Journal of Korean Endocrine Society 2002;17(4):583-588.
Published online August 1, 2002.
A Case of Metastatic Pulmonary Calcification in Primary Hyperparathyroidism.
Kwang Eun Lee, Hae Jin Kim, Si Hoon Lee, Sang Woon Bae, Eun Seok Kang, Hae Won Chung, Hye Sun Seo, Dae Jung Kim, Sang Soo Chung, Sun Jung Kim, Young Duk Song, Sung Kil Lim
1Department of Internal Medicine, Yonsei University, College of Medicine, Korea.
2Department of Endocrinology, National Health Insurance Corporation Ilsan Hospital, Korea.
3Department of Nuclear Medicine, National Health Insurance Corporation Ilsan Hospital, Korea.
Metastatic calcification is the deposition of calcium, in previously normal tissue, as a result of elevated plasma calcium and phosphorus product levels and has been reported in patients with parathyroid adenoma, parathyroid carcinoma, hyperparathyroidism due to chronic renal failure, vitamin D intoxication, and osteolytic bone tumors, such as multiple myelomas. The lungs are the most common site of metastatic calcification. We have experienced metastatic pulmonary calcification in a case of primary hyperparathyroidism. A 55-year old woman was admitted due to general weakness. From the laboratory evaluation, hypercalcemia and excess production of parathyroid hormone (PTH) were noted. technetium-99m-labelled sestamibi scintigraphy indicated an intense uptake in the lower pole area of the left thyroid gland, suggestive of a parathyroid adenoma. A technetium-99m phosphate (99mTc-MDP) bone scan showed increased uptakes in both lungs. A parathyroid lobectomy was performed, and primary hyperparathyroidism, due to a parathyroid adenoma, was finally diagnosed. A follow-up 99mTc-MDP bone scan showed the disappearance of the metastatic pulmonary calcification, with the clinical symptoms and biochemical parameters normalizing after 6 months.
Key Words: Metastatic pulmonary calcification, Primary hyperparathyroidism

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