Endocrinol Metab > Volume 27(4); 2012 > Article
Endocrinology and Metabolism 2012;27(4):318-322.
DOI: https://doi.org/10.3803/EnM.2012.27.4.318    Published online December 20, 2012.
A Case of Latent Autoimmune Diabetes in Adults Developed after Surgical Cure of Growth Hormone Secreting Pituitary Tumor.
Wonjin Kim, Jung Ho Kim, Youngsook Kim, Ji Hye Huh, Su Jin Lee, Mi Sung Park, Eun Yeong Choe, Jeong Kyung Park, Myung Won Lee, Jae Won Hong, Byung Wan Lee, Eun Seok Kang, Bong Soo Cha, Eun Jig Lee, Hyun Chul Lee
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. edgo@yuhs.ac
2Institute of Endocrinology, Goodmorning Hospital, Pyeongtaek, Korea.
3Institute of Endocrinology, Gwangmyung Sungae Hospital, Gwangmyeong, Korea.
4Institute of Endocrine Research, Yonsei University College of Medicine, Seoul, Korea.
5Diabetes Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Abstract
Acromegaly is generally caused by a benign growth hormone (GH)-secreting pituitary adenoma. It is characterized by a wide range of complications; cardiovascular, respiratory, bone and joint, and metabolic complications. Among them, impaired glucose tolerance and diabetes mellitus, due to GH-induced insulin resistance, has been reported in approximately 16-46% and 19-56%. They are usually improved following the treatment of acromegaly, surgical or medical therapy. We report a first case of 36-year-old man who was paradoxically diagnosed with GAD antibody positive latent autoimmune diabetes in adults (LADA) after the surgical cure of acromegaly.
Key Words: Acromegaly, Type 2 diabetes mellitus


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