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The Influence of Obesity and Metabolic Health on Vascular Health

Article information

Endocrinol Metab. 2022;37(1):1-8
Publication date (electronic) : 2022 February 28
doi : https://doi.org/10.3803/EnM.2022.101
Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
Corresponding author: Eun-Jung Rhee. Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul 03181, Korea, Tel: +82-2-2001-2485, Fax: +82-2-2001-2049, E-mail: hongsiri@hanmail.net
Received 2022 January 25; Revised 2022 January 30; Accepted 2022 February 8.


The prevalence of obesity is rapidly increasing worldwide. Obesity should not be understood only as the accumulation of fat in the body, but instead as a phenomenon that exerts different effects on our health according to the place of fat deposition and its stability. Obesity is the starting point of most metabolic diseases, such as diabetes, hypertension, metabolic syndrome, sleep apnea, and eventually cardiovascular disease. There are different kinds of obesity, ranging from simple obesity to sarcopenic obesity. The main purpose of intervening to address obesity is to decrease the ultimate consequence of obesity—namely, cardiovascular disease. The main mechanism through which obesity, especially abdominal obesity, increases cardiovascular risk is the obesity-induced derangement of metabolic health, leading to the development of metabolic diseases such as diabetes, non-alcoholic fatty liver disease, and metabolic syndrome, which are the main initiators of vascular damage. In this review, I discuss the influence of various types of obesity on the risk of metabolic diseases, and how these diseases increase cardiovascular disease risk.


Obesity is renowned for its tendency to be accompanied by comorbid diseases, such as diabetes, atherosclerosis, metabolic syndrome (MS), and sleep apnea [13]. The prevalence of obesity in adults older than 30 has reached 30% worldwide, and this high rate of obesity is particularly pronounced in Asians, due to rapid changes in dietary patterns and a sedentary lifestyle [4].

Abdominal obesity is known to be a major risk factor for diabetes and cardiovascular disease (CVD) [5]. This increased risk for metabolic diseases results from insulin resistance, which visceral fat causes differently from subcutaneous fat accumulation. The presence of abdominal obesity indicates that ectopic fat infiltration has started in a person’s body, and this is not only confined to the abdomen. Ectopic fat accumulation is known to be caused by insulin resistance; more specifically, our body resists the role of insulin in promoting the storage of excess energy as triglycerides in adipose tissue, and excess fat therefore accumulates in places other than adipose tissue, such as the liver, muscle, abdomen, and perivascular area [6,7]. These ectopically accumulated fat deposits derange organ function, causing insulin resistance in the target organ. In turn, insulin resistance causes metabolic diseases such as non-alcoholic fatty liver disease (NAFLD), MS, and type 2 diabetes.

The Kangbuk Samsung Health Study (KSHS) is one of the largest health screening cohorts currently ongoing in Koreans, supporting prospective and retrospective research, and it screens more than 150,000 subjects every year. As a clinician and researcher working at Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, the author has had the opportunity to have full access to the KSHS dataset.

The Korean National Health Insurance Service (NHIS) system is a mandatory health insurance program that covers 97.1% of the Korean population [8]. In Korea, the NHIS is the single insurer, managed by the government. The NHIS includes an eligibility database, a medical treatment claims database (based on medical bills that were claimed by medical service providers for their medical expenses), a health examination database (with results of general health examinations and questionnaires on lifestyle and behavior), a medical care institution database (types of medical care institutions, location, equipment, and number of physicians), and a death register.

This review discusses the clinical implications, based on up-to-date knowledge, of the influence of obesity and metabolic health on vascular health, with a primary focus on the results of analyses of KSHS and NHIS data drawn from the author’s own work.


