Endocrinol Metab > Volume 21(4); 2006 > Article
Journal of Korean Endocrine Society 2006;21(4):333-337.
DOI: https://doi.org/10.3803/jkes.2006.21.4.333    Published online August 1, 2006.
A Case of Sheehan's Syndrome Presenting Central Diabetes Insipidus.
Dong Jin Kim, Nan Hee Kim, Ju Ri Park, Sae Jeong Yang, Hye Suk Kim, Hye Jin Yoo, Soo Yeon Park, Ohk Hyun Ryu, Kye Won Lee, Hee Young Kim, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi
Department of Internal Medicine, Korea University College of Medicine, Korea.
Sheehan's syndrome occurs as a result of ischemic pituitary necrosis due to severe postpartum hemorrhage. The manifestations of this clinical syndrome are most often caused by a deficiency in the hormones produced by the anterior pituitary gland, whereas the neurohypophysis is usually preserved but can be involved in severe cases that manifest as diabetes insipidus. This is a report of Sheehan's syndrome that manifested with diabetes insipidus as presenting symptom 2 month's after delivery. The patient suffered massive bleeding, so received a blood transfusion. A combined pituitary stimulation and water deprivation test revealed deficiencies of not only anterior pituitary hormones, such as growth hormone and prolactin, but also of anti-diuretic hormone. We report this case, with a review of the literature.
Key Words: Central diabetes insipidus, Hypopituitarism, Postpartum hemorrhage, Sheehan's syndrome

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