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Case Report 2 Cases of Ectopic ACTH Syndrome due to Thymic Neuroendocrine Carcinoma Associated with Different Clinical Manifestations.
Yu Jeong Park, Moon Kyu Lee, Jong Ryeal Hahm, Jung Ho Do, Sang Taek Heo, Ju Sung Kim, Yong Ki Min, Myung Shik Lee, Kwang Won Kim, Joung Ho Han
Endocrinology and Metabolism 2001;16(1):115-122

Published online: February 1, 2001
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1Division of Endocrinology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University of Medical School, Seoul, Korea.
2Department of Pathology, Samsung Medical Center, Sungkyunkwan University of Medical School, Seoul, Korea.
3Departmeut of Internal Medicine, College of Medicine, Gyeongsang National University, Chinju, Korea.

Primary neuroendocrine carcinoma of the thymus (formerly known as thymic carcinoids) are unusual tumors that account for 5% of all anterior mediastinal neoplasms. Thymic neuroendocrine carcinomas exhibit a much more aggressive behavior than those originating from other foregut locations and are associated with the ectopic ACTH syndrome in 38% of cases. Patients having a thymic neuroendocrine carcinoma usually present with symptoms such as chest tightness, dyspnea, a palpable neck mass and sometimes a weight gain. We report on 2 patients with thymic neuroendocrine carcinoma who showed different clinical manifestations each other. One presented with a typical. Cushingoid appearance and the other had symptoms of fatigue and weight loss which is a common symptom of malignant tumors.

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