Endocrinol Metab > Volume 23(3); 2008 > Article
Journal of Korean Endocrine Society 2008;23(3):204-209.
DOI: https://doi.org/10.3803/jkes.2008.23.3.204    Published online June 1, 2008.
Two Cases of Primary Hyperparathyroidism Associated with Colon Cancer.
Sang Hoon Chun, Yun Kyung Kim, Jae Seung Yun, Eun Hee Jang, Shin Ae Park, Jae Hyung Cho, Seung Hyun Ko, Yu Bai Ahn, Young Jin Suh, Jun Gi Kim
1Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Korea.
2Department of Surgery, The Catholic University of Korea, College of Medicine, Korea.
Abstract
Hypercalcemia is often observed in cancer patients secondary to parathyroid hormone (PTH) related peptide production. However, primary hyperparathyroidism and colon cancer rarely present simultaneously. Calcium is believed to have a chemopreventive effect against colorectal cancer because it reduces crypt cell hyperproliferation in both humans and in animals. There is evidence to suggest that the incidence of colorectal cancer in humans is reduced by high calcium intake. In patients with primary hyperparathyroidism, increased PTH activates 1,25(OH)2D and enhances calcium absorption in the gut. Consequently, the calcium level in the lumen is decreased, leading to an elevated risk of colorectal cancer. We report two patients with colon cancer and hypercalcemia secondary to primary hyperparathyroidism, along with a brief review of the literature.
Key Words: colonic neoplasms, hypercalcemia, hyperparathyroidism


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