Journal of Korean Endocrine Society 2001;16(2):265-270.
Published online April 1, 2001.
A Case of Postpregnancy Spinal Osteoporosis.
Ji Young Seo, Hyeon Kyu Kim, Cheol Soo Choi, Doo Man Kim, Sung Hee Lim, Jae Myung Yoo, Moon Gi Choi, Huung Joon Yoo, Sung Woo Park, Jin Young Lee
1Department of Internal Medicine, Hallym University,College of Medicine, Chuncheon, Korea.
2Department of Orthopedics, Hallym University,College of Medicine, Chuncheon, Korea.
Osteoporosis is a common disease of the elderly and occurs especially in the postmenopausal women. Rarely, it occurs during a pregnancy or shortly thereafter and is accompanied by a substantial bone loss, resulting in fractures. The clinical significance of pregnancy-associated osteoporosis has been noted since the 1950s. Although its etiology is still unknown, it has recently been proposed that PTHrP may be an important causative factor in pregnancy-associated osteoporosis. There are three types of the pregnancy-associated osteoporosis, (1) a transient osteoporosis of the hip pregnancy, (2) a postpregnancy spinal osteoporosis and (3) a lactation-associated osteoporosis. Postpregnancy spinal osteoporosis typically occurs within three months after a first delivery and usually involving the axial skeleton accompanied by back pain, bone loss and a fracture. We present a case of postpregnancy spinal osteoporosis that developed three months after a first delivery. Our patient also showed multiple compression fractures in her lumbar spine and biochemical evidence of increased bone resorption.
Key Words: Pregnancy-associated osteoporosis, Fracture, PTHRP

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