Journal of Korean Endocrine Society 1999;14(4):771-778.
Published online January 1, 2001.
A Case of Ectopic ACTH Syndrome Caused by Thymic Carcinoid Tumor and Localized by PET.
Jong Chul Won, Sung Kwan Hong, Hyun Ju Lee, Sang Ook Kim, Yun Hee Jeong, Dae Hyuk Moon, Dong Kwan Kim, Kyung Yub Kong, Jae Sung Lee, Ki Soo Kim
1Division of endocrinology, Department of Internal medicine, Ulsan university, College of medicine, Asan Medical Center, Seoul, Korea.
2Department of Nuclear medicine, Ulsan university, College of medicine, Asan Medical Center, Seoul, Korea.
3Department of Chest surgery, Ulsan university, College of medicine, Asan Medical Center, Seoul, Korea.
4Department of diagnostic pathology, Ulsan university, College of medicine, Asan Medical Center, Seoul, Korea.
5Department of nuclear medicine, Korea Cancer Center Hospital, Seoul, Korea.
Abstract
Ectopic ACTH syndrome is frequently caused by lung cancer and uncommonly by other tumors such as thymic carcinoid. For its treatment, early diagnosis and complete resection is irresponsible, but some cases are remained unlocalized in spite of all diagnostic modalities. Here we report a case of ectopic ACTH syndrome which was localized by PET but could not be localized by conventional technique. A tumor at thymic area was ACTH secreting thymic carcinoid which was operated but couldnt resect completly. Glucocorticoid hypersecretion was persisted with chemotherapy, radiotherapy, and ketoconazole treatment. Patient died of sepsis after 12 months of diagnosis.
Key Words: Ectopic ACTH syndrome, PET, Thymic carcinoid


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