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HOME > Endocrinol Metab > Volume 18(2); 2003 > Article
Case Report A Case of Pheochromocytoma with Ganglioneuronal Differentiation Producing Vasoactive Intestinal Peptide.
Min Ah Na, Sang Soo Kim, Dong Uk Kim, Jae Hoon Choi, Tae Kun Lee, Ok Nyu Kong, Jun Hyeop An, Jee Yeon Kim, Han Dong Sung, Chul Ho Joung, Seok Man Son, In Joo Kim, Yong Ki Kim
Endocrinology and Metabolism 2003;18(2):227-231
DOI: https://doi.org/
Published online: April 1, 2003
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1Department of Internal Medicine, Pusan National University, Korea.
2Department of Pathology, College of Medicine, Pusan National University, Korea.
3Wallace Memorial Baptist Hospital, Busan, Korea.

Vasoactive intestinal peptide(VIP) is a 28-amino acid peptide, which may cause secretory diarrhea by stimulating the production of adenylate cyclase. Neuroendocrine tumors, secreting vasoactive intestinal peptide (VIP), are almost always of a pancreatic in origin. However, a pheochromocytoma may produce several neuropeptides, containing VIP, as they are considered to be neuroendocrine tumors. A 57-year-old woman, who presented with chronic watery diarrhea, hypokalemia, weight loss and a left adrenal mass, is described. Histologically, the tumor was diagnosed as a pheoch-romocytoma, with ganglioneuronal differentiation, and was histochemically confirmed to produce a vasoactive intestinal polypeptide. A left adrenal VIP-producing pheochromocytoma was successfully resected. After surgery, her diarrhea subsided and the electrolytes, affected neuroendocrine hormone levels, blood pressure and blood sugar level were normalized.

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