Journal of Korean Endocrine Society 2003;18(4):426-432.
Published online August 1, 2003.
A Case of Atypical McCune-Albright Syndrome Associated with Hyperthyroidism and Hypersecretion of Growth Hormone.
Moon Bin You, Ki Hoon Kang, Byung Soo Lee, Eun Ha Chae, Myung Chan Kim, Jae Il Jung, Sun Hee Park, Hyo Jin Lee, Seok Tae Jung
1Department of internal medicine, Seoul Adventist Hospital, Seoul, Korea.
2Department of anatomical pathology, Seoul Adventist Hospital, Seoul, Korea.
3Department of radiology, Seoul Adventist Hospital, Seoul, Korea.
McCune-Albright syndrome is characterized by polyostotic fibrous dysplasia, Caf -au-lait pigmentation and precocious puberty or other endocrinopathy. It can be caused by substitution of His, Cys or Gly for Arg 201st amino acid of the Gs protein subunit. The case of a 32-year-old woman, with atypical McCune-Albright syndrome, is reported. She had no skin lesion or precocity puberty. The polyostotic fibrous dysplasia was examined by a simple radiological image and whole body scan. She developed hyperthyroidism, with a multinodular toxic goiter. No thyroid related autoantibodies were detected. The cause of hyperthyroidism was thought to be a non- autoimmune thyroid hyperfunction. The level of growth hormone was not suppressed by oral glucose load. After a bromocriptine suppression test, the level of growth hormone decreased. There was no mass in the pituitary gland on a sellar MRI. A case of atypical McCune-Albright syndrome, including hyperthyroidism and hypersecretion of growth hormone, is reported.
Key Words: McCune-Albright syndrome, Fibrous dysplasia, Hyperthyroidism, Growth hormone hypersecretion

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