Journal of Korean Endocrine Society 1999;14(1):197-202.
Published online January 1, 2001.
A Case of Humoral Hypercalcemia of Malignancy Associated with Hepatoma: A Case in which both PTHrP and 1,25 (OH) 2D were elevated.
Seol Young Yoon, Chang Ryol Lee, Jun Ho Lee, So Jin Choi, Seung Pyo Son
Department of Internal Medicine, St. Benedict Hospital, Pusan, Korea.
Hypercalcemia is one of the most common paraneoplastic syndromes and believed to occur through two general mechanisms, one humoral and the other local. The former mechanism has been termed humoral hypercalcemia of malignancy (HHM) and has been associated with the secretion of various cytokines, including parathyroid hormone-related protein (PTHrP). PTHrP beats sttuctural and functional similarities to PTH and seems to play a key role in the pathogenesis of HHM. We experienced the case of HHM associated with hepatoma, a rare cause of HHM, in 48 year-old male. We found no evidence of bone metastasis. In this case, contrary to our general acknowledgment, serum 1,25 (OH)D concentration was elevated. We report this case with a brief review of related literatures.
Key Words: Hepatoma, Humoral Hypercalcemia of Malignancy, PTHrP

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