In recent decades, the prevalence of risk factors for CVD, such as diabetes, hypertension, obesity, and dyslipidemia, has been steadily increasing in Koreans. According to the Obesity Fact Sheet released by Korean Society for the Study of Obesity in 2020, based on NHIS data in 2018, the prevalence of obesity in Korea was 32.5% [4]. According to the Diabetes Fact Sheet released by the Korean Diabetes Association (KDA) in 2020, the prevalence of diabetes was 13.8% in Koreans older than 30 years, based on 2018 data from the Korean National Health and Nutrition Examination Survey [9]. In addition, the prevalence of hypertension in the total population of Korea in 2018 was 28.3% according to the Hypertension Fact Sheet produced by the Korean Society of Hypertension [10]. Lastly, the prevalence of dyslipidemia in 2018 was 40.5% according to the Dyslipidemia Fact Sheet published by the Korean Society of Lipid and Atherosclerosis [11]. The prevalence of all these risk factors has steadily increased over the last decade according to these fact sheets.

Not only is the prevalence of these risk factors rising, but their incidence is also increasing. According to the “Diabetes & Complications in Korea” report released by the KDA, during the period of 2006 to 2015, the prevalence of macrovascular complications—ischemic heart disease, stroke, and myocardial infarction—all tended to decline [12]. However, rising trends were seen in the rates of heart failure (HF) and peripheral artery disease, as well as diabetic retinopathy and diabetic nephropathy among Korean patients with diabetes. Diabetic nephropathy was the most common cause of end-stage renal disease (ESRD), and the prevalence of ESRD also increased.

In conclusion, the prevalence of risk factors for CVDs has been gradually rising for the last decade despite the efforts of physicians and healthcare providers in these fields. A particularly ominous trend is the increase in microvascular complications, such as ESRD and loss of vision.


MS is defined as a cluster of metabolic risk factors, such as abdominal obesity, hyperglycemia, hypertension, and dyslipidemia [13]. Although there have been disagreements regarding the definition of MS, the currently accepted definition is the presence of two or more of five risk factors, as suggested by harmonized consensus of multiple associations [14]. MS is a syndrome in which insulin resistance, which is caused by abdominal obesity, induces various CVD risk factors and further causes diabetes and CVD.

After the existence of MS was proposed by Prof. Reaven in 1988 as “Syndrome X,” many associations attempted to define MS [15]. A debate ensued regarding the application of the same waist circumference (WC) cutoff for the definition of MS in Asians as in Caucasians. Our group argued for the first time in the literature that different WC cutoffs should be applied to define MS in Asians and Caucasians, based on results showing a significantly lower prevalence of MS when different WC and body mass index values were applied in these ethnic groups [16]. Based on our suggestions, different WC cutoffs have been recommended for the definition of MS in Asians and Caucasians.

Some debates took place regarding the components of the MS definition, and in particular whether diabetes and hypertension should be counted as components of MS [17,18]. Our group analyzed the differences that would arise depending on whether the definition of MS included or excluded patients with diabetes or hypertension [19]. In 159,971 Korean participants in KSHS without a previous history of CVD from 2002 to 2009 with a median follow-up of 3.7 years, the mortality rate was assessed within the same period. We observed higher risks for all-cause and CVD mortality in subjects with MS than in those who did not have MS. However, these increased risks were attenuated after the exclusion of subjects with diabetes or hypertension, suggesting that inclusion of these metabolic diseases accounts for the increased CVD mortality attributable to MS, challenging the definition of MS used at that time.

In the early 2010s, a slightly different concept from MS, the concept of “metabolically healthy obesity” (MHO), was introduced [20]. MHO refers to the concept that there is a type of “healthy” obesity. People with MHO are obese, but have less abdominal obesity, higher muscle mass, a higher level of mitochondrial function, and better metabolic flexibility than metabolically unhealthy (MUH) obese people.

Our group designed a study to analyze the cardiovascular status of people with MHO using a subclinical atherosclerosis marker, the coronary artery calcium score (CACS). The CACS is known to be a global indicator of a patient’s coronary heart disease (CHD) risk by virtue of its strong association with the total coronary atherosclerotic disease burden [21]. Many cohort studies, for example the Multi-Ethnic Study of Atherosclerosis (MESA) study, have shown that the baseline CACS predicts future CHD events very well, suggesting that the CACS can serve as a predictive marker for CHD risk [22,23].

