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HOME > Endocrinol Metab > Volume 23(6); 2008 > Article
Case Report Two Cases of the Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma.
Hee Kwan Won, Myoung Jun Lee, Joo Ho Park, In Girl Song, Go Eun Lee, Ji Hyun Jeong, Jee Young Cheon, Hae Joung Sul, Dong Mi Lim, Keun Young Park
Endocrinology and Metabolism 2008;23(6):430-437
DOI: https://doi.org/10.3803/jkes.2008.23.6.430
Published online: December 1, 2008
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1Department of Internal Medicine, Konyang University Medical School, Daejeon, Korea.
2Department of Pathology, Konyang University Medical School, Daejeon, Korea.
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Abstract

The diffuse sclerosing variant of papillary thyroid carcinoma (DSPTC) is a rare histological subtype characterized by diffuse involvement of one or both thyroid lobes, widespread lymphatic permeation, prominent fibrosis, squamous metaplasia, abundant psammoma body and lymphatic infiltration. This subtype usually occurs in young female, and exhibits a higher frequency of cervical and distant metastasis. DSPTC clinically resembles Hashimoto's thyroiditis, and often delays the correct diagnosis. We experienced two patients with DSPTC: the one patient presented with a neck mass lasting for a month, and in the other patient, a thyroid lesion was incidentally found during a medical examination.

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