Journal of Korean Endocrine Society 2004;19(4):426-432.
Published online August 1, 2004.
A Case of Hashimoto's Thyroiditis Associated with Multiple Sclerosis.
Beom Ju Lee, Jong Chan Oh, Sang Yong Kim, Dong Hyun Choi, Jung In Kim, Gyung Nam Kim, Jin Hwa Kim, Hak Yeon Bae
Division of Endocrinology, Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, Korea.
Abstract
Multiple sclerosis is an autoimmune disorder, which may be associated with other rheumatologic or endocrine diseases induced by autoantibodies. Hashimoto's thyroiditis is also an organ-specific autoimmune disorder, and its association with multiple sclerosis during interferon therapy has been reported. Cases of Hashimoto's thyroiditis with multiple sclerosis are very rare. Herein is reported our experience of a 27 year-old woman who presented with general weakness, cold intolerance and progressive muscle weakness. She had been treated with levothyroxine due to subclinical hypothyroidism, which rather aggravated the symptom. In a CSF analysis, the myelin basic protein level was above 10 ng/dL and that of the IgG and the IgG index were 135 mg/dL and 7.8, respectively. In a brain MRI, demyelinating lesions in the left middle pontocerebellar junction and right subcortex were shown. She was diagnosed with multiple sclerosis, and the symptom improved after glucocorticoid and levothyroxine therapy. Herein is reported the first Korean case of Hashimoto's thyroiditis associated with multiple sclerosis
Key Words: Hashimoto's thyroiditis, Hypothyroidism, Multiple sclerosis


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