Endocrinol Metab > Volume 21(6); 2006 > Article
Journal of Korean Endocrine Society 2006;21(6):548-551.
DOI: https://doi.org/10.3803/jkes.2006.21.6.548    Published online December 1, 2006.
A Case of Methimazole-induced Pancytopenia: Successful Treatment with Recombinant Human Granulocyte Colony-stimulating Factor.
Joo Hyoung Lee, Jihyun Lee, Sang Hun Sung, Sung Hwa Bae, Sang Gyung Kim, Hoon Kyu Oh
1Department of Internal Medicine, School of Medicine, Daegu Catholic University, Korea.
2Department of Laboratory Medicine, School of Medicine, Daegu Catholic University, Korea.
3Department of Pathology, School of Medicine, Daegu Catholic University, Korea.
Abstract
Methimazole has remained the cornerstone for the treatment of hyperthyroidism since 1940's and it is a well-tolerated antithyroid drug. Pancytopenia is one of the major side effects of methimazole, but its occurrence is very rare. There have been some case reports about methimazole-induced pancytopenia that was treated with recombinant human granulocyte colony-stimulating factor (G-CSF), but its usefulness is still controversial. We present here a case of a 50-year-old female who had been treated with methimazole for hyperthyroidism and she subsequently presented pancytopenia. G-CSF was given for 10 days and she successfully recovered from the pancytopenia.
Key Words: Hyperthyroidism, Methimazole, Pancytopenia, Recombinant human granulocyte colony-stimulating factor


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