Endocrinology and Metabolism

Metabolic Regulation of Nuclear Receptors.: Eun Kyung Lee, Young Joo Park; J Korean Endocr Soc. 2008;23(3):155-164. Published online June 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.3.155

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Microwave-Promoted Total Synthesis of Puniceloid D for Modulating the Liver X Receptor
Young Jin Jung, Narges Hosseininasab, Jungjin Park, Soonsil Hyun, Jae-Kyung Jung, Jae-Hwan Kwak
Molecules.2024; 29(2): 416. CrossRef

Update of Precocious Puberty.: Ho Seong Kim; J Korean Endocr Soc. 2008;23(3):165-173. Published online June 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.3.165

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BMI trajectory and inflammatory effects on metabolic syndrome in adolescents
Ui-Jeong Kim, Eun Jeong Choi, Hyunjin Park, Hye Ah Lee, Bohyun Park, Jungwon Min, Eun Ae Park, Su Jin Cho, Hae Soon Kim, Hwayoung Lee, Young Ju Kim, Young Sun Hong, Eun Hee Ha, Seungyoun Jung, Hyesook Park
Pediatric Research.2023; 94(1): 153. CrossRef
Relationships of Lead, Mercury and Cadmium Levels with the Timing of Menarche among Korean Girls
Hye Seon Choi
Child Health Nursing Research.2020; 26(1): 98. CrossRef
Association of maxillary dental developmental abnormality with precocious puberty: a case-control study
Yesel Kim, Nam-Ki Lee, Jae Hyun Kim, Jeong-Kui Ku, Bu-Kyu Lee, Hoi-In Jung, Sun-Kyu Choi
Maxillofacial Plastic and Reconstructive Surgery.2020;[Epub] CrossRef
Evaluation of Characteristics of the Dental Maturity in Girls with Precocious Puberty
Chi Hoon Kim, Chung-Min Kang, Ik-Hwan Kim, Je Seon Song, Seong Oh Kim
THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY.2020; 47(3): 312. CrossRef
Sexual Maturation, Attitudes towards Sexual Maturity, and Body Esteem in Elementary-School Children
Sunah Park, Eunyoung Choi, Eunhee Lee, Mikyeong Byeon, Byeongju Lee, Kyea Jung
Korean Journal of Women Health Nursing.2018; 24(2): 219. CrossRef
Psychosocial Aspects in Girls with Idiopathic Precocious Puberty
Eun Young Kim, Moon In Lee
Psychiatry Investigation.2012; 9(1): 25. CrossRef

Clinical Applications of Thyrotropin Binding Inhibitor Immunoglobulin (TBII) Assays.: Won Bae Kim; J Korean Endocr Soc. 2008;23(3):174-178. Published online June 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.3.174

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Medical Treatment of Graves' Disease
Hyun-Kyung Chung
International Journal of Thyroidology.2019; 12(2): 79. CrossRef
When should antithyroid drug therapy to reduce the relapse rate of hyperthyroidism in Graves’ disease be discontinued?
Suyeon Park, Eyun Song, Hye-Seon Oh, Mijin Kim, Min Ji Jeon, Won Gu Kim, Tae Yong Kim, Young Kee Shong, Doo Man Kim, Won Bae Kim
Endocrine.2019; 65(2): 348. CrossRef
Usefulness of Measuring Thyroid Stimulating Antibody at the Time of Antithyroid Drug Withdrawal for Predicting Relapse of Graves Disease
Hyemi Kwon, Won Gu Kim, Eun Kyung Jang, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Jin-Sook Ryu, Young Kee Shong, Won Bae Kim
Endocrinology and Metabolism.2016; 31(2): 300. CrossRef

Clinical Usefulness of the Second Generation TSH-Binding Inhibitory Immunoglobulin Assay Using Recombinant Human TSH Receptor in Patients with Graves' Disease.: Jung Eun Huh, Ji Hye Suk, Mi Kyung Kim, Im Jeong Choi, Seok Man Son, In Joo Kim, Yong Ki Kim; J Korean Endocr Soc. 2008;23(3):179-185. Published online June 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.3.179

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BACKGROUND
AND AIM: Detection of TSH receptor antibody in patients with Graves' disease (GD) has been widely used in clinical practice. This has been performed mostly by commercial radio-receptor assays that measure TSH-binding inhibitory immunoglobulin (TBII) with using porcine TSH receptor as the ligand. To increase the sensitivity of the assay, many research groups have tried to replace the porcine source of TSH receptor with recombinant human TSH receptor. In this study we evaluated the clinical usefulness of the second generation TBII assay, which uses recombinant human TSH receptor, for making the diagnosis of GD, as compared to the conventional TBII assay. MATERIALS AND METHODS: We obtained sera from 76 patients with newly diagnosed or relapsing GD without or with less than 4 weeks of antithyroid drugs, and 54 patients with Hashimoto's thyroiditis who had not received thyroid hormone treatment or quit thyroid hormone more than 3 months before. TBII was measured by using both the conventional porcine TBII assay (pTBII) and the human recombinant TBII assay (hTBII). TBII was also measured in the sera from 66 healthy controls. RESULTS: The cut-off values of the pTBII and hTBII assay were defined as two geometric standard deviations from the geometric mean of the values in healthy controls, and these values were 10.8 IU/L and 1.0 IU/L, respectively. The sensitivity was 62% (47/76) for pTBII, as compared to 100% (76/76) for the hTBII, for diagnosing GD. Of the 54 patients with Hashimoto's thyroiditis, 3 (5.6%) and 7 (13.0%) patients had positive pTBII and positive hTBII, respectively. CONCLUSION: These data showed that the hTBII assay was a comparable method in terms of the sensitivity for the diagnosis of GD, as compared to the pTBII assay. It can be suggested that this new hTBII assay, rather than the pTBII assay, should be more widely used as the first line diagnostic test for GD.

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Changes in Thyroid Peroxidase and Thyroglobulin Antibodies Might Be Associated with Graves' Disease Relapse after Antithyroid Drug Therapy
Yun Mi Choi, Mi Kyung Kwak, Sang Mo Hong, Eun-Gyoung Hong
Endocrinology and Metabolism.2019; 34(3): 268. CrossRef
Usefulness of Measuring Thyroid Stimulating Antibody at the Time of Antithyroid Drug Withdrawal for Predicting Relapse of Graves Disease
Hyemi Kwon, Won Gu Kim, Eun Kyung Jang, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Jin-Sook Ryu, Young Kee Shong, Won Bae Kim
Endocrinology and Metabolism.2016; 31(2): 300. CrossRef
Clinical Applications of Thyrotropin Binding Inhibitor Immunoglobulin (TBII) Assays
Won Bae Kim
Journal of Korean Endocrine Society.2008; 23(3): 174. CrossRef

Correlation between S100A4 and COX2 Overexpression and Invasiveness of Papillary Thyroid Carcinoma.: Kyungji Lee, Youn Soo Lee, Kyo Young Lee, Woo Chan Park, Young Sil Kim; J Korean Endocr Soc. 2008;23(3):186-192. Published online June 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.3.186

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Abstract PDF: PURPOSE: Tumor cell invasion is characteristic of malignant neoplasms. S100A4, a member of a family of small calcium binding proteins, and COX2, seem to have a role in promoting progression and invasion of many human cancers. The clinical stage of a papillary thyroid carcinoma (PTC) depends on age, tumor size, and extrathyroidal extension. Extrathyroidal extension is correlated with the invasiveness of a tumor. However, there are no reliable prediction markers for invasiveness. We evaluated S100A4 and COX2 expression in PTCs to determine if expression correlates with invasiveness, and if expression of S100A4 and COX2 are useful as prediction markers. METHODS: The expression of S100A4 and COX2 were evaluated using immunohistochemical analysis in 35 PTC specimens. RESULTS: More intense staining in cells that invaded the front portion rather than the central portion of a PTC was indicative of increased expression of S100A4 and COX2. Therefore, cases were analyzed for extent of staining in tumor cells that invaded the front portion of a PTC. High expression group (higher expression than average expression rate) of S100A4 and COX2 were significantly correlated with extrathyroidal extension (P = 0.0094 and P = 0.0433, respectively). However, no other clinicopathological factors including age, lymph node involvement, and multiplicity were related to expression of S100A4 and COX2, as determined in this study. CONCLUSION: Extrathyroidal extension of a PTC had an unfavorable effect on prognosis. S100A4 and COX2 expression were associated with extrathyroidal extension. These findings suggest that expression of S100A4 and COX2 could be prognostic markers for PTC.

A Case of Slipped Capital Femoral Epiphysis in Association with Panhypopituitarism after Treatment of Craniopharyngioma.: Jin Ook Chung, Se In Hong, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung; J Korean Endocr Soc. 2008;23(3):193-198. Published online June 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.3.193

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Craniopharyngioma accounts for 2~5% of all primary intracranial neoplasms. It may present with a variety of manifestations including neurological, visual, and/or hypothalamic-pituitary dysfunction. Treatment options include radical surgery or radiotherapy, or a combination of these modalities. Craniopharyngioma ablation results in anterior and/or posterior pituitary hormone deficits. Slipped capital femoral epiphysis (SCFE), in which the femoral head slips downward and backward on the femoral neck at the epiphyseal plate, most commonly occurs during the rapid growth phase of puberty. Its actual cause is unknown, but the clinical association between SCFE and endocrine disorders is well known. We report a case of an adult male patient who developed SCFE in association with panhypopituitarism after treatment of a craniopharyngioma.

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A Case of Slipped Capital Femoral Epiphysis in Association With Craniopharyngioma
Mehran Soleymanha, Ali Karimi, Seyed Mojtaba Mehrdad
Trauma Monthly.2015;[Epub] CrossRef
Panhypopituitarism due to craniopharyngioma with bilateral slipped capital femoral epiphysis
Sun Woo Kim, Young-Jin Song, Eun Jeong Choi, Dong Hee Han, Hyun Yon Jung, Sung Hoon Yu, Hyung Joon Yoo, Jae Myung Yu
Yeungnam University Journal of Medicine.2014; 31(1): 61. CrossRef

A Case of Diffuse Hemorrhage into the Thyroid Gland after Fine Needle Aspiration, and This was Treated by Arterial Embolization.: Eui Young Kim, Jung Min Kim, Eun Hee Kim, Ji Yun Jeong, Sang Ah Lee, Ji Young Choi, Ji Hye Yim, Pil Hyung Lee, Tae Yong Kim, Young Kee Shong, Won Bae Kim; J Korean Endocr Soc. 2008;23(3):199-203. Published online June 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.3.199

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Although hematoma formation after fine needle aspiration cytology fine needle aspiration cytology (FNAC) is a most common complication and most of these hematomas are self-limiting with minimal pain, a massive intra-thyroidal hemorrhage that produces acute airway obstruction had rarely been reported on.

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Characteristics Evaluation of Hobun Pigments according to Shell Types and Calcination
Ju Hyun Park, Sun Myung Lee, Myoung Nam Kim, Jin Young Hong
Economic and Environmental Geology.2023; 56(6): 899. CrossRef
Endovascular treatment of massive hemorrhage arising from inferior thyroid artery after fine needle aspiration of thyroid: a case report
Ho Sig Jang, Yook Kim
BMC Surgery.2021;[Epub] CrossRef

Two Cases of Primary Hyperparathyroidism Associated with Colon Cancer.: Sang Hoon Chun, Yun Kyung Kim, Jae Seung Yun, Eun Hee Jang, Shin Ae Park, Jae Hyung Cho, Seung Hyun Ko, Yu Bai Ahn, Young Jin Suh, Jun Gi Kim; J Korean Endocr Soc. 2008;23(3):204-209. Published online June 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.3.204

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Abstract PDF: Hypercalcemia is often observed in cancer patients secondary to parathyroid hormone (PTH) related peptide production. However, primary hyperparathyroidism and colon cancer rarely present simultaneously. Calcium is believed to have a chemopreventive effect against colorectal cancer because it reduces crypt cell hyperproliferation in both humans and in animals. There is evidence to suggest that the incidence of colorectal cancer in humans is reduced by high calcium intake. In patients with primary hyperparathyroidism, increased PTH activates 1,25(OH)2D and enhances calcium absorption in the gut. Consequently, the calcium level in the lumen is decreased, leading to an elevated risk of colorectal cancer. We report two patients with colon cancer and hypercalcemia secondary to primary hyperparathyroidism, along with a brief review of the literature.

A Case of Intravenous Pamidronate-Related Osteonecrosis of the Jaw in a Patient with Waldenstrom's Macroglobulinemia.: Da Mi Lee, Mi Sun Ann, Tae Ho Kim, Tae Jin Park, Yoon Sok Chung, Joon Seong Park, Seung Il Song, Kyi Beom Lee, Hee Jae Joo; J Korean Endocr Soc. 2008;23(3):210-214. Published online June 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.3.210

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Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a rare, but serious, side effect of bisphosphonate therapy that produces significant morbidity in affected patients. It is characterized by poor wound healing and spontaneous intra-oral soft tissue breakdown, which lead to exposure of necrotic maxillary and mandibular bone.

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Dental sinus tracts mimicking scrofuloderma: cutaneous presentation of underlying bisphosphonate-related osteonecrosis of the jaw
H.-S. Kang, J.-W. Lee, J.-S. Kim
Clinical and Experimental Dermatology.2011; 36(6): 624. CrossRef

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