Endocrinol Metab > Volume 27(3); 2012 > Article
Endocrinology and Metabolism 2012;27(3):173-179.
DOI: https://doi.org/10.3803/EnM.2012.27.3.173    Published online September 19, 2012.
RET: A Multi-Faceted Gene in Human Cancer.
Massimo Santoro, Francesca Carlomagno, Rosa Marina Melillo
Department of Biology and Cellular and Molecular Pathology, University of Naples Federico II School of Medicine and Surgery, Naples, Italy. masantor@unina.it
REarranged during Transfection (RET) gene encodes a receptor tyrosine kinase and it was initially discovered as an in vitro transforming gene. For many years, RET has been involved in papillary thyroid carcinoma and medullary thyroid carcinoma. More recently, lung adenocarcinoma and chronic myelomonocytic leukemia samples have been found to display RET gene rearrangements. This knowledge is stimulating the search for protein kinase inhibitors to combat RET-driven malignancies.
Key Words: Kinase, Neoplasms, Oncogenes, Rearranged during transfection, Signal transduction, Thyroid

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