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Original Article Adiponectin and Ghrelin Polymorphism in Korean Women with Polycystic Ovary Syndrome.
Hyejin Lee, Eun Kyung Byun, Hwi Ra Park, Jee Young Oh, Youngsun Hong, Yeon Ah Sung, Hyewon Chung
Endocrinology and Metabolism 2006;21(5):394-401
DOI: https://doi.org/10.3803/jkes.2008.21.5.394
Published online: October 1, 2006
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1Department of Internal Medicine, Ewha Womans University College of Medicine, Korea.
2Department of Gynecology, Ewha Womans University College of Medicine, Korea.

BACKGROUND
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and chronic anovulation, and this is a common disorder in premenopausal women. However, the pathogenesis is still uncertain. There has been no studies about PCOS-related genetic abnormalities in Korea. In this study, we examined the frequency of the adiponectin and ghrelin genotypes in Korean women with PCOS. METHODS: Fifty four women with PCOS and 174 regular cycling healthy women were recruited for the study, and their reproductive hormones and metabolic profiles were measured. The polymorphisms of the ghrelin and adiponectin genes were analyzed. RESULTS: The frequency of ghrelin gene polymorphism was not different between the women with PCOS and the controls. The frequency of the TG adiponectin genotype was higher and the frequency of the TT genotype was lower in the women with PCOS compared to the controls (P < 0.05). For the PCOS women with GG adiponectin genotype, their triglycerides levels were significantly higher compared to the PCOS women with the TT and TG genotypes even after adjusting for the BMI. CONCLUSION: Adiponectin gene polymorphism is associated with presence of PCOS and it is responsible for the dyslipidemia seen in PCOS. Yet further study is required to confirm the role of this genetic polymorphism in the susceptibility to PCOS and the associated metabolic features.

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