Two Cases of Apathetic Hyperthyroidism associated with Peripheral Eosinophilia.

Kim, Mi Jin; Yoo, Kwang Ha; Kim, Byung Kook; Chang, Won Chul; Yeon, Jai Ho; Shin, Sang Youl

doi:2005.20.1.78

Endocrinol Metab > Volume 20(1); 2005 > Article

Case Report

Journal of Korean Endocrine Society 2005;20(1):78-83.
DOI: https://doi.org/10.3803/jkes.2005.20.1.78 Published online February 1, 2005.

Two Cases of Apathetic Hyperthyroidism associated with Peripheral Eosinophilia.

Mi Jin Kim, Kwang Ha Yoo, Byung Kook Kim, Won Chul Chang, Jai Ho Yeon, Sang Youl Shin

Department of Internal Medicine, College of Medicine, Konkuk University, Seoul, Korea.

Abstract

Peripheral eosinophilia is perpetually associated with many disease conditions like asthma, parasitic disease, IL-2 therapy, hypereosinophilic syndrome and eosinophilia/myalgia syndrome. Furthermore, peripheral eosinophilia may also be linked with Graves' disease, which is induced by thyroid-stimulating anti-TSH receptor antibodies and is related to type 2 helper T cell(Th2) predominant condition that is dependent on humoral immunity. In some of the cases of Graves' disease, thyrotoxicosis may induce peripheral eosinophilia associated with relative cortisol deficiency. In our present study, we present a case of two patients who were suffering from Graves' disease without any thyrotoxic symptoms and exhibited increased levels of peripheral eosinophil count. But, the count was observed to decreas in euthyroid state.

Key Words: Eosinophilia, Graves' disease