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Original Article Relationship between Serum Adiponectin and Development of the Metabolic Syndrome.
S S Park, K M Choi, S B Kwon, O H Ryu, H J Ryu, S Y Park, H Y Kim, J A Seo, K W Lee, S G Kim, N H Kim, D S Choi, S H Baik
Endocrinology and Metabolism 2004;19(5):492-500

Published online: October 1, 2004
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Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.

BACKGROUND
We investigated whether low serum adiponectin concentrations are able to predict the future development of type 2 diabetes and metabolic syndrome. METHODS: This was a prospective cohort study, which included 372 elderly Koreans that participated in the South-West Seoul (SWS) study, conducted in 1999 and 2002 in Seoul, Korea. Fasting and post-challenge 2-hour plasma glucose, body mass index (BMI), waist-to-hip ratio (WHR), blood pressure, lipid profiles, and serum adiponectin data were examined. RESULTS: Adiponectin concentrations obtained in 1999 and 2002 were highly correlated (r = 0.63, P < 0.0001), and the three-year within-person variation of the adiponectin concentrations was not significant (P=0.61). The serum adiponectin level was closely correlated with metabolic syndrome; negatively with BMI, WHR, blood pressure, triglyceride and blood glucose, and positively with HDL cholesterol. Subjects with metabolic syndrome showed lower serum adiponectin concentrations than those without (P < 0.0001). The baseline adiponectin levels were found to be correlated with subsequent changes in the WHR, LDL cholesterol, and fasting and post-load 2h glucose over the 3-year period, after adjusting the baseline values. A multiple logistic regression analysis showed that lower baseline serum adiponectin concentrations were significantly associated with the developments of type 2 diabetes and the metabolic syndrome after adjusting for age, gender, obesity, history of impaired fasting glucose or impaired glucose tolerance, hypertension and dyslipidemia. CONCLUSION: Reduced concentrations of adiponectin were found to be independently associated with increase risks of both type 2 diabetes and metabolic syndrome in elderly Koreans

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