepore, Marialuisa Sponziello, Francesca Rosignolo, Valeria Pecce, Antonella Verrienti, Federica Baldan, Catia Mio, Lorenzo Allegri, Marianna Maranghi, Rosa Falcone, Giuseppe Damante, Diego Russo, Stef
Endocrine.2019; 63(3): 545. CrossRef
Role of Emerging Environmental Risk Factors in Thyroid Cancer: A Brief Review
Maria Fiore, Gea Oliveri Conti, Rosario Caltabiano, Antonino Buffone, Pietro Zuccarello, Livia Cormaci, Matteo Angelo Cannizzaro, Margherita Ferrante
International Journal of Environmental Research and Public Health.2019; 16(7): 1185. CrossRef

First
Prev
Page of 1
Next
Last

Search