Journal of Korean Endocrine Society 2003;18(3):306-310.
Published online June 1, 2003.
Rhabdomyolysis Associated with Hyponatremia.
Kyoung Wook Lee, Seong Bin Hong, Seung Baik Han, Bon Ju Jeong, Hwi Ra Park, Eun Sil Kim, Dong Hyo Hyun, Moon Suk Nam, Yong Seong Kim
Department of Internal Medicine, Inha University College of Medicine, Inchon, Korea.
Hyponatremia is a frequent condition of body fluid and electrolyte imbalance encountered in clinical practice. However, rhabdomyolysis has rarely been reported in association with hyponatremia. We experienced a 56-year-old woman who had developed symptomatic hyponatremia after prolonged nausea and subsequent rhabdomyolysis. Hyponatremia was probably mediated by hypersecretion of antidiuretic hormones.The woman had developed severe hypotonic hyponatremia with an alternation in mental status after suffering from severe nausea and vomiting for x months/years. She recovered with intensive supportive therapy, including hypertonic saline administration. One day after hospitalization, she complained of thigh pains; furthermore her serum creatine phosphokinase level had increased. She was treated with alkaline diuresis. Renal failure or compartment syndrome did not complicate the clinical course. The patient was discharged and returned to her normal daily activities. The possibility of rhabdomyolysis should be considered in patients with acute hyponatremia who have developed muscle pain.
Key Words: Hyponatremia, Rhabdomyolysis, Antidiuretic hormone

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