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Original Article Cyclic Pamidronate Infusion in Primary Osteoporotic Women.
Bong Nam Chae, Eun Gyoung Hong, Seone Kyu Lee, Yoon Sok Chung, Kwan Wook Lee, Hyeon Man Kim
Endocrinology and Metabolism 2001;16(2):221-230

Published online: April 1, 2001
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1Department of Endocrinology and Metabolism, College of Medicine, Kwandong University, Gangnung, Korea.
2Department of Internal Medicine, Kumi CHA General Hospital, College of Medicine, Pochon CHA University, Pochon, Korea.
3Division of Endocrinology, Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
4Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea.

Bisphosphonates are now well established as successful antiresorptive agents for the prevention and treatment of osteoporosis. We investigated the effect of cyclic intravenous treatment with an aminobisphosphonate, pamidronate in cases of primary osteoporosis. METHODS: Eighteen patients with primary osteoporosis (bone mineral density BMD t-score < -2.5) received four courses of pamidronate (30 mg with 500 mL normal saline over 2 hours every 3 months). The serum biochemical parameters and bone turnover markers were measured before each treatment. The bone pain score, medication score, and the side effects were also monitored. BMD and simple spine X-ray were performed before and 1 year after of treatment. RESULTS: BMD at the lumbar spine (L2-4) significantly increased from 0.798+/-0.110 g/cm2 to 0.860+/-0.107 g/cm2 after 1 year of treatment with pamidronate: by +8.3+/-9.4% of baseline. BMDs at the femoral neck, Ward s triangle and the trochanter also increased, but not significantly. Serum total alkaline phosphatase (p<0.05) and urine deoxypyridinoline/creatinine (p=0.069) decreased with treatment. Other bone turnover markers were unchanged. The bone pain score decreased significantly. None of the patients experienced a new fracture during treatment. The frequency of the side effects following the first infusion was 61.1% (a transient fever and myalgia with flu-like symptoms in 10 patients and mild phlebitis in 1 patient). However, only two patients complained of flu-like symptoms after second infusion, and no patient complained following the third infusion. CONCLUSION: Cyclic intravenous treatment of pamidronate every three months was effective in increasing BMD and in the decreasing bone turnover rate, and was relatively well tolerated in primary osteoporotic women.

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