Endocrinol Metab > Volume 21(2); 2006 > Article
Journal of Korean Endocrine Society 2006;21(2):146-152.
DOI: https://doi.org/10.3803/jkes.2006.21.2.146    Published online April 1, 2006.
Reversible Pituitary Dysfunction in a Patient with Cushing's Syndrome due to Adrenal Adenoma.
Jee Hyun Kong, Kyung Wook Kim, Hei Jin Kim, Ji Sun Nam, Jin A Park, Jong Sook Park, Chul Sik Kim, Byung Soo Moon, Soon Won Hong, Chul Woo Ahn, Kyung Rae Kim
1Department of Internal Medicine, Yonsei University College of Medicine, Korea.
2Department of Pathology, Yonsei University College of Medicine, Korea.
Abstract
A 45-year-old woman who complained of weight gain and irregular menstruation was diagnosed as having Cushing's syndrome due to a 3 cm sized left adrenal adenoma. She underwent left adrenalectomy, and she also underwent combined anterior pituitary tests before and 9 months after the surgery. The growth hormone and adrenocorticotropic hormone levels failed to respond to hypoglycemia before the surgery, but their responses recovered after the surgery. Cortisol and thyroid stimulating hormone failed to respond to hypoglycemia and thyrotropin releasing hormone (TRH) before the surgery, respectively, but these were improved after the surgery. Luteinizing hormone, follicle stimulating hormone, and prolactin adequately responded to gonadotropin-releasing hormone and TRH, respectively, before and after the surgery. However, the basal levels of these hormones were higher after adrenalectomy, suggesting that hypercortisolemia had a significant influence on all the pituitary hormones.
Key Words: Cushing's syndrome, Hypopituitarism, Growth hormone, Thyroid stimulating hormone, Hypercortisolism


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