Endocrinol Metab > Volume 21(3); 2006 > Article
Journal of Korean Endocrine Society 2006;21(3):245-250.
DOI: https://doi.org/10.3803/jkes.2006.21.3.245    Published online June 1, 2006.
A Case of Pituitary Mucormycosis in Diabetic Patient with Acromegaly and Gastric Cancer.
Pyoung Rak Choi, Hong Jun Yu, Seung Wu Yang, Gyu Jong Kim, Hark Rim, Yu Ri Kim, Young Sik Choi, Yo Han Park, Bong Kwon Chun
1Department of Internal Medicine, Kosin University College of Medicine, Korea.
2Department of Pathology, Kosin University College of Medicine, Korea.
Abstract
Rhino-orbito-cerebral mucormycosis (ROCM) is an uncommon, acute, and aggressive fungal infection occurring in several immunocompromised states including poorly controlled diabetes. ROCM causes a very high residual morbidity and mortality due to the angioinvasion property of the fungus. Acromegaly is a chronic condition resulting from the excessive secretion of growth hormone, generally from pituitary adenoma. Although it has been demonstrated that acromegalic patients have an increased risk of neoplasm, gastric cancer with acromegaly is very rare. We experienced a case of pituitary mucormycosis in the diabetic patient with acromegaly and gastric cancer. The patient was treated successfully with subtotal gastrectomy for early gastric cancer, transsphenoidal surgery for pituitary adenoma, and a systemic application of amphotericin B for the mucormycosis.
Key Words: Acromegaly, Diabetes, Gastric cancer, Mucormycosis


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