Endocrinol Metab > Volume 23(4); 2008 > Article
Journal of Korean Endocrine Society 2008;23(4):260-265.
DOI: https://doi.org/10.3803/jkes.2008.23.4.260    Published online August 1, 2008.
A Case of Panhypopituitarism and Central Diabetes Insipidus Caused by Primary Central Nervous System Lymphoma.
Mi Sun Ahn, Soon Sun Kim, Tae Ho Kim, Seung Jin Han, Dae Jung Kim, Hugh Chul Kim, Se Hyuk Kim, Jae Ho Han, Ho Sung Kim, Yoon Sok Chung
1Department of Endocrinology and Metabolism, Ajou University School of MedicineKorea.
2Department of Hematology-Oncology, Ajou University School of MedicineKorea.
3Department of Neurosurgery, Ajou University School of MedicineKorea.
4Department of Pathology, Ajou University School of MedicineKorea.
5Department of Radiology, Ajou University School of Medicine, Korea.
Primary central nervous system (CNS) lymphoma is an uncommon neoplasm. However, the incidence of primary CNS lymphoma has increased more than 10-fold over the past three decades, and continues to accelerate. Currently, primary CNS lymphoma represents 4 to 7 percent of all newly diagnosed primary CNS tumors. Primary CNS lymphoma may arise from different parts of the brain, with deep hemispheric periventricular white matter being the most common site of origin. The presenting symptoms in primary CNS lymphoma vary depending on the location of the mass. Involvement of the hypothalamic-pituitary axis may cause hypopituitarism, diabetes insipidus, headache, diplopia, and blurred vision.
Key Words: central diabetes insipidus, panhypopituitarism, primary CNS lymphoma

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