We analyzed the association between metabolic health and the CACS in 24,063 participants in the KSHS and found that the CACS was significantly higher in MUH people than in metabolically healthy people regardless of obesity, suggesting the existence of MHO [24]. We analyzed the risk of developing diabetes in people with MHO, and found that people with MHO had a lower risk of diabetes than MUH obese people [25]. Although both of our studies demonstrated the existence of MHO as a distinct phenotype, many subsequent studies have debated the existence of MHO, arguing that it is highly dependent on the definition [26].


Hyperglycemia is known to increase the risk for atherosclerosis and mortality through increased levels of advanced glycation end-products and increased oxidative stress [27]. In 241,299 KSHS participants between 2005 and 2012, the risk of death from all causes, CVD, and cancer was calculated based on the baseline glycemic status (normoglycemia, prediabetes, and diabetes) and glycated hemoglobin (HbA1c) levels [28]. The risks of all-cause and cancer mortality were significantly higher in patients with baseline diabetes than in those with normoglycemia. In subjects not taking anti-diabetic medications, both high and low HbA1c levels were associated with an elevated risk for all-cause mortality.

The presence of diabetes or hyperglycemia increases the risk for coronary artery calcification (CAC) development. In 2,076 subjects without diabetes who had a CACS of 0 at baseline, the risk for CAC development was assessed according to baseline glycemic status [29]. Over 4 years, the subjects who developed diabetes showed the highest proportion of subjects with incident CAC among the three groups. Insulin resistance was associated with a significantly increased risk for incident CAC, both in subjects who progressed from normal to impaired fasting glycemia and in subjects who developed diabetes. However, subjects without insulin resistance at baseline showed no significantly increased risk for incident CAC, even in those who developed diabetes, suggesting that the increased risk of incident CAC in relation to diabetes development was pronounced only in subjects with insulin resistance at baseline.

From the findings of this study, we could conclude that hyperglycemia and insulin resistance showed a significant association with the development and progression of subclinical atherosclerosis, as assessed by the CACS.


Adipose tissue is not simply an accumulation of fat; instead, it is an organ that stores excess energy in the form of triglycerides, secretes adipocytokines, and engages in cross-talk with other tissues [30]. Insulin is the hormone that causes excess energy to be stored in adipose tissue and not in other organs. However, in people with insulin resistance, excess energy could be stored in other tissues, such as the liver, abdomen, muscle, and perivascular area. This phenomenon is known as ectopic fat accumulation. NAFLD is a disease characterized by fat accumulation in the liver without a history of alcohol drinking [31]. As the liver is an organ where ectopic fat accumulation occurs, if someone has NAFLD, it means that ectopic fat accumulation has already taken place in that person, indicating that insulin resistance has developed.

NAFLD and diabetes are inextricably linked, as shown by many epidemiological studies [32]. It is known that 70% to 80% of patients with diabetes have NAFLD, and diabetic complications are more severe in patients with diabetes and NAFLD. It has also been established that NAFLD patients are more prone to non-alcoholic steatohepatitis and fibrosis if they have diabetes; therefore, preventing and controlling both diseases is a key component of CVD prevention.

In another study, we analyzed the associations of the visceral-to-subcutaneous abdominal fat ratio (VSR) with NAFLD and liver fibrosis [33]. In 7,456 KSHS examinees, the presence of fibrosis was defined by the fibrosis-4 score (FIB-4), and a high VSR predicted NAFLD risk and advanced fibrosis as assessed by the FIB-4 score.

We also retrospectively analyzed the association between insulin concentration and NAFLD risk [34]. In 4,956 KSHS subjects, higher baseline insulin concentrations were associated with a higher risk of developing NAFLD after 5 years, suggesting that hyperinsulinemia influences the development of NAFLD. Perhaps unsurprisingly, few studies have measured insulin levels in such a large number of subjects. In another study that analyzed the association between baseline homeostasis model assessment of insulin resistance (HOMA-IR) and NAFLD in 32,060 KSHS participants with 8 years of follow-up, we found that the degree of baseline insulin resistance, as assessed by HOMA-IR values, was positively associated with future fibrosis progression in patients with NAFLD who did not have diabetes.

The evidence from recent studies suggests that NAFLD is a CVD risk factor [35]. In 21,335 participants in the KSHS, the risk for CAC was compared between those with or without NAFLD and obesity assessed by body mass index. The risk for CAC was the highest in the group with both abnormalities, and the NAFLD-only group showed a significantly higher risk for CAC than the abdominal obesity-only group, suggesting that the presence of NAFLD could increase the risk for subclinical atherosclerosis regardless of the presence of obesity. In another study performed in 1,575 KSHS participants, the risk for CAC development was the highest in subjects with both NAFLD and high-sensitivity C-reactive protein (hs-CRP) levels ≥0.06 mg/dL, followed by those with only NAFLD, those with only hs-CRP ≥0.06 mg/dL, and those without NAFLD and hs-CRP <0.06 mg/dL, suggesting that the concomitant presence of NAFLD and systemic inflammation, as assessed by hs-CRP, increases the risk of CAC development.

NAFLD is one of the hottest research areas in the field of endocrinology and metabolism, and it has recently attracted considerable interest due to the increasing prevalence of metabolic diseases related to obesity, such as diabetes and MS. Further research is warranted to elucidate the relationship of NAFLD with other metabolic diseases.


There has recently been intense interest in the relationship between the variability of CVD risk factors and the risk of actual CVD or diabetes [36]. The details of the associations between the variability of CVD risk factors and increased CVD or diabetes risk vary among individual risk factors; however, a common mechanism could be increased oxidative stress and inflammation caused by the instability of risk factors.

We analyzed the relationship between the variability of total cholesterol (TC) levels and the risk for type 2 diabetes development in 2,827,950 participants of NHIS health check-ups without diabetes [37]. The highest risk of diabetes development was found in the highest decile of cholesterol variation compared with the lowest decile. Consistent results were obtained regardless of the use of anti-hyperlipidemic medication and baseline TC levels, suggesting that participants with a large variation in TC levels showed a higher risk of diabetes development.

In another study, we analyzed the association between body weight variability and the risk of diabetes development [38]. In 4,818 KSHS examinees in whom health examinations were performed in 5 consecutive years, high body weight variability had a significant association with an increased risk of diabetes development over 4 years, and this was particularly evident in those who were overweight or obese.

The hemoglobin glycation index (HGI) is calculated by subtracting the predicted HbA1c level from the measured HbA1c level. The predicted HbA1c level is calculated on the basis of the observed mean blood glucose level by using a linear regression equation between blood glucose and HbA1c levels. Individuals with a high or low HGI have HbA1c levels that are higher or lower than those expected from their blood glucose levels; these could be considered individual signatures [39,40]. We analyzed the association between incident CAC and changes in the HGI among participants without diabetes over 4 years [41]. Participants with a high baseline HGI and consistently high HGI showed a higher risk for incident CAC than those with a low baseline HGI, and an increased HGI over 4 years significantly increased the risk for CAC regardless of baseline HbA1c levels.


Recent Korean nationwide studies have suggested associations between glycemic status, obesity status, and various diseases in large numbers of participants. In 9,720,220 Korean adults who underwent national health examinations in 2009, the risk of HF was assessed according to baseline obesity and glycemic status [42]. Obesity showed an inverse-J-shape correlation with the risk of HF, and the risk increased in people with low body weight and those with class II or higher obesity. In addition, we, for the first time in the literature for a Korean population, reported 8% and 86% increased risks for HF in individuals with prediabetes and diabetes.

Furthermore, we analyzed the association between glycemic status and the risk of Parkinson’s disease in 8,443,353 Koreans who underwent national health examinations from 2009 to 2010 and were followed up until 2016 for the assessment of Parkinson’s disease [43]. The risk of Parkinson’s disease significantly increased as the baseline glycemic status worsened from normoglycemia to diabetes with a longer duration.

Although the exact mechanism underlying the association between these two diseases has not been fully elucidated, mitochondrial dysfunction, endoplasmic reticulum stress, chronic low-grade inflammation, and alterations in metabolism are thought to cause insulin resistance and ultimately neurodegenerative disorders, as well as diabetes.


The prevalence of risk factors related to MS, such as obesity, hyperglycemia, hypertension, and dyslipidemia is rapidly increasing, and variability of these risk factors is known to be related to unfavorable outcomes in terms of CVD and diabetes. NAFLD, which was thought to be only caused by fatty infiltration of the liver, is a well-known cause of diabetes, as well as a consequence of diabetes (and vice versa). Researchers have recently focused on NAFLD as a significant risk factor for CVD. In addition, MHO was a hot area of research due to the unknown mechanism by which obesity might not increase CVD risk, but recently published studies have debated the existence of MHO and argued that it is highly dependent on the definition. Lastly, as the global population of people with obesity and diabetes has rapidly increased, it has been reported that obesity and diabetes are related to diseases that were previously thought to be unrelated, such as HF and Parkinson’s disease.

As the content of the present review was drawn primarily from the results of the author’s own research, it might not have covered some of the puzzles that remain to be solved. However, these results allow us to conclude that the phenotypes of obesity can be completely different depending on the depots of accumulated fat, the corresponding muscle amount, and the presence of ectopic fat accumulation. Furthermore, NAFLD is a field of interest for both endocrinologists and hepatologists, and it is an area where excellent results can be achieved through collaboration. As NAFLD is considered to be a risk factor for CVD, further research in this field could prevent CVD in patients with obesity and diabetes. The most important lesson from research in this field is that when it comes to treating obesity, it is important to focus not just on losing weight, but losing weight in a healthy way, so that our patients can live without obesity-related comorbidities as long as possible.

In conclusion, from the results of the author’s own research, obesity (especially abdominal obesity) and its variability are strongly associated with various metabolic diseases related to ectopic fat accumulation and insulin resistance. In addition, hyperglycemia and insulin resistance, which could be caused by abdominal obesity, are related to type 2 diabetes and other unexpected diseases, such as Parkinson’s disease and HF. Finally, these relationships between metabolic risk factors could all influence vascular health, eventually leading to an increased risk of CVD (Fig. 1).

Fig. 1

Obesity and its associations with metabolic diseases and vascular health.


I, Eun-Jung Rhee, would like to express my sincere gratitude to emeritus professor Hun Ki Min (Namgok) for giving me the prestigious Namgok Award and hope that he rests in peace. I would like to thank Prof. Sun-Woo Kim, Prof. Won-Young Lee, Prof. Sung Koo Kang, Prof. Moo-Il Kang, Prof. Ki-Hyun Baek, and Prof. Ki-Won Oh for their unlimited support for my career as a researcher and as a clinician. I also would like to thank my colleagues in my department and my excellent fellows who had been trained in our department for their support. Finally, I would like to thank Prof. Mee Kyoung Kim and Hye Yeon Jang, the managing editor of Endocrinology and Metabolism (EnM), for her passion and love for EnM.


The Namgok Award is the highest scientific award of the Korean Endocrine Society, and is given to honor an individual who has made excellent contributions to progress in the field of endocrinology and metabolism. The Namgok Award is named after the pen name of Professor Hun Ki Min, who founded the Korean Endocrine Society in 1982. Professor Eun-Jung Rhee received the Namgok Award at the 9th Seoul International Congress of Endocrinology and Metabolism of the Korean Endocrine Society in October 2021.


No potential conflict of interest relevant to this article was reported.


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Fig. 1

Obesity and its associations with metabolic diseases and vascular health.