Endocrinol Metab > Volume 26(3); 2011 > Article
Endocrinology and Metabolism 2011;26(3):239-242.
DOI: https://doi.org/10.3803/EnM.2011.26.3.239    Published online September 1, 2011.
A Case of Adrenocortical Carcinoma Secreting Cortisol, Androgen and Aldosterone.
Jae Ho Choi, Ye Ri So, Yu Chul Hwang, In Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung, Seung Ae Yang
1Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea. chy1009@hotmail.com
2College of Nursing, Sungshin Women's University, Seoul, Korea.
Abstract
Primary adrenocortical carcinoma is a rare tumor, and is characterized by a peri-tumor mass effect and hormone excess signs. Adrenocortical carcinoma most commonly secretes cortisol, but tumors that secrete other adrenal hormones (aldosterone, androgen) are rare. Herein, we report the case of a 70-year-old woman with cortisol, androgen, and aldosterone-secreting adrenal carcinoma. The patient complained of generalized weakness, moon face, and central obesity. On laboratory examination, hypokalemia and metabolic alkalosis was detected. On the hormone test, cortisol, DHEA-S, and aldosterone were all increased. Abdominal CT showed a large right adrenal mass. She underwent right adrenalectomy and the histology revealed the presence of an adrenocortical carcinoma. After adrenalectomy, the patient was treated with hydrocortisone and mitotane.
Key Words: Adrenocortical carcinoma, Androgen, Cortisol, Cushing's syndrome, Primary aldosteronism


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