Journal of Korean Endocrine Society 1999;14(4):752-756.
Published online January 1, 2001.
A Case of Secondary Amyloid Goiter with Hypothyroidism.
Cheul Kag Park, Yeun Cheul Yang, Cheul Hee Lee, Jae Rak Jeong, Do Ha Kim, Jae Hee Suh, Jae Hoo Park, Young II Kim
1Department of Internal Medicine, Ulsan University Hospital, University of Ulsan, College of Medicine, Ulsan, Korea
2Department of Pathology, Ulsan University Hospital, University of Ulsan, College of Medicine, Ulsan, Korea
Abstract
Amyloidosis results from the deposition of insoluble, fibrous amyloid proteins, nearly always in the extracellular spaces of organs and tissues. There are several varieties of amyloidosis, each of which is identified by the immunochemical nature of amyloid protein fibrils. Amyloid goiter is a very rare clinical entity and can be confused with a neoplasm. We have experienced a case of amyloid goiter with hypothyroidism secondary to tuberculosis. A 20 years old women with 5 months history of pulmonary tuberculosis was admitted with complaints of diarrhea, abdominal pain, weight loss at one year ago. She had a non-tender, diffuse and firm goiter. Also she had normal thyroid function at the first admission but was found to be hypothyroid at the second admission, 10 months later. Histologic examination revealed amyloid deposition in thyroid gland, stomach, colon and rectum.
Key Words: Tuberculosis, Amyloid goiter, Hypothyroidism